Micromapping testicular sperm extraction: A new technique for microscopic testicular sperm extraction in nonobstructive azoospermia
CONCLUSIONS: MMTSE shows promise as a simple method that comprehensively searches testicular tissue and retrieves sperm using an appropriate method while minimizing patient burden.PMID:38476958 | PMC:PMC10927935 | DOI:10.1002/rmb2.12566 (Source: Reproductive Biology)
Source: Reproductive Biology - March 13, 2024 Category: Reproduction Medicine Authors: Toshihiro Tai Wakaba Miyamoto Yuriko Fukuoka Sena Shibasaki Mizuho Takahashi Noriyuki Okuyama Hiromitsu Hattori Ikue Ishikawa Satoko Nagaura Koki Yoshinaga Masae Koizumi Tomoko Hashimoto Mayumi Toya Jin Kumagai Hideki Igarashi Koichi Kyono Source Type: research
The Utilization of Fine Needle Vasography to Localize Obstruction of the Male Reproductive Tract
To report our experience using fine needle vasography (FNV) to identify a site of obstruction and determine candidacy for reconstructive procedures in patients presenting with suspected obstructive azoospermia or cryptozoospermia. (Source: Urology)
Source: Urology - March 12, 2024 Category: Urology & Nephrology Authors: Abrar Mian, Emily Huang, Nathan R. Starke, Landon Trost, Sevann Helo Source Type: research
The Utilization of Fine-Needle Vasography to Localize Obstruction of the Male Reproductive Tract
To report our experience using fine-needle vasography (FNV) to identify a site of obstruction and determine candidacy for reconstructive procedures in patients presenting with suspected obstructive azoospermia (OA) or cryptozoospermia. (Source: Urology)
Source: Urology - March 12, 2024 Category: Urology & Nephrology Authors: Abrar Mian, Emily Huang, Nathan R. Starke, Landon Trost, Sevann Helo Tags: Infertility Source Type: research
Effects of < em > Perilla frutescens < /em > Var. Acuta in Busulfan-Induced Spermatogenesis Dysfunction Mouse Model
CONCLUSIONS: This study shows that PFA exerts a protective effect against testicular damage by attenuating OS induced by busulfan. Our results suggest that PFA is a potentially relevant drug used to decrease the side effects induced by busulfan on testicular function and sperm during cancer chemotherapy.PMID:38449453 | DOI:10.5534/wjmh.230254 (Source: Cancer Control)
Source: Cancer Control - March 7, 2024 Category: Cancer & Oncology Authors: Hyung Jong Nam Min Jung Park Bo Sun Joo Yean Kyoung Koo SukJin Kim Sang Don Lee Hyun Jun Park Source Type: research
Achieving an optimal pregnancy outcome through the combined utilization of micro-TESE and ICSI in cryptorchidism associated with a non-canonical splicing variant in RXFP2
ConclusionThis is the first cryptorchidism case carrying a novel causative non-canonical splicingRXFP2 variant. The combined approach of micro-TESE and ICSI contributed to an optimal pregnancy outcome. Our literature review demonstrated thatRXFP2 variants caused cryptorchidism in a recessive inheritance pattern, rather than a dominant pattern. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - March 2, 2024 Category: Reproduction Medicine Source Type: research
A detection model of testis ‐derived circular RNAs in serum for predicting testicular sperm retrieval rate in non‐obstructive azoospermia patients
Discussion and conclusionOur study was the first to report that testis-derived circular RNAs in serum have the ability to predict sperm retrieval rate in non-obstructive azoospermia patients, whether it is a single-circular RNA or a combination of multi-circular RNAs. (Source: Andrology)
Source: Andrology - February 29, 2024 Category: Urology & Nephrology Authors: Mo ‐qi Lv,
Yan‐qi Yang,
Yi‐Xin Li,
Liang Zhou,
Pan Ge,
Rui‐fang Sun,
Jian Zhang,
Jun‐cheng Gao,
Liu‐qing Qu,
Qi‐ya Jing,
Pin‐cheng Li,
Yu‐jia Yan,
Hai‐xu Wang,
He‐cheng Li,
Dang‐xia Zhou Tags: ORIGINAL ARTICLE Source Type: research
Association of Y chromosome AZF region microdeletions with recurrent miscarriage in Iranian couples: A case-control study
CONCLUSION: Microdeletions in sY134 (AZFb) were significantly associated with RPL in Iranian men (p = 0.03). AZF microdeletion screening in couples with RPL can provide valuable information for ethnical genetic counseling and management of recurrent miscarriage. Further studies on larger populations or across various ethnic groups, conclusions and the inclusion of other factors like epigenetic changes explain the role of AZF microdeletions in RPL.PMID:38407572 | DOI:10.1002/mgg3.2392 (Source: Molecular Medicine)
Source: Molecular Medicine - February 26, 2024 Category: Molecular Biology Authors: Nasrin Pazoki Mitra Salehi Seyed Abdolhamid Angaji Meghdad Abdollahpour-Alitappeh Source Type: research
Genetic profiling of azoospermic men to identify the etiology and predict reproductive potential
ConclusionsSperm genome profiling provides invaluable information on azoospermia etiology and identifies gene-related mechanistic links to reproductive performance. Moreover, RNAseq assessment of seminal fluid from NOA men can help predict sperm retrieval during testicular biopsies. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - February 26, 2024 Category: Reproduction Medicine Source Type: research
Discovery of a novel miRNA involved in the regulation of male infertility in zebrafish
In this study, by analyzing miRNA transcriptome of the mature triploid zebrafish testis afflicted with spermatogenic dysfunctions, leading to the identification of 36 miRNAs that are differentially expressed in comparison with diploid, which are predicted to target 2737 genes. Subsequent functional annotation of these genes pinpointed two miRNAs might association with spermatogenesis. Inhibitory experiments showed that NC_007115.7.7_998,413 inhibited conducts a substantial decline in sperm density, and conducted lower embryo fertilization rate than control. And putative target genes qRT-PCR evaluation showed that spata2 wa...
Source: Genomics - February 25, 2024 Category: Genetics & Stem Cells Authors: Wen Fu Feng Liu Yingying Wang Ze Li Wenpei Deng Wenbin Liu Jinhui Liu Liangyue Peng Yamei Xiao Source Type: research
Discovery of a novel miRNA involved in the regulation of male infertility in zebrafish
In this study, by analyzing miRNA transcriptome of the mature triploid zebrafish testis afflicted with spermatogenic dysfunctions, leading to the identification of 36 miRNAs that are differentially expressed in comparison with diploid, which are predicted to target 2737 genes. Subsequent functional annotation of these genes pinpointed two miRNAs might association with spermatogenesis. Inhibitory experiments showed that NC_007115.7.7_998413 inhibited conducts a substantial decline in sperm density, and conducted lower embryo fertilization rate than control. And putative target genes qRT-PCR evaluation showed that spata2 was...
Source: Genomics - February 25, 2024 Category: Genetics & Stem Cells Authors: Wen Fu Feng Liu Yingying Wang Ze Li Wenpei Deng Wenbin Liu Jinhui Liu Liangyue Peng Yamei Xiao Source Type: research
Discovery of a novel miRNA involved in the regulation of male infertility in zebrafish
In this study, by analyzing miRNA transcriptome of the mature triploid zebrafish testis afflicted with spermatogenic dysfunctions, leading to the identification of 36 miRNAs that are differentially expressed in comparison with diploid, which are predicted to target 2737 genes. Subsequent functional annotation of these genes pinpointed two miRNAs might association with spermatogenesis. Inhibitory experiments showed that NC_007115.7.7_998413 inhibited conducts a substantial decline in sperm density, and conducted lower embryo fertilization rate than control. And putative target genes qRT-PCR evaluation showed that spata2 was...
Source: Genomics - February 25, 2024 Category: Genetics & Stem Cells Authors: Wen Fu Feng Liu Yingying Wang Ze Li Wenpei Deng Wenbin Liu Jinhui Liu Liangyue Peng Yamei Xiao Source Type: research
Discovery of a novel miRNA involved in the regulation of male infertility in zebrafish
In this study, by analyzing miRNA transcriptome of the mature triploid zebrafish testis afflicted with spermatogenic dysfunctions, leading to the identification of 36 miRNAs that are differentially expressed in comparison with diploid, which are predicted to target 2737 genes. Subsequent functional annotation of these genes pinpointed two miRNAs might association with spermatogenesis. Inhibitory experiments showed that NC_007115.7.7_998413 inhibited conducts a substantial decline in sperm density, and conducted lower embryo fertilization rate than control. And putative target genes qRT-PCR evaluation showed that spata2 was...
Source: Genomics - February 25, 2024 Category: Genetics & Stem Cells Authors: Wen Fu Feng Liu Yingying Wang Ze Li Wenpei Deng Wenbin Liu Jinhui Liu Liangyue Peng Yamei Xiao Source Type: research
Discovery of a novel miRNA involved in the regulation of male infertility in zebrafish
In this study, by analyzing miRNA transcriptome of the mature triploid zebrafish testis afflicted with spermatogenic dysfunctions, leading to the identification of 36 miRNAs that are differentially expressed in comparison with diploid, which are predicted to target 2737 genes. Subsequent functional annotation of these genes pinpointed two miRNAs might association with spermatogenesis. Inhibitory experiments showed that NC_007115.7.7_998413 inhibited conducts a substantial decline in sperm density, and conducted lower embryo fertilization rate than control. And putative target genes qRT-PCR evaluation showed that spata2 was...
Source: Genomics - February 25, 2024 Category: Genetics & Stem Cells Authors: Wen Fu Feng Liu Yingying Wang Ze Li Wenpei Deng Wenbin Liu Jinhui Liu Liangyue Peng Yamei Xiao Source Type: research
