Incidence and management of prostatic urethra recurrence in a cohort of 21 patients who received BCG induction for non-muscle invasive bladder cancer
CONCLUSION: Patients with PU recurrences following intravesical BCG have a high-risk disease phenotype with a significant risk of recurrence. Conservative management may be appropriate for well-selected patients who do not desire a cystoprostatectomy.PMID:38688797 | DOI:10.1016/j.urolonc.2024.04.017 (Source: Urologic Oncology)
Source: Urologic Oncology - April 30, 2024 Category: Urology & Nephrology Authors: Justin W Ingram Rainjade Chung Caroline Laplaca James M McKiernan Andrew T Lenis Christopher B Anderson Source Type: research
Cystectomy for bladder cancer in Sweden - short-term outcomes after centralization
CONCLUSION: After the centralization of the cystectomy-care in Sweden, older patients and individuals with more extensive comorbidity were offered RC whereas 90-day mortality and the proportion of patients subjected to reoperations within 90 days of surgery decreased without increasing waiting times.PMID:38685576 | DOI:10.2340/sju.v59.40120 (Source: Scandinavian Journal of Urology)
Source: Scandinavian Journal of Urology - April 30, 2024 Category: Urology & Nephrology Authors: Fredrik Liedberg Oskar Hagberg Firas Aljabery Ove Andr én Victor Falini Truls G årdmark Viveka Str öck Tomas Jerlstr öm Source Type: research
Incidence and management of prostatic urethra recurrence in a cohort of 21 patients who received BCG induction for non-muscle invasive bladder cancer
CONCLUSION: Patients with PU recurrences following intravesical BCG have a high-risk disease phenotype with a significant risk of recurrence. Conservative management may be appropriate for well-selected patients who do not desire a cystoprostatectomy.PMID:38688797 | DOI:10.1016/j.urolonc.2024.04.017 (Source: Urologic Oncology)
Source: Urologic Oncology - April 30, 2024 Category: Urology & Nephrology Authors: Justin W Ingram Rainjade Chung Caroline Laplaca James M McKiernan Andrew T Lenis Christopher B Anderson Source Type: research
Genes, Vol. 15, Pages 577: Comprehensive Bioinformatic Investigation of TP53 Dysregulation in Diverse Cancer Landscapes
ynski
P53 overexpression plays a critical role in cancer pathogenesis by disrupting the intricate regulation of cellular proliferation. Despite its firmly established function as a tumor suppressor, elevated p53 levels can paradoxically contribute to tumorigenesis, influenced by factors such as exposure to carcinogens, genetic mutations, and viral infections. This phenomenon is observed across a spectrum of cancer types, including bladder (BLCA), ovarian (OV), cervical (CESC), cholangiocarcinoma (CHOL), colon adenocarcinoma (COAD), diffuse large B-cell lymphoma (DLBC), esophageal carcinoma (ESCA), head and neck squamou...
Source: Genes - April 30, 2024 Category: Genetics & Stem Cells Authors: Ruby Khan Bakht Pari Krzysztof Puszynski Tags: Article Source Type: research
Overexpressed KCNK1 regulates potassium channels affecting molecular mechanisms and biological pathways in bladder cancer
ConclusionsKCNK1 was significantly overexpressed in BC. A complex and sophisticated three-dimensional spatial transcriptional regulatory network existed in the KCNK1 TSS and promoted the upregulated of KCNK1 expression. The high expression of KCNK1 might be involved in the cell cycle, cellular metabolism, and tumour microenvironment through the regulation of potassium channels, and ultimately contributed to the deterioration of BC. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 30, 2024 Category: Research Source Type: research
