Metabolomic analysis of seminal fluids in infertile individuals
CONCLUSIONS: The data obtained from the study highlights the significant potential of metabolites in assessing infertility and gaining a more in-depth understanding of the underlying pathological mechanisms.PMID:38164856 | DOI:10.26355/eurrev_202312_34791 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - January 2, 2024 Category: Drugs & Pharmacology Authors: E Arslan I Koyuncu E Tem ız M Ar ı H Uyan ıkoglu Source Type: research
A bibliometric perspective with research trends and global productivity on the modernization of andrology from the founder of modern clinical andrology Edward Martin to the present
CONCLUSIONS: The trend topics that have been researched more in recent years include erectile dysfunction, oxidative stress, prostate cancer, sperm quality, sperm parameters, infertility, premature ejaculation, diabetes mellitus, obesity, prognosis, sperm DNA fragmentation/damage, antioxidant, asthenozoospermia, varicocelectomy, COVID-19, inflammation, prostatectomy, metabolic syndrome, hypogonadism, benign prostatic hyperplasia, lower urinary tract symptoms, meta-analysis, sexual dysfunction, peyronie's disease, and proliferation. We identified the research leadership of China, Japan, Turkey and India, in addition to West...
Source: European Review for Medical and Pharmacological Sciences - January 2, 2024 Category: Drugs & Pharmacology Authors: M Ekici E Demir C Ayd ın Source Type: research
Metabolomic analysis of seminal fluids in infertile individuals
CONCLUSIONS: The data obtained from the study highlights the significant potential of metabolites in assessing infertility and gaining a more in-depth understanding of the underlying pathological mechanisms.PMID:38164856 | DOI:10.26355/eurrev_202312_34791 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 2, 2024 Category: Drugs & Pharmacology Authors: E Arslan I Koyuncu E Tem ız M Ar ı H Uyan ıkoglu Source Type: research
A bibliometric perspective with research trends and global productivity on the modernization of andrology from the founder of modern clinical andrology Edward Martin to the present
CONCLUSIONS: The trend topics that have been researched more in recent years include erectile dysfunction, oxidative stress, prostate cancer, sperm quality, sperm parameters, infertility, premature ejaculation, diabetes mellitus, obesity, prognosis, sperm DNA fragmentation/damage, antioxidant, asthenozoospermia, varicocelectomy, COVID-19, inflammation, prostatectomy, metabolic syndrome, hypogonadism, benign prostatic hyperplasia, lower urinary tract symptoms, meta-analysis, sexual dysfunction, peyronie's disease, and proliferation. We identified the research leadership of China, Japan, Turkey and India, in addition to West...
Source: Pharmacological Reviews - January 2, 2024 Category: Drugs & Pharmacology Authors: M Ekici E Demir C Ayd ın Source Type: research
Metabolomic analysis of seminal fluids in infertile individuals
CONCLUSIONS: The data obtained from the study highlights the significant potential of metabolites in assessing infertility and gaining a more in-depth understanding of the underlying pathological mechanisms.PMID:38164856 | DOI:10.26355/eurrev_202312_34791 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - January 2, 2024 Category: Drugs & Pharmacology Authors: E Arslan I Koyuncu E Tem ız M Ar ı H Uyan ıkoglu Source Type: research
A bibliometric perspective with research trends and global productivity on the modernization of andrology from the founder of modern clinical andrology Edward Martin to the present
CONCLUSIONS: The trend topics that have been researched more in recent years include erectile dysfunction, oxidative stress, prostate cancer, sperm quality, sperm parameters, infertility, premature ejaculation, diabetes mellitus, obesity, prognosis, sperm DNA fragmentation/damage, antioxidant, asthenozoospermia, varicocelectomy, COVID-19, inflammation, prostatectomy, metabolic syndrome, hypogonadism, benign prostatic hyperplasia, lower urinary tract symptoms, meta-analysis, sexual dysfunction, peyronie's disease, and proliferation. We identified the research leadership of China, Japan, Turkey and India, in addition to West...
Source: European Review for Medical and Pharmacological Sciences - January 2, 2024 Category: Drugs & Pharmacology Authors: M Ekici E Demir C Ayd ın Source Type: research
Metabolomic analysis of seminal fluids in infertile individuals
CONCLUSIONS: The data obtained from the study highlights the significant potential of metabolites in assessing infertility and gaining a more in-depth understanding of the underlying pathological mechanisms.PMID:38164856 | DOI:10.26355/eurrev_202312_34791 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 2, 2024 Category: Drugs & Pharmacology Authors: E Arslan I Koyuncu E Tem ız M Ar ı H Uyan ıkoglu Source Type: research
AZF microdeletion affects semen parameters, sex hormone levels, and chromosome karyotypes in infertile men in Xinjiang
In conclusion, AZF microdeletions can lead to a decline in semen quality in men, and different types of deletions have different effects on semen parameters, sex hormone levels, and karyotype analysis. Further treatments should be selected based on the AZF microdeletion area.PMID:38158680 | DOI:10.14715/cmb/2023.69.13.17 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - December 30, 2023 Category: Molecular Biology Authors: Ningning Han Xiaoran Liu Source Type: research
AZF microdeletion affects semen parameters, sex hormone levels, and chromosome karyotypes in infertile men in Xinjiang
In conclusion, AZF microdeletions can lead to a decline in semen quality in men, and different types of deletions have different effects on semen parameters, sex hormone levels, and karyotype analysis. Further treatments should be selected based on the AZF microdeletion area.PMID:38158680 | DOI:10.14715/cmb/2023.69.13.17 (Source: Mol Biol Cell)
Source: Mol Biol Cell - December 30, 2023 Category: Molecular Biology Authors: Ningning Han Xiaoran Liu Source Type: research
Contralateral surgical exploration after unsuccessful unilateral microscopic testicular sperm extraction —a recurrent challenge
Nonobstructive azoospermia (NOA) is the most severe form of male infertility and often requires surgical sperm extraction for assisted reproduction. Microdissection testicular sperm extraction (micro-TESE), has emerged as the gold standard technique for men with NOA (1). Jensen et al. (2) demonstrated the direct comparison between micro-TESE and multiple needle-pass percutaneous testicular sperm aspiration in men with NOA. Spermatozoa were retrieved in 43% of men receiving micro-TESE, compared with only 22% received using multiple needle-pass testicular sperm aspiration. (Source: Fertility and Sterility)
Source: Fertility and Sterility - December 29, 2023 Category: Reproduction Medicine Authors: Francis Petrella, Thomas Ambrose Masterson Tags: Reflections Source Type: research
Genes, Vol. 15, Pages 45: Russian Regional Differences in Allele Frequencies of CFTR Gene Variants: Genetic Monitoring of Infertile Couples
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Oleg S. Glotov
A male factor, commonly associated with poor semen quality, is revealed in about 50% of infertile couples. CFTR gene variants are one of the common genetic causes of azoospermia-related male infertility. Notably, the spectrum and frequency of pathogenic CFTR variants vary between populations and geographical regions. In this work, we made an attempt to evaluate the allele frequency (AF) of 12 common CFTR variants in infertile Russian men and healthy individuals from different districts of Russia. Because of the limited number of population-based studies on Russian individuals, we characterized the p...
Source: Genes - December 27, 2023 Category: Genetics & Stem Cells Authors: Andrey S. Glotov Vyacheslav B. Chernykh Olga A. Solovova Aleksander V. Polyakov Maksim Yu. Donnikov Ludmila V. Kovalenko Yury A. Barbitoff Yulia A. Nasykhova Tatyana E. Lazareva Oleg S. Glotov Tags: Communication Source Type: research
A bi-allelic REC114 loss-of-function variant causes meiotic arrest and nonobstructive azoospermia
Clin Genet. 2023 Dec 26. doi: 10.1111/cge.14473. Online ahead of print.ABSTRACTNonobstructive azoospermia (NOA), the most severe manifestation of male infertility, lacks a comprehensive understanding of its genetic etiology. Here, a bi-allelic loss-of-function variant in REC114 (c.568C > T: p.Gln190*) were identified through whole exome sequencing (WES) in a Chinese NOA patient. Testicular histopathological analysis and meiotic chromosomal spread analysis were conducted to assess the stage of spermatogenesis arrested. Co-immunoprecipitation (Co-IP) and Western blot (WB) were used to investigate the influence of variant ...
Source: Clinical Genetics - December 26, 2023 Category: Genetics & Stem Cells Authors: Shuai Xu Jingpeng Zhao Feng Gao Yuxiang Zhang Jiaqiang Luo Chenwang Zhang Ruhui Tian Erlei Zhi Jianxiong Zhang Furong Bai Hongfang Sun Fujun Zhao Yuhua Huang Peng Li Liren Jiang Zheng Li Chencheng Yao Zhi Zhou Source Type: research
The Effect of Chitosan/Alginate/Graphene Oxide Nanocomposites on Proliferation of Mouse Spermatogonial Stem Cells
J Funct Biomater. 2023 Nov 22;14(12):556. doi: 10.3390/jfb14120556.ABSTRACTMale survivors of childhood cancer have been known to be afflicted with azoospermia. To combat this, the isolation and purification of spermatogonial stem cells (SSCs) are crucial. Implementing scaffolds that emulate the extracellular matrix environment is vital for promoting the regeneration and proliferation of SSCs. This research aimed to evaluate the efficiency of nanocomposite scaffolds based on alginate, chitosan, and graphene oxide (GO) in facilitating SSCs proliferation. To analyze the cytotoxicity of the scaffolds, an MTT assay was conducte...
Source: Cancer Control - December 22, 2023 Category: Cancer & Oncology Authors: Alaa Moeinzadeh Behnaz Ashtari Heriberto Garcia Morteza Koruji Carlo Alberto Velazquez Zohreh Bagher Mahmood Barati Ronak Shabani Seyed Mohammad Davachi Source Type: research
An overview of CFTR mutation profiles and assisted reproductive technology outcomes in Chinese patients with congenital obstructive azoospermia
ConclusionApart from the IVS9-5T mutation, the genetic mutation pattern ofCFTR in Chinese OA patients is heterogeneous, which is significantly different from that of Caucasians. Although carrying twoCFTR mutations or not had no effect on the pregnancy outcomes in OA patients after ICSI, genetic counseling is still recommended for such patients. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - December 20, 2023 Category: Reproduction Medicine Source Type: research
