Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: Journal of Physiology and Pharmacology - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: J Physiol Pharmacol - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: Journal of Physiology and Pharmacology - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: J Physiol Pharmacol - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: Journal of Physiology and Pharmacology - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: J Physiol Pharmacol - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
ALSUntangled #74: Withania Somnifera (Ashwagandha)
. (Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration)
Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - February 6, 2024 Category: Neurology Authors: Sartaj JhootyPaul BarkhausAndrew BrownJavier Mascias CadavidGregory T. CarterJesse CrayleTerry Heiman-PattersonXiaoyan LiElise MallonChristopher McdermottTasnim MushannenGary PatteeDylan RatnerPaul WicksMartina WiedauRichard Bedlack1 Department of Neurosc Source Type: research
New withanolides from leaves along with alkyl glucoside from roots and stem as well as variations in withanolide contents in leaves of accessions of Withania somnifera, Ashwagandha- the Indian ginseng$
. (Source: Journal of Asian Natural Products Research)
Source: Journal of Asian Natural Products Research - February 5, 2024 Category: Complementary Medicine Authors: Payare LalLaxminarain MisraNeelam S. SangwanRajender S. Sangwana CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, Indiab Department of Biochemistry, Central University of Haryana, Mahendergarh 123031, Indiac Faculty of Life Science Source Type: research
Anti-COVID-19 Potential of Withaferin-A and Caffeic Acid Phenethyl Ester
CONCLUSION: Wi-A and CAPE possess multimodal anti-COVID-19 potential, and their combination (Wi-ACAPE) is expected to provide better activity and hence warrant further attention in the laboratory and clinic.PMID:38279743 | DOI:10.2174/0115680266280720231221100004 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - January 27, 2024 Category: Chemistry Authors: Vipul Kumar Anissa Nofita Sari Dharmender Gupta Yoshiyuki Ishida Keiji Terao Sunil C Kaul Sudhanshu Vrati Durai Sundar Renu Wadhwa Source Type: research
< em > Withania Somnifera < /em > Extract Mitigates Experimental Acute Graft versus Host Disease Without Abrogating Graft Versus Leukemia Effect
Cell Transplant. 2024 Jan-Dec;33:9636897241226573. doi: 10.1177/09636897241226573.ABSTRACTAcute graft versus host disease (aGvHD) is the major contributor of nonrelapse mortality in alloHSCT. It is associated with an inflammatory immune response manifesting as cytokine storm with ensuing damage to target organs such as liver, gut, and skin. Prevention of aGvHD while retaining the beneficial graft versus leukemia (GvL) effect remains a major challenge. Withania somnifera extract (WSE) is known for its anti-inflammatory, immune-modulatory, and anticancer properties, which are appealing in the context of aGvHD. Herein, we dem...
Source: Cell Transplantation - January 23, 2024 Category: Cytology Authors: Saurabh Kumar Gupta Dievya Gohil Mohd Bashar Momin Subhash Yadav Akanksha Chichra Sachin Punatar Anant Gokarn Sumeet Mirgh Nishant Jindal Lingaraj Nayak Lal Hingorani Navin Khattry Vikram Gota Source Type: research
Dietary inclusion of Withania somnifera and Asparagus racemosus induces growth, activities of digestive enzymes, and transcriptional modulation of MyoD, MyoG, Myf5, and MRF4 genes in fish, Channa punctatus
Comp Biochem Physiol B Biochem Mol Biol. 2024 Jan 17;271:110944. doi: 10.1016/j.cbpb.2024.110944. Online ahead of print.ABSTRACTThe present study explores growth potential of two medicinal herbs, Withania somnifera (Ashwagandha or 'A') and Asparagus racemosus (Shatavari or 'S') after their dietary inclusion in fish, Channa punctatus (13.5 ± 2 g; 11.5 ± 1 cm). Three hundred well-acclimatized fish were distributed into 10 groups- C (Control), S1 (1% S), S2 (2% S), S3 (3% S), A1 (1% A), A2 (2% A), A3 (3% A), AS1 (1% A and S), AS2 (2% A and S), and AS3 (3% A and S), each having 10 specimens. Fish were fed with these diets fo...
Source: Comparative biochemistry and physiology. Part B, Biochemistry and molecular biology. - January 18, 2024 Category: Biochemistry Authors: Sunil P Trivedi Shikha Dwivedi Abha Trivedi Adeel Ahmad Khan Shefalee Singh Kamlesh K Yadav Vivek Kumar Shraddha Dwivedi Vidyanand Tiwari Yashika Awasthi Source Type: research
In vitro cytotoxicity of Withania somnifera (L.) roots and fruits on oral squamous cell carcinoma cell lines: a study supported by flow cytometry, spectral, and computational investigations
Oral cancer is a severe health problem that accounts for an alarmingly high number of fatalities worldwide. Withania somnifera (L.) Dunal has been extensively studied against various tumor cell lines from different body organs, rarely from the oral cavity. We thus investigated the cytotoxicity of W. somnifera fruits (W-F) and roots (W-R) hydromethanolic extracts and their chromatographic fractions against oral squamous cell carcinoma (OSCC) cell lines [Ca9-22 (derived from gingiva), HSC-2, HSC-3, and HSC-4 (derived from tongue)] and three normal oral mesenchymal cells [human gingival fibroblast (HGF), human periodontal lig...
Source: Frontiers in Pharmacology - January 18, 2024 Category: Drugs & Pharmacology Source Type: research
< em > In Vitro < /em > Cytotoxicity of Reproductive Stage < em > Withania somnifera < /em > Leaf and Stem on HepG2 Cell Line
CONCLUSION: The results of our study have confirmed that the methanolic extracts of both the leaf and stem of W. somnifera exhibit significant in vitro cytotoxicity in HepG2 cell lines, while displaying no significant cytotoxicity in the L929 cell line. Furthermore, the data obtained from the MTT assay indicate that the leaf methanolic extract possesses a more potent cytotoxic activity than the stem methanolic extract with respect to the HepG2 cell line. Further studies on the identification and isolation of bioactive metabolites are required to explore the mechanisms underlying their in vitro cytotoxicity.PMID:38169931 | ...
Source: Evidence-based Complementary and Alternative Medicine - January 3, 2024 Category: Complementary Medicine Authors: Lali Lingfa Aravinda Tirumala Srinivas Ankanagari Source Type: research
