Preoperative Amiodarone and Primary Graft Dysfunction in Heart Transplantation
CONCLUSION AND RELEVANCE: A trend toward increased PGD was present in patients receiving preoperative amiodarone. This finding combined with the regression showing significantly increased odds of PGD with increasing 3 and 6 month cumulative amiodarone dose is clinically concerning. Escalation of care with pacemaker implantation was required more frequently in patients on pre-OHT amiodarone.PMID:38361242 | DOI:10.1177/10600280241232032 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 16, 2024 Category: Drugs & Pharmacology Authors: Abigail Servais Scott Lundgren Stephanie Bowman Douglas Stoller Adam Burdorf Marshall Hyden Brian Lowes Ronald Zolty Don Klepser Heidi Brink Source Type: research
Preoperative Amiodarone and Primary Graft Dysfunction in Heart Transplantation
CONCLUSION AND RELEVANCE: A trend toward increased PGD was present in patients receiving preoperative amiodarone. This finding combined with the regression showing significantly increased odds of PGD with increasing 3 and 6 month cumulative amiodarone dose is clinically concerning. Escalation of care with pacemaker implantation was required more frequently in patients on pre-OHT amiodarone.PMID:38361242 | DOI:10.1177/10600280241232032 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 16, 2024 Category: Drugs & Pharmacology Authors: Abigail Servais Scott Lundgren Stephanie Bowman Douglas Stoller Adam Burdorf Marshall Hyden Brian Lowes Ronald Zolty Don Klepser Heidi Brink Source Type: research
Preoperative Amiodarone and Primary Graft Dysfunction in Heart Transplantation
CONCLUSION AND RELEVANCE: A trend toward increased PGD was present in patients receiving preoperative amiodarone. This finding combined with the regression showing significantly increased odds of PGD with increasing 3 and 6 month cumulative amiodarone dose is clinically concerning. Escalation of care with pacemaker implantation was required more frequently in patients on pre-OHT amiodarone.PMID:38361242 | DOI:10.1177/10600280241232032 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 16, 2024 Category: Drugs & Pharmacology Authors: Abigail Servais Scott Lundgren Stephanie Bowman Douglas Stoller Adam Burdorf Marshall Hyden Brian Lowes Ronald Zolty Don Klepser Heidi Brink Source Type: research
Interventions to prevent postoperative atrial fibrillation in Dutch cardiothoracic centres: a survey study
CONCLUSION: Despite the use of various preventive strategies, the reported incidence of POAF was similar in Dutch cardiothoracic centres. This study highlights limited use of prophylactic amiodarone and colchicine, despite recommendations by numerous guidelines, and restricted implementation of surgical strategies to prevent POAF.PMID:38358408 | DOI:10.1007/s12471-023-01849-1 (Source: Netherlands Heart Journal)
Source: Netherlands Heart Journal - February 15, 2024 Category: Cardiology Authors: Angelique Emiola Jolanda Kluin Sulayman El Mathari Joris R de Groot Wim-Jan van Boven Cardiothoracic Surgery Data Registration Committee of the Netherlands Heart Registry Source Type: research
Interventions to prevent postoperative atrial fibrillation in Dutch cardiothoracic centres: a survey study
CONCLUSION: Despite the use of various preventive strategies, the reported incidence of POAF was similar in Dutch cardiothoracic centres. This study highlights limited use of prophylactic amiodarone and colchicine, despite recommendations by numerous guidelines, and restricted implementation of surgical strategies to prevent POAF.PMID:38358408 | DOI:10.1007/s12471-023-01849-1 (Source: Netherlands Heart Journal)
Source: Netherlands Heart Journal - February 15, 2024 Category: Cardiology Authors: Angelique Emiola Jolanda Kluin Sulayman El Mathari Joris R de Groot Wim-Jan van Boven Cardiothoracic Surgery Data Registration Committee of the Netherlands Heart Registry Source Type: research
Relevance of mexiletine in the era of evolving antiarrhythmic therapy of ventricular arrhythmias
AbstractDespite impressive developments in the field of ventricular arrhythmias, there is still a relevant number of patients with ventricular arrhythmias who require antiarrhythmic drug therapy and may, e.g., in otherwise drug and/or ablation refractory situations, benefit from agents known for decades, such as mexiletine. Through its capability of blocking fast sodium channels in cardiomyocytes, it has played a minor to moderate antiarrhythmic role throughout the recent decades. Nevertheless, certain patients with structural heart disease suffering from drug-refractory, i.e., mainly amiodarone refractory ventricular arrh...
Source: Clinical Research in Cardiology - February 14, 2024 Category: Cardiology Source Type: research
Safety and Effectiveness of Antidysrhythmic Drugs for Pharmacologic Cardioversion of Recent-Onset Atrial Fibrillation: a Systematic Review and Bayesian Network Meta-analysis
ConclusionsAmong guideline-recommended antidysrhythmic drugs, the combination of digoxin IV and amiodarone IV is definitely among the least safe for cardioversion of recent onset AF; flecainide, vernakalant, ibutilide, propafenone, and amiodarone IV are definitely among the most effective for cardioversion within 4 h; flecainide is definitely among the most effective for cardioversion within 24 h. Further, randomized controlled trials with predetermined and strictly defined, hemodynamic adverse event outcomes are recommended. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - February 7, 2024 Category: Cardiology Source Type: research
Monitoring thyroid function during amiodarone use
Br J Hosp Med (Lond). 2024 Jan 2;85(1):1-5. doi: 10.12968/hmed.2023.0214. Epub 2024 Jan 31.ABSTRACTAmiodarone is an antiarrhythmic drug used to treat cardiac tachyarrhythmias. It has many adverse effects, with thyroid dysfunction one of the most notable. Through various mechanisms, both thyrotoxicosis and hypothyroidism can occur secondary to amiodarone therapy. There are two types of amiodarone-induced thyrotoxicosis: type 1 occurs in those with pre-existing thyroid disease and is treated with thionamide, whereas type 2 occurs in those without and is treated with glucocorticoids. Patients with amiodarone-induced hypothyro...
Source: British Journal of Hospital Medicine - February 1, 2024 Category: Internal Medicine Authors: Priya Sharma Riyad Sheikh Nipuna Siribaddana Abilash Sathyanarayanan Devaka Fernando Vakkat Muraleedharan Source Type: research
Monitoring thyroid function during amiodarone use
Br J Hosp Med (Lond). 2024 Jan 2;85(1):1-5. doi: 10.12968/hmed.2023.0214. Epub 2024 Jan 31.ABSTRACTAmiodarone is an antiarrhythmic drug used to treat cardiac tachyarrhythmias. It has many adverse effects, with thyroid dysfunction one of the most notable. Through various mechanisms, both thyrotoxicosis and hypothyroidism can occur secondary to amiodarone therapy. There are two types of amiodarone-induced thyrotoxicosis: type 1 occurs in those with pre-existing thyroid disease and is treated with thionamide, whereas type 2 occurs in those without and is treated with glucocorticoids. Patients with amiodarone-induced hypothyro...
Source: British Journal of Hospital Medicine - February 1, 2024 Category: Internal Medicine Authors: Priya Sharma Riyad Sheikh Nipuna Siribaddana Abilash Sathyanarayanan Devaka Fernando Vakkat Muraleedharan Source Type: research
Monitoring thyroid function during amiodarone use
Br J Hosp Med (Lond). 2024 Jan 2;85(1):1-5. doi: 10.12968/hmed.2023.0214. Epub 2024 Jan 31.ABSTRACTAmiodarone is an antiarrhythmic drug used to treat cardiac tachyarrhythmias. It has many adverse effects, with thyroid dysfunction one of the most notable. Through various mechanisms, both thyrotoxicosis and hypothyroidism can occur secondary to amiodarone therapy. There are two types of amiodarone-induced thyrotoxicosis: type 1 occurs in those with pre-existing thyroid disease and is treated with thionamide, whereas type 2 occurs in those without and is treated with glucocorticoids. Patients with amiodarone-induced hypothyro...
Source: British Journal of Hospital Medicine - February 1, 2024 Category: Internal Medicine Authors: Priya Sharma Riyad Sheikh Nipuna Siribaddana Abilash Sathyanarayanan Devaka Fernando Vakkat Muraleedharan Source Type: research
Monitoring thyroid function during amiodarone use
Br J Hosp Med (Lond). 2024 Jan 2;85(1):1-5. doi: 10.12968/hmed.2023.0214. Epub 2024 Jan 31.ABSTRACTAmiodarone is an antiarrhythmic drug used to treat cardiac tachyarrhythmias. It has many adverse effects, with thyroid dysfunction one of the most notable. Through various mechanisms, both thyrotoxicosis and hypothyroidism can occur secondary to amiodarone therapy. There are two types of amiodarone-induced thyrotoxicosis: type 1 occurs in those with pre-existing thyroid disease and is treated with thionamide, whereas type 2 occurs in those without and is treated with glucocorticoids. Patients with amiodarone-induced hypothyro...
Source: British Journal of Hospital Medicine - February 1, 2024 Category: Internal Medicine Authors: Priya Sharma Riyad Sheikh Nipuna Siribaddana Abilash Sathyanarayanan Devaka Fernando Vakkat Muraleedharan Source Type: research
Monitoring thyroid function during amiodarone use
Br J Hosp Med (Lond). 2024 Jan 2;85(1):1-5. doi: 10.12968/hmed.2023.0214. Epub 2024 Jan 31.ABSTRACTAmiodarone is an antiarrhythmic drug used to treat cardiac tachyarrhythmias. It has many adverse effects, with thyroid dysfunction one of the most notable. Through various mechanisms, both thyrotoxicosis and hypothyroidism can occur secondary to amiodarone therapy. There are two types of amiodarone-induced thyrotoxicosis: type 1 occurs in those with pre-existing thyroid disease and is treated with thionamide, whereas type 2 occurs in those without and is treated with glucocorticoids. Patients with amiodarone-induced hypothyro...
Source: British Journal of Hospital Medicine - February 1, 2024 Category: Internal Medicine Authors: Priya Sharma Riyad Sheikh Nipuna Siribaddana Abilash Sathyanarayanan Devaka Fernando Vakkat Muraleedharan Source Type: research
Monitoring thyroid function during amiodarone use
Br J Hosp Med (Lond). 2024 Jan 2;85(1):1-5. doi: 10.12968/hmed.2023.0214. Epub 2024 Jan 31.ABSTRACTAmiodarone is an antiarrhythmic drug used to treat cardiac tachyarrhythmias. It has many adverse effects, with thyroid dysfunction one of the most notable. Through various mechanisms, both thyrotoxicosis and hypothyroidism can occur secondary to amiodarone therapy. There are two types of amiodarone-induced thyrotoxicosis: type 1 occurs in those with pre-existing thyroid disease and is treated with thionamide, whereas type 2 occurs in those without and is treated with glucocorticoids. Patients with amiodarone-induced hypothyro...
Source: British Journal of Hospital Medicine - February 1, 2024 Category: Internal Medicine Authors: Priya Sharma Riyad Sheikh Nipuna Siribaddana Abilash Sathyanarayanan Devaka Fernando Vakkat Muraleedharan Source Type: research
