Mechanism of Smilax china L. in the treatment of intrauterine adhesions based on network pharmacology, molecular docking and experimental validation
In this study, we explored the... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - April 5, 2024 Category: Complementary Medicine Authors: Tingting Shi, Chuqi Hou, Yongzhen Duan, Yuliang Li, Wenqin Liu, Peixian Huang, Yuhua Zhou, Shanshan Yu and Luyao Song Tags: Research Source Type: research
Endometrium sparing technique during hysteroscopic myomectomy
Intrauterine adhesion formation is a possible complication of hysteroscopic myomectomy, especially in the presence of submucosal myomas on the opposing surfaces. Various approaches have been proposed to reduce postoperative intrauterine adhesions after operative hysteroscopy, such as intrauterine device (IUD), Foley catheter, and Malecot catheter. The described techniques of hysteroscopic myomectomy with morcellation or resection remove the endometrial layer covering the myoma. A technique to spare the endometrial layer may prove beneficial in reducing intrauterine adhesion formation. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - March 21, 2024 Category: OBGYN Authors: S Joseph, M Merida, M Love, A Akinpeloye, M Abuzeid Source Type: research
Reproductive and Obstetric Outcomes After Treatment of Retained Products of Conception: Hysteroscopic Removal Versus Ultrasound-Guided Electric Vacuum Aspiration, a prospective follow-up study
Traditionally, curettage is the most widely performed surgical intervention used to remove retained products of conception. However, hysteroscopic removal is increasingly performed as an alternative due to the potentially lower risk of intrauterine adhesions and higher rates of complete removal. Until recently, studies comparing curettage with hysteroscopic removal regarding reproductive and obstetric outcomes were limited, and data conflicting. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - March 21, 2024 Category: OBGYN Authors: Liselot P. Wagenaar, Wouter L.J. van Vugt, Aleida G. Huppelschoten, Celine M. Radder, Louisette W. Peters, Steven Weyers, Steffi van Wessel, Benedictus C. Schoot, Tjalina W.O. Hamerlynck, Huib A. van Vliet Tags: Original Research: Gynecology Source Type: research
Analysis of factors affecting the prognosis of patients with intrauterine adhesions after transcervical resection of adhesions
Capsule: Prognosis of intrauterine adhesion patients after transcervical resection of adhesions is related to severe preoperative adhesions, presence of chronic endometritis, and intrauterine adhesion barrier gel reapplication 5 days after resection. (Source: Fertility and Sterility)
Source: Fertility and Sterility - March 20, 2024 Category: Reproduction Medicine Authors: Jiantong Zhang, Cong Shi, Jianhua Sun, Jumin Niu Tags: Reproductive surgery Source Type: research
Integrating Network Pharmacology and In Vitro Experimental Verification Revealing Bushenhuoxue Recipe Against Intrauterine Adhesions via PI3K-AKT Signaling Pathway
Biochem Genet. 2024 Mar 19. doi: 10.1007/s10528-024-10732-6. Online ahead of print.ABSTRACTWe aimed to investigate therapeutic effect of Bushenhuoxue recipe in intrauterine adhesions (IUA) and explore the underlying molecular mechanism via integrating network pharmacology and in vitro experimental verification. The active compounds and gene targets of Bushenhuoxue recipe were screened in the TCMSP database and the IUA-related genes were identified using GeneCards database by the keyword "Intrauterine adhesions". Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were conducted to reveal the unde...
Source: Biochemical Genetics - March 19, 2024 Category: Genetics & Stem Cells Authors: Lingli Wang Lingzi Zhuang Yajing Lu Jin Jia Cailing Chen Ying Zhang Zhejing Hong Xiaohong Wang Source Type: research
Integrating Network Pharmacology and In Vitro Experimental Verification Revealing Bushenhuoxue Recipe Against Intrauterine Adhesions via PI3K-AKT Signaling Pathway
Biochem Genet. 2024 Mar 19. doi: 10.1007/s10528-024-10732-6. Online ahead of print.ABSTRACTWe aimed to investigate therapeutic effect of Bushenhuoxue recipe in intrauterine adhesions (IUA) and explore the underlying molecular mechanism via integrating network pharmacology and in vitro experimental verification. The active compounds and gene targets of Bushenhuoxue recipe were screened in the TCMSP database and the IUA-related genes were identified using GeneCards database by the keyword "Intrauterine adhesions". Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were conducted to reveal the unde...
Source: Biochemical Genetics - March 19, 2024 Category: Genetics & Stem Cells Authors: Lingli Wang Lingzi Zhuang Yajing Lu Jin Jia Cailing Chen Ying Zhang Zhejing Hong Xiaohong Wang Source Type: research
Integrating Network Pharmacology and In Vitro Experimental Verification Revealing Bushenhuoxue Recipe Against Intrauterine Adhesions via PI3K-AKT Signaling Pathway
Biochem Genet. 2024 Mar 19. doi: 10.1007/s10528-024-10732-6. Online ahead of print.ABSTRACTWe aimed to investigate therapeutic effect of Bushenhuoxue recipe in intrauterine adhesions (IUA) and explore the underlying molecular mechanism via integrating network pharmacology and in vitro experimental verification. The active compounds and gene targets of Bushenhuoxue recipe were screened in the TCMSP database and the IUA-related genes were identified using GeneCards database by the keyword "Intrauterine adhesions". Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were conducted to reveal the unde...
Source: Biochemical Genetics - March 19, 2024 Category: Genetics & Stem Cells Authors: Lingli Wang Lingzi Zhuang Yajing Lu Jin Jia Cailing Chen Ying Zhang Zhejing Hong Xiaohong Wang Source Type: research
Reproductive outcomes following copper ‑containing intrauterine device after hysteroscopic lysis for intrauterine adhesions
Exp Ther Med. 2024 Feb 29;27(4):175. doi: 10.3892/etm.2024.12463. eCollection 2024 Apr.ABSTRACTThe present study aimed to investigate the reproductive outcomes of copper-containing intrauterine devices (IUDs) after hysteroscopic lysis in patients with mild to severe intrauterine adhesions (IUAs), according to the American Fertility Society (AFS) classification. Therefore, a prospective randomized controlled study was conducted at the Affiliated Jinhua Hospital of Wenzhou Medical University (Jinhua, China). A total of 173 women with IUAs were initially recruited between January 2020 and June 2021 and were then randomized to...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Pan Xu Heng Xu Qiaoqiao Lu Shanshan Ling E Hu Ying Song Jie Liu Bixia Yi Source Type: research
Intrauterine adhesions treated with hysteroscopic adhesiolysis and subsequent obstetric outcome: A retrospective matched cohort study
CONCLUSIONS: This study found that a history of HA-treated IUAs, especially a history of repeated HAs, was associated with an increased risk of adverse obstetrical outcomes.PMID:38418403 | DOI:10.1111/1471-0528.17793 (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - February 28, 2024 Category: OBGYN Authors: Wei Hong Zhiping Wu Li Li Beiying Wang Xiaocui Li Source Type: research
