The Potential Role of Urinary Microbiota in Bladder Carcinogenesis: A Systematic Review
CONCLUSION: The included studies demonstrate that the composition of urinary microbiota is altered in patients with BC. However, the differentially enriched genera in the urine of these patients vary between studies, and there is too much heterogeneity across studies to make any reliable and valid conclusions. Furthermore, well-designed research is necessary to assess the role of microbiota in the carcinogenesis and progression of BC.PMID:38716613 | DOI:10.22037/uj.v20i.8036 (Source: Urology Journal)
Source: Urology Journal - May 8, 2024 Category: Urology & Nephrology Authors: Amir Ghabousian Ashkan Shafigh Sona Tayebi Hanieh Salehi-Pourmehr Hadi Mostafaei Ursula Lemberger Keiichiro Mori Fatemeh Sadeghi-Ghyassi Hoora Hassanzadeh Sakineh Hajebrahimi Shahrokh F Shariat Source Type: research
Extra-peritoneal vs. Trans-peritoneal Radical Cystectomy pros and cons
Urol J. 2024 May 7. doi: 10.22037/uj.v20i.8140. Online ahead of print.ABSTRACTOne of the most common cancers of the urinary tract is bladder tumors. Bladder cancers are divided into two groups: non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer. (1) Trans-Peritoneal Radical Cystectomy (RC) with pelvic lymphadenectomy is the standard technique in muscle invasive and high risk non-muscle invasive bladder cancer (2). and Urologist around the world are more familiar with trans-peritoneal technique. In some articles extra-peritoneal Radical Cystectomy (RC) implied as an decreased postoperative complic...
Source: Urology Journal - May 8, 2024 Category: Urology & Nephrology Authors: Farzad Allameh Amir Hossein Eslami Source Type: research
Evaluation of magnetic resonance imaging for bladder cancer detection following transurethral resection of bladder tumour (TURBT)
ConclusionNon-contrast MRI with DWI showed high sensitivity and relatively high specificity for detection of residual tumour after TURBT. Inter-reader agreement improved from fair to moderate with the addition of DWI. MRI can be useful after TURBT in order to guide further management.Graphical abstract (Source: Abdominal Imaging)
Source: Abdominal Imaging - May 8, 2024 Category: Radiology Source Type: research
Applications of artificial intelligence in urologic oncology
CONCLUSIONS: AI technology is actively being investigated in the field of urological cancers as a tool for diagnosis, prediction of prognosis, and decision-making and is expected to be applied in additional clinical areas soon. Despite technological, legal, and ethical concerns, AI will change the landscape of urological cancer management.PMID:38714511 | DOI:10.4111/icu.20230435 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - May 7, 2024 Category: Cancer & Oncology Authors: Sahyun Pak Sung Gon Park Jeonghyun Park Sung Tae Cho Young Goo Lee Hanjong Ahn Source Type: research
Revealing the potential of solute carrier family 31 (copper transporters), member 1: Insights into its role in bladder cancer progression and therapeutic implications
Conclusion: Our comprehensive investigation highlights SLC31A1 as a promising biomarker for bladder cancer development, progression, and therapy.PMID:38712735 | DOI:10.1177/03946320241240706 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - May 7, 2024 Category: Allergy & Immunology Authors: Yun-Zhi Lin Wei-Hui Liu Yu-Peng Wu Hai Cai Qing-Shui Zheng Yong Wei Ning Xu Xue-Yi Xue Source Type: research
Application of PLK1 and HOXA13 Gene Expression Levels in Urine in the Diagnosis of Non-muscle Invasive Bladder Cancer
This study aimed to develop an accurate and non-invasive urine-based gene expression assay, including fibroblast growth factor receptor 3 (FGFR3), homeobox A13 (HOXA13), and polo-like kinase 1 (PLK1), to diagnose non-muscle-invasive bladder cancer (NMIBC) at stages Ta and T1. The samples were acquired from 62 patients with NMIBC, 31 control individuals, and 31 patients with non-cancerous genitourinary tract diseases. The expression levels of three relevant genes were determined using quantitative RT-PCR. In addition, the sensitivity and specificity of the data for these genes were computed. Our results showed that PLK1, HO...
Source: Cancer Control - May 7, 2024 Category: Cancer & Oncology Authors: Sahar Valizadeh Sana Taghiyar Serajedin Vahidi Omid Abazari Mahmood Akhavan Tafti Javad Zavar Reza Source Type: research
Effectiveness and Safety of Extended Lymph Node Dissection during Radical Surgery in Patients with Bladder Cancer: A Meta-Analysis
CONCLUSIONS: Among patients with BC undergoing radical cystectomy, extended lymph node dissection did not have a significant effect on operative time, 90-day readmission rates or postoperative complication rates. Thus, extended lymph node dissection is a safe treatment that does not increase the patient's surgical risk.PMID:38715172 | DOI:10.56434/j.arch.esp.urol.20247703.40 (Source: Archivos Espanoles de Urologia)
Source: Archivos Espanoles de Urologia - May 7, 2024 Category: Urology & Nephrology Authors: Heyi Hu Source Type: research
Application of PLK1 and HOXA13 Gene Expression Levels in Urine in the Diagnosis of Non-muscle Invasive Bladder Cancer
This study aimed to develop an accurate and non-invasive urine-based gene expression assay, including fibroblast growth factor receptor 3 (FGFR3), homeobox A13 (HOXA13), and polo-like kinase 1 (PLK1), to diagnose non-muscle-invasive bladder cancer (NMIBC) at stages Ta and T1. The samples were acquired from 62 patients with NMIBC, 31 control individuals, and 31 patients with non-cancerous genitourinary tract diseases. The expression levels of three relevant genes were determined using quantitative RT-PCR. In addition, the sensitivity and specificity of the data for these genes were computed. Our results showed that PLK1, HO...
Source: Biochemical Genetics - May 7, 2024 Category: Genetics & Stem Cells Authors: Sahar Valizadeh Sana Taghiyar Serajedin Vahidi Omid Abazari Mahmood Akhavan Tafti Javad Zavar Reza Source Type: research
The challenge of survivors of gynecological carcinomas: a retrospective study on occurrence of second tumors
ConclusionPatients with gynecological tumors have a significantly higher risk of malignant tumors in other systems compared to ordinary population. It is necessary to be vigilant against subsequent high-risk tumors and tumors with poor prognosis within 5 years of initial diagnosis. (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - May 6, 2024 Category: OBGYN Source Type: research
Cancers, Vol. 16, Pages 1780: How Immunotherapy Has Redefined the Treatment Paradigm of Metastatic or Locally Advanced Muscle-Invasive Urothelial Bladder Carcinoma
oss-Goupil
In the past decade, the therapeutic arsenal for metastatic bladder cancer has expanded considerably, with the development of immune checkpoint inhibitors (ICIs), antibody–drug conjugates such as enfortumab vedotin, and anti-fibroblast growth factor receptor agents. Clinical trials evaluating ICIs as neoadjuvants, adjuvants, or first- or second-line treatments have produced conflicting results. However, first-line therapeutic strategies have been redefined by the recent publication of results from two clinical trials: CheckMate-901, which demonstrated the superiority of combined treatment with n...
Source: Cancers - May 5, 2024 Category: Cancer & Oncology Authors: Mathieu Larroquette F élix Lefort Charlotte Domblides Luc H éraudet Gr égoire Robert Alain Ravaud Marine Gross-Goupil Tags: Review Source Type: research
Automatic detection method of bladder tumor cells based on color and shape features
In this study, based on microscopic hyperspectral data, an automatic detection algorithm of bladder tumor cells combining color features and shape features is proposed. Support vector machine (SVM) is used to build classification models and compare the classification performance of spectral feature, spectral and shape fusion feature, and the fusion feature proposed in this paper on the same classifier. The results show that the sensitivity, specificity, and accuracy of our classification algorithm based on shape and color fusion features are 0.952, 0.897, and 0.920, respectively, which are better than the classification al...
Source: Journal of Innovative Optical Health Sciences - May 4, 2024 Category: Biomedical Science Authors: Zitong Zhao Yanbo Wang Jiaqi Chen Mingjia Wang Shulong Feng Jin Yang Nan Song Jinyu Wang Ci Sun Source Type: research
A novel model of artificial intelligence based automated image analysis of CT urography to identify bladder cancer in patients investigated for macroscopic hematuria
CONCLUSIONS: We developed and tested an AI model for automatic image analysis of CTUs to detect UBC in patients with macroscopic hematuria. This model showed promising results with a high detection rate and excessive NPV. Further developments could lead to a decreased need for invasive investigations and prioritising patients with serious tumours.PMID:38698545 | DOI:10.2340/sju.v59.39930 (Source: Scandinavian Journal of Urology)
Source: Scandinavian Journal of Urology - May 3, 2024 Category: Urology & Nephrology Authors: Suleiman Abuhasanein Lars Edenbrandt Olof Enqvist Staffan Jahnson Henrik Leonhardt Elin Tr ägårdh Johannes Ul én Henrik Kj ölhede Source Type: research
Metabolic reprogramming of tumor-associated macrophages using glutamine antagonist JHU083 drives tumor immunity in myeloid-rich prostate and bladder cancer tumors
Cancer Immunol Res. 2024 May 3. doi: 10.1158/2326-6066.CIR-23-1105. Online ahead of print.ABSTRACTGlutamine metabolism in tumor microenvironments critically regulates anti-tumor immunity. Using glutamine-antagonist prodrug JHU083, we report potent tumor growth inhibition in urologic tumors by JHU083-reprogrammed tumor-associated macrophages (TAMs) and tumor-infiltrating monocytes (TIMs). We show JHU083-mediated glutamine antagonism in tumor microenvironments induces TNF, pro-inflammatory, and mTORC1 signaling in intratumoral TAM clusters. JHU083-reprogrammed TAMs also exhibit increased tumor cell phagocytosis and diminishe...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Monali Praharaj Fan Shen Alex J Lee Liang Zhao Thomas R Nirschl Debebe Theodros Alok K Singh Xiaoxu Wang Kenneth M Adusei Kara A Lombardo Raekwon A Williams Laura A Sena Elizabeth A Thompson Ada Tam Srinivasan Yegnasubramanian Edward J Pearce Robert D Leo Source Type: research
A novel model of artificial intelligence based automated image analysis of CT urography to identify bladder cancer in patients investigated for macroscopic hematuria
CONCLUSIONS: We developed and tested an AI model for automatic image analysis of CTUs to detect UBC in patients with macroscopic hematuria. This model showed promising results with a high detection rate and excessive NPV. Further developments could lead to a decreased need for invasive investigations and prioritising patients with serious tumours.PMID:38698545 | DOI:10.2340/sju.v59.39930 (Source: Scandinavian Journal of Urology)
Source: Scandinavian Journal of Urology - May 3, 2024 Category: Urology & Nephrology Authors: Suleiman Abuhasanein Lars Edenbrandt Olof Enqvist Staffan Jahnson Henrik Leonhardt Elin Tr ägårdh Johannes Ul én Henrik Kj ölhede Source Type: research
The Missing Trial Variable: A Case Report on Dietary Modification in a Patient with Durable Complete Remission After an Immunotherapy Clinical Trial for Metastatic Bladder Cancer
Altern Ther Health Med. 2024 May 3:AT9333. Online ahead of print.ABSTRACTA patient with metastatic bladder cancer has had an ongoing 9-year complete remission on a clinical trial of immunotherapy with nivolumab and ipimumab, but he also was following an intensive dietary and nutritional supplement regimen. Whether this combination or the immunotherapy alone brought about his good outcome is unknown but could be clarified in future trials by improved data collection about dietary and supplement choices.PMID:38702166 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - May 3, 2024 Category: Complementary Medicine Authors: Linda L Isaacs Nicholas J Gonzalez Source Type: research
