The ion channel basis of pharmacological effects of amiodarone on myocardial electrophysiological properties, a comprehensive review
Biomed Pharmacother. 2024 Apr 1;174:116513. doi: 10.1016/j.biopha.2024.116513. Online ahead of print.ABSTRACTAmiodarone is a benzofuran-based class III antiarrhythmic agent frequently used for the treatment of atrial and ventricular arrhythmias. The primary target of class III antiarrhythmic drugs is the cardiac human ether-a-go-go-related gene (hERG) encoded channel, KCNH2, commonly known as HERG, that conducts the rapidly activating delayed rectifier potassium current (IKr). Like other class III antiarrhythmic drugs, amiodarone exerts its physiologic effects mainly through IKr blockade, delaying the repolarization phase ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 2, 2024 Category: Drugs & Pharmacology Authors: Illia Gelman Neelakshi Sharma Olivia Mckeeman Peter Lee Noah Campagna Nicole Tomei Adrian Baranchuk Shetuan Zhang Mohammad El-Diasty Source Type: research
Preoperative Amiodarone Use Does Not Affect Pacemaker Implantation After Heart Transplantation
Purpose: Following bi-atrial orthotopic heart transplantation (HTx), approximately 20% of patients require permanent pacemaker (PPM) implantation. Several risk factors, including preoperative amiodarone use have been reported, although previous studies show contradictory results. We aimed to assess the association between preoperative amiodarone use and PPM implantation in patients who underwent HTx at the University Medical Centre of Utrecht (UMCU). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , L.C. Kieviet, M.K. Szymanski, M.G. van der Meer, N.P. van der Kaaij, L.W. Van Laake, A.E. Tuinenburg, K.A. Jacob, E.E. van Aarnhem, M.I. Oerlemans Source Type: research
Acute Hepatitis After Lung Transplant in a Recipient from Hep C Donor: The Chicken or the Egg Phenomenon?
We present a case of acute hepatitis after lung transplant from an HCV positive donor confounded by amiodarone toxicity. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J.P. Braat, A. Arjuna Source Type: research
Amiodarone Association with PGD After Heart Transplant
Purpose: Amiodarone use prior to heart transplantation (HT) has been associated with primary graft dysfunction (PGD), although data are mixed. Our aim was to determine if amiodarone use was associated with severe PGD at our center. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: N. Stringer Dorsey, A. Biscopink, J. Atkins, S.K. O'Connor, A. Carnicelli, V. Rao, L. Witer, C. Inampudi, D. Silverman, A. Van Bakel, G. Jackson, , A. Kilic, R.J. Tedford, J.M. Griffin Source Type: research
Amiodarone Use in Post-Orthotopic Transplant Patients - A Pilot Study
Purpose: Data is lacking regarding outcomes of patients who receive amiodarone post-orthotopic heart transplant (OHT). The primary aim of this pilot study was the association between amiodarone use within 1-mo post-OHT and mortality at 6-mo and 1-yr. Secondary aims were the association between amiodarone use post-OHT and need for new mechanical circulatory support (MCS), duration of inotropes, length of ICU stay, and left ventricular ejection fraction (LVEF) at discharge. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: A. Chanda, G. Panza, A. Jaiswal, A. Feingold, L. O'Bara, Source Type: research
Story of magnesium for torsade de pointes
Torsade de pointes (TdP) was not a rare arrhythmia in Israel during the 1970s –1980s as many patients, mainly with atrial fibrillation (AF), were treated with QT-prolonging antiarrhythmic drugs. We published several articles on the use of cardiac pacing and intravenous (IV) isoproterenol in patients who developed TdP from quinidine, disopyramide, or amiodarone. Our experien ce was published in 1981 in Circulation.1 (Source: Heart Rhythm)
Source: Heart Rhythm - March 26, 2024 Category: Cardiology Authors: Dan Tzivoni, Shmuel Banai, Andre Keren Tags: Iconic Figure Source Type: research
Amiodarone inhibits the Toll-like receptor 3-mediated nuclear factor κB signaling pathway by blocking organelle acidification
Biochem Biophys Res Commun. 2024 Mar 19;708:149801. doi: 10.1016/j.bbrc.2024.149801. Online ahead of print.ABSTRACTToll-like receptor (TLR) agonists or pro-inflammatory cytokines converge to activate the nuclear factor κB (NF-κB) signaling pathway, which provokes inflammatory responses. In the present study, we identified amiodarone hydrochloride as a selective inhibitor of the TLR3-mediated NF-κB signaling pathway by screening the RIKEN NPDepo Chemical Library. In human umbilical vein endothelial cells (HUVEC), amiodarone selectively inhibited the expression of intercellular adhesion molecule-1 (ICAM-1) induced by poly...
Source: Biochemical and Biophysical Research communications - March 26, 2024 Category: Biochemistry Authors: Yuka Yokota Keiko Takaki Kosuke Baba Saki Sasaki Hiroyuki Hirano Hiroyuki Osada Takao Kataoka Source Type: research
Amiodarone inhibits the Toll-like receptor 3-mediated nuclear factor κB signaling pathway by blocking organelle acidification
Biochem Biophys Res Commun. 2024 Mar 19;708:149801. doi: 10.1016/j.bbrc.2024.149801. Online ahead of print.ABSTRACTToll-like receptor (TLR) agonists or pro-inflammatory cytokines converge to activate the nuclear factor κB (NF-κB) signaling pathway, which provokes inflammatory responses. In the present study, we identified amiodarone hydrochloride as a selective inhibitor of the TLR3-mediated NF-κB signaling pathway by screening the RIKEN NPDepo Chemical Library. In human umbilical vein endothelial cells (HUVEC), amiodarone selectively inhibited the expression of intercellular adhesion molecule-1 (ICAM-1) induced by poly...
Source: Cell Research - March 26, 2024 Category: Cytology Authors: Yuka Yokota Keiko Takaki Kosuke Baba Saki Sasaki Hiroyuki Hirano Hiroyuki Osada Takao Kataoka Source Type: research
Amiodarone inhibits the Toll-like receptor 3-mediated nuclear factor κB signaling pathway by blocking organelle acidification
Biochem Biophys Res Commun. 2024 Mar 19;708:149801. doi: 10.1016/j.bbrc.2024.149801. Online ahead of print.ABSTRACTToll-like receptor (TLR) agonists or pro-inflammatory cytokines converge to activate the nuclear factor κB (NF-κB) signaling pathway, which provokes inflammatory responses. In the present study, we identified amiodarone hydrochloride as a selective inhibitor of the TLR3-mediated NF-κB signaling pathway by screening the RIKEN NPDepo Chemical Library. In human umbilical vein endothelial cells (HUVEC), amiodarone selectively inhibited the expression of intercellular adhesion molecule-1 (ICAM-1) induced by poly...
Source: Biochemical and Biophysical Research communications - March 26, 2024 Category: Biochemistry Authors: Yuka Yokota Keiko Takaki Kosuke Baba Saki Sasaki Hiroyuki Hirano Hiroyuki Osada Takao Kataoka Source Type: research
Postoperative atrial fibrillation (POAF) after cardiac surgery: clinical practice review
J Thorac Dis. 2024 Feb 29;16(2):1503-1520. doi: 10.21037/jtd-23-1626. Epub 2024 Feb 23.ABSTRACTPostoperative atrial fibrillation (POAF) after cardiac surgery is associated with elevated morbidity and mortality. Although current prediction models have limited efficacy, several perioperative interventions can reduce patients' risk of POAF. These begin with preoperative medications, including beta-blockers and amiodarone. Moreover, patients should be screened for preexisting atrial fibrillation (AF) so that concomitant surgical ablation and left atrial appendage occlusion can be performed in appropriate candidates. Intraopera...
Source: Journal of Thoracic Disease - March 20, 2024 Category: Respiratory Medicine Authors: Orlando R Suero Ahmed K Ali Lauren R Barron Matthew W Segar Marc R Moon Subhasis Chatterjee Source Type: research
