A panel of four plasma amino acids is a promising biomarker for newly diagnosed bladder cancer.
Metastasis and recurrence are the main causes of death in post-operative bladder cancer (BC), emphasizing the importance of exploring early-stage diagnostic markers. Serum biomarkers constitute a promising diagnostic approach for asymptomatic stage cancer as they are non-invasive, have high accuracy and low cost. (Source: Clinical Nutrition)
Source: Clinical Nutrition - May 17, 2024 Category: Nutrition Authors: Zhipeng Liu, Chunying Teng, Wenting Wan, Fan Wu, Chao Wu, Weiping Ji, Yujuan Shan Source Type: research
Social Vulnerability and Receipt of Neoadjuvant Chemotherapy in Patients Undergoing Radical Cystectomy for Bladder Cancer
To evaluate the association between a population-level measure of social determinants of health, the Centers for Disease Control and Prevention Social Vulnerability Index (SVI), and receipt of neoadjuvant chemotherapy in patients with muscle-invasive bladder cancer (MIBC) undergoing radical cystectomy. (Source: Urology)
Source: Urology - May 17, 2024 Category: Urology & Nephrology Authors: Rishi R. Sekar, Sarosh Irani, Avinash Maganty, Jeff S. Montgomery, Lindsey A. Herrel Source Type: research
Bladder Cancer, Version 3.2024
J Natl Compr Canc Netw. 2024 May;22(4):216-225. doi: 10.6004/jnccn.2024.0024.ABSTRACTBladder cancer, the sixth most common cancer in the United States, is most commonly of the urothelial carcinoma histologic subtype. The clinical spectrum of bladder cancer is divided into 3 categories that differ in prognosis, management, and therapeutic aims: (1) non-muscle-invasive bladder cancer (NMIBC); (2) muscle invasive, nonmetastatic disease; and (3) metastatic bladder cancer. These NCCN Guidelines Insights detail recent updates to the NCCN Guidelines for Bladder Cancer, including changes in the fifth edition of the WHO Classificat...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - May 16, 2024 Category: Cancer & Oncology Authors: Thomas W Flaig Philippe E Spiess Michael Abern Neeraj Agarwal Rick Bangs Mark K Buyyounouski Kevin Chan Sam S Chang Paul Chang Terence Friedlander Richard E Greenberg Khurshid A Guru Harry W Herr Jean Hoffman-Censits Hristos Kaimakliotis Amar U Kishan Shi Source Type: research
Management of the Devastated Bladder Outlet after Prostate CANCER Treatment
AbstractPurpose of ReviewDevastating complications of the bladder outlet resulting from prostate cancer treatments are relatively uncommon. However, the combination of the high incidence of prostate cancer and patient longevity after treatment have raised awareness of adverse outcomes deteriorating patients ’ quality of life. This narrative review discusses the diagnostic work-up and management options for bladder outlet obstruction resulting from prostate cancer treatments, including those that require urinary diversion.Recent FindingsThe devastated bladder outlet can be a consequence of the treatment of benign conditio...
Source: Current Urology Reports - May 16, 2024 Category: Urology & Nephrology Source Type: research
The clinical effect of gratitude extension-construction theory nursing program on bladder cancer patients with fear of cancer recurrence
CONCLUSION: After applying the gratitude extension construction theory nursing program, the FCR of bladder cancer patients is significantly reduced. The quality of life and compliance rate are significantly improved, and anxiety and depression are relieved.PMID:38746673 | PMC:PMC11091306 | DOI:10.3389/fonc.2024.1364702 (Source: Cancer Control)
Source: Cancer Control - May 15, 2024 Category: Cancer & Oncology Authors: Liping Qian Yin Zhang Hui Chen Yuan Pang Chenchen Wang Liangmei Wang Xiaoqing Zhang Source Type: research
Retraction: Wang C, Chen Z, Ge Q, Hu J, Li F, Hu J, Xu H, Ye Z, Li LC (2014) Up ‐regulation of p21WAF1/CIP1 by miRNAs and its implications in bladder cancer cells. FEBS Letters 588, 4654–4664. https://doi.org/10.1016/j.febslet.2014.10.037
The above article, published online on November 11, 2014, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief Michael Brunner, FEBS Press, and John Wiley and Sons Ltd. The retraction has been agreed following an investigation into concerns raised by a third party, which revealed inappropriate duplications of image panels in Figs 6B, 7A, and S1C. The authors responded to an inquiry by the publisher and provided images related to the duplicated microscopy images and Western blots. Upon review of the provided images, the editors determined that these images did...
Source: FEBS Letters - May 15, 2024 Category: Biochemistry Tags: Retraction Source Type: research
Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity
CONCLUSION: These supplements may be useful in combination with radiotherapy in patients with pelvic malignancy. Video Abstract.PMID:38745230 | DOI:10.1186/s40168-024-01804-1 (Source: Cancer Control)
Source: Cancer Control - May 14, 2024 Category: Cancer & Oncology Authors: Chee Kin Then Salome Paillas Aliu Moomin Mariya D Misheva Rachel A Moir Susan M Hay David Bremner Kristine S Roberts Nee Nellany Ellen E Smith Zeynab Heidari Daniel Sescu Xuedan Wang Alejandro Su árez-Bonnet Nadine Hay Sarah L Murdoch Ryoichi Saito Elain Source Type: research
NMF-guided feature selection and genetic algorithm-driven framework for tumor mutational burden classification in bladder cancer using multi-omics data
AbstractAccurately classifying bladder cancer patients based on Tumor Mutational Burden (TMB) is of paramount significance for prognosis and treatment decisions. To achieve that, we present a novel approach leveraging multi-omics data to differentiate between low and high TMB classes. The model combines feature selection and predictive modeling to unveil robust biomarkers associated with TMB classification. The Genetic Algorithm is employed to perform feature selection across DNA methylation, copy number alteration, and RNA-seq datasets. This process effectively reduces the dimensionality of the input data while retaining ...
Source: Network Modeling Analysis in Health Informatics and Bioinformatics - May 14, 2024 Category: Bioinformatics Source Type: research
Endoscopic intervention versus radical nephroureterectomy for the management of localized upper urinary tract urothelial carcinoma: a systematic review and meta-analysis of comparative studies
ConclusionsOur review showed that E-KSS is a viable option for patients with localized UTUC with non-inferior oncological outcomes as compared with RNU, except for 5-year OS in high-grade tumors which favoured RNU. (Source: World Journal of Urology)
Source: World Journal of Urology - May 14, 2024 Category: Urology & Nephrology Source Type: research
The dual role of LOXL4 in the pathogenesis and development of human malignant tumors: a narrative review
CONCLUSIONS: LOXL4 exerts a bidirectional regulatory role, either inhibiting or promoting tumors depending on the type of cancer. We still need more research to further confirm the molecular mechanism of LOXL4 in cancer progression.PMID:38737700 | PMC:PMC11082665 | DOI:10.21037/tcr-23-2003 (Source: Cell Research)
Source: Cell Research - May 13, 2024 Category: Cytology Authors: Ruai Liu Bin Li Jiaji Zi Ruopeng Zhang Min Yu Jinghua Zhou Yuanqian Pu Wei Xiong Source Type: research
Risk of prostate cancer death in men diagnosed with prostate cancer at cystoprostat-ectomy. A nationwide population-based study
CONCLUSIONS: For a large majority of men diagnosed with incidental PCa at cystoprostatectomy performed for bladder cancer, the risk of PCa death is very small so there is no rationale for PSA testing during follow-up.PMID:38738332 | DOI:10.2340/sju.v59.40001 (Source: Scandinavian Journal of Urology)
Source: Scandinavian Journal of Urology - May 13, 2024 Category: Urology & Nephrology Authors: Pietro Scilipoti Fredrik Liedberg Hans Garmo Andri Wilberg Orrason P är Stattin Marcus Westerberg Source Type: research
Efficiency of bladder-sparing strategies for bladder cancer: an umbrella review
Ther Adv Med Oncol. 2024 May 10;16:17588359241249068. doi: 10.1177/17588359241249068. eCollection 2024.ABSTRACTBladder preservation (BP) has emerged as a clinical alternative to radical cystectomy (RC) for alleviating the substantial physical and psychological burden imposed on localized bladder cancer patients. Nevertheless, disparities persist in the comparative evaluations of BP and RC. We aimed to address the disparities between BP and RC. An umbrella review and meta-analysis were conducted to explore these disparities. We extracted data from meta-analyses and randomized controlled trials (RCTs) selected after searchin...
Source: Adv Data - May 13, 2024 Category: Epidemiology Authors: Deng-Xiong Li Qing-Xin Yu Rui-Cheng Wu Jie Wang De-Chao Feng Shi Deng Source Type: research
The dual role of LOXL4 in the pathogenesis and development of human malignant tumors: a narrative review
CONCLUSIONS: LOXL4 exerts a bidirectional regulatory role, either inhibiting or promoting tumors depending on the type of cancer. We still need more research to further confirm the molecular mechanism of LOXL4 in cancer progression.PMID:38737700 | PMC:PMC11082665 | DOI:10.21037/tcr-23-2003 (Source: Cell Research)
Source: Cell Research - May 13, 2024 Category: Cytology Authors: Ruai Liu Bin Li Jiaji Zi Ruopeng Zhang Min Yu Jinghua Zhou Yuanqian Pu Wei Xiong Source Type: research
Risk of prostate cancer death in men diagnosed with prostate cancer at cystoprostat-ectomy. A nationwide population-based study
CONCLUSIONS: For a large majority of men diagnosed with incidental PCa at cystoprostatectomy performed for bladder cancer, the risk of PCa death is very small so there is no rationale for PSA testing during follow-up.PMID:38738332 | DOI:10.2340/sju.v59.40001 (Source: Scandinavian Journal of Urology)
Source: Scandinavian Journal of Urology - May 13, 2024 Category: Urology & Nephrology Authors: Pietro Scilipoti Fredrik Liedberg Hans Garmo Andri Wilberg Orrason P är Stattin Marcus Westerberg Source Type: research
