Implementation of Office Hysteroscopy for the Evaluation and Treatment of Intrauterine Pathology
We describe miniaturized equipment for use in the office setting and "no-touch" vaginoscopic approaches to limit patient discomfort. With appropriate training and experience, office hysteroscopy presents a simple and cost-effective modality for optimizing gynecologic care for our patients.PMID:35926213 | DOI:10.1097/AOG.0000000000004898 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - August 4, 2022 Category: OBGYN Authors: Megan S Orlando Linda D Bradley Source Type: research
The Mechanism of Wnt Pathway Regulated by Telocytes to Promote the Regeneration and Repair of Intrauterine Adhesions
CONCLUSIONS: TCs may enhance the regeneration and repair of IUA through the Wnt signaling pathway.PMID:35844454 | PMC:PMC9279088 | DOI:10.1155/2022/3809792 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - July 18, 2022 Category: Statistics Authors: Cai-Zhen Zhao Ping Fu Wen-Ying Peng Na Pan Yuqiu Peng Min Zhao Weiquan Xie Source Type: research
Human umbilical cord blood-derived MSCs trans-differentiate into endometrial cells and regulate Th17/Treg balance through NF- κB signaling in rabbit intrauterine adhesions endometrium
CONCLUSIONS: Our study demonstrated that hUCB-MSCs can repair damaged endometrium through trans-differentiation, immunomodulatory capacities and NF-κB signaling, suggesting the treatment value of hUCB-MSCs in IUA.PMID:35841027 | DOI:10.1186/s13287-022-02990-1 (Source: Cell Research)
Source: Cell Research - July 15, 2022 Category: Cytology Authors: Qing Hua Yong Zhang Hongjuan Li Haoran Li Ranran Jin Li Li Yuancui Xiang Meng Tian Jingjing Wang Lei Sun Yali Wang Source Type: research
Human umbilical cord blood-derived MSCs trans-differentiate into endometrial cells and regulate Th17/Treg balance through NF- κB signaling in rabbit intrauterine adhesions endometrium
CONCLUSIONS: Our study demonstrated that hUCB-MSCs can repair damaged endometrium through trans-differentiation, immunomodulatory capacities and NF-κB signaling, suggesting the treatment value of hUCB-MSCs in IUA.PMID:35841027 | DOI:10.1186/s13287-022-02990-1 (Source: Cell Research)
Source: Cell Research - July 15, 2022 Category: Cytology Authors: Qing Hua Yong Zhang Hongjuan Li Haoran Li Ranran Jin Li Li Yuancui Xiang Meng Tian Jingjing Wang Lei Sun Yali Wang Source Type: research
Human Endometrium ‐Derived Adventitial Cell Spheroid‐Loaded Antimicrobial Microneedles for Uterine Regeneration
The flexible microneedles fabricated with gelatin methacryloyl and lactoferrin exhibit rapid degradation and antimicrobial activity. Benefiting from microwells on microneedles, human endometrium-derived adventitial cells (En-ADVs) rapidly form 3D cell spheroids, displaying higher potentials of cell proliferation, differentiation, and migration in comparison to dissociated cells. Transplantation of En-ADV spheroid-loaded hierarchical microneedles (MN/En-ADV) patches efficiently repairs the injured uterus and restores the reproductive function in Asherman's syndrome model rats. AbstractAsherman's syndrome (AS) occurs as a co...
Source: Small - July 7, 2022 Category: Nanotechnology Authors: Shiyuan Li,
Yifan Li,
Fei Yu,
Ning Li,
Chuanming Liu,
Jialian Mao,
Haixiang Sun,
Yali Hu,
Yujuan Zhu,
Min Zhou,
Lijun Ding Tags: Research Article Source Type: research
Hysteroscopic and ultrasound evaluation of a novel degradable polymer film for the prevention of intrauterine adhesion formation after hysteroscopic surgery
Intrauterine adhesions (IUAs) are dense or filmy bands of scar tissue between the inner walls of the uterine cavity. They can be partial or complete resulting in a reduction in the uterine cavity volume and its deformation or, in severe cases, its complete obliteration [1]. IUAs can occur following intrauterine diagnostic and therapeutic procedures that lead to endometrial trauma resulting in scarring, adhesions or fusion of the opposing uterine walls. Women who have IUAs are sometimes asymptomatic, however, infertility, recurrent pregnancy loss, menstrual abnormalities and pelvic pain are common presenting complaints in s...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - June 15, 2022 Category: OBGYN Authors: Brunella Zizolfi, Gabriele Saccone, Elena Cancelliere, Jose Carugno, Alessandra Gallo, Maria Chiara De Angelis, Attilio Di Spiezio Sardo Source Type: research
Comparison of the Reproductive Outcome Between 2 and 4 mg Daily Doses of Estradiol After Hysteroscopic Adhesiolysis: A Propensity Score Matching Analysis–Retrospective Cohort Study
ConclusionsWe suggest the use of a lower dose (2 mg/day) of estradiol valerate as an adjuvant therapy for IUAs to minimize estrogen-related side effects. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - June 13, 2022 Category: Endocrinology Source Type: research
First Use Of A Novel Barrier Film In An Infertile Woman With Severe Asherman Syndrome.
A 38-year-old woman (G6P0) referred with oligomenorrhea and secondary subfertility. A diagnostic hysteroscopy revealed dense intrauterine adhesions (IUAs) at the cervical isthmus, lateral uterine walls and in front of both tubal ostia. Hysteroscopic adhesiolysis was performed using a Versapoint resectoscope restoring the normal cavity. Hyaluronic acid (HA) gel was injected as an adhesion prevention barrier. A 6-month follow-up diagnostic hysteroscopy revealed recurrence of dense IUAs. The patient was re-listed for a second operative hysteroscopy under ultrasound guidance three months later and the dense IUAs were resected ...
Source: The Journal of Minimally Invasive Gynecology - June 11, 2022 Category: OBGYN Authors: Jeremy Sroussi, Cynthia Lecurieux-Lafayette, Jean Louis Benifla Tags: IMAGES IN Gynecological Surgery Source Type: research
First Use of a Novel Barrier Film in an Infertile Woman with Severe Asherman Syndrome
A 38-year-old woman Gravida 6, Para 0 was referred with oligomenorrhea and secondary subfertility. A diagnostic hysteroscopy revealed dense intrauterine adhesions (IUAs) at the cervical isthmus, lateral uterine walls, and in front of both tubal ostia. Hysteroscopic adhesiolysis was performed using a Versapoint resectoscope, restoring the normal cavity. Hyaluronic acid (HA) gel was injected as an adhesion prevention barrier. A 6-month follow-up diagnostic hysteroscopy revealed recurrence of dense IUAs. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - June 11, 2022 Category: OBGYN Authors: Jeremy Sroussi, Cynthia Lecurieux-Lafayette, Jean Louis Benifla Tags: IMAGES IN Gynecologic Surgery Source Type: research
First Use of a Novel Barrier Film in an Infertile Woman with Severe Asherman's Syndrome
A 38-year-old woman Gravida 6, Para 0 was referred with oligomenorrhea and secondary subfertility. A diagnostic hysteroscopy revealed dense intrauterine adhesions (IUAs) at the cervical isthmus, lateral uterine walls, and in front of both tubal ostia. Hysteroscopic adhesiolysis was performed using a Versapoint resectoscope, restoring the normal cavity. Hyaluronic acid (HA) gel was injected as an adhesion prevention barrier. A 6-month follow-up diagnostic hysteroscopy revealed recurrence of dense IUAs. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - June 11, 2022 Category: OBGYN Authors: Jeremy Sroussi, Cynthia Lecurieux-Lafayette, Jean Louis Benifla Tags: IMAGES IN Gynecologic Surgery Source Type: research
Does hyaluronic acid gel reduce intrauterine adhesions after dilation and curettage in women with miscarriage? multicentric randomized controlled trial (hyfaco study)
Hyaluronic acid gel reduces the rate of intrauterine adhesions in women with miscarriage. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - June 3, 2022 Category: OBGYN Authors: J érémy Sroussi, Antoine Bourret, Anne-Gaëlle Pourcelot, Thibault Thubert, Magali Lesavre, Guillaume Legendre, Sophie Tuffet, Alexandra Rousseau, Jean-Louis Benifla, HYFACO group Tags: Original Research: Gynecology Source Type: research
Short-and long-term outcomes of postoperative intrauterine application of hyaluronic acid gel: a meta-analysis of randomized controlled trials
To systematically evaluate the role of hyaluronic acid (HA) gel and its derivatives in the postoperative prevention of intrauterine adhesions (IUA) and to assess whether HA gel could improve the pregnancy rate. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - May 13, 2022 Category: OBGYN Authors: Yuya Dou, Tingting Yu, Zhen Li, Jingjing Wang, Yuting Jiang, Yu Liu Tags: Review article Source Type: research
Short- and Long-term Outcomes of Postoperative Intrauterine Application of Hyaluronic Acid Gel: A Meta-analysis of Randomized Controlled Trials
To systematically evaluate the role of hyaluronic acid (HA) gel and its derivatives in the postoperative prevention of intrauterine adhesions (IUA) and to assess whether HA gel could improve the pregnancy rate. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - May 13, 2022 Category: OBGYN Authors: Yuya Dou, Tingting Yu, Zhen Li, Jingjing Wang, Yuting Jiang, Yu Liu Tags: Review Article Source Type: research
Diagnosis and management of uterine perforation with omental incarceration after dilation and curettage
A 36-year-old G3P2 with an incomplete miscarriage underwent dilation and curettage to evacuate the uterus. The patient had amenorrhea and mild pelvic pain for seven months postoperatively. When she re-presented, her pelvic exam was unremarkable, however a transvaginal ultrasound demonstrated discontinuity in the uterine serosa with a hyperechoic mass protruding from the peritoneal cavity into the myometrium (Fig. 1). This suggested an incarcerated pelvic organ, likely due to uterine perforation at the time of D&C, with further consideration of Asherman's syndrome given the patient's amenorrhea. (Source: The Journal of Mini...
Source: The Journal of Minimally Invasive Gynecology - May 12, 2022 Category: OBGYN Authors: Adel Sedrati, Adriana J. Wong, Luis Alonso, Jose Carugno Tags: IMAGES IN Gynecological Surgery Source Type: research
