Homogenous subpopulation of human mesenchymal stem cells and their extracellular vesicles restore function of endometrium in an experimental rat model of Asherman syndrome
CONCLUSION: Transplantation of MSCs and EVs contributed to endometrial repair and restoration of reproductive function, likely by inhibition of excessive fibrosis and inflammation, enhancement of endometrial cell proliferation, and regulation of molecular markers related to endometrial receptivity. Compared to classical hMSCs, cMSCs were more efficient than hMSCs in restoration of reproductive function. Moreover, EV20K is more cost-effective and feasible for prevention of AS in comparison with conventional EVs (EV110K).PMID:37013655 | DOI:10.1186/s13287-023-03279-7 (Source: Cell Research)
Source: Cell Research - April 4, 2023 Category: Cytology Authors: Nahid Mansouri-Kivaj Abdoreza Nazari Fereshteh Esfandiari Faezeh Shekari Marefat Ghaffari Mohammad Pakzad Hossein Baharvand Source Type: research
A meta-analysis of obstetric and neonatal outcomes in patients after treatment of hysteroscopic adhesiolysis
DiscussionDue to the paucity of good quality comparative data, the question of whether there is an increased prevalence of obstetric and neonatal complications in women after hysteroscopic adhesiolysis compared with the general population remains unanswered. The findings from this review will provide a basis for more well-designed studies in the future.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=364021, identifier [CRD42022364021]. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 24, 2023 Category: Endocrinology Source Type: research
Hormone Therapy with or without Platelet-Rich Plasma (PRP) for Treatment Asherman Syndrome; A Randomized Clinical Trial
CONCLUSION: Hormone therapy with PRP compared to hormone therapy alone after routine surgical treatment had not a significant effect on the IUA stage, duration, and severity of menstruation.PMID:36926432 | PMC:PMC10012034 | DOI:10.4103/abr.abr_411_21 (Source: Biomed Res)
Source: Biomed Res - March 17, 2023 Category: Research Authors: Elham Naghshineh Safoura Rouholamin Zahra Derakhshandeh Source Type: research
Hormone Therapy with or without Platelet-Rich Plasma (PRP) for Treatment Asherman Syndrome; A Randomized Clinical Trial
CONCLUSION: Hormone therapy with PRP compared to hormone therapy alone after routine surgical treatment had not a significant effect on the IUA stage, duration, and severity of menstruation.PMID:36926432 | PMC:PMC10012034 | DOI:10.4103/abr.abr_411_21 (Source: Adv Data)
Source: Adv Data - March 17, 2023 Category: Epidemiology Authors: Elham Naghshineh Safoura Rouholamin Zahra Derakhshandeh Source Type: research
Hormone Therapy with or without Platelet-Rich Plasma (PRP) for Treatment Asherman Syndrome; A Randomized Clinical Trial
CONCLUSION: Hormone therapy with PRP compared to hormone therapy alone after routine surgical treatment had not a significant effect on the IUA stage, duration, and severity of menstruation.PMID:36926432 | PMC:PMC10012034 | DOI:10.4103/abr.abr_411_21 (Source: Biomed Res)
Source: Biomed Res - March 17, 2023 Category: Research Authors: Elham Naghshineh Safoura Rouholamin Zahra Derakhshandeh Source Type: research
Hormone Therapy with or without Platelet-Rich Plasma (PRP) for Treatment Asherman Syndrome; A Randomized Clinical Trial
CONCLUSION: Hormone therapy with PRP compared to hormone therapy alone after routine surgical treatment had not a significant effect on the IUA stage, duration, and severity of menstruation.PMID:36926432 | PMC:PMC10012034 | DOI:10.4103/abr.abr_411_21 (Source: Adv Data)
Source: Adv Data - March 17, 2023 Category: Epidemiology Authors: Elham Naghshineh Safoura Rouholamin Zahra Derakhshandeh Source Type: research
A comparison of special intrauterine balloons and intrauterine contraceptive devices in the treatment of intrauterine adhesions
ConclusionPatients in the special IUB group had better outcomes than those in the IUD group, which has a certain guiding significance for clinical work. (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - March 10, 2023 Category: OBGYN Source Type: research
Subserosal pregnancy: a new type of ectopic pregnancy?
Subserosal pregnancy (SP) is defined as rare variant of intramural pregnancy, where “a portion of the gestational sac was surrounded only by the serosa of the uterus”[1,2,3]. The case of a 39 year old Caucasian woman is reported. She had a previous incomplete spontaneous abortion followed by uterine curettage, with subsequent Asherman's syndrome treated by laparotomic hysteroto my with a transverse cut to the fundus of the uterus and complete opening of the uterine body. A second pregnancy occurred 4 years later. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - March 9, 2023 Category: OBGYN Authors: Guglielmo Stabile, Giulia Zinicola, Francesco Cracco, Francesco Paolo Mangino, Francesco Fanfani, Antonio Simone Lagan à, Giuseppe Ricci Tags: IMAGES IN Gynecological Surgery Source Type: research
Transdermal estrogen gel vs oral estrogen after hysteroscopy for intrauterine adhesion separation: A prospective randomized study
ConclusionsTransdermal administration of estrogen is equally efficacious as oral estrogen in postoperative treatment of IUA patients with a relatively safe profile. It is very likely to broaden its indication to the field of IUA.Trial Registrationhttp://www.chictr.org.cn/showproj.aspx?proj=37197, identifier ChiCTR1900022110. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 8, 2023 Category: Endocrinology Source Type: research
Cost savings analysis of routine hysteroscopy for early detection and treatment of intrauterine adhesions
There are many uterine procedures known to cause intrauterine adhesions (IUA). The standard of care for detection of IUA is initiation of workup after a woman reports symptoms, such as menstrual irregularity, pelvic pain, or infertility. Routine hysteroscopy is not currently performed after an event that may cause IUA. Our objective was to determine if the use of routine diagnostic hysteroscopy following procedures that are high risk for developing IUA could be a cost saving alternative to the current standard of care from a medical system perspective. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - March 1, 2023 Category: OBGYN Authors: A. Zelivianskaia, A. Arcaz, J. Robinson, N. Hazen Tags: Non-Oral Poster Source Type: research
Asherman syndrome after uterine artery embolization: a cohort study about surgery management and fertilty outcomes
To study severity of intrauterine adhesions after uterine arterial embolization and to evaluate fertility, pregnancy and obstetrical outcomes after hysteroscopic treatment. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - February 20, 2023 Category: OBGYN Authors: Margaux JEGADEN, C écile BLEAS, Elodie DEBRAS, Déborah COUET, Anne-Gaëlle POURCELOT, Perrine CAPMAS, Hervé FERNANDEZ Tags: ORIGINAL ARTICLE Source Type: research
Restoring fertility of patients with severe asherman's syndrome in the office setting. a step-by-step recipe for success
To describe an effective in-office hysteroscopic strategy to restore fertility of patients with severe Asherman's Syndrome. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - February 8, 2023 Category: OBGYN Authors: Attilio Di Spiezio Sardo, Chiara De Angelis Maria, Alfonso Manzi, Brunella Zizolfi, Jose Carugno, Keith Isaacson Source Type: research
Restoring Fertility of Patients with Severe Asherman's Syndrome in the Office Setting: A Step-by-Step Recipe for Success
To describe an effective in-office hysteroscopic strategy to restore fertility of patients with severe Asherman's syndrome. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - February 8, 2023 Category: OBGYN Authors: Attilio Di Spiezio-Sardo, Maria Chiara De Angelis, Kafetzis Dimitrios, Alfonso Manzi, Brunella Zizolfi, Jose Carugno, Keith Isaacson Tags: Video Article Source Type: research
Evaluation of different rat models with intrauterine adhesions and improved technique for its establishment
In conclusion, our study found that mechanical injury caused by the curette can be completely repaired after two estrus cycles. However, dual injury (mechanical injury with infection) and 95% ethanol injection can be used to establish the IUA rat model, and the dual damage is closer to the clinic-pathological characteristics of IUA.PMID:36642541 | DOI:10.1538/expanim.22-0153 (Source: Experimental Animals)
Source: Experimental Animals - January 15, 2023 Category: Research Authors: Jin Xi Yan Pan Chunchun Jin Jingyu Liu Jie Cheng Bin Xu Source Type: research
