Efficacy and Toxicity of Vincristine and CYP3A5 Genetic Polymorphism in Rhabdomyosarcoma Pediatric Egyptian Patients
CONCLUSION: CYP3A5*1/*1 have less severe vincristine-induced neuropathy than CYP3A5 *1/*3, CYP3A5 *1/*6 and CYP3A5 *3/*3, CYP3A5 *3/*6. There is a significant influence of CYP3A5 mutation on neuropathy grade and assist of ADL as a part of neurotoxicity.PMID:38680001 | DOI:10.31557/APJCP.2024.25.4.1391 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Norhan Shalaby Hala F Zaki Osama A Badary Sherif Kamal Mohamed Nagy Dalia Makhlouf Amr Elnashar Enas Elnadi Sameh A Abdelshafi Sherif Abouelnaga Mona M Saber Source Type: research
Correlation between Ki-67 or Profilin-1 Expression Levels, Clinicopathological Characteristics and Postoperative Prognosis in Patients with Bladder Cancer
CONCLUSION: The positive expression rates of Ki-67 and PFN1 in bladder tumor tissue are significantly higher than those in bladder tissue, and pathological pattern, histological grade, clinical stage, infiltration, and lymph node metastasis are related to the positive expression rates of Ki-67 and PFN1, and different genders, ages, tumors diameter and vascular invasion are not related to the positive expression rates of Ki-67 and PFN1. The survival time and three-year survival rates of bladder cancer patients with Ki-67 positive and PFN1 positive expression are shorter.PMID:38684494 | DOI:10.62713/aic.3335 (Source: Annali ...
Source: Annali Italiani di Chirurgia - April 29, 2024 Category: Surgery Authors: Jianwen Li Source Type: research
Efficacy and Toxicity of Vincristine and CYP3A5 Genetic Polymorphism in Rhabdomyosarcoma Pediatric Egyptian Patients
CONCLUSION: CYP3A5*1/*1 have less severe vincristine-induced neuropathy than CYP3A5 *1/*3, CYP3A5 *1/*6 and CYP3A5 *3/*3, CYP3A5 *3/*6. There is a significant influence of CYP3A5 mutation on neuropathy grade and assist of ADL as a part of neurotoxicity.PMID:38680001 | DOI:10.31557/APJCP.2024.25.4.1391 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Norhan Shalaby Hala F Zaki Osama A Badary Sherif Kamal Mohamed Nagy Dalia Makhlouf Amr Elnashar Enas Elnadi Sameh A Abdelshafi Sherif Abouelnaga Mona M Saber Source Type: research
Correlation between Ki-67 or Profilin-1 Expression Levels, Clinicopathological Characteristics and Postoperative Prognosis in Patients with Bladder Cancer
CONCLUSION: The positive expression rates of Ki-67 and PFN1 in bladder tumor tissue are significantly higher than those in bladder tissue, and pathological pattern, histological grade, clinical stage, infiltration, and lymph node metastasis are related to the positive expression rates of Ki-67 and PFN1, and different genders, ages, tumors diameter and vascular invasion are not related to the positive expression rates of Ki-67 and PFN1. The survival time and three-year survival rates of bladder cancer patients with Ki-67 positive and PFN1 positive expression are shorter.PMID:38684494 | DOI:10.62713/aic.3335 (Source: Annali ...
Source: Annali Italiani di Chirurgia - April 29, 2024 Category: Surgery Authors: Jianwen Li Source Type: research
Efficacy and Toxicity of Vincristine and CYP3A5 Genetic Polymorphism in Rhabdomyosarcoma Pediatric Egyptian Patients
CONCLUSION: CYP3A5*1/*1 have less severe vincristine-induced neuropathy than CYP3A5 *1/*3, CYP3A5 *1/*6 and CYP3A5 *3/*3, CYP3A5 *3/*6. There is a significant influence of CYP3A5 mutation on neuropathy grade and assist of ADL as a part of neurotoxicity.PMID:38680001 | DOI:10.31557/APJCP.2024.25.4.1391 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Norhan Shalaby Hala F Zaki Osama A Badary Sherif Kamal Mohamed Nagy Dalia Makhlouf Amr Elnashar Enas Elnadi Sameh A Abdelshafi Sherif Abouelnaga Mona M Saber Source Type: research
Correlation between Ki-67 or Profilin-1 Expression Levels, Clinicopathological Characteristics and Postoperative Prognosis in Patients with Bladder Cancer
CONCLUSION: The positive expression rates of Ki-67 and PFN1 in bladder tumor tissue are significantly higher than those in bladder tissue, and pathological pattern, histological grade, clinical stage, infiltration, and lymph node metastasis are related to the positive expression rates of Ki-67 and PFN1, and different genders, ages, tumors diameter and vascular invasion are not related to the positive expression rates of Ki-67 and PFN1. The survival time and three-year survival rates of bladder cancer patients with Ki-67 positive and PFN1 positive expression are shorter.PMID:38684494 | DOI:10.62713/aic.3335 (Source: Annali ...
Source: Annali Italiani di Chirurgia - April 29, 2024 Category: Surgery Authors: Jianwen Li Source Type: research
Efficacy and Toxicity of Vincristine and CYP3A5 Genetic Polymorphism in Rhabdomyosarcoma Pediatric Egyptian Patients
CONCLUSION: CYP3A5*1/*1 have less severe vincristine-induced neuropathy than CYP3A5 *1/*3, CYP3A5 *1/*6 and CYP3A5 *3/*3, CYP3A5 *3/*6. There is a significant influence of CYP3A5 mutation on neuropathy grade and assist of ADL as a part of neurotoxicity.PMID:38680001 | DOI:10.31557/APJCP.2024.25.4.1391 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Norhan Shalaby Hala F Zaki Osama A Badary Sherif Kamal Mohamed Nagy Dalia Makhlouf Amr Elnashar Enas Elnadi Sameh A Abdelshafi Sherif Abouelnaga Mona M Saber Source Type: research
Correlation between Ki-67 or Profilin-1 Expression Levels, Clinicopathological Characteristics and Postoperative Prognosis in Patients with Bladder Cancer
CONCLUSION: The positive expression rates of Ki-67 and PFN1 in bladder tumor tissue are significantly higher than those in bladder tissue, and pathological pattern, histological grade, clinical stage, infiltration, and lymph node metastasis are related to the positive expression rates of Ki-67 and PFN1, and different genders, ages, tumors diameter and vascular invasion are not related to the positive expression rates of Ki-67 and PFN1. The survival time and three-year survival rates of bladder cancer patients with Ki-67 positive and PFN1 positive expression are shorter.PMID:38684494 | DOI:10.62713/aic.3335 (Source: Annali ...
Source: Annali Italiani di Chirurgia - April 29, 2024 Category: Surgery Authors: Jianwen Li Source Type: research
Cancers, Vol. 16, Pages 1725: C-Reactive Protein Is a Potential Prognostic Marker in Patient with Advanced or Metastatic Urothelial Carcinoma Treated with Enfortumab Vedotin: A Multi-Center Retrospective Study
Conclusions: Our study provides real-world data showing that enfortumab vedotin prolonged survival in Asian patients similar to the EV-301 trial. Additionally, the C-reactive protein level might be considered a prognostic marker of enfortumab vedotin therapy in such patients. (Source: Cancers)
Source: Cancers - April 28, 2024 Category: Cancer & Oncology Authors: Toshiharu Morikawa Taku Naiki Yosuke Sugiyama Aya Naiki-Ito Takashi Nagai Toshiki Etani Keitaro Iida Teruki Isobe Yusuke Noda Nobuhiko Shimizu Maria Aoki Masakazu Gonda Rika Banno Hiroki Kubota Ryosuke Ando Yukihiro Umemoto Noriyasu Kawai Takahiro Yasui Tags: Article Source Type: research
Lysine Methyltransferase 9 (KMT9) Is an Actionable Target in Muscle-Invasive Bladder Cancer
In this study, we show that KMT9 regulates proliferation, migration, and invasion of various MIBC cell lines with different genetic mutations. KMT9α depletion results in the differential expression of genes regulating the cell cycle, cell adhesion, and migration. Differentially expressed genes include oncogenes such as EGFR and AKT1 as well as mediators of cell adhesion or migration such as DAG1 and ITGA6. Reduced cell proliferation upon KMT9α depletion is also observed in Pten/Trp53 knockout bladder tumor organoids, which cannot be rescued with an enzymatically inactive KMT9α mutant. In accordance with the idea that th...
Source: Cancer Control - April 27, 2024 Category: Cancer & Oncology Authors: Sainab Totonji Anna Ramos-Triguero Dominica Willmann Manuela Sum Sylvia Urban Helena Bauer Astrid Rieder Sheng Wang Holger Greschik Eric Metzger Roland Sch üle Source Type: research
A novel LINC02321 promotes cell proliferation and decreases cisplatin sensitivity in bladder cancer by regulating RUVBL2
In this study, A high expression of LINC02321 was found in BC tissues, which was associated with poor prognosis in patients. LINC02321 promoted both proliferation and G1-G0 progression in BC cells, while also inhibited sensitivity to cisplatin. Mechanistically, LINC02321 can bind to RUVBL2 and regulate the expression levels of RUVBL2 protein by affecting its half-life. RUVBL2 is involved in the DNA damage response. The potential of DNA damage repair pathways to exert chemosensitization has been demonstrated in vivo. The rescue experiment demonstrated that RUVBL2 overexpression can markedly abolish the decreased cell prolif...
Source: Translational Oncology - April 27, 2024 Category: Cancer & Oncology Authors: Chuncheng Lu Hongbin Gao Haiyuan Li Ning Luo Shipeng Fan Xi Li Renbin Deng Danpeng He Hui Zhao Source Type: research
Neoadjuvant cisplatin-based chemotherapy in nonmetastatic muscle-invasive bladder cancer: A systematic review and pooled meta-analysis to determine the preferred regimen
To determine whether neoadjuvant gemcitabine and cisplatin (GC) versus dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin (ddMVAC) before radical cystectomy improves overall survival (OS), progression-free survival (PFS), and pathologic complete response (pCR) for patients with muscle-invasive bladder cancer (MIBC) with secondary analyses of pathological downstaging and toxicity. (Source: Urology)
Source: Urology - April 27, 2024 Category: Urology & Nephrology Authors: Corbin J. Eule, Adam Warren, Elizabeth Molina Kuna, Eryn B. Callihan, Simon P. Kim, Thomas W. Flaig Source Type: research
Predicting preoperative muscle invasion status for bladder cancer using computed tomography-based radiomics nomogram
The aim of the study is to assess the efficacy of the established computed tomography (CT)-based radiomics nomogram combined with radiomics and clinical features for predicting muscle invasion status in bladde... (Source: BMC Medical Imaging)
Source: BMC Medical Imaging - April 27, 2024 Category: Radiology Authors: Rui Zhang, Shijun Jia, Linhan Zhai, Feng Wu, Shuang Zhang and Feng Li Tags: Research Source Type: research
Antibody-Drug Conjugates in the Treatment of Genitourinary Cancers: An Updated Review of Data
In this study, we have thoroughly completed a narrative review of the current literature and summarized preclinical studies and clinical trials that evaluated the utility, activity, and toxicity of ADCs in GU cancers, the prospects of ADC development, and the ongoing clinical trials. Prospective clinical trials, retrospective studies, case reports, and scoping reviews were included.PMID:38668075 | DOI:10.3390/curroncol31040172 (Source: Current Oncology)
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Prathana Nathan Adnan Rajeh Meh Noor Gabriel Boldt Ricardo Fernandes Source Type: research
Active Surveillance in Non-Muscle Invasive Bladder Cancer, the Potential Role of Biomarkers: A Systematic Review
Curr Oncol. 2024 Apr 12;31(4):2201-2220. doi: 10.3390/curroncol31040163.ABSTRACTBladder cancer (BC) is the tenth most common cause of cancer worldwide and is the thirteenth leading cause of cancer mortality. The non-muscle invasive (NMI) variant represents 75% of cases and has a mortality rate of less than 1%; however, it has a high recurrence rate. The gold standard of management is transurethral resection in the case of new lesions. However, this is associated with significant morbidity and costs, so the reduction of these procedures would contribute to reducing complications, morbidity, and the burden to the health syst...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Diego Parrao Nemecio Lizana Catalina Saavedra Mat ías Larrañaga Carolina B Lindsay Ignacio F San Francisco Juan Crist óbal Bravo Source Type: research
