Monitoring thyroid function during amiodarone use
Br J Hosp Med (Lond). 2024 Jan 2;85(1):1-5. doi: 10.12968/hmed.2023.0214. Epub 2024 Jan 31.ABSTRACTAmiodarone is an antiarrhythmic drug used to treat cardiac tachyarrhythmias. It has many adverse effects, with thyroid dysfunction one of the most notable. Through various mechanisms, both thyrotoxicosis and hypothyroidism can occur secondary to amiodarone therapy. There are two types of amiodarone-induced thyrotoxicosis: type 1 occurs in those with pre-existing thyroid disease and is treated with thionamide, whereas type 2 occurs in those without and is treated with glucocorticoids. Patients with amiodarone-induced hypothyro...
Source: British Journal of Hospital Medicine - February 1, 2024 Category: Internal Medicine Authors: Priya Sharma Riyad Sheikh Nipuna Siribaddana Abilash Sathyanarayanan Devaka Fernando Vakkat Muraleedharan Source Type: research
Monitoring thyroid function during amiodarone use
Br J Hosp Med (Lond). 2024 Jan 2;85(1):1-5. doi: 10.12968/hmed.2023.0214. Epub 2024 Jan 31.ABSTRACTAmiodarone is an antiarrhythmic drug used to treat cardiac tachyarrhythmias. It has many adverse effects, with thyroid dysfunction one of the most notable. Through various mechanisms, both thyrotoxicosis and hypothyroidism can occur secondary to amiodarone therapy. There are two types of amiodarone-induced thyrotoxicosis: type 1 occurs in those with pre-existing thyroid disease and is treated with thionamide, whereas type 2 occurs in those without and is treated with glucocorticoids. Patients with amiodarone-induced hypothyro...
Source: British Journal of Hospital Medicine - February 1, 2024 Category: Internal Medicine Authors: Priya Sharma Riyad Sheikh Nipuna Siribaddana Abilash Sathyanarayanan Devaka Fernando Vakkat Muraleedharan Source Type: research
Monitoring thyroid function during amiodarone use
Br J Hosp Med (Lond). 2024 Jan 2;85(1):1-5. doi: 10.12968/hmed.2023.0214. Epub 2024 Jan 31.ABSTRACTAmiodarone is an antiarrhythmic drug used to treat cardiac tachyarrhythmias. It has many adverse effects, with thyroid dysfunction one of the most notable. Through various mechanisms, both thyrotoxicosis and hypothyroidism can occur secondary to amiodarone therapy. There are two types of amiodarone-induced thyrotoxicosis: type 1 occurs in those with pre-existing thyroid disease and is treated with thionamide, whereas type 2 occurs in those without and is treated with glucocorticoids. Patients with amiodarone-induced hypothyro...
Source: British Journal of Hospital Medicine - February 1, 2024 Category: Internal Medicine Authors: Priya Sharma Riyad Sheikh Nipuna Siribaddana Abilash Sathyanarayanan Devaka Fernando Vakkat Muraleedharan Source Type: research
Monitoring thyroid function during amiodarone use
Br J Hosp Med (Lond). 2024 Jan 2;85(1):1-5. doi: 10.12968/hmed.2023.0214. Epub 2024 Jan 31.ABSTRACTAmiodarone is an antiarrhythmic drug used to treat cardiac tachyarrhythmias. It has many adverse effects, with thyroid dysfunction one of the most notable. Through various mechanisms, both thyrotoxicosis and hypothyroidism can occur secondary to amiodarone therapy. There are two types of amiodarone-induced thyrotoxicosis: type 1 occurs in those with pre-existing thyroid disease and is treated with thionamide, whereas type 2 occurs in those without and is treated with glucocorticoids. Patients with amiodarone-induced hypothyro...
Source: British Journal of Hospital Medicine - February 1, 2024 Category: Internal Medicine Authors: Priya Sharma Riyad Sheikh Nipuna Siribaddana Abilash Sathyanarayanan Devaka Fernando Vakkat Muraleedharan Source Type: research
A Novel Strategy for the Discovery of Drug Targets: Integrating Clinical Evidence with Molecular Studies
Biol Pharm Bull. 2024;47(2):345-349. doi: 10.1248/bpb.b23-00831.ABSTRACTThe mechanisms of several drugs remain unclear, limiting our understanding of how they exert their effects. Receptor affinities have not been comprehensively measured during drug development, and the safety investigations in humans are limited. Therefore, numerous unknown adverse and beneficial effects of drugs in humans persist. In this review, I highlight our achievements in identifying the unexpected beneficial effects of drugs through the analysis of real-world clinical data, which can contribute to drug repositioning and target finding. (1) Throug...
Source: Biological and Pharmaceutical Bulletin - January 31, 2024 Category: Drugs & Pharmacology Authors: Shuji Kaneko Source Type: research
Exploring the dynamics of the ABCB1 membrane transporter P-glycoprotein in the presence of ATP and active/non-active compounds through molecular dynamics simulations
This study provides comprehensive insights into P-gp behavior with various ligands and ATP, offering implications for drug development, toxicity assessment and demonstrating the validity of the results derived from the MD simulations.PMID:38272384 | DOI:10.1016/j.tox.2024.153732 (Source: Toxicology)
Source: Toxicology - January 25, 2024 Category: Toxicology Authors: Liadys Mora Lagares Yunierkis P érez-Castillo Marjana Novi č Source Type: research
Amiodarone-induced thyrotoxicosis: Should surgery be considered?
Ann Endocrinol (Paris). 2024 Jan 19:S0003-4266(24)00006-4. doi: 10.1016/j.ando.2024.01.006. Online ahead of print.ABSTRACTAmiodarone is the most widely prescribed antiarrhythmic drug worldwide, but induces thyrotoxicosis or hypothyroidism in 15 to 20% of patients. Hyperthyroidism is less frequent than hypothyroidism, and two types of thyrotoxicosis are distinguished according to presence of underlying thyroid disease. Diagnosis is made in case of low TSH and high levels of T3 and T4. Initial treatment is based on anti-thyroid drugs and/or glucocorticoids. Some patients do not respond to medication, which increases the time...
Source: Annales d'Endocrinologie - January 21, 2024 Category: Endocrinology Authors: Samuel Frey C écile Caillard Pascale Mahot Delphine Drui Eric Miralli é Source Type: research
GSE253113 Repurposing amiodarone as a targeted SIRT3 activator that induces autophagic/mitophagic cell death in acute myelocytic leukemia
Contributors : Jin Zhang ; Wei Liu ; Wenke Jin ; Bo LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe made a RNAseq in HL-60 cells to measure the changes in global transcript levels in HL-60 cells after amiodarone treatment. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - January 18, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Amiodarone Advances the Apoptosis of Cardiomyocytes by Repressing Sigmar1 Expression and Blocking KCNH2-related Potassium Channels
CONCLUSION: Amiodarone facilitates the apoptosis of H9c2 cells by restraining Sigmar1 expression and blocking KCNH2-related potassium channels.PMID:38204277 | DOI:10.2174/0115665240265771231129105108 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - January 11, 2024 Category: Molecular Biology Authors: Huiqing Liang Huixian Li Fangjiang Li Xiaobo Xiong Yang Gao Source Type: research
Cardiac-specific overexpression of CREM-Ib ΔC-X via CRISPR/Cas9 in mice presents a new model of atrial cardiomyopathy with spontaneous atrial fibrillation
Transl Res. 2024 Jan 8:S1931-5244(24)00011-2. doi: 10.1016/j.trsl.2024.01.001. Online ahead of print.ABSTRACTAtrial cardiomyopathy (ACM) forms the substrate for atrial fibrillation (AF) and underlies the potential for atrial thrombus formation and subsequent stroke. However, generating stable animal models that accurately replicate the entire progression of atrial lesions, particularly the onset of AF, presents significant challenges. In the present study, we found that the isoform of CRE-binding protein modulator (CREM-IbΔC-X), which is involved in the regulation of cardiac development and atrial rhythm, was highly expre...
Source: Translational Research : the journal of laboratory and clinical medicine - January 10, 2024 Category: Laboratory Medicine Authors: Jiuzhou Chen Huiyuan Qin Jingzhe Hao Qing Wang Shaojie Chen Gang Yang Mingfang Li Xiyu Zhu Dongjin Wang Hongwu Chen Chang Cui Minglong Chen Source Type: research
Management of arrhythmogenic right ventricular cardiomyopathy
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disease characterised by fibrofatty replacement of the ventricular myocardium due to specific mutations, leading to ventricular arrhythmias and sudden cardiac death. Treating this condition can be challenging due to progressive fibrosis, phenotypic variations and small patient cohorts limiting the feasibility of conducting meaningful clinical trials. Although widely used, the evidence base for anti-arrhythmic drugs is limited. Beta-blockers are theoretically sound, yet their efficacy in reducing arrhythmic risk is not robust. Additionally, the impact of sotalol an...
Source: Heart - January 10, 2024 Category: Cardiology Authors: Al-Aidarous, S., Protonotarios, A., Elliott, P. M., Lambiase, P. D. Tags: Review articles Reviews Source Type: research
Perchlorates in the treatment of hyperthyroidism and thyrotoxicosis: a comprehensive review
ConclusionDespite the low level of evidence, perchlorates could be considered in such specific forms of thyroid disorders, including iodine-induced hyperthyroidism and thyroid storm. (Source: Endocrine)
Source: Endocrine - January 9, 2024 Category: Endocrinology Source Type: research
Amiodarone producing insidious optic neuropathy
Can J Neurol Sci. 2024 Jan 4:1-5. doi: 10.1017/cjn.2023.269. Online ahead of print.NO ABSTRACTPMID:38174412 | DOI:10.1017/cjn.2023.269 (Source: The Canadian Journal of Neurological Sciences)
Source: The Canadian Journal of Neurological Sciences - January 4, 2024 Category: Neurology Authors: Ryan H Mason Armin Handzic Prem A H Nichani Edward A Margolin Source Type: research
Amiodarone Case
Amiodarone is an antiarrhythmic drug notorious for causing adverse pulmonary adverse effects that can lead to pulmonary hypertension and hemodynamic change. The following case illustrates the use of echocardiography for the early detection of these adverse effects. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Anas Zaqut, Mahmoud Odeh, Anas Zayad, Mohammad Abu Suailiek, Ahmad Z. Turk Tags: 404 Source Type: research
