Molecular mechanisms of cellular dysfunction in testes from men with non-obstructive azoospermia

Nature Reviews Urology, Published online: 18 December 2023; doi:10.1038/s41585-023-00837-9Understanding the cell-type-specific mechanisms of cellular dysfunction is necessary to develop precision medicine strategies that promote regeneration of spermatogenesis. In this Review, the authors discuss mechanisms of cellular dysfunction that have been elucidated in non-obstructive azoospermia testicular cells, in both somatic cells and germ cells, and consider how identifying modulators of cellular transcription and translation will be key for future research.
Source: Nature Reviews Urology - Category: Urology & Nephrology Authors: Source Type: research