< em > In Vitro < /em > Cytotoxicity of Reproductive Stage < em > Withania somnifera < /em > Leaf and Stem on HepG2 Cell Line

CONCLUSION: The results of our study have confirmed that the methanolic extracts of both the leaf and stem of W. somnifera exhibit significant in vitro cytotoxicity in HepG2 cell lines, while displaying no significant cytotoxicity in the L929 cell line. Furthermore, the data obtained from the MTT assay indicate that the leaf methanolic extract possesses a more potent cytotoxic activity than the stem methanolic extract with respect to the HepG2 cell line. Further studies on the identification and isolation of bioactive metabolites are required to explore the mechanisms underlying their in vitro cytotoxicity.PMID:38169931 | PMC:PMC10761218 | DOI:10.1155/2023/8832166
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Authors: Source Type: research