Optimizing pharmacokinetics of intravesical chemotherapy for bladder cancer
Nature Reviews Urology, Published online: 21 August 2019; doi:10.1038/s41585-019-0220-4Intravesical chemotherapy is a mainstay of treatment for non-muscle-invasive bladder cancer; however, the biology of the bladder means that intravesical therapy is limited by washout of the agent during voiding and systemic effects caused by absorption through the bladder wall. In this Review, the authors consider novel approaches to improving the pharmacokinetics of intravesical chemotherapy, such as chemohyperthermia, sustained release devices, and nanoparticle conjugation. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - August 21, 2019 Category: Urology & Nephrology Authors: Gregory A. Joice Trinity J. Bivalacqua Max Kates Source Type: research

Genomics and risk stratification in high-risk prostate cancer
Nature Reviews Urology, Published online: 21 August 2019; doi:10.1038/s41585-019-0227-xClinical and pathological risk grouping defines management in localized prostate cancer. Recent work suggests men with high-risk prostate cancer can be further subdivided into three risk groups (favourable high-risk, standard high-risk and very-high-risk) and that these groups correlate with measures of genomic risk, testing of which is increasingly being integrated into risk prediction. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - August 21, 2019 Category: Urology & Nephrology Authors: Bashir Al Hussein Al Awamlh Jonathan E. Shoag Source Type: research

Advancing knowledge of transgender medical intervention effects
Nature Reviews Urology, Published online: 09 August 2019; doi:10.1038/s41585-019-0222-2In a recently published study, surveys of transgender individuals on hormone therapy provide insight into the self-reported effects of medication where previous thinking was only speculative. Still, controlled studies are required to avoid overinterpreting the clinical significance of specific findings in the context of what might be expected in the general population. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - August 9, 2019 Category: Urology & Nephrology Authors: Joshua D. Safer Source Type: research

Priming antitumour immunity in NMIBC
Nature Reviews Urology, Published online: 08 August 2019; doi:10.1038/s41585-019-0225-zPriming antitumour immunity in NMIBC (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - August 8, 2019 Category: Urology & Nephrology Authors: Louise Stone Source Type: research

One-carbon metabolism in RCC
Nature Reviews Urology, Published online: 08 August 2019; doi:10.1038/s41585-019-0224-0One-carbon metabolism in RCC (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - August 8, 2019 Category: Urology & Nephrology Authors: Louise Stone Source Type: research

Different FOXA1 classes drive prostate cancer
Nature Reviews Urology, Published online: 08 August 2019; doi:10.1038/s41585-019-0223-1Different FOXA1 classes drive prostate cancer (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - August 8, 2019 Category: Urology & Nephrology Authors: Louise Stone Source Type: research

Combining epigenetic and immune checkpoint inhibitors in bladder cancer
Nature Reviews Urology, Published online: 06 August 2019; doi:10.1038/s41585-019-0221-3Combining epigenetic and immune checkpoint inhibitors in bladder cancer (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - August 6, 2019 Category: Urology & Nephrology Authors: Clemens Thoma Source Type: research

PrEP for HIV: grade A for evidence but pending for impact
Nature Reviews Urology, Published online: 30 July 2019; doi:10.1038/s41585-019-0219-xThe US Preventive Services Task Force has issued a grade A recommendation that clinicians offer pre-exposure prophylaxis (PrEP) to people at high risk of acquiring HIV. Currently, many fewer individuals receive PrEP than those who would benefit from it; whether PrEP can have a real impact on reducing the global burden of HIV is yet to be determined. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - July 30, 2019 Category: Urology & Nephrology Authors: Jared M. Baeten Source Type: research

AVPR1A: a target in CRPC?
Nature Reviews Urology, Published online: 25 July 2019; doi:10.1038/s41585-019-0218-yAVPR1A: a target in CRPC? (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - July 25, 2019 Category: Urology & Nephrology Authors: Annette Fenner Source Type: research

New approaches for effective and safe pelvic radiotherapy in high-risk prostate cancer
Nature Reviews Urology, Published online: 25 July 2019; doi:10.1038/s41585-019-0213-3The risk of pelvic nodal involvement in patients with high-risk prostate cancer has led to the development of whole-pelvis radiotherapy (WPRT); however, this approach remains controversial. In this Review, the authors discuss the mixed data surrounding WPRT and consider how advanced imaging techniques and ‘big data’ mining could improve patient selection and optimize WPRT by improving localization of subclinical disease. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - July 25, 2019 Category: Urology & Nephrology Authors: Hannah Tharmalingam Ananya Choudhury Marcel Van Herk Alan McWilliam Peter J. Hoskin Source Type: research

Combining options in metastatic prostate cancer
Nature Reviews Urology, Published online: 18 July 2019; doi:10.1038/s41585-019-0217-zIntensifying systemic therapy improves outcomes in metastatic prostate cancer. As apalutamide and enzalutamide join abiraterone and docetaxel as treatment options for patients, the choice of therapy for individual patients becomes more complex. We anticipate precision targeted and immune therapies will build on the advances of recently completed large-scale trials. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - July 18, 2019 Category: Urology & Nephrology Authors: Ryan P. Kopp Tomasz M. Beer Source Type: research

Multiparametric MRI for prostate cancer diagnosis: current status and future directions
Nature Reviews Urology, Published online: 17 July 2019; doi:10.1038/s41585-019-0212-4In this Review, Stabile and colleagues describe the current status of the role of mpMRI in prostate cancer diagnosis, its clinical application and consider its future direction in this disease. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - July 17, 2019 Category: Urology & Nephrology Authors: Armando Stabile Francesco Giganti Andrew B. Rosenkrantz Samir S. Taneja Geert Villeirs Inderbir S. Gill Clare Allen Mark Emberton Caroline M. Moore Veeru Kasivisvanathan Source Type: research

The Urology Care Foundation — trusted online resources in an era of misinformation
Nature Reviews Urology, Published online: 12 July 2019; doi:10.1038/s41585-019-0215-1The Internet can be a valuable resource for patients, but it is also a minefield of misinformation and hidden bias. The Urology Care Foundation is attempting to mitigate this flood of inaccurate information by providing high-quality online resources for clinicians, patients and caregivers. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - July 12, 2019 Category: Urology & Nephrology Authors: Brian Stork Stacy Loeb Source Type: research

Mechanisms of high-dose testosterone
Nature Reviews Urology, Published online: 11 July 2019; doi:10.1038/s41585-019-0216-0Mechanisms of high-dose testosterone (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - July 11, 2019 Category: Urology & Nephrology Authors: Clemens Thoma Source Type: research

Can circulating microRNAs solve clinical dilemmas in testicular germ cell malignancy?
Nature Reviews Urology, Published online: 11 July 2019; doi:10.1038/s41585-019-0214-2Current clinical issues in testicular germ cell tumour management include limited sensitivity and specificity of conventional biomarkers and, therefore, reliance on serial CT imaging in follow-up monitoring, as well as poor ability to risk stratify patients. Circulating microRNAs are likely to help overcome these challenges and, importantly, could offer cost savings to health-care systems. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - July 11, 2019 Category: Urology & Nephrology Authors: Matthew J. Murray Nicholas Coleman Source Type: research

Molecular and histopathology directed therapy for advanced bladder cancer
Nature Reviews Urology, Published online: 09 July 2019; doi:10.1038/s41585-019-0208-0In this Review, the authors discuss the molecular and histopathological evidence supporting pathology-driven therapy for advanced bladder cancer, including rare histological subtypes of urothelial carcinoma and non-urothelial carcinomas, and highlight novel molecular taxonomies, relevant biomarkers and promising future therapies. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - July 9, 2019 Category: Urology & Nephrology Authors: Constantine Alifrangis Ursula McGovern Alex Freeman Thomas Powles Mark Linch Source Type: research

The Cancer Genome Atlas of renal cell carcinoma: findings and clinical implications
Nature Reviews Urology, Published online: 05 July 2019; doi:10.1038/s41585-019-0211-5This Review by Ricketts and Linehan comprehensively summarizes the findings of The Cancer Genome Atlas analyses of renal cell carcinoma and their clinical implications. The authors highlight unique and shared features of the tumour histological subtypes, their predictive power and their possible utility as therapeutic targets. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - July 5, 2019 Category: Urology & Nephrology Authors: W. Marston Linehan Christopher J. Ricketts Source Type: research

Physical activity as an adjunct treatment for erectile dysfunction
Nature Reviews Urology, Published online: 25 June 2019; doi:10.1038/s41585-019-0210-6Physical activity has been shown to help erectile dysfunction (ED); however, the use of physical activity to actually treat ED is limited, and explicit guidelines are required. In this Review, Allen describes mechanisms underlying the effect and suggests an exercise treatment programme for ED. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - June 25, 2019 Category: Urology & Nephrology Authors: Mark S. Allen Source Type: research

Organ preservation in bladder cancer: an opportunity for truly personalized treatment
Nature Reviews Urology, Published online: 13 June 2019; doi:10.1038/s41585-019-0199-xIncreasing evidence suggests that patients undergoing trimodality bladder-preserving treatment (TMT) and radical cystectomy have comparable outcomes but many continue to be offered surgery. This Review discusses the development of TMT and highlights how technological and biological advances could inform personalized treatment strategies. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - June 13, 2019 Category: Urology & Nephrology Authors: Yee Pei Song Alan McWilliam Peter J. Hoskin Ananya Choudhury Source Type: research

A deep dish of urology advances in Chicago for AUA2019
Nature Reviews Urology, Published online: 12 June 2019; doi:10.1038/s41585-019-0209-zA deep dish of urology advances in Chicago for AUA2019 (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - June 12, 2019 Category: Urology & Nephrology Authors: Clemens Thoma Source Type: research

Atezolizumab in understudied populations with bladder cancer
Nature Reviews Urology, Published online: 11 June 2019; doi:10.1038/s41585-019-0200-8Immune checkpoint therapy is beneficial for patients with advanced bladder cancer; however, trials generally exclude patients with comorbidities or uncommon histologies. The SAUL trial demonstrates that atezolizumab is safe and efficacious in a patient population that more accurately reflects the real-world scenario, but its benefit might still be limited in historically poorly performing populations. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - June 11, 2019 Category: Urology & Nephrology Authors: Tyler F. Stewart Daniel P. Petrylak Source Type: research

Neisseria gonorrhoeae resistance driven by antibiotic use
Nature Reviews Urology, Published online: 10 June 2019; doi:10.1038/s41585-019-0206-2A new ecological analysis has shown that antimicrobial consumption is positively associated with decreased antimicrobial susceptibility in Neisseria gonorrhoeae across European countries. Efforts at the policy, provider and community level need to be strengthened to address and help mitigate the continued emergence of antimicrobial resistance in N. gonorrhoeae. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - June 10, 2019 Category: Urology & Nephrology Authors: Huan V. Dong Jeffrey D. Klausner Source Type: research

Equal access = equal outcomes in black and white men
Nature Reviews Urology, Published online: 10 June 2019; doi:10.1038/s41585-019-0207-1Equal access = equal outcomes in black and white men (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - June 10, 2019 Category: Urology & Nephrology Authors: Annette Fenner Source Type: research

AR variants: lost in translation to clinical practice?
Nature Reviews Urology, Published online: 10 June 2019; doi:10.1038/s41585-019-0204-4The concept that resistance against androgen receptor (AR) signalling inhibitors is explained by AR variants (ARVs) has spread as a seductive meme. However, two problems have delayed the translation of these findings to clinical practice: the complexity of the mechanism of action and the challenging development of clinical decision-making tools involving ARVs. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - June 10, 2019 Category: Urology & Nephrology Authors: Florian Handle Frank Claessens Source Type: research

Regenerative and engineered options for urethroplasty
Nature Reviews Urology, Published online: 06 June 2019; doi:10.1038/s41585-019-0198-yTissue engineering using different cell types and tissue scaffolds offers a promising alternative to substitution urethroplasty, which can be associated with complications, restenosis and poor quality of life. In this Review, the authors describe advances in tissue engineering for urethral replacement and consider the future of the field. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - June 6, 2019 Category: Urology & Nephrology Authors: Filippo Pederzoli Gregory Joice Andrea Salonia Trinity J. Bivalacqua Nikolai A. Sopko Source Type: research

The perfect PARTNER: no HIV transmission with ART
Nature Reviews Urology, Published online: 05 June 2019; doi:10.1038/s41585-019-0205-3The perfect PARTNER: no HIV transmission with ART (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - June 5, 2019 Category: Urology & Nephrology Authors: Louise Stone Source Type: research

Genomic correlates of clinical outcomes
Nature Reviews Urology, Published online: 28 May 2019; doi:10.1038/s41585-019-0201-7Genomic correlates of clinical outcomes (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - May 28, 2019 Category: Urology & Nephrology Authors: Annette Fenner Source Type: research

No gentamicin for first-line gonorrhoea therapy
Nature Reviews Urology, Published online: 28 May 2019; doi:10.1038/s41585-019-0203-5No gentamicin for first-line gonorrhoea therapy (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - May 28, 2019 Category: Urology & Nephrology Authors: Annette Fenner Source Type: research

Understanding obesity interactions with germ cell tumours
Nature Reviews Urology, Published online: 28 May 2019; doi:10.1038/s41585-019-0202-6Understanding obesity interactions with germ cell tumours (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - May 28, 2019 Category: Urology & Nephrology Authors: Annette Fenner Source Type: research

Extracellular matrix and the immune system: friends or foes
Nature Reviews Urology, Published online: 20 May 2019; doi:10.1038/s41585-019-0196-0A new study describes antitumour cell activity inherent in the extracellular matrix of porcine urinary bladder, which is not the result of direct tumour cell killing but is indirectly mediated through immune cells. The findings highlight opportunities to explore shared interests of the tissue engineering and regenerative medicine and the immunology and cancer communities. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - May 20, 2019 Category: Urology & Nephrology Authors: Stephen F. Badylak Source Type: research

Long non-coding RNAs in genitourinary malignancies: a whole new world
Nature Reviews Urology, Published online: 20 May 2019; doi:10.1038/s41585-019-0195-1In this Review, the authors discuss the emerging oncogenic roles of long non-coding RNAs in prostate, kidney and bladder cancers, highlighting unique opportunities to improve diagnosis, treatment and precision medicine strategies in these genitourinary malignancies. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - May 20, 2019 Category: Urology & Nephrology Authors: Ronan Flippot Guillaume Beinse Alice Boil ève Julien Vibert Gabriel G. Malouf Source Type: research

An adaptive approach to therapy
Nature Reviews Urology, Published online: 20 May 2019; doi:10.1038/s41585-019-0197-zAn adaptive approach to therapy (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - May 20, 2019 Category: Urology & Nephrology Authors: Louise Stone Source Type: research

Prostate cancer in sexual minorities and the influence of HIV status
Nature Reviews Urology, Published online: 17 May 2019; doi:10.1038/s41585-019-0194-2In this Review, Amarasekera and colleagues consider the effect of prostate cancer diagnosis and treatment on men in sexual minority groups, including men who have sex with men and transgender women as well as men with HIV, and discuss how and why efforts to study this population are complicated and evolving. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - May 17, 2019 Category: Urology & Nephrology Authors: Channa Amarasekera Vincent Wong Emily Yura Adarsh Manjunath Edward Schaeffer Shilajit Kundu Source Type: research

A new era: artificial intelligence and machine learning in prostate cancer
Nature Reviews Urology, Published online: 15 May 2019; doi:10.1038/s41585-019-0193-3Machine learning (ML) is revolutionizing and reshaping health care, and computer-based systems can be trained to perform complex tasks in bioinformatics, medical imaging and medical robotics. In this Review, Goldenberg et al. consider ML in the management of prostate cancer, with growing applications in diagnostic imaging, surgical interventions, skills training and assessment, digital pathology and genomics. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - May 15, 2019 Category: Urology & Nephrology Authors: S. Larry Goldenberg Guy Nir Septimiu E. Salcudean Source Type: research

Cancer metabolomic markers in urine: evidence, techniques and recommendations
Nature Reviews Urology, Published online: 15 May 2019; doi:10.1038/s41585-019-0185-3Urinalysis has long been used as a tool for managing diseases, but 21st century techniques have enabled measurement of metabolomic urinary cancer biomarkers using NMR and mass spectrometry. In this Review, the authors discuss the current status of research developments and offer recommendations to help systematize future research in the field. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - May 15, 2019 Category: Urology & Nephrology Authors: Sarah S. Dinges Annika Hohm Lindsey A. Vandergrift Johannes Nowak Piet Habbel Igor A. Kaltashov Leo L. Cheng Source Type: research

Bacteriophages of the lower urinary tract
Bacteriophages of the lower urinary tractBacteriophages of the lower urinary tract, Published online: 09 May 2019; doi:10.1038/s41585-019-0192-4Many of the bacterial components of the female urinary tract have been characterized, but the viral fraction of this community is largely unknown. Here, the authors describe the current knowledge of bacteriophages within the urinary tract and their possible contribution to urinary tract health. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - May 9, 2019 Category: Urology & Nephrology Authors: Andrea Garretto Taylor Miller-Ensminger Alan J. Wolfe Catherine Putonti Source Type: research

Publisher Correction: The UMBRELLA SIOP–RTSG 2016 Wilms tumour pathology and molecular biology protocol
Publisher Correction: The UMBRELLA SIOP–RTSG 2016 Wilms tumour pathology and molecular biology protocolPublisher Correction: The UMBRELLA SIOP–RTSG 2016 Wilms tumour pathology and molecular biology protocol, Published online: 01 May 2019; doi:10.1038/s41585-019-0191-5Publisher Correction: The UMBRELLA SIOP–RTSG 2016 Wilms tumour pathology and molecular biology protocol (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - May 1, 2019 Category: Urology & Nephrology Authors: Gordan M. Vujani ć Manfred Gessler Ariadne H. A. G. Ooms Paola Collini Aurore Coulomb-l ’Hermine Ellen D ’Hooghe Ronald R. de Krijger Daniela Perotti Kathy Pritchard-Jones Christian Vokuhl Marry M. van den Heuvel-Eibrink Norbert Graf Source Type: research

Enzalutamide, apalutamide, or darolutamide: are apples or bananas best for patients?
Enzalutamide, apalutamide, or darolutamide: are apples or bananas best for patients?, Published online: 30 April 2019; doi:10.1038/s41585-019-0186-2The PROSPER, SPARTAN, and ARAMIS trials demonstrated the efficacy of enzalutamide, apalutamide, and darolutamide, respectively, to extend metastasis-free survival in men with nonmetastatic castration-resistant prostate cancer. However, questions remain regarding patient selection for these agents, particularly concerning adverse effects, patient PSA doubling time, and cost and formulary considerations. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - April 30, 2019 Category: Urology & Nephrology Authors: Celestia Higano Source Type: research

Targeting DLL3 in neuroendocrine prostate cancer
Targeting DLL3 in neuroendocrine prostate cancer, Published online: 30 April 2019; doi:10.1038/s41585-019-0190-6Targeting DLL3 in neuroendocrine prostate cancer (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - April 30, 2019 Category: Urology & Nephrology Authors: Clemens Thoma Source Type: research

DDR pathway mediates radiosensitization in prostate cancer
DDR pathway mediates radiosensitization in prostate cancer, Published online: 26 April 2019; doi:10.1038/s41585-019-0188-0DDR pathway mediates radiosensitization in prostate cancer (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - April 26, 2019 Category: Urology & Nephrology Authors: Louise Stone Source Type: research

Budding prognostic technique for muscle-invasive bladder cancer
Budding prognostic technique for muscle-invasive bladder cancer, Published online: 26 April 2019; doi:10.1038/s41585-019-0187-1Budding prognostic technique for muscle-invasive bladder cancer (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - April 26, 2019 Category: Urology & Nephrology Authors: Louise Stone Source Type: research

Risk of urolithiasis increased with testosterone replacement therapy
Risk of urolithiasis increased with testosterone replacement therapy, Published online: 26 April 2019; doi:10.1038/s41585-019-0189-zRisk of urolithiasis increased with testosterone replacement therapy (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - April 26, 2019 Category: Urology & Nephrology Authors: Louise Stone Source Type: research

Blue light flexible cystoscopy with hexaminolevulinate in non-muscle-invasive bladder cancer: review of the clinical evidence and consensus statement on optimal use in the USA — update 2018
Blue light flexible cystoscopy with hexaminolevulinate in non-muscle-invasive bladder cancer: review of the clinical evidence and consensus statement on optimal use in the USA — update 2018Blue light flexible cystoscopy with hexaminolevulinate in non-muscle-invasive bladder cancer: review of the clinical evidence and consensus statement on optimal use in the USA — update 2018, Published online: 24 April 2019; doi:10.1038/s41585-019-0184-4In this Consensus Statement, experts in the field detail the current evidence regarding blue light flexible cystoscopy for bladder cancer surveillance and make recommendations ...
Source: Nature Reviews Urology - April 24, 2019 Category: Urology & Nephrology Authors: Yair Lotan Trinity J. Bivalacqua Tracy Downs William Huang Jeffrey Jones Ashish M. Kamat Badrinath Konety Per-Uno Malmstr öm James McKiernan Michael O ’Donnell Sanjay Patel Kamal Pohar Matthew Resnick Alexander Sankin Angela Smith Gary Steinberg Edouar Source Type: research

Galectins in prostate and bladder cancer: tumorigenic roles and clinical opportunities
Galectins in prostate and bladder cancer: tumorigenic roles and clinical opportunities, Published online: 23 April 2019; doi:10.1038/s41585-019-0183-5Galectins have established roles in cancer, but their function in genitourinary cancer is unclear. In this Opinion, the authors discuss the emerging roles of galectins in prostate and bladder cancer development and progression and speculate regarding opportunities for clinical translation. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - April 23, 2019 Category: Urology & Nephrology Authors: Neus Mart ínez-Bosch Alejo Rodriguez-Vida N úria Juanpere Josep Lloreta Ana Rovira Joan Albanell Joaquim Bellmunt Pilar Navarro Source Type: research

Grady — the miracle monkey born from cryopreserved prepubertal testis graft
Grady — the miracle monkey born from cryopreserved prepubertal testis graftGrady — the miracle monkey born from cryopreserved prepubertal testis graft, Published online: 12 April 2019; doi:10.1038/s41585-019-0182-6Grady — the miracle monkey born from cryopreserved prepubertal testis graft (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - April 12, 2019 Category: Urology & Nephrology Authors: Annette Fenner Source Type: research

68Ga-PSMA-11 PET enables accurate detection of recurrent disease
68Ga-PSMA-11 PET enables accurate detection of recurrent disease, Published online: 10 April 2019; doi:10.1038/s41585-019-0181-768Ga-PSMA-11 PET enables accurate detection of recurrent disease (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - April 10, 2019 Category: Urology & Nephrology Authors: Conor A. Bradley Source Type: research

Merging new-age biomarkers and nanodiagnostics for precision prostate cancer management
Merging new-age biomarkers and nanodiagnostics for precision prostate cancer management, Published online: 08 April 2019; doi:10.1038/s41585-019-0178-2In this Review, the authors discuss biomarker-driven prostate cancer molecular subtyping and the development of nanodiagnostic strategies to refine biomarker detection. They also describe the challenges of merging both aspects for precision prostate cancer management. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - April 8, 2019 Category: Urology & Nephrology Authors: Kevin M. Koo Paul N. Mainwaring Scott A. Tomlins Matt Trau Source Type: research

Internet information on focal prostate cancer therapy: help or hindrance?
Internet information on focal prostate cancer therapy: help or hindrance?Internet information on focal prostate cancer therapy: help or hindrance?, Published online: 05 April 2019; doi:10.1038/s41585-019-0180-8In the absence of standards of care and defined best treatments for localized prostate cancer, Internet search engines provide patients with first information — or often misinformation. Clinicians need to guide patients to sources of high-quality evidence on focal ablative treatments for prostate cancer. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - April 5, 2019 Category: Urology & Nephrology Authors: Sangeet Ghai John Trachtenberg Source Type: research

First point-of-care PSA test for prostate cancer detection
First point-of-care PSA test for prostate cancer detection, Published online: 04 April 2019; doi:10.1038/s41585-019-0179-1The FDA’s approval of the first point-of-care total PSA test for prostate cancer has the potential to improve patient care by streamlining PSA testing. However, a Clinical Laboratory Improvement Amendments waiver is needed before this test can be fully integrated into clinical care. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - April 4, 2019 Category: Urology & Nephrology Authors: Alexa R. Meyer Michael A. Gorin Source Type: research

The resilience of men: quality of life after prostate cancer
The resilience of men: quality of life after prostate cancer, Published online: 03 April 2019; doi:10.1038/s41585-019-0176-4Health-related quality of life encompasses a wide range of experiences and is especially relevant for men with prostate cancer. A recent study reports that across disease stages, overall self-reported health status and urinary and bowel function were good, but sexual function was poor. Overall, men face prostate cancer with resilience. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - April 3, 2019 Category: Urology & Nephrology Authors: Mark S. Litwin Source Type: research