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State-independent inhibition of the oncogenic Kv10.1 channel by desethylamiodarone, a comparison with amiodarone
Pflugers Arch. 2023 Dec 8. doi: 10.1007/s00424-023-02893-x. Online ahead of print.ABSTRACTKv10.1 is a voltage-dependent K channel whose ectopic expression is associated with several human cancers. Additionally, Kv10.1 has structure-function properties which are not yet well understood. We are using drugs of clinical importance in an attempt to gain insight on the relationship between pharmacology and characteristic functional properties of this channel. Herein, we report the interaction of desethylamiodarone (desAd), the active metabolic product of the antiarrhythmic amiodarone with Kv10.1: desAd binds to both closed and o...
Source: Pflugers Archiv : European Journal of Physiology - December 8, 2023 Category: Physiology Authors: F Gomez-Lagunas C Barriga-Montoya J P Pardo Source Type: research

Comparison of Efficacy and Safety Between Dronedarone and Amiodarone Used During the Blind Period in Patients with Atrial Fibrillation After Catheter Ablation
(Source: International Journal of COPD)
Source: International Journal of COPD - December 8, 2023 Category: Respiratory Medicine Tags: Clinical Pharmacology: Advances and Applications Source Type: research

Protective effect of isoliquiritigenin in amiodarone ‐induced damage of human umbilical vein endothelial cells
ConclusionISL shows promise in the prevention and treatment of clinical phlebitis and can be used as a potential therapeutic drug to prevent phlebitis. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 28, 2023 Category: Allergy & Immunology Authors: Jin ‐Li Guo, Xiang Han, Xian‐Yan Yan, Juan‐Juan Wang, Ya‐Qiong Chang, Bei‐Lei Zhang, Xiu‐Juan Guo Tags: ORIGINAL ARTICLE Source Type: research

Evolving Contemporary Management of Atrial Fibrillation in Hypertrophic Cardiomyopathy
Circulation. 2023 Nov 28;148(22):1797-1811. doi: 10.1161/CIRCULATIONAHA.123.065037. Epub 2023 Nov 27.ABSTRACTAtrial fibrillation (AF) is the most common sustained arrhythmia in hypertrophic cardiomyopathy (HCM) with clinical and subclinical episodes occurring in nearly one-half of patients. AF in HCM historically has been characterized as a decisive disease complication associated with substantial risk for thromboembolic stroke and increased morbidity and mortality. However, there have been many advances in treatment strategy resulting in improved outcomes for this patient group. For example, stroke risk in HCM has been gr...
Source: Circulation - November 27, 2023 Category: Cardiology Authors: Ethan J Rowin Mark S Link Martin S Maron Barry J Maron Source Type: research

Comparison of amiodarone and esmolol for prevention of reperfusion ventricular fibrillation in individuals undergoing heart valve or aortic surgery: a study protocol for a randomized controlled clinical trial
Amiodarone and esmolol can help to prevent and treat post-cardiac surgery reperfusion ventricular fibrillation. However, the relative efficacies of these two drugs remain unknown. The aim of the current trial ... (Source: Trials)
Source: Trials - November 27, 2023 Category: General Medicine Authors: Dan Zhu, Yu Li, A-yong Tian and Hong-nan Wang Tags: Study protocol Source Type: research

Antiarrhythmic drugs for pharmacological cardioversion of atrial fibrillation and gender differences - insights from CANT II Study
CONCLUSION: Female patients with AF share different clinical profile and similar efficacy and safety of AAD as compared to male participants. Propafenone has significantly lower efficacy in men, which requires further investigation.PMID:37997824 | DOI:10.33963/v.kp.97392 (Source: Polish Heart Journal)
Source: Polish Heart Journal - November 24, 2023 Category: Cardiology Authors: Maciej T Wybraniec Aleksander Maci ąg Dawid Mi śkowiec Beata Ceynowa-Sielawko Pawe ł Balsam Maciej W ójcik Wojciech Wr óbel Micha ł Farkowski Edyta Ćwiek-Rębowska Marek Szo łkiewicz Krzysztof Oziera ński Robert B łaszczyk Karolina Bula Tomasz D Source Type: research

Antiarrhythmic drugs for pharmacological cardioversion of atrial fibrillation and gender differences - insights from CANT II Study
CONCLUSION: Female patients with AF share different clinical profile and similar efficacy and safety of AAD as compared to male participants. Propafenone has significantly lower efficacy in men, which requires further investigation.PMID:37997824 | DOI:10.33963/v.kp.97392 (Source: Kardiologia Polska)
Source: Kardiologia Polska - November 24, 2023 Category: Cardiology Authors: Maciej T Wybraniec Aleksander Maci ąg Dawid Mi śkowiec Beata Ceynowa-Sielawko Pawe ł Balsam Maciej W ójcik Wojciech Wr óbel Micha ł Farkowski Edyta Ćwiek-Rębowska Marek Szo łkiewicz Krzysztof Oziera ński Robert B łaszczyk Karolina Bula Tomasz D Source Type: research