Complementary and Integrative Approaches to Sleep Disorders in Children
Sleep problems are very common in children and adolescents. Chronic insomnia is the leading cause of sleep disorders in children and adolescents. Adjunctive interventions that address low ferritin levels and vitamin D3 deficiency are helpful in children and adolescents. The addition of l-5-hydroxytryptophan, gabadone, l-theanine, Ashwagandha, omega 3 fatty acids, probiotics in bipolar disorder, and children with colic, meditation, and changing from a high-fat diet to a Mediterranean diet are also helpful adjunctive interventions. Actigraphy data should be collected in future sleep studies because subjective data may not in...
Source: Child and Adolescent Psychiatric Clinics of North America - April 1, 2023 Category: Psychiatry Authors: Swapna N. Deshpande, Deborah R. Simkin Source Type: research
An updated review on phytochemistry and molecular targets of Withania somnifera (L.) Dunal (Ashwagandha)
Withania somnifera (L.) Dunal belongs to the nightshade family Solanaceae and is commonly known as Ashwagandha. It is pharmacologically a significant medicinal plant of the Indian sub-continent, used in Ayurvedic and indigenous systems of medicine for more than 3,000 years. It is a rich reservoir of pharmaceutically bioactive constituents known as withanolides (a group of 300 naturally occurring C-28 steroidal lactones with an ergostane-based skeleton). Most of the biological activities of W. somnifera have been attributed to two key withanolides, namely, withaferin-A and withanolide-D. In addition, bioactive constituents...
Source: Frontiers in Pharmacology - March 29, 2023 Category: Drugs & Pharmacology Source Type: research
An update on potential pharmacotherapies for cognitive impairment in bipolar disorder
Expert Opin Pharmacother. 2023 Mar 22. doi: 10.1080/14656566.2023.2194488. Online ahead of print.ABSTRACTINTRODUCTION: Cognitive impairment is a core feature of bipolar disorder (BD) that impedes recovery by preventing the return to optimal socio-occupational functioning and reducing quality of life. Presently, there are no efficacious treatments for cognitive impairment in BD, but many pharmacological interventions are being considered as they have the potential to target the underlying pathophysiology of the disorder.AREAS COVERED: This review summarizes the available evidence for pharmacological interventions for cognit...
Source: Expert Opinion on Pharmacotherapy - March 22, 2023 Category: Drugs & Pharmacology Authors: Danica E Johnson Roger S McIntyre Rodrigo B Mansur Joshua D Rosenblat Source Type: research
Ashwagandha ‐induced acute liver injury: A case report
Liver biopsy revealing prominent hepatocellular and canalicular cholestasis as well as spotty hepatocellular necrosis with ceroid-laden macrophages caused byashwagandha intake. AbstractDrug-induced liver injury became one of the most important liver disorders and diagnostic challenge for clinicians and pathologists. Here, we report a rare case ofashwagandha-induced acute liver injury. The patient developed jaundice 2 weeks after startingashwagandha intake and recovered within 5 months after withdrawal without any specific treatment. (Source: Clinical Case Reports)
Source: Clinical Case Reports - March 15, 2023 Category: General Medicine Authors: Marcell T óth,
Andrea E. Benedek,
Thomas Longerich,
Helmut‐Karl Seitz Tags: CASE REPORT Source Type: research
Withania somnifera influences MDMA-induced hyperthermic, cognitive, neurotoxic and neuroinflammatory effects in mice
This study aimed to investigate the effect of a standardized extract of W. somnifera (WSE) on MDMA-induced neurotoxicity, neuroinflammation, memory impairment and hyperthermia. Mice received a 3-day pretreatment with vehicle or WSE. Thereafter, vehicle- and WSE-pretreated mice were randomly divided into four groups: saline, WSE, MDMA alone, WSE plus MDMA. Body temperature was recorded throughout treatment, and memory performance was assessed by a novel object recognition (NOR) task at the end of treatment. Thereafter, immunohistochemistry was performed to evaluate in the substantia nigra pars compacta (SNc) and striatum th...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 11, 2023 Category: Drugs & Pharmacology Authors: Giulia Costa Marcello Serra Riccardo Maccioni Maria Antonietta Casu Sanjay B Kasture Elio Acquas Micaela Morelli Source Type: research
Pharmacological potential of Withania somnifera (L.) Dunal and Tinospora cordifolia (Willd.) Miers on the experimental models of COVID-19, T cell differentiation, and neutrophil functions
Cytokine release syndrome (CRS) due to severe acute respiratory coronavirus-2 (SARS-CoV-2) infection leads to life-threatening pneumonia which has been associated with coronavirus disease (COVID-19) pathologies. Centuries-old Asian traditional medicines such as Withania somnifera (L.) Dunal (WS) and Tinospora cordifolia (Willd.) Miers (TC) possess potent immunomodulatory effects and were used by the AYUSH ministry, in India during the COVID-19 pandemic. In the present study, we investigated WS and TC’s anti-viral and immunomodulatory efficacy at the human equivalent doses using suitable in vitro and in vivo models. While...
Source: Frontiers in Immunology - March 7, 2023 Category: Allergy & Immunology Source Type: research
< em > Withania somnifera < /em > -derived carbon dots protect human epidermal cells against UVB-induced cell death and support growth factor-mediated wound healing
Nanoscale Adv. 2022 Dec 9;5(5):1331-1344. doi: 10.1039/d2na00545j. eCollection 2023 Feb 28.ABSTRACTSolar radiation comprising UVA and UVB regions is considered a skin-damaging factor inducing inflammation, oxidative stress, hyperpigmentation, and photo-aging. Photoluminescent carbon dots (CDs) were synthesized from the root extract of a Withania somnifera (L.) Dunal plant and urea, using a one-step microwave method. These Withania somnifera CDs (wsCDs) were 14.4 ± 0.18 d nm in diameter and presented photoluminescence. UV absorbance showed the presence of π-π* (C[double bond, length as m-dash]C) and n-π* (C[double bond,...
Source: Cell Research - March 3, 2023 Category: Cytology Authors: Acharya Balkrishna Meenu Tomar Kunal Bhattacharya Anurag Varshney Source Type: research
The immunomodulatory role of withania somnifera (L.) dunal in inflammatory diseases
Withania somnifera (L.) Dunal (Solanaceae) (also known as Ashwagandha) is a botanical drug that has been used for centuries to treat many chronic diseases like high blood pressure, arthritis, diabetes, Alzheimer’s disease, and depression. As many botanical drugs, w. Somnifera possesses anti-inflammatory, antioxidant, anticarinogenic, anti-diabetic, and anti-asthmatic properties. W. somnifera is often compared to the ginseng plant due to its ability to reduce stress, improve cognitive functions (e.g., memory), and promote a healthy immune system. It promotes immunomodulatory effects whose function is to balance the humora...
Source: Frontiers in Pharmacology - February 22, 2023 Category: Drugs & Pharmacology Source Type: research
IJERPH, Vol. 20, Pages 3921: Liver Dangers of Herbal Products: A Case Report of Ashwagandha-Induced Liver Injury
-Kaźmierczak
In recent years, cases of liver damage caused by ashwagandha herbal supplements have been reported from different parts of the world (Japan, Iceland, India, and the USA). Here, we describe the clinical phenotype of suspected ashwagandha-induced liver injury and the potential causative mechanism. The patient was admitted to the hospital because of jaundice. In the interview, it was reported that he had been taking ashwagandha for a year. Laboratory results showed an increase in total bilirubin, alanine transaminase (ALT), aspartate transaminase (AST), (gamma-glutamyl transpherase (GGT), alkaline phosphatas...
Source: International Journal of Environmental Research and Public Health - February 22, 2023 Category: Environmental Health Authors: Marta Lubarska Przemys ław Hałasiński Szymon Hryhorowicz Dagmara Santabye Mahadea Liliana Łykowska-Szuber Piotr Eder Agnieszka Dobrowolska Iwona Krela-Ka źmierczak Tags: Case Report Source Type: research
Herbal Therapeutics for Alzheimer's Disease: Ancient Indian Medicine System from the Modern Viewpoint
This article presents a modern perspective on the herbs available in the ancient Indian medicine system as well as their possible mechanisms of action for AD treatment. The main objective of this research is to provide a systematic review of herbal drugs that are easily accessible and effective for the treatment of AD.PMID:36797613 | DOI:10.2174/1570159X21666230216094353 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - February 16, 2023 Category: Drugs & Pharmacology Authors: Shikha Kushwah Neha Shree Maurya Sandeep Kushwaha Luciana Scotti Aakash Chawade Ashutosh Mani Source Type: research
Herbal Therapeutics for Alzheimer's Disease: Ancient Indian Medicine System from the Modern Viewpoint
This article presents a modern perspective on the herbs available in the ancient Indian medicine system as well as their possible mechanisms of action for AD treatment. The main objective of this research is to provide a systematic review of herbal drugs that are easily accessible and effective for the treatment of AD.PMID:36797613 | DOI:10.2174/1570159X21666230216094353 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - February 16, 2023 Category: Drugs & Pharmacology Authors: Shikha Kushwah Neha Shree Maurya Sandeep Kushwaha Luciana Scotti Aakash Chawade Ashutosh Mani Source Type: research
Herbal Therapeutics for Alzheimer's Disease: Ancient Indian Medicine System from the Modern Viewpoint
This article presents a modern perspective on the herbs available in the ancient Indian medicine system as well as their possible mechanisms of action for AD treatment. The main objective of this research is to provide a systematic review of herbal drugs that are easily accessible and effective for the treatment of AD.PMID:36797613 | DOI:10.2174/1570159X21666230216094353 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - February 16, 2023 Category: Drugs & Pharmacology Authors: Shikha Kushwah Neha Shree Maurya Sandeep Kushwaha Luciana Scotti Aakash Chawade Ashutosh Mani Source Type: research
Herbal Therapeutics for Alzheimer's Disease: Ancient Indian Medicine System from the Modern Viewpoint
This article presents a modern perspective on the herbs available in the ancient Indian medicine system as well as their possible mechanisms of action for AD treatment. The main objective of this research is to provide a systematic review of herbal drugs that are easily accessible and effective for the treatment of AD.PMID:36797613 | DOI:10.2174/1570159X21666230216094353 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - February 16, 2023 Category: Drugs & Pharmacology Authors: Shikha Kushwah Neha Shree Maurya Sandeep Kushwaha Luciana Scotti Aakash Chawade Ashutosh Mani Source Type: research
Herbal Therapeutics for Alzheimer's Disease: Ancient Indian Medicine System from the Modern Viewpoint
This article presents a modern perspective on the herbs available in the ancient Indian medicine system as well as their possible mechanisms of action for AD treatment. The main objective of this research is to provide a systematic review of herbal drugs that are easily accessible and effective for the treatment of AD.PMID:36797613 | DOI:10.2174/1570159X21666230216094353 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - February 16, 2023 Category: Drugs & Pharmacology Authors: Shikha Kushwah Neha Shree Maurya Sandeep Kushwaha Luciana Scotti Aakash Chawade Ashutosh Mani Source Type: research
