Comparative analysis of simultaneous integrated boost and sequential boost radiotherapy in node-positive cervical cancer: dosimetric and radiobiological considerations
This study undertakes a comprehensive dosimetric and radiobiological comparison between these two boost strategies. The study encompassed ten patients who underwent RT for cervical cancer with node-positive disease. Two sets of treatment plans were generated for each patient: SIB-VMAT and SEQ-VMAT. Dosimetric as well as radiobiological parameters including tumour control probability (TCP) and normal tissue complication probability (NTCP) were compared. Both techniques were analyzed for two different levels of LN involvement - only pelvic LNs and pelvic with para-aortic LNs. Statistical analysis was performed using SPSS sof...
Source: Cancer Control - May 9, 2024 Category: Cancer & Oncology Authors: Ritusha Mishra Shreya Singh Ganesh Patel Abhijit Mandal Himanshu Mishra Ankita Pandey Bajarang Bahadur Pramod Kumar Singh Shikha Sachan Mallika Tewari Source Type: research
J-AVENUE: A retrospective, real-world study evaluating patient characteristics and outcomes in patients with advanced urothelial carcinoma treated with avelumab first-line maintenance therapy in Japan
CONCLUSIONS: Findings from J-AVENUE show the effectiveness of avelumab first-line maintenance in patients with advanced urothelial carcinoma in Japan in clinical practice, with similar progression-free survival to JAVELIN Bladder 100 and previous real-world studies, supporting its use as a standard of care.PMID:38722221 | DOI:10.1111/iju.15473 (Source: Cancer Control)
Source: Cancer Control - May 9, 2024 Category: Cancer & Oncology Authors: Eiji Kikuchi Nozomi Hayakawa Masashi Nakayama Masahiro Uno Hiroomi Nakatsu Chiyoe Kitagawa Hideaki Miyake Takeshi Yamada Kazutoshi Fujita Hideaki Shimoyama Kiyoaki Nishihara Mizuki Kobayashi Motonobu Nakamura Kiyohide Fujimoto Takeshi Sano Naotaka Nishiya Source Type: research
CRISPR-based gene expression platform for precise regulation of bladder cancer
Cell Mol Biol Lett. 2024 May 9;29(1):66. doi: 10.1186/s11658-024-00569-7.ABSTRACTThe development of compact CRISPR systems has facilitated delivery but has concurrently reduced gene editing efficiency, thereby limiting the further utilization of CRISPR systems. Enhancing the efficiency of CRISPR systems poses a challenging task and holds significant implications for the advancement of biotechnology. In our work, we report a synthetic dual-antibody system that can stably exist in the intracellular environment, specifically inhibiting the functions of NF-κB and β-catenin. This not only elevates the transgenic expression of...
Source: Mol Biol Cell - May 9, 2024 Category: Molecular Biology Authors: Tianying Zhan Xiao Li Jiumin Liu Chujin Ye Source Type: research
CRISPR-based gene expression platform for precise regulation of bladder cancer
Cell Mol Biol Lett. 2024 May 9;29(1):66. doi: 10.1186/s11658-024-00569-7.ABSTRACTThe development of compact CRISPR systems has facilitated delivery but has concurrently reduced gene editing efficiency, thereby limiting the further utilization of CRISPR systems. Enhancing the efficiency of CRISPR systems poses a challenging task and holds significant implications for the advancement of biotechnology. In our work, we report a synthetic dual-antibody system that can stably exist in the intracellular environment, specifically inhibiting the functions of NF-κB and β-catenin. This not only elevates the transgenic expression of...
Source: Cellular and Molecular Biology Letters - May 9, 2024 Category: Biochemistry Authors: Tianying Zhan Xiao Li Jiumin Liu Chujin Ye Source Type: research
Comparative analysis of simultaneous integrated boost and sequential boost radiotherapy in node-positive cervical cancer: dosimetric and radiobiological considerations
This study undertakes a comprehensive dosimetric and radiobiological comparison between these two boost strategies. The study encompassed ten patients who underwent RT for cervical cancer with node-positive disease. Two sets of treatment plans were generated for each patient: SIB-VMAT and SEQ-VMAT. Dosimetric as well as radiobiological parameters including tumour control probability (TCP) and normal tissue complication probability (NTCP) were compared. Both techniques were analyzed for two different levels of LN involvement - only pelvic LNs and pelvic with para-aortic LNs. Statistical analysis was performed using SPSS sof...
Source: Radiation and Environmental Biophysics - May 9, 2024 Category: Physics Authors: Ritusha Mishra Shreya Singh Ganesh Patel Abhijit Mandal Himanshu Mishra Ankita Pandey Bajarang Bahadur Pramod Kumar Singh Shikha Sachan Mallika Tewari Source Type: research
Localized Urinary Bladder Amyloidosis as Urothelial Cancer Mimicker
CONCLUSIONS.—: These cases of urinary bladder amyloidosis highlight the importance of considering rare amyloidosis in the differential diagnosis of hematuria and cystoscopy with a lesion mimicking malignancy.PMID:38724031 | DOI:10.5858/arpa.2023-0559-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - May 9, 2024 Category: Laboratory Medicine Authors: Aayushma Regmi Maitri Mehta Ahmer V Farooq Thomas M Turk Eva M Wojcik Maria M Picken Source Type: research
CRISPR-based gene expression platform for precise regulation of bladder cancer
Cell Mol Biol Lett. 2024 May 9;29(1):66. doi: 10.1186/s11658-024-00569-7.ABSTRACTThe development of compact CRISPR systems has facilitated delivery but has concurrently reduced gene editing efficiency, thereby limiting the further utilization of CRISPR systems. Enhancing the efficiency of CRISPR systems poses a challenging task and holds significant implications for the advancement of biotechnology. In our work, we report a synthetic dual-antibody system that can stably exist in the intracellular environment, specifically inhibiting the functions of NF-κB and β-catenin. This not only elevates the transgenic expression of...
Source: Cellular and Molecular Biology Letters - May 9, 2024 Category: Biochemistry Authors: Tianying Zhan Xiao Li Jiumin Liu Chujin Ye Source Type: research
Comparative analysis of simultaneous integrated boost and sequential boost radiotherapy in node-positive cervical cancer: dosimetric and radiobiological considerations
This study undertakes a comprehensive dosimetric and radiobiological comparison between these two boost strategies. The study encompassed ten patients who underwent RT for cervical cancer with node-positive disease. Two sets of treatment plans were generated for each patient: SIB-VMAT and SEQ-VMAT. Dosimetric as well as radiobiological parameters including tumour control probability (TCP) and normal tissue complication probability (NTCP) were compared. Both techniques were analyzed for two different levels of LN involvement - only pelvic LNs and pelvic with para-aortic LNs. Statistical analysis was performed using SPSS sof...
Source: Radiation and Environmental Biophysics - May 9, 2024 Category: Physics Authors: Ritusha Mishra Shreya Singh Ganesh Patel Abhijit Mandal Himanshu Mishra Ankita Pandey Bajarang Bahadur Pramod Kumar Singh Shikha Sachan Mallika Tewari Source Type: research
Localized Urinary Bladder Amyloidosis as Urothelial Cancer Mimicker
CONCLUSIONS.—: These cases of urinary bladder amyloidosis highlight the importance of considering rare amyloidosis in the differential diagnosis of hematuria and cystoscopy with a lesion mimicking malignancy.PMID:38724031 | DOI:10.5858/arpa.2023-0559-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - May 9, 2024 Category: Laboratory Medicine Authors: Aayushma Regmi Maitri Mehta Ahmer V Farooq Thomas M Turk Eva M Wojcik Maria M Picken Source Type: research
Comparative analysis of simultaneous integrated boost and sequential boost radiotherapy in node-positive cervical cancer: dosimetric and radiobiological considerations
This study undertakes a comprehensive dosimetric and radiobiological comparison between these two boost strategies. The study encompassed ten patients who underwent RT for cervical cancer with node-positive disease. Two sets of treatment plans were generated for each patient: SIB-VMAT and SEQ-VMAT. Dosimetric as well as radiobiological parameters including tumour control probability (TCP) and normal tissue complication probability (NTCP) were compared. Both techniques were analyzed for two different levels of LN involvement - only pelvic LNs and pelvic with para-aortic LNs. Statistical analysis was performed using SPSS sof...
Source: Radiation and Environmental Biophysics - May 9, 2024 Category: Physics Authors: Ritusha Mishra Shreya Singh Ganesh Patel Abhijit Mandal Himanshu Mishra Ankita Pandey Bajarang Bahadur Pramod Kumar Singh Shikha Sachan Mallika Tewari Source Type: research
Localized Urinary Bladder Amyloidosis as Urothelial Cancer Mimicker
CONCLUSIONS.—: These cases of urinary bladder amyloidosis highlight the importance of considering rare amyloidosis in the differential diagnosis of hematuria and cystoscopy with a lesion mimicking malignancy.PMID:38724031 | DOI:10.5858/arpa.2023-0559-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - May 9, 2024 Category: Laboratory Medicine Authors: Aayushma Regmi Maitri Mehta Ahmer V Farooq Thomas M Turk Eva M Wojcik Maria M Picken Source Type: research
Comparative analysis of simultaneous integrated boost and sequential boost radiotherapy in node-positive cervical cancer: dosimetric and radiobiological considerations
This study undertakes a comprehensive dosimetric and radiobiological comparison between these two boost strategies. The study encompassed ten patients who underwent RT for cervical cancer with node-positive disease. Two sets of treatment plans were generated for each patient: SIB-VMAT and SEQ-VMAT. Dosimetric as well as radiobiological parameters including tumour control probability (TCP) and normal tissue complication probability (NTCP) were compared. Both techniques were analyzed for two different levels of LN involvement - only pelvic LNs and pelvic with para-aortic LNs. Statistical analysis was performed using SPSS sof...
Source: Radiation and Environmental Biophysics - May 9, 2024 Category: Physics Authors: Ritusha Mishra Shreya Singh Ganesh Patel Abhijit Mandal Himanshu Mishra Ankita Pandey Bajarang Bahadur Pramod Kumar Singh Shikha Sachan Mallika Tewari Source Type: research
Comparative analysis of simultaneous integrated boost and sequential boost radiotherapy in node-positive cervical cancer: dosimetric and radiobiological considerations
This study undertakes a comprehensive dosimetric and radiobiological comparison between these two boost strategies. The study encompassed ten patients who underwent RT for cervical cancer with node-positive disease. Two sets of treatment plans were generated for each patient: SIB-VMAT and SEQ-VMAT. Dosimetric as well as radiobiological parameters including tumour control probability (TCP) and normal tissue complication probability (NTCP) were compared. Both techniques were analyzed for two different levels of LN involvement - only pelvic LNs and pelvic with para-aortic LNs. Statistical analysis was performed using SPSS sof...
Source: Radiation and Environmental Biophysics - May 9, 2024 Category: Physics Authors: Ritusha Mishra Shreya Singh Ganesh Patel Abhijit Mandal Himanshu Mishra Ankita Pandey Bajarang Bahadur Pramod Kumar Singh Shikha Sachan Mallika Tewari Source Type: research
Comparative analysis of simultaneous integrated boost and sequential boost radiotherapy in node-positive cervical cancer: dosimetric and radiobiological considerations
This study undertakes a comprehensive dosimetric and radiobiological comparison between these two boost strategies. The study encompassed ten patients who underwent RT for cervical cancer with node-positive disease. Two sets of treatment plans were generated for each patient: SIB-VMAT and SEQ-VMAT. Dosimetric as well as radiobiological parameters including tumour control probability (TCP) and normal tissue complication probability (NTCP) were compared. Both techniques were analyzed for two different levels of LN involvement - only pelvic LNs and pelvic with para-aortic LNs. Statistical analysis was performed using SPSS sof...
Source: Radiation and Environmental Biophysics - May 9, 2024 Category: Physics Authors: Ritusha Mishra Shreya Singh Ganesh Patel Abhijit Mandal Himanshu Mishra Ankita Pandey Bajarang Bahadur Pramod Kumar Singh Shikha Sachan Mallika Tewari Source Type: research
Comparative analysis of simultaneous integrated boost and sequential boost radiotherapy in node-positive cervical cancer: dosimetric and radiobiological considerations
This study undertakes a comprehensive dosimetric and radiobiological comparison between these two boost strategies. The study encompassed ten patients who underwent RT for cervical cancer with node-positive disease. Two sets of treatment plans were generated for each patient: SIB-VMAT and SEQ-VMAT. Dosimetric as well as radiobiological parameters including tumour control probability (TCP) and normal tissue complication probability (NTCP) were compared. Both techniques were analyzed for two different levels of LN involvement - only pelvic LNs and pelvic with para-aortic LNs. Statistical analysis was performed using SPSS sof...
Source: Radiation and Environmental Biophysics - May 9, 2024 Category: Physics Authors: Ritusha Mishra Shreya Singh Ganesh Patel Abhijit Mandal Himanshu Mishra Ankita Pandey Bajarang Bahadur Pramod Kumar Singh Shikha Sachan Mallika Tewari Source Type: research
