Electrospun polyvinyl alcohol/Withania somnifera extract nanofibers incorporating tadalafil-loaded nanoparticles for diabetic ulcers
Nanomedicine, Ahead of Print. (Source: Future Medicine: Nanomedicine)
Source: Future Medicine: Nanomedicine - October 6, 2023 Category: Nanotechnology Authors: Asmaa M Elsherbini Sally A Sabra Shimaa A Rashed Doaa A Abdelmonsif Medhat Haroun Thanaa I Shalaby Source Type: research
Electrospun polyvinyl alcohol/Withania somnifera extract nanofibers incorporating tadalafil-loaded nanoparticles for diabetic ulcers
Nanomedicine, Ahead of Print. (Source: Nanomedicine)
Source: Nanomedicine - October 6, 2023 Category: Nanotechnology Authors: Asmaa M Elsherbini Sally A Sabra Shimaa A Rashed Doaa A Abdelmonsif Medhat Haroun Thanaa I Shalaby Source Type: research
Harder, better, faster, stronger? Retrospective chart review of adverse events of interactions between adaptogens and antidepressant drugs
Conclusion: Clinicians should monitor the adverse events associated with the concomitant use of adaptogens and antidepressant drugs in patients with mental disorders. Aggregation of side effects and pharmacokinetic interactions (inhibition of CYP and p-glycoprotein) between those medicines may result in clinically significant adverse events. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 27, 2023 Category: Drugs & Pharmacology Source Type: research
Enhancement of hippocampal-dependent spatial memory by Ashwagandha (Withania somnifera) characterized by activation of NMDA receptors against monosodium glutamate-induced neurotoxicity in rats
. (Source: International Journal of Neuroscience)
Source: International Journal of Neuroscience - September 2, 2023 Category: Neuroscience Authors: Rawand H. Al-DmourNafe M. Al-TawarahNesrin MwafiBanan M. AlkhataybehKhaled M. KhleifatAmjad TarawnehAnas O. SatariSahem M. AlkharabshehLayla Albustanjia Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Mutah University, Al-Ka Source Type: research
Withania-somnifera
(Source: Reactions Weekly)
Source: Reactions Weekly - September 1, 2023 Category: Drugs & Pharmacology Source Type: research
Over the Counter Supplements for Memory: A Review of Available Evidence
AbstractIn 2021, the Global Brain Health Supplement Industry Market size was valued at US$7.6 billion. It is predicted to increase to US$15.59 billion by 2030. Memory and its enhancement are a segment of the market that comprised the highest global revenue share in 2021. In the USA alone, dietary supplement sales reached US$18 billion in 2018. The US Food and Drug Administration (FDA) does not have the authority to approve dietary supplements’ safety, effectiveness, or labeling before products go on the market. The FDA often does not even review supplements before they go to market. Supplement manufacturers are thus re...
Source: CNS Drugs - August 21, 2023 Category: Neurology Source Type: research
A critical assessment of the whole plant-based phytotherapeutics from Withania somnifera (L.) Dunal with respect to safety and efficacy vis-a-vis leaf or root extract-based formulation
. (Source: Toxicology Mechanisms and Methods)
Source: Toxicology Mechanisms and Methods - August 15, 2023 Category: Toxicology Authors: Pawan Kumar Samudra P. Banik Apurva Goel Sanjoy Chakraborty Manashi Bagchi Debasis Bagchi Source Type: research
Withania somnifera extracts induced attenuation of HIV-1: a mechanistic approach to restrict viral infection
Several anti-retroviral drugs are available against Human immunodeficiency virus type-1, but have multiple adverse side effects. Hence, there is an incessant compulsion for effectual anti-retroviral agents wit... (Source: Virology Journal)
Source: Virology Journal - August 3, 2023 Category: Virology Authors: Pratiksha Jadaun, R Harshithkumar, Shraddha Y Gaikwad, Chandrabhan Seniya, Swapnil Borse, Ashish A Gawai, Preeti Chavan-Gautam, Girish Tillu and Anupam Mukherjee Tags: Research Source Type: research
Efficacy and Anti-Inflammatory Activity of Ashwagandha Sustained-Release Formulation on Depression and Anxiety Induced by Chronic Unpredictable Stress: in vivo and in vitro Studies
(Source: International Journal of Nanomedicine)
Source: International Journal of Nanomedicine - July 25, 2023 Category: Nanotechnology Tags: Journal of Experimental Pharmacology Source Type: research
Simultaneous estimation of five biomarkers of neuroprotective herb Ashwagandha NMITLI-118R AF1 in rat plasma and brain using LC-ESI-MS/MS: Application to its pharmacokinetic and stability studies
This study aimed to develop and validate a sensitive and selective LC-ESI-MS/MS method for these biomarkers in male Sprague Dawley rats plasma and brain matrix. Rats were divided into eight groups, each containing five rats. A plant extract of NMITLI-118R AF1 at 50 mg/kg was orally administered to the rats for in-vivo pharmacokinetic investigation. All the analytes had a linear calibration curve (r2 > 0.999), and intra-day and inter-day precision (%) were found in the range of 2.46 - 13.71% and accuracy were within the acceptable range (±15%). The biomarkers of NMITLI-118R AF1 were found stable in in-vitro plasma and s...
Source: Biomed Res - July 23, 2023 Category: Research Authors: Shailesh D Dadge Neerja Tiwari Athar Husain Saurabh Verma Arun Agarwal Richa Garg Srikanta K Rath Karuna Shanker Jiaur R Gayen Source Type: research
Ashwagandha (Withania somnifera) and Shunthi (Zingiber officinale) in mild and moderate COVID-19: An open-label randomized controlled exploratory trial
CONCLUSIONS: The Ayurveda interventions, Ashwagandha and Shunthi, can effectively reduce the duration of clinical recovery and improve time for viral clearance in mild and moderate COVID-19 is safe and well-tolerated during the duration of the trial.TRIAL REGISTRATION: Clinical Trial Registry of India - CTRI/2020/08/027224.PMID:37482107 | DOI:10.1016/j.ctim.2023.102966 (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - July 23, 2023 Category: Complementary Medicine Authors: Harbans Singh Babita Yadav Amit K Rai Sumit Srivastava Ajv Saiprasad Sophia Jameela Richa Singhal Sanuj Muralidharan Rijin Mohan Shikha Chaudhary Rakesh Rana Shruti Khanduri Bhagwan S Sharma Bhogavalli Chandrasekhararao Narayanam Srikanth Kartar S Dhiman Source Type: research
Simultaneous estimation of five biomarkers of neuroprotective herb Ashwagandha NMITLI-118R AF1 in rat plasma and brain using LC-ESI-MS/MS: Application to its pharmacokinetic and stability studies
This study aimed to develop and validate a sensitive and selective LC-ESI-MS/MS method for these biomarkers in male Sprague Dawley rats plasma and brain matrix. Rats were divided into eight groups, each containing five rats. A plant extract of NMITLI-118R AF1 at 50 mg/kg was orally administered to the rats for in-vivo pharmacokinetic investigation. All the analytes had a linear calibration curve (r2 > 0.999), and intra-day and inter-day precision (%) were found in the range of 2.46 - 13.71% and accuracy were within the acceptable range (±15%). The biomarkers of NMITLI-118R AF1 were found stable in in-vitro plasma and s...
Source: Biomed Res - July 23, 2023 Category: Research Authors: Shailesh D Dadge Neerja Tiwari Athar Husain Saurabh Verma Arun Agarwal Richa Garg Srikanta K Rath Karuna Shanker Jiaur R Gayen Source Type: research
