Withaferin-A alleviates acute graft versus host disease without compromising graft versus leukemia effect
In conclusion, our study demonstrates the utility of WA for the prevention and treatment of aGvHD, which should be further evaluated in a clinical setting.PMID:37311352 | DOI:10.1016/j.intimp.2023.110437 (Source: International Immunopharmacology)
Source: International Immunopharmacology - June 13, 2023 Category: Allergy & Immunology Authors: Saurabh Kumar Gupta Dievya Gohil Deepshikha Dutta Girish Ch Panigrahi Puja Gupta Kajal Dalvi Twinkle Khanka Subhash Yadav Rajiv Kumar Kaushal Akanksha Chichra Sachin Punatar Anant Gokarn Sumeet Mirgh Nishant Jindal Lingaraj Nayak Prashant R Tembhare Syed Source Type: research
The aqueous root extract of Withania somnifera ameliorates LPS-induced inflammatory changes in the in vitro cell-based and mice models of inflammation
Introduction: Most critically ill COVID-19 patients have bronchitis, pneumonia, and acute respiratory distress syndrome (ARDS) due to excessive inflammatory conditions. Corticosteroids have largely been prescribed for the management of inflammation in these patients. However, long-term use of corticosteroids in patients with comorbidities such as metabolic, cardiovascular, and other inflammatory disorders is ideally not recommended due to safety issues. A potential and safer anti-inflammatory therapy is therefore the need of the hour. Withania somnifera (WS), a well-known herbal medicine used during the pandemic in India t...
Source: Frontiers in Pharmacology - June 12, 2023 Category: Drugs & Pharmacology Source Type: research
Golden berry leaf extract containing withanolides suppresses TNF- α and IL-17 induced IL-6 expression in HeLa Cells
In this study, we established an experimental system for overexpression of IL-6 in HeLa cells stimulated by TNF-α and IL-17, along with identification of anti-inflammatory materials and components from local agricultural, forestry, and fishery resources. We constructed a library of extracts from natural sources, of which 111 samples were evaluated for their anti-inflammatory activities. The MeOH extract of Golden Berry (Physalis peruviana L) leaf was found to exhibit strong anti-inflammatory properties (IC50 = 4.97 µg/mL). Preparative chromatography identified two active constituents, 4β-hydroxywithanolide E (4β-HWE) (...
Source: Bioscience, Biotechnology, and Biochemistry - June 6, 2023 Category: Biochemistry Authors: Akira Yano Sayaka Yuki Akiko Shiraishi Mayuka Hakozaki Yuko Kanno Kimura Ken-Ichi Shota Uesugi Source Type: research
Golden berry leaf extract containing withanolides suppresses TNF- α and IL-17 induced IL-6 expression in HeLa Cells
In this study, we established an experimental system for overexpression of IL-6 in HeLa cells stimulated by TNF-α and IL-17, along with identification of anti-inflammatory materials and components from local agricultural, forestry, and fishery resources. We constructed a library of extracts from natural sources, of which 111 samples were evaluated for their anti-inflammatory activities. The MeOH extract of Golden Berry (Physalis peruviana L) leaf was found to exhibit strong anti-inflammatory properties (IC50 = 4.97 µg/mL). Preparative chromatography identified two active constituents, 4β-hydroxywithanolide E (4β-HWE) (...
Source: Bioscience, Biotechnology, and Biochemistry - June 6, 2023 Category: Biochemistry Authors: Akira Yano Sayaka Yuki Akiko Shiraishi Mayuka Hakozaki Yuko Kanno Kimura Ken-Ichi Shota Uesugi Source Type: research
Golden berry leaf extract containing withanolides suppresses TNF- α and IL-17 induced IL-6 expression in HeLa Cells
In this study, we established an experimental system for overexpression of IL-6 in HeLa cells stimulated by TNF-α and IL-17, along with identification of anti-inflammatory materials and components from local agricultural, forestry, and fishery resources. We constructed a library of extracts from natural sources, of which 111 samples were evaluated for their anti-inflammatory activities. The MeOH extract of Golden Berry (Physalis peruviana L) leaf was found to exhibit strong anti-inflammatory properties (IC50 = 4.97 µg/mL). Preparative chromatography identified two active constituents, 4β-hydroxywithanolide E (4β-HWE) (...
Source: Bioscience, Biotechnology, and Biochemistry - June 6, 2023 Category: Biochemistry Authors: Akira Yano Sayaka Yuki Akiko Shiraishi Mayuka Hakozaki Yuko Kanno Kimura Ken-Ichi Shota Uesugi Source Type: research
Correction to: Indian ginseng (Withania somnifera) supplementation ameliorates oxidative stress and mitochondrial dysfunctions in experimental model of stroke
(Source: Metabolic Brain Disease)
Source: Metabolic Brain Disease - June 1, 2023 Category: Neurology Source Type: research
