IJERPH, Vol. 20, Pages 3921: Liver Dangers of Herbal Products: A Case Report of Ashwagandha-Induced Liver Injury

IJERPH, Vol. 20, Pages 3921: Liver Dangers of Herbal Products: A Case Report of Ashwagandha-Induced Liver Injury International Journal of Environmental Research and Public Health doi: 10.3390/ijerph20053921 Authors: Marta Lubarska Przemysław Hałasiński Szymon Hryhorowicz Dagmara Santabye Mahadea Liliana Łykowska-Szuber Piotr Eder Agnieszka Dobrowolska Iwona Krela-Kaźmierczak In recent years, cases of liver damage caused by ashwagandha herbal supplements have been reported from different parts of the world (Japan, Iceland, India, and the USA). Here, we describe the clinical phenotype of suspected ashwagandha-induced liver injury and the potential causative mechanism. The patient was admitted to the hospital because of jaundice. In the interview, it was reported that he had been taking ashwagandha for a year. Laboratory results showed an increase in total bilirubin, alanine transaminase (ALT), aspartate transaminase (AST), (gamma-glutamyl transpherase (GGT), alkaline phosphatase (ALP), total cholesterol, triglycerides, and ferritin. Based on clinical symptoms and additional tests, the patient was diagnosed with acute hepatitis and referred to a facility with a higher reference rate to exclude drug-induced liver injury. An R-value was assessed, indicative of hepatocellular injury. The result of the 24 h urine collection exceeded the upper limit of normal for copper excretion in urine twice. The clinical condition improved after intensive pharmacologica...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Case Report Source Type: research