Ferroptosis contributes to endometrial fibrosis in intrauterine adhesions
Free Radic Biol Med. 2023 Jun 9:S0891-5849(23)00476-8. doi: 10.1016/j.freeradbiomed.2023.06.001. Online ahead of print.ABSTRACTIntrauterine adhesions (IUA), characterized by endometrial fibrosis, is a challenging clinical issue in reproductive medicine. We previously demonstrated that epithelial-mesenchymal transition (EMT) and fibrosis of endometrial stromal cells (HESCs) played a vital role in the development of IUA, but the precise pathogenesis remains elucidated. Ferroptosis has now been recognized as a unique form of oxidative cell death, but whether it is involved in endometrial fibrosis remains unknown. In the prese...
Source: Free Radical Biology and Medicine - June 11, 2023 Category: Biology Authors: Qi Zhu Simin Yao Ziying Ye Peipei Jiang Huiyan Wang Xiwen Zhang Dan Liu Haining Lv Chenrui Cao Zhenhua Zhou Zihan Zhou Weichen Pan Guangfeng Zhao Yali Hu Source Type: research
Using Type I Collagen Gel to Prevent Postoperative Intrauterine Adhesion: A Multicenter Retrospective Study
J Clin Med. 2023 May 30;12(11):3764. doi: 10.3390/jcm12113764.ABSTRACTWe evaluated the clinical outcomes of using type 1 collagen gel after therapeutic resectoscopy; overall, 150 women aged > 20 who planned to undergo therapeutic resectoscopy were enrolled. The patients were randomly assigned to either of the anti-adhesive treatment groups: the type 1 collagen gel (Collabarrier®) (study group; N = 75) or the sodium hyaluronate and sodium carboxymethylcellulose gel group (control group; N = 75) after resectoscopy. One month after applying anti-adhesive materials, postoperative intrauterine adhesions were evaluated using...
Source: Cancer Control - June 10, 2023 Category: Cancer & Oncology Authors: Kwang Beom Lee Seung Joo Chon Sunghoon Kim Dae Yeon Kim Chan Woo Park So Jin Shin Seok Mo Kim Ki Hwan Lee Yong Il Ji Source Type: research
Reproductive outcomes and risk factors of women with septate uterus after hysteroscopic metroplasty
ConclusionsHysteroscopic metroplasty could lead to improved reproductive outcomes of women with septate uterus. Both age and primary infertility were independent factors for postoperative reproductive outcomes.Trial registrationChi ECRCT20210343 (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - June 8, 2023 Category: Endocrinology Source Type: research
Clinical evidence of positive correlation between intrauterine adhesions and chronic endometritis: a retrospective study
CONCLUSIONS: A correlation was observed between CE and IUA. Patients presenting both conditions had more severe IUA stage and higher recurrence rates after TCRA.PMID:37259742 | DOI:10.26355/eurrev_202305_32467 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - June 1, 2023 Category: Drugs & Pharmacology Authors: Z-N Wang M-S Wang X Xi Source Type: research
