Synthesis, characterization, and assessment of chitosan-nanomatrix enriched with antifungal formulation against biodeterioration of active ingredients of selected herbal raw materials
Int J Biol Macromol. 2023 Feb 13:123684. doi: 10.1016/j.ijbiomac.2023.123684. Online ahead of print.ABSTRACTAflatoxin B1 (AFB1), a potent natural group 1 carcinogen produced by Aspergillus flavus is considered an unavoidable toxic contaminant of herbal raw materials, which often deteriorates their active ingredients making them less effective and hazardous during their formulation in herbal drugs. The present investigation reports the antifungal (0.5 μl/ml) and AFB1 inhibitory (0.4 μl/ml) effects of the developed formulation CIM based on a mixture of essential oils (Carum carvi, and Illicium verum), and methyl anthranila...
Source: International Journal of Biological Macromolecules - February 15, 2023 Category: Biochemistry Authors: Vishal Gupta Prem Pratap Singh Bhanu Prakash Source Type: research
Synthesis, characterization, and assessment of chitosan-nanomatrix enriched with antifungal formulation against biodeterioration of active ingredients of selected herbal raw materials
Int J Biol Macromol. 2023 Feb 13:123684. doi: 10.1016/j.ijbiomac.2023.123684. Online ahead of print.ABSTRACTAflatoxin B1 (AFB1), a potent natural group 1 carcinogen produced by Aspergillus flavus is considered an unavoidable toxic contaminant of herbal raw materials, which often deteriorates their active ingredients making them less effective and hazardous during their formulation in herbal drugs. The present investigation reports the antifungal (0.5 μl/ml) and AFB1 inhibitory (0.4 μl/ml) effects of the developed formulation CIM based on a mixture of essential oils (Carum carvi, and Illicium verum), and methyl anthranila...
Source: International Journal of Biological Macromolecules - February 15, 2023 Category: Biochemistry Authors: Vishal Gupta Prem Pratap Singh Bhanu Prakash Source Type: research
Alkaloids in < b > < i > Withania somnifera < /i > < /b > (L.) Dunal Root Extract Contribute to Its Anti-Inflammatory Activity
The anti-inflammatory properties of the medicinal plantWithania somnifera (L.) Dunal (WS) are generally related to withanolides; consistently, several strategies are under investigation to increase the concentration of these compounds in WS extracts. However, a potential toxicity of withanolides has been highlighted, thus questioning the safety of such preparations. At variance, the relative contribution of alkaloids is underrated, in spite of preliminary evidence underlining a possible pharmacological relevance. Starting from these considerations, the efficacy/safety profile of WS root extract (WSE) was compared with thos...
Source: Pharmacology - February 8, 2023 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 28, Pages 1208: Biodiversity, Biochemical Profiling, and Pharmaco-Commercial Applications of Withania somnifera: A Review
Javier Palazon
Withania somnifera L. Dunal (Ashwagandha), a key medicinal plant native to India, is used globally to manage various ailments. This review focuses on the traditional uses, botany, phytochemistry, and pharmacological advances of its plant-derived constituents. It has been reported that at least 62 crucial and 48 inferior primary and secondary metabolites are present in the W. somnifera leaves, and 29 among these found in its roots and leaves are chiefly steroidal compounds, steroidal lactones, alkaloids, amino acids, etc. In addition, the whole shrub parts possess various medicinal activities such as a...
Source: Molecules - January 26, 2023 Category: Chemistry Authors: Harshita Gaurav Divyanshu Yadav Ankita Maurya Himanshu Yadav Ramanand Yadav Amritesh Chandra Shukla Minaxi Sharma Vijai Kumar Gupta Javier Palazon Tags: Review Source Type: research
Molecules, Vol. 28, Pages 1117: In Silico Study on the Interactions, Molecular Docking, Dynamics and Simulation of Potential Compounds from Withania & nbsp;somnifera (L.) Dunal Root against Cancer by Targeting KAT6A
Molecules, Vol. 28, Pages 1117: In Silico Study on the Interactions, Molecular Docking, Dynamics and Simulation of Potential Compounds from Withania somnifera (L.) Dunal Root against Cancer by Targeting KAT6A
Molecules doi: 10.3390/molecules28031117
Authors:
Sanjay H. Deshpande
Abdullatif Bin Muhsinah
Zabin K. Bagewadi
Gireesh M. Ankad
Mater H. Mahnashi
Deepak A. Yaraguppi
Ibrahim Ahmed Shaikh
Aejaz Abdullatif Khan
Harsha V. Hegde
Subarna Roy
Cancer is characterized by the abnormal development of cells that divide in an uncontrolled manner and further take over the body and destroy the no...
Source: Molecules - January 22, 2023 Category: Chemistry Authors: Sanjay H. Deshpande Abdullatif Bin Muhsinah Zabin K. Bagewadi Gireesh M. Ankad Mater H. Mahnashi Deepak A. Yaraguppi Ibrahim Ahmed Shaikh Aejaz Abdullatif Khan Harsha V. Hegde Subarna Roy Tags: Article Source Type: research
Early cancer detection using the fluorescent Ashwagandha chitosan nanoparticles combined with near-infrared light diffusion characterization: in vitro study
AbstractEarly cancer diagnosis through characterizing light propagation and nanotechnology increases the survival rate. The present research is aimed at evaluating the consequence of using natural nanoparticles in cancer therapy and diagnosis. Colon cancer cells were differentiated from the normal cells via investigating light diffusion combined with the fluorescence effect of the Ashwagandha chitosan nanoparticles (Ash C NPs). Ionic gelation technique synthesized theAsh C NPs. High-resolution transmission electron microscope, dynamic light scattering, and zeta potential characterizedAsh C NPs. Fourier transform infrared s...
Source: Lasers in Medical Science - January 11, 2023 Category: Laser Surgery Source Type: research
Withania somnifera (L.) Dunal (Ashwagandha); current understanding and future prospect as a potential drug candidate
Cancer and Neurodegenerative diseases are one of the most dreadful diseases to cure and chemotherapy has found a prime place in cancerous treatments while as different strategies have been tested in neurodegenerative diseases as well. However, due to adverse shortcomings like the resistance of cancerous cells and inefficiency in neurodegenerative disease, plant sources have always found a prime importance in medicinal use for decades, Withania somnifera (L.) Dunal (W. somnifera) is a well-known plant with medicinal use reported for centuries. It is commonly known as winter cherry or ashwagandha and is a prime source of pha...
Source: Frontiers in Pharmacology - December 12, 2022 Category: Drugs & Pharmacology Source Type: research
Ashwagandha Modulates Stress, Sleep Dynamics, and Mental Clarity
Journal of Medicinal Food,Volume 25, Issue 12, Page 1073-1073, December 2022. (Source: Journal of Medicinal Food)
Source: Journal of Medicinal Food - December 12, 2022 Category: Nutrition Authors: Michael B. Zemel, PhD Source Type: research
Phyto-Extract-Mediated Synthesis of Silver Nanoparticles (AgNPs) and Their Biological Activities
CONCLUSIONS: Both crude and AgNPs showed potent activity; however, in comparison, silver nanoparticles showed slightly enhanced activity. Crude and AgNPs of both plants showed good phytotoxic and insecticidal inhibition. Antimicrobial studies of AgNPs on diseases causing pathogens open a door for new antimicrobial agents and could be the answer to antibiotic resistance after further analysis.PMID:36440367 | PMC:PMC9683943 | DOI:10.1155/2022/9845022 (Source: Biomed Res)
Source: Biomed Res - November 28, 2022 Category: Research Authors: Muhammad Adnan Asma Akbar Sakina Mussarat Waheed Murad Ishfaq Hameed Shaheen Begum Ruqia Nazir Nawab Ali Essam A Ali Ahmed Bari Muhammad Abdul Aziz Shahid Niaz Khan Source Type: research
Appraisal of selected ethnomedicinal plants as alternative therapies against onychomycosis: Evaluation of synergy and time-kill kinetics
Conclusion: The extracts of A. sativum, Z. officinale, M. piperita, L. inermis, and C. longa have proven to be promising alternatives to combat oxidative stress, resistance, and other treatment challenges of onychomycosis. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 24, 2022 Category: Drugs & Pharmacology Source Type: research
Characterization and anticancer potential of Withania somnifera fruit bioactives (a native species to Pakistan) using gas chromatography-mass spectrometer, nuclear magnetic resonance and liquid chromatography-mass spectrometry-electrospray ionization
CONCLUSION: We found that a variety of bioactive compounds existed in this plant. One identified compound that was not investigated for cytotoxicity in previous studies was purified and its application showed cytotoxicity on breast cancer cell lines. A number of bioactive identified from fruit may have an effective potential for development into chemotherapy drugs.PMID:36378048 | DOI:10.19852/j.cnki.jtcm.2022.06.006 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - November 15, 2022 Category: Complementary Medicine Authors: Qudsia Tabassam Tahir Mehmood Sibtain Ahmed Farooq Anwar Abdul Rauf Raza Source Type: research
Characterization and anticancer potential of Withania somnifera fruit bioactives (a native species to Pakistan) using gas chromatography-mass spectrometer, nuclear magnetic resonance and liquid chromatography-mass spectrometry-electrospray ionization
CONCLUSION: We found that a variety of bioactive compounds existed in this plant. One identified compound that was not investigated for cytotoxicity in previous studies was purified and its application showed cytotoxicity on breast cancer cell lines. A number of bioactive identified from fruit may have an effective potential for development into chemotherapy drugs.PMID:36378048 | DOI:10.19852/j.cnki.jtcm.2022.06.006 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - November 15, 2022 Category: Complementary Medicine Authors: Qudsia Tabassam Tahir Mehmood Sibtain Ahmed Farooq Anwar Abdul Rauf Raza Source Type: research
Characterization and anticancer potential of Withania somnifera fruit bioactives (a native species to Pakistan) using gas chromatography-mass spectrometer, nuclear magnetic resonance and liquid chromatography-mass spectrometry-electrospray ionization
CONCLUSION: We found that a variety of bioactive compounds existed in this plant. One identified compound that was not investigated for cytotoxicity in previous studies was purified and its application showed cytotoxicity on breast cancer cell lines. A number of bioactive identified from fruit may have an effective potential for development into chemotherapy drugs.PMID:36378048 | DOI:10.19852/j.cnki.jtcm.2022.06.006 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - November 15, 2022 Category: Complementary Medicine Authors: Qudsia Tabassam Tahir Mehmood Sibtain Ahmed Farooq Anwar Abdul Rauf Raza Source Type: research
Characterization and anticancer potential of Withania somnifera fruit bioactives (a native species to Pakistan) using gas chromatography-mass spectrometer, nuclear magnetic resonance and liquid chromatography-mass spectrometry-electrospray ionization
CONCLUSION: We found that a variety of bioactive compounds existed in this plant. One identified compound that was not investigated for cytotoxicity in previous studies was purified and its application showed cytotoxicity on breast cancer cell lines. A number of bioactive identified from fruit may have an effective potential for development into chemotherapy drugs.PMID:36378048 | DOI:10.19852/j.cnki.jtcm.2022.06.006 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - November 15, 2022 Category: Complementary Medicine Authors: Qudsia Tabassam Tahir Mehmood Sibtain Ahmed Farooq Anwar Abdul Rauf Raza Source Type: research
