Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (VIII): six new withanolides from Physalis philadelphica
In this study, we attempted to isolate their active compounds against MT-1 and MT-2 from extracts ofP. philadelphica. We identified 13 withanolides, including six newly isolated compounds [24R, 25S-4 β, 16β, 20R-trihydroxy-1-oxowitha-2-en-5 β, 6 β -epoxy-22,26-olide (1), 4 β, 7β,20R-trihydroxy-1-oxowitha-2-en-5 β, 6β -epoxy-22,26-olide (2), 17 β,20S-dihydroxywithanone (3), 2,3-dihydro-3 β-methoxy-23β-hydroxywithaphysacarpin (4), 3-O-(4-rhamnosyl)glucosyl-physalolactone B (5), and 17R, 20R, 22S, 23S, 24R, 25R-4 β, 5α, 6β, 20β, 22α -tetrahydroxy-16β, 23-diepoxy-1-oxowitha-2-en-26, 23-olide (6)], from the ext...
Source: Journal of Natural Medicines - May 18, 2023 Category: Drugs & Pharmacology Source Type: research
Editorial: Investigating the molecular targets and therapeutic potential of Withania somnifera (Ashwagandha) in various pathophysiological conditions
(Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - May 2, 2023 Category: Drugs & Pharmacology Source Type: research
Therapeutic Implications of Some Natural Products for Neuroimmune Diseases: A Narrative of Clinical Studies Review
Evid Based Complement Alternat Med. 2023 Apr 13;2023:5583996. doi: 10.1155/2023/5583996. eCollection 2023.ABSTRACTNeuroimmune diseases are a group of disorders that occur due to the dysregulation of both the nervous and immune systems, and these illnesses impact tens of millions of people worldwide. However, patients who suffer from these debilitating conditions have very few FDA-approved treatment options. Neuroimmune crosstalk is important for controlling the immune system both centrally and peripherally to maintain tissue homeostasis. This review aims to provide readers with information on how natural products modulate ...
Source: Evidence-based Complementary and Alternative Medicine - April 24, 2023 Category: Complementary Medicine Authors: Gayathri Wijeweera Nalaka Wijekoon Lakmal Gonawala Yoonus Imran Chandra Mohan K Ranil D De Silva Source Type: research
The Therapeutic Effects of Withaferin A against Cancer: Overview and Updates
Curr Mol Med. 2023 Apr 18. doi: 10.2174/1566524023666230418094708. Online ahead of print.ABSTRACTCancer is a rapidly rising health problem among the global population, and this burden causes a significant challenge for public health. Current chemotherapeutic agents have different limitations, including drug resistance and severe side effects, and it demands a robust approach to accessing promising anti-cancer therapeutics. The natural compounds have been extensively studied to identify improved therapeutic agents for cancer therapy. Withaferin A (WA) is a steroidal lactone found in Withania somnifera and possesses anti-inf...
Source: Molecular Medicine - April 18, 2023 Category: Molecular Biology Authors: Prathapan Abeesh Chandrasekaran Guruvayoorappan Source Type: research
The Therapeutic Effects of Withaferin A against Cancer: Overview and Updates
Curr Mol Med. 2023 Apr 18. doi: 10.2174/1566524023666230418094708. Online ahead of print.ABSTRACTCancer is a rapidly rising health problem among the global population, and this burden causes a significant challenge for public health. Current chemotherapeutic agents have different limitations, including drug resistance and severe side effects, and it demands a robust approach to accessing promising anti-cancer therapeutics. The natural compounds have been extensively studied to identify improved therapeutic agents for cancer therapy. Withaferin A (WA) is a steroidal lactone found in Withania somnifera and possesses anti-inf...
Source: Current Molecular Medicine - April 18, 2023 Category: Molecular Biology Authors: Prathapan Abeesh Chandrasekaran Guruvayoorappan Source Type: research
1420 Ashwagandha-derived exosome-like nanoparticles promote human hair growth ex vivo
Novel strategies to inhibit hair loss are in high demand. Therapies using human-derived exosomes are currently being explored to promote hair growth with promising results, however the production of human-derived exosomes for large-scale use is proving challenging. Recently, the discovery that plant-derived exosome-like-nanoparticles may offer a valid substitute has opened new research venues. Here, we investigated whether this emerging therapy may be beneficial to modulate hair growth by selecting Ashwagandha, an herb traditionally used for improving overall health and relieving stress, as the source of plant-derived exos...
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: A. Le Riche, J. Nienhaus, M. Sousa, R. Scotland, M. Bertolini, G. Dell' Acqua, J. Edelkamp Source Type: research
Correction to: The Impact of Ashwagandha on Stress, Sleep Quality, and Food Cravings in College Students: Quantitative Analysis of a Double-Blind Randomized Control Trial by O'Conner J, et al. J Med Food 25 (12) 2022, 1086 –1094; DOI: 10.1089/jmf.2022.0040
Journal of Medicinal Food,Volume 26, Issue 4, Page 275-275, April 2023. (Source: Journal of Medicinal Food)
Source: Journal of Medicinal Food - April 14, 2023 Category: Nutrition Source Type: research
Achievements in Hypothyroidism Treatment with Herbal Medicine: A Systematic Review of Randomized Controlled Trials
Conclusion Some herbal remedies, including Nigella sativa L., ashwagandha, and Mentha x Piperita L., can improve the signs and symptoms of primary hypothyroidism, but using a more extensive and advanced methodology will provide us with more complete results.PMID:37013429 | DOI:10.2174/1570163820666230403091841 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - April 4, 2023 Category: Drugs & Pharmacology Authors: Najmeh Javidi Zahra Mazloum Khorasani Roshanak Salari Shabnam Niroumand Mahdi Yousefi Source Type: research
Achievements in Hypothyroidism Treatment with Herbal Medicine: A Systematic Review of Randomized Controlled Trials
Conclusion Some herbal remedies, including Nigella sativa L., ashwagandha, and Mentha x Piperita L., can improve the signs and symptoms of primary hypothyroidism, but using a more extensive and advanced methodology will provide us with more complete results.PMID:37013429 | DOI:10.2174/1570163820666230403091841 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - April 4, 2023 Category: Drugs & Pharmacology Authors: Najmeh Javidi Zahra Mazloum Khorasani Roshanak Salari Shabnam Niroumand Mahdi Yousefi Source Type: research
Achievements in Hypothyroidism Treatment with Herbal Medicine: A Systematic Review of Randomized Controlled Trials
Conclusion Some herbal remedies, including Nigella sativa L., ashwagandha, and Mentha x Piperita L., can improve the signs and symptoms of primary hypothyroidism, but using a more extensive and advanced methodology will provide us with more complete results.PMID:37013429 | DOI:10.2174/1570163820666230403091841 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - April 4, 2023 Category: Drugs & Pharmacology Authors: Najmeh Javidi Zahra Mazloum Khorasani Roshanak Salari Shabnam Niroumand Mahdi Yousefi Source Type: research
Achievements in Hypothyroidism Treatment with Herbal Medicine: A Systematic Review of Randomized Controlled Trials
Conclusion Some herbal remedies, including Nigella sativa L., ashwagandha, and Mentha x Piperita L., can improve the signs and symptoms of primary hypothyroidism, but using a more extensive and advanced methodology will provide us with more complete results.PMID:37013429 | DOI:10.2174/1570163820666230403091841 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - April 4, 2023 Category: Drugs & Pharmacology Authors: Najmeh Javidi Zahra Mazloum Khorasani Roshanak Salari Shabnam Niroumand Mahdi Yousefi Source Type: research
Achievements in Hypothyroidism Treatment with Herbal Medicine: A Systematic Review of Randomized Controlled Trials
Conclusion Some herbal remedies, including Nigella sativa L., ashwagandha, and Mentha x Piperita L., can improve the signs and symptoms of primary hypothyroidism, but using a more extensive and advanced methodology will provide us with more complete results.PMID:37013429 | DOI:10.2174/1570163820666230403091841 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - April 4, 2023 Category: Drugs & Pharmacology Authors: Najmeh Javidi Zahra Mazloum Khorasani Roshanak Salari Shabnam Niroumand Mahdi Yousefi Source Type: research
Achievements in Hypothyroidism Treatment with Herbal Medicine: A Systematic Review of Randomized Controlled Trials
Conclusion Some herbal remedies, including Nigella sativa L., ashwagandha, and Mentha x Piperita L., can improve the signs and symptoms of primary hypothyroidism, but using a more extensive and advanced methodology will provide us with more complete results.PMID:37013429 | DOI:10.2174/1570163820666230403091841 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - April 4, 2023 Category: Drugs & Pharmacology Authors: Najmeh Javidi Zahra Mazloum Khorasani Roshanak Salari Shabnam Niroumand Mahdi Yousefi Source Type: research
Achievements in Hypothyroidism Treatment with Herbal Medicine: A Systematic Review of Randomized Controlled Trials
Conclusion Some herbal remedies, including Nigella sativa L., ashwagandha, and Mentha x Piperita L., can improve the signs and symptoms of primary hypothyroidism, but using a more extensive and advanced methodology will provide us with more complete results.PMID:37013429 | DOI:10.2174/1570163820666230403091841 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - April 4, 2023 Category: Drugs & Pharmacology Authors: Najmeh Javidi Zahra Mazloum Khorasani Roshanak Salari Shabnam Niroumand Mahdi Yousefi Source Type: research
Achievements in Hypothyroidism Treatment with Herbal Medicine: A Systematic Review of Randomized Controlled Trials
Conclusion Some herbal remedies, including Nigella sativa L., ashwagandha, and Mentha x Piperita L., can improve the signs and symptoms of primary hypothyroidism, but using a more extensive and advanced methodology will provide us with more complete results.PMID:37013429 | DOI:10.2174/1570163820666230403091841 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - April 4, 2023 Category: Drugs & Pharmacology Authors: Najmeh Javidi Zahra Mazloum Khorasani Roshanak Salari Shabnam Niroumand Mahdi Yousefi Source Type: research
