Integrating network pharmacology and in silico analysis deciphers Withaferin-A's anti-breast cancer potential via hedgehog pathway and target network interplay
This study examines the remarkable effectiveness of Withaferin-A (WA), a withanolide obtained from Withania somnifera (Ashwagandha), in encountering the mortiferous breast malignancy, a global peril. The predominant objective is to investigate WA's intrinsic target proteins and hedgehog (Hh) pathway proteins in breast cancer targeting through the application of in silico computational techniques and network pharmacology predictions. The databases and webtools like Swiss target prediction, GeneCards, DisGeNet and Online Mendelian Inheritance in Man were exploited to identify the common target proteins. The culmination of th...
Source: Briefings in Bioinformatics - March 6, 2024 Category: Bioinformatics Authors: Mythili Srinivasan Apeksha Gangurde Ashwini Y Chandane Amol Tagalpallewar Anil Pawar Akshay M Baheti Source Type: research
Integrating network pharmacology and in silico analysis deciphers Withaferin-A's anti-breast cancer potential via hedgehog pathway and target network interplay
This study examines the remarkable effectiveness of Withaferin-A (WA), a withanolide obtained from Withania somnifera (Ashwagandha), in encountering the mortiferous breast malignancy, a global peril. The predominant objective is to investigate WA's intrinsic target proteins and hedgehog (Hh) pathway proteins in breast cancer targeting through the application of in silico computational techniques and network pharmacology predictions. The databases and webtools like Swiss target prediction, GeneCards, DisGeNet and Online Mendelian Inheritance in Man were exploited to identify the common target proteins. The culmination of th...
Source: Briefings in Bioinformatics - March 6, 2024 Category: Bioinformatics Authors: Mythili Srinivasan Apeksha Gangurde Ashwini Y Chandane Amol Tagalpallewar Anil Pawar Akshay M Baheti Source Type: research
Integrating network pharmacology and in silico analysis deciphers Withaferin-A's anti-breast cancer potential via hedgehog pathway and target network interplay
This study examines the remarkable effectiveness of Withaferin-A (WA), a withanolide obtained from Withania somnifera (Ashwagandha), in encountering the mortiferous breast malignancy, a global peril. The predominant objective is to investigate WA's intrinsic target proteins and hedgehog (Hh) pathway proteins in breast cancer targeting through the application of in silico computational techniques and network pharmacology predictions. The databases and webtools like Swiss target prediction, GeneCards, DisGeNet and Online Mendelian Inheritance in Man were exploited to identify the common target proteins. The culmination of th...
Source: Briefings in Bioinformatics - March 6, 2024 Category: Bioinformatics Authors: Mythili Srinivasan Apeksha Gangurde Ashwini Y Chandane Amol Tagalpallewar Anil Pawar Akshay M Baheti Source Type: research
Integrating network pharmacology and in silico analysis deciphers Withaferin-A's anti-breast cancer potential via hedgehog pathway and target network interplay
This study examines the remarkable effectiveness of Withaferin-A (WA), a withanolide obtained from Withania somnifera (Ashwagandha), in encountering the mortiferous breast malignancy, a global peril. The predominant objective is to investigate WA's intrinsic target proteins and hedgehog (Hh) pathway proteins in breast cancer targeting through the application of in silico computational techniques and network pharmacology predictions. The databases and webtools like Swiss target prediction, GeneCards, DisGeNet and Online Mendelian Inheritance in Man were exploited to identify the common target proteins. The culmination of th...
Source: Briefings in Bioinformatics - March 6, 2024 Category: Bioinformatics Authors: Mythili Srinivasan Apeksha Gangurde Ashwini Y Chandane Amol Tagalpallewar Anil Pawar Akshay M Baheti Source Type: research
Integrating network pharmacology and in silico analysis deciphers Withaferin-A's anti-breast cancer potential via hedgehog pathway and target network interplay
This study examines the remarkable effectiveness of Withaferin-A (WA), a withanolide obtained from Withania somnifera (Ashwagandha), in encountering the mortiferous breast malignancy, a global peril. The predominant objective is to investigate WA's intrinsic target proteins and hedgehog (Hh) pathway proteins in breast cancer targeting through the application of in silico computational techniques and network pharmacology predictions. The databases and webtools like Swiss target prediction, GeneCards, DisGeNet and Online Mendelian Inheritance in Man were exploited to identify the common target proteins. The culmination of th...
Source: Briefings in Bioinformatics - March 6, 2024 Category: Bioinformatics Authors: Mythili Srinivasan Apeksha Gangurde Ashwini Y Chandane Amol Tagalpallewar Anil Pawar Akshay M Baheti Source Type: research
Antibacterial activity and phytochemical screening of traditional medicinal plants most preferred for treating infectious diseases in Habru District, North Wollo Zone, Amhara Region, Ethiopia
The objective of this study was to investigate the antibacterial activity and phytochemical screening on five selected medicinal plant species, namelySolanum somalense Franchet.,Verbascum sinaiticum Benth.,Rumex nervosus Vahl,Withania somnifera (L.) Dunal andCalpurnia aurea (Ait.) Benth. The plants were first identified jointly with local informants and later considering mainly their high informant consensus and fidelity level values for their efficacy in treating infectious diseases in the area. Ethanol and aqueous extracts were prepared from the plant materials, and their antibacterial activities were evaluated against s...
Source: PLoS One - March 5, 2024 Category: Biomedical Science Authors: Mulugeta Alemu Source Type: research
Molecules, Vol. 29, Pages 866: Anti-Neuroinflammatory Effects of Adaptogens: A Mini-Review
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Introduction: Adaptogens are a group of plants that exhibit complex, nonspecific effects on the human body, increasing its ability to adapt, develop resilience, and survive in stress conditions. They are found in many traditional medicinal systems and play a key role in restoring the body’s strength and stamina. Research in recent years has attempted to elucidate the mechanisms behind their pharmacological effects, but it appears that these effects are difficult to define precisely and involve multiple molecular pathways. Neuroinflammation: In recent years, chronic inflammation has been recognized as o...
Source: Molecules - February 15, 2024 Category: Chemistry Authors: Dagmara Wr óbel-Biedrawa Irma Podolak Tags: Review Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: J Physiol Pharmacol - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: Journal of Physiology and Pharmacology - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: J Physiol Pharmacol - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: Journal of Physiology and Pharmacology - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: J Physiol Pharmacol - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: Journal of Physiology and Pharmacology - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: J Physiol Pharmacol - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7.ABSTRACTWithaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. As reported, it has the potential to safely cure rheumatoid arthritis (RA) in animal models. Nevertheless, the action mechanism of WFA in treating RA has not been completely illuminated. The study was to explore the action and mechanism of WFA on arthritic rats. First, a collagen-induced arthritis rat model was established. WFA administration alleviated inflammation and injury in arthritic rats. Subsequently, fibroblast synovial cells (FLS)...
Source: Journal of Physiology and Pharmacology - February 12, 2024 Category: Drugs & Pharmacology Authors: J D Sheng J Liu J W Du Y P Wang Source Type: research
