Presacral Neuroendocrine Neoplasms: A Multi-site Review of Surgical Outcomes
CONCLUSION: The study underscores the complex management of PNENs and emphasizes the need for multicenter research to better understand and manage these tumors. It provides valuable insights into surgical outcomes, recurrence rates, and overall survival, guiding future treatment strategies for PNEN patients.PMID:38679679 | DOI:10.1245/s10434-024-15328-3 (Source: Ann Oncol)
Source: Ann Oncol - April 28, 2024 Category: Cancer & Oncology Authors: Tommaso Violante Brenda Murphy Davide Ferrari Rondell P Graham Patrick Navin Amit Merchea David W Larson Eric J Dozois Thorvardur R Halfdanarson William R Perry Source Type: research
Estradiol modulates the role of the spinal α < sub > 6 < /sub > -subunit containing GABA < sub > A < /sub > receptors in female rats with neuropathic pain
Eur J Pharmacol. 2024 Apr 26:176616. doi: 10.1016/j.ejphar.2024.176616. Online ahead of print.ABSTRACTThe purpose of this study was to investigate the mechanisms underlying sex differences in the role of spinal α6-subunit containing GABAA (α6GABAA) receptors in rats with neuropathic pain. Intrathecal 2,5-dihydro-7-methoxy-2-(4-methoxyphenyl)-3H-pyrazolo [4,3-c] quinoline-3-one (PZ-II-029, positive allosteric modulator of α6GABAA receptors) reduced tactile allodynia in female but not in male rats with neuropathic pain. PZ-II-029 was also more effective in females than males in inflammatory and nociplastic pain. Ovariecto...
Source: European Journal of Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Erick J Rodr íguez-Palma Ana M Islas-Espinoza Itzel I Ramos-Rodr íguez Juan Miguel Piza ña-Encarnación Miguel Á Gutiérez-Agredano Ciciolil Morales-Moreno Alonso Fern ández-Guasti Vinicio Granados-Soto Source Type: research
Approach for contact medical device development via integrated testing, skeletal muscle modeling, and finite element analysis
J Mech Behav Biomed Mater. 2024 Apr 16;155:106541. doi: 10.1016/j.jmbbm.2024.106541. Online ahead of print.ABSTRACTDevelopment of novel medical devices for the treatment of musculoskeletal pain associated with neuro-muscular trigger points requires a model for relating the mechanical responses of in vivo biological tissues to applied palliative physical pressures and a method to design treatments for optimal effects. It is reasonable to hypothesize that the efficacy of therapeutic treatment is proportional to the maximum tensile strain at trigger point locations. This work presents modeling of the mechanical behavior of bi...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 28, 2024 Category: Materials Science Authors: Conor Shanley Q Jane Wang Bruce Livingston Source Type: research
Construct validation of the Japanese Core Outcome Measures Index and the impact of diseases on patient-reported outcome measures in preoperative patients with lumbar spinal stenosis and disk herniation: a single-center observational study
ConclusionsThis study highlights the distinct impact of LSS and LDH on preoperative QOL in older patients undergoing lumbar spinal surgery. Tailored interventions are essential to address the specific challenges posed by these conditions and improve patient-centered outcomes and postoperative recovery. (Source: European Spine Journal)
Source: European Spine Journal - April 28, 2024 Category: Orthopaedics Source Type: research
IJERPH, Vol. 21, Pages 559: DEXA Body Composition Asymmetry Analysis and Association to Injury Risk and Low Back Pain in University Soccer Players
Fortin
Soccer is a laterally dominant sport owing to the repetitive nature of unilateral kicking. The relationship between functional and body composition asymmetries related to limb dominance in soccer players has yet to be established. When present, asymmetries can increase the risk of injury and low back pain. Our study investigated whether lateral dominance is associated with limb asymmetries in a comprehensive body composition assessment among varsity soccer players. Twenty-seven varsity soccer players (age 20.4 &plusmn; 1.7 years old; BMI 22.6 &plusmn; 4.6 kg/m2) participated in this study. Body ...
Source: International Journal of Environmental Research and Public Health - April 28, 2024 Category: Environmental Health Authors: Nicolas Vaillancourt Chanelle Montpetit Victoria Carile Maryse Fortin Tags: Article Source Type: research
Percutaneous tendon dry needling and thrust manipulation as an adjunct to multimodal physical therapy in patients with lateral elbow tendinopathy: A multicenter randomized clinical trial
CONCLUSIONS: The inclusion of percutaneous tendon electrical dry needling and thrust manipulation into a multimodal program of exercise, mobilization and ultrasound was more effective than multimodal physical therapy alone in individuals with lateral elbow tendinopathy.Trial Registration: www.clinicaltrials.gov NCT03167710 May 30, 2017.PMID:38676324 | DOI:10.1177/02692155241249968 (Source: Clinical Rehabilitation)
Source: Clinical Rehabilitation - April 27, 2024 Category: Rehabilitation Authors: James Dunning Firas Mourad Paul Bliton Casey Charlebois Patrick Gorby Noah Zacharko Brus Layson Filippo Maselli Ian Young C ésar Fernández-de-Las-Peñas Source Type: research
Bone Mesenchymal Stem Cells Inhibit Oxidative Stress-Induced Pyroptosis in Annulus Fibrosus Cells to Alleviate Intervertebral Disc Degeneration Based on Matric Hydrogels
This study was aimed to investigate the role of bone mesenchymal stem cells (BMSCs) in IVDD and the molecular mechanism. Annulus fibrosus cells (AFCs) were treated with tert-butyl hydroperoxide (TBHP) to induce oxidative stress injury. AFC biological functions were analyzed using a lactate dehydrogenase kit, enzyme-linked immunosorbent assay, flow cytometry, and western blot. The molecular mechanisms of BMSC functions were assessed using quantitative real-time PCR, western blot, immunoprecipitation (IP), co-IP, GST pull-down, and cycloheximide treatment. Furthermore, the impacts of BMSCs in IVDD progression in vivo were ev...
Source: Applied Biochemistry and Biotechnology - April 27, 2024 Category: Biochemistry Authors: Ping Sang Xuepeng Li Ziyu Wang Source Type: research
Percutaneous tendon dry needling and thrust manipulation as an adjunct to multimodal physical therapy in patients with lateral elbow tendinopathy: A multicenter randomized clinical trial
CONCLUSIONS: The inclusion of percutaneous tendon electrical dry needling and thrust manipulation into a multimodal program of exercise, mobilization and ultrasound was more effective than multimodal physical therapy alone in individuals with lateral elbow tendinopathy.Trial Registration: www.clinicaltrials.gov NCT03167710 May 30, 2017.PMID:38676324 | DOI:10.1177/02692155241249968 (Source: Clinical Rehabilitation)
Source: Clinical Rehabilitation - April 27, 2024 Category: Rehabilitation Authors: James Dunning Firas Mourad Paul Bliton Casey Charlebois Patrick Gorby Noah Zacharko Brus Layson Filippo Maselli Ian Young C ésar Fernández-de-Las-Peñas Source Type: research
Bone Mesenchymal Stem Cells Inhibit Oxidative Stress-Induced Pyroptosis in Annulus Fibrosus Cells to Alleviate Intervertebral Disc Degeneration Based on Matric Hydrogels
This study was aimed to investigate the role of bone mesenchymal stem cells (BMSCs) in IVDD and the molecular mechanism. Annulus fibrosus cells (AFCs) were treated with tert-butyl hydroperoxide (TBHP) to induce oxidative stress injury. AFC biological functions were analyzed using a lactate dehydrogenase kit, enzyme-linked immunosorbent assay, flow cytometry, and western blot. The molecular mechanisms of BMSC functions were assessed using quantitative real-time PCR, western blot, immunoprecipitation (IP), co-IP, GST pull-down, and cycloheximide treatment. Furthermore, the impacts of BMSCs in IVDD progression in vivo were ev...
Source: Applied Biochemistry and Biotechnology - April 27, 2024 Category: Biochemistry Authors: Ping Sang Xuepeng Li Ziyu Wang Source Type: research
Percutaneous tendon dry needling and thrust manipulation as an adjunct to multimodal physical therapy in patients with lateral elbow tendinopathy: A multicenter randomized clinical trial
CONCLUSIONS: The inclusion of percutaneous tendon electrical dry needling and thrust manipulation into a multimodal program of exercise, mobilization and ultrasound was more effective than multimodal physical therapy alone in individuals with lateral elbow tendinopathy.Trial Registration: www.clinicaltrials.gov NCT03167710 May 30, 2017.PMID:38676324 | DOI:10.1177/02692155241249968 (Source: Clinical Rehabilitation)
Source: Clinical Rehabilitation - April 27, 2024 Category: Rehabilitation Authors: James Dunning Firas Mourad Paul Bliton Casey Charlebois Patrick Gorby Noah Zacharko Brus Layson Filippo Maselli Ian Young C ésar Fernández-de-Las-Peñas Source Type: research
Erratum to: “Racial Disparities in Opioid Use and Lumbar Spine Surgery for Chronic Pain and in Pain and Function Over 3 Years: A Retrospective Cohort Study,” The Journal of Pain, Volume 25, Issue 3, March 2024, Pages 659-671
The publisher regrets an incorrect disclosure was added to the manuscript Racial Disparities in Opioid Use and Lumbar Spine Surgery for Chronic Pain and in Pain and Function Over 3 Years: A Retrospective Cohort Study. National Institutes of Health funding does not pertain to the research, and the text was added during the production process after the author's final review of the proof. The incorrect disclosure text has been removed, and the authors have no disclosures. The publisher would like to apologize for any inconvenience caused. (Source: The Journal of Pain)
Source: The Journal of Pain - April 27, 2024 Category: Materials Science Authors: John C. Licciardone, Chase L. Miller, Alex J. Nazzal, Christian T. Hernandez, Linh H. Nguyen, Subhash Aryal Source Type: research
PCR-positive meningococcal CSF infection without pleocytosis but high IL-6 and IL-8
ConclusionsWe present a rare case of meningococcal infection of the CSF in a SLE patient without further CSF abnormalities. We discuss the involvement of early antibiotic treatment and the role of the patient ’s immune status in the normal CSF findings of this case. Moreover, this case demonstrates the importance of early antibiotic therapy in bacterial meningitis for the clinical outcome. (Source: Infection)
Source: Infection - April 27, 2024 Category: Infectious Diseases Source Type: research
Goal setting in people with low back pain attending an education and exercise program (GLA:D Back) and the impact of demographic factors
Individual goal setting is a fundamental element in self-management supportive interventions, serving to guide actions and enhance motivation for engagement. Despite this, little is known about the goals peopl... (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - April 27, 2024 Category: Orthopaedics Authors: Mette H.M. Gregersen, Kristine R. Nielsen, Nana H. Lynge, Bibi D. Heiberg, Jan Hartvigsen, Greg Kawchuk and Alice Kongsted Tags: Research Source Type: research
The effect of graded activity and pain education after lumbar spinal fusion on sedentary behavior 3 and 12 months post-surgery: a randomized controlled trial
To examine the effect of an early post-surgical intervention consisting of graded activity and pain education (GAPE) in patients with chronic low back pain (CLBP) undergoing lumbar spinal fusion (LSF) on sedentary behaviour, disability, pain, fear of movement, self-efficacy for exercise and health-related quality of life (HRQoL) at three-, six- and 12 months follow-up. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - April 27, 2024 Category: Rehabilitation Authors: Heidi Tegner, Nanna Rolving, Marius Henriksen, Rachid Bech-Azeddine, Mari Lundberg, Bente Appel Esbensen Tags: Original Research Source Type: research
Cauda equina syndrome
(CES) is a surgical emergency that often leads to debilitating chronic neuropathic pain, lower limb paralysis, loss of both faecal and urinary continence, and loss of sexual function; all of which cause a large degree of morbidity often causing psychological issues in the patient and a strain on family and their personal relationships. It is usually caused by a space occupying lesion in the lumbrosacral spinal canal causing a compressive mass effect on the peripheral nerve fibres of the cauda equina. (Source: Surgery (Medicine Publishing))
Source: Surgery (Medicine Publishing) - April 27, 2024 Category: Surgery Authors: Will Swadling, Saumil Shah, Richard Harker Tags: Orthopaedics: spine, pelvis and general trauma Source Type: research
