Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: J Physiol Pharmacol - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: Journal of Physiology and Pharmacology - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: J Physiol Pharmacol - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: Journal of Physiology and Pharmacology - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: J Physiol Pharmacol - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: Journal of Physiology and Pharmacology - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: J Physiol Pharmacol - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: Journal of Physiology and Pharmacology - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: J Physiol Pharmacol - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: Journal of Physiology and Pharmacology - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: J Physiol Pharmacol - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: Journal of Physiology and Pharmacology - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: J Physiol Pharmacol - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: Journal of Physiology and Pharmacology - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: J Physiol Pharmacol - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
