ICSI using testicular spermatozoa after failure of ICSI with ejaculated spermatozoa could be a good choice: A propensity score ‐matched cohort study
ConclusionThe present study supports that the use of testicular spermatozoa outside the classical indication of azoospermia is a good option when the indication is well established. However, before proposing a testicular biopsy, an improvement in sperm characteristics should be considered by treating the causes of sperm alteration. (Source: Andrology)
Source: Andrology - December 19, 2023 Category: Urology & Nephrology Authors: Mehdi Benchaib,
Elsa Labrune,
Sandrine Giscard d'Estaing,
Cynthia Jovet,
Ga ëlle Soignon,
Pauline Jaeger,
Bruno Salle Tags: ORIGINAL ARTICLE Source Type: research
Reproductive and obstetric outcomes in TESE –ICSI cycles: A comparison between obstructive and non‐obstructive azoospermia
ConclusionsDespite impaired spermatogenesis in non-obstructive azoospermia patients, there were no substantial differences in reproductive outcomes compared to patients with obstructive azoospermia, even in terms of obstetric safety and neonatal well-being. (Source: Andrology)
Source: Andrology - December 18, 2023 Category: Urology & Nephrology Authors: Massimo Romano,
Federico Cirillo,
Noemi Ravaioli,
Emanuela Morenghi,
Luciano Negri,
Bulbul Ozgur,
Elena Albani,
Paolo Emanuele Levi ‐Setti Tags: ORIGINAL ARTICLE Source Type: research
Molecular mechanisms of cellular dysfunction in testes from men with non-obstructive azoospermia
Nature Reviews Urology, Published online: 18 December 2023; doi:10.1038/s41585-023-00837-9Understanding the cell-type-specific mechanisms of cellular dysfunction is necessary to develop precision medicine strategies that promote regeneration of spermatogenesis. In this Review, the authors discuss mechanisms of cellular dysfunction that have been elucidated in non-obstructive azoospermia testicular cells, in both somatic cells and germ cells, and consider how identifying modulators of cellular transcription and translation will be key for future research. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - December 18, 2023 Category: Urology & Nephrology Authors: Arina Piechka Sydney Sparanese Luke Witherspoon Faraz Hach Ryan Flannigan Source Type: research
Identification of a valuable gene network for the diagnosis and treatment of non-obstructive azoospermia: in-silico analyses - experimental research
CONCLUSION: The two miRNAs, hsa-miR-134-3p and hsa-miR-513C-3p, the three genes, VCAN, NFATC3, and PRDM5, and their associated circRNAs can perform as a valuable gene network in the diagnosis and treatment of NOA pathogenesis.PMID:38098601 | PMC:PMC10718319 | DOI:10.1097/MS9.0000000000001358 (Source: Annals of Medicine)
Source: Annals of Medicine - December 15, 2023 Category: Internal Medicine Authors: Mohammad Reza Zabihi Narges Norouzkhani Samad Karkhah Mohammad Akhoondian Source Type: research
Complete or partial loss of the Y chromosome in an unselected cohort of 865 non-vasectomized, azoospermic men
ConclusionsIn men with azoospermia, Y chromosome loss ranging from small microdeletions to complete loss of the Y chromosome was found in 6.1% (53/865). Partial AZFb microdeletions may give a milder testicular phenotype compared to complete AZFb microdeletions. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - December 14, 2023 Category: Urology & Nephrology Source Type: research
Case report: Obstructive azoospermia as the first presentation of Von Hippel-Lindau disease
We report the case of a 38-year-old man whose diagnostic workup for primary infertility led to the discovery of obstructive azoospermia due to bilateral papillary cystadenoma of the epididymis (PCE). Given the rarity of this finding and because PCE could be a manifestation of Von Hippel-Lindau disease (VHL), although the patient had no family or personal history of VHL, the VHL gene was tested, and a known pathogenetic variant (c.464-1G>A; p.)? was found. Screening for other Von Hippel-Lindau disease-associated neoplasms revealed bilateral retinal capillary hemangioblastomas, clear cell renal cell carcinoma, and multipl...
Source: Frontiers in Oncology - December 12, 2023 Category: Cancer & Oncology Source Type: research
BNC1 deficiency induces mitochondrial dysfunction-triggered spermatogonia apoptosis through the CREB/SIRT1/FOXO3 pathway: the therapeutic potential of nicotinamide riboside and metformin
Biol Reprod. 2023 Dec 11:ioad168. doi: 10.1093/biolre/ioad168. Online ahead of print.ABSTRACTMale infertility is a global health problem that disturbs numerous couples worldwide. Basonuclin 1 (BNC1) is a transcription factor mainly expressed in proliferative keratinocytes and germ cells. A frameshift mutation of BNC1 was identified in a large Chinese primary ovarian insufficiency pedigree. The expression of BNC1 was significantly decreased in the testis biopsies of infertile patients with nonobstructive azoospermia. Previous studies have revealed that mice with BNC1 deficiency are generally subfertile and undergo gradual s...
Source: Biology of Reproduction - December 11, 2023 Category: Reproduction Medicine Authors: Feida Ni Feixia Wang Jingyi Li Yifeng Liu Xiao Sun Jianpeng Chen Jiaqun Li Yanye Zhang Jiani Jin Xiaohang Ye Mixue Tu Jianhua Chen Chuan Chen Dan Zhang Source Type: research
BNC1 deficiency induces mitochondrial dysfunction-triggered spermatogonia apoptosis through the CREB/SIRT1/FOXO3 pathway: the therapeutic potential of nicotinamide riboside and metformin
Biol Reprod. 2023 Dec 11:ioad168. doi: 10.1093/biolre/ioad168. Online ahead of print.ABSTRACTMale infertility is a global health problem that disturbs numerous couples worldwide. Basonuclin 1 (BNC1) is a transcription factor mainly expressed in proliferative keratinocytes and germ cells. A frameshift mutation of BNC1 was identified in a large Chinese primary ovarian insufficiency pedigree. The expression of BNC1 was significantly decreased in the testis biopsies of infertile patients with nonobstructive azoospermia. Previous studies have revealed that mice with BNC1 deficiency are generally subfertile and undergo gradual s...
Source: Reproductive Biology - December 11, 2023 Category: Reproduction Medicine Authors: Feida Ni Feixia Wang Jingyi Li Yifeng Liu Xiao Sun Jianpeng Chen Jiaqun Li Yanye Zhang Jiani Jin Xiaohang Ye Mixue Tu Jianhua Chen Chuan Chen Dan Zhang Source Type: research
Pre- and post-chemotherapy spermatogenesis in male patients with malignant bone and soft tissue tumors
This study aims to assess spermatogenesis in male patients diagnosed with malignant bone and soft tissue tumors before and after chemotherapy.Methods: This study involved 34 male patients diagnosed with malignant bone and soft tissue tumors and subsequently underwent sperm cryopreservation before initiating treatment. Medical records included details about the primary disease, age, marital status at presentation, semen analysis results, treatment regimen and number of courses, post-treatment semen analysis, renewal status and outcomes.Results: The mean age at the time of sperm cryopreservation was 22.8 years. The median s...
Source: Frontiers in Pharmacology - December 6, 2023 Category: Drugs & Pharmacology Source Type: research
Y chromosome microdeletions in Chinese men with infertility: prevalence, phenotypes, and intracytoplasmic sperm injection outcomes
CONCLUSIONS: This is the largest epidemiological study on Y chromosome microdeletions in Chinese men with infertility. The study results underline the necessity for detecting Y chromosome microdeletion in men with infertility and severe sperm count abnormalities, especially those with cryptozoospermia. The combined deletion of sY254 and sY255 in the AZFc region and sY152 in the AZFd region was the most prevalent Y chromosome microdeletion pattern. Among patients with AZFcd deletion and ejaculated sperm, ICSI treatment can result in pregnancy outcomes, similar to those without AZFcd deletion.PMID:38053137 | DOI:10.1186/s129...
Source: Reproductive Biology - December 5, 2023 Category: Reproduction Medicine Authors: Dongjia Chen Guoqing Fan Xianqing Zhu Qinyun Chen Xuren Chen Feng Gao Zexin Guo Peng Luo Yong Gao Source Type: research
Y chromosome microdeletions in Chinese men with infertility: prevalence, phenotypes, and intracytoplasmic sperm injection outcomes
CONCLUSIONS: This is the largest epidemiological study on Y chromosome microdeletions in Chinese men with infertility. The study results underline the necessity for detecting Y chromosome microdeletion in men with infertility and severe sperm count abnormalities, especially those with cryptozoospermia. The combined deletion of sY254 and sY255 in the AZFc region and sY152 in the AZFd region was the most prevalent Y chromosome microdeletion pattern. Among patients with AZFcd deletion and ejaculated sperm, ICSI treatment can result in pregnancy outcomes, similar to those without AZFcd deletion.PMID:38053137 | PMC:PMC10696855 ...
Source: Reproductive Biology - December 5, 2023 Category: Reproduction Medicine Authors: Dongjia Chen Guoqing Fan Xianqing Zhu Qinyun Chen Xuren Chen Feng Gao Zexin Guo Peng Luo Yong Gao Source Type: research
Surgery to improve male fertility
CONCLUSION: Whenever possible, the urologist should present the surgical options for improving male fertility to the ART team and to the couple, discussing the benefit/risk balance of the operation as part of a personalized approach.PMID:38012911 | DOI:10.1016/j.purol.2023.09.011 (Source: Progres en Urologie)
Source: Progres en Urologie - November 28, 2023 Category: Urology & Nephrology Authors: Eric Huyghe Antoine Faix Charlotte Methorst Source Type: research
Medical treatments for male infertility
CONCLUSION: This review should help urologists gain a better understanding of the various medical treatments and enable them to define an appropriate therapeutic strategy, tailored to the patient and the couple, in order to obtain the best results.PMID:38012910 | DOI:10.1016/j.purol.2023.09.019 (Source: Progres en Urologie)
Source: Progres en Urologie - November 28, 2023 Category: Urology & Nephrology Authors: C Methorst A Faix E Huyghe Source Type: research
