Amiodarone in a rush: caution on speed of delivery and new guidance
A boy aged 11 months presented to his local hospital with a short history of being febrile with vomiting. He was found to be shocked with a pulsed broad complex tachycardia of around 240 and increased work of breathing. He was managed as per the APLS (Advanced Paediatric Life Support) protocol and had short-lived terminations after his first two shocks. He was loaded with amiodarone over 5 min prior to his third shock, but promptly arrested with loss of electrical activity requiring 20 min cardiopulmonary resuscitation. This transitioned to a return of broad complex tachycardia with output and a further 20 min of shocks an...
Source: Archives of Disease in Childhood - April 18, 2024 Category: Pediatrics Authors: Banerji, O., Schadenberg, A. Tags: PostScript Source Type: research
The Pharmacologic Management of Cardiac Arrest
This article covers the current state of evidence for the effectiveness of the vasopressor epinephrine and the combination of vasopressin-steroids-epinephrine and antiarrhythmic medications amiodarone and lidocaine and reviews the role of other med ications such as calcium, sodium bicarbonate, magnesium, and atropine in cardiac arrest care. We additionally review the role of β-blockers for refractory pulseless ventricular tachycardia/ventricular fibrillation and thrombolytics in undifferentiated cardiac arrest and suspected fatal pulmonary em bolism. (Source: Cardiology Clinics)
Source: Cardiology Clinics - April 16, 2024 Category: Cardiology Authors: Amandeep Singh, Megan Heeney, Martha E. Montgomery Source Type: research
Analysis of a Serious Adverse Reaction of Pulmonary Fibrosis Caused by Dronedarone
CONCLUSIONS: It is recommended that clinicians monitor the diffusion capacity of carbon monoxide and lung ventilation function of patients before and after using dronedarone for treatment. For patients with a history of amiodarone exposure, intermittent monitoring of chest X-rays and lung function is necessary. If lung function decreases, dronedarone should be immediately discontinued.PMID:38617895 | PMC:PMC11015333 | DOI:10.1016/j.curtheres.2024.100743 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Yuyan Chen Zhendong Fu Xue Wen Mingxia Zhang Qiong Min Peng Wang Jin Zhang Jun Ren Wenbin Li Rong Wang Source Type: research
Analysis of a Serious Adverse Reaction of Pulmonary Fibrosis Caused by Dronedarone
CONCLUSIONS: It is recommended that clinicians monitor the diffusion capacity of carbon monoxide and lung ventilation function of patients before and after using dronedarone for treatment. For patients with a history of amiodarone exposure, intermittent monitoring of chest X-rays and lung function is necessary. If lung function decreases, dronedarone should be immediately discontinued.PMID:38617895 | PMC:PMC11015333 | DOI:10.1016/j.curtheres.2024.100743 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Yuyan Chen Zhendong Fu Xue Wen Mingxia Zhang Qiong Min Peng Wang Jin Zhang Jun Ren Wenbin Li Rong Wang Source Type: research
Extracellular acidification reveals the antiarrhythmic properties of amiodarone related to late sodium current-induced atrial arrhythmia
CONCLUSION: The pharmacological properties of AMIO concerning healthy rat atrial tissue are not dependent on pHe. However, the prevention of arrhythmias induced by INa-Late is pHe-dependent. The development of drugs analogous to AMIO with charge stabilization may help to create more effective drugs to treat arrhythmias related to the INa-Late.PMID:38619735 | DOI:10.1007/s43440-024-00597-2 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 15, 2024 Category: Drugs & Pharmacology Authors: Michael Ramon de Lima Concei ção Jorge Lucas Teixeira-Fonseca Leisiane Pereira Marques Diego Santos Souza Fabiana da Silva Alc ântara Diego Jose Belato Orts Danilo Roman-Campos Source Type: research
Extracellular acidification reveals the antiarrhythmic properties of amiodarone related to late sodium current-induced atrial arrhythmia
CONCLUSION: The pharmacological properties of AMIO concerning healthy rat atrial tissue are not dependent on pHe. However, the prevention of arrhythmias induced by INa-Late is pHe-dependent. The development of drugs analogous to AMIO with charge stabilization may help to create more effective drugs to treat arrhythmias related to the INa-Late.PMID:38619735 | DOI:10.1007/s43440-024-00597-2 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 15, 2024 Category: Drugs & Pharmacology Authors: Michael Ramon de Lima Concei ção Jorge Lucas Teixeira-Fonseca Leisiane Pereira Marques Diego Santos Souza Fabiana da Silva Alc ântara Diego Jose Belato Orts Danilo Roman-Campos Source Type: research
Amiodarone-Induced Psoriasiform Dermatitis
Ann Pharmacother. 2024 Apr 8:10600280241244511. doi: 10.1177/10600280241244511. Online ahead of print.NO ABSTRACTPMID:38590149 | DOI:10.1177/10600280241244511 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 9, 2024 Category: Drugs & Pharmacology Authors: Myriam Agrebi Dhouha Sahnoun Najet Ghariani Mohamed Denguezli Chaker Ben Salem Source Type: research
Amiodarone-Induced Psoriasiform Dermatitis
Ann Pharmacother. 2024 Apr 8:10600280241244511. doi: 10.1177/10600280241244511. Online ahead of print.NO ABSTRACTPMID:38590149 | DOI:10.1177/10600280241244511 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 9, 2024 Category: Drugs & Pharmacology Authors: Myriam Agrebi Dhouha Sahnoun Najet Ghariani Mohamed Denguezli Chaker Ben Salem Source Type: research
Amiodarone-Induced Psoriasiform Dermatitis
Ann Pharmacother. 2024 Apr 8:10600280241244511. doi: 10.1177/10600280241244511. Online ahead of print.NO ABSTRACTPMID:38590149 | DOI:10.1177/10600280241244511 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 9, 2024 Category: Drugs & Pharmacology Authors: Myriam Agrebi Dhouha Sahnoun Najet Ghariani Mohamed Denguezli Chaker Ben Salem Source Type: research
Amiodarone-Induced Psoriasiform Dermatitis
Ann Pharmacother. 2024 Apr 8:10600280241244511. doi: 10.1177/10600280241244511. Online ahead of print.NO ABSTRACTPMID:38590149 | DOI:10.1177/10600280241244511 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 9, 2024 Category: Drugs & Pharmacology Authors: Myriam Agrebi Dhouha Sahnoun Najet Ghariani Mohamed Denguezli Chaker Ben Salem Source Type: research
Amiodarone-Induced Psoriasiform Dermatitis
Ann Pharmacother. 2024 Apr 8:10600280241244511. doi: 10.1177/10600280241244511. Online ahead of print.NO ABSTRACTPMID:38590149 | DOI:10.1177/10600280241244511 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 9, 2024 Category: Drugs & Pharmacology Authors: Myriam Agrebi Dhouha Sahnoun Najet Ghariani Mohamed Denguezli Chaker Ben Salem Source Type: research
The ion channel basis of pharmacological effects of amiodarone on myocardial electrophysiological properties, a comprehensive review
Biomed Pharmacother. 2024 Apr 1;174:116513. doi: 10.1016/j.biopha.2024.116513. Online ahead of print.ABSTRACTAmiodarone is a benzofuran-based class III antiarrhythmic agent frequently used for the treatment of atrial and ventricular arrhythmias. The primary target of class III antiarrhythmic drugs is the cardiac human ether-a-go-go-related gene (hERG) encoded channel, KCNH2, commonly known as HERG, that conducts the rapidly activating delayed rectifier potassium current (IKr). Like other class III antiarrhythmic drugs, amiodarone exerts its physiologic effects mainly through IKr blockade, delaying the repolarization phase ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 2, 2024 Category: Drugs & Pharmacology Authors: Illia Gelman Neelakshi Sharma Olivia Mckeeman Peter Lee Noah Campagna Nicole Tomei Adrian Baranchuk Shetuan Zhang Mohammad El-Diasty Source Type: research
Preoperative Amiodarone Use Does Not Affect Pacemaker Implantation After Heart Transplantation
Purpose: Following bi-atrial orthotopic heart transplantation (HTx), approximately 20% of patients require permanent pacemaker (PPM) implantation. Several risk factors, including preoperative amiodarone use have been reported, although previous studies show contradictory results. We aimed to assess the association between preoperative amiodarone use and PPM implantation in patients who underwent HTx at the University Medical Centre of Utrecht (UMCU). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , L.C. Kieviet, M.K. Szymanski, M.G. van der Meer, N.P. van der Kaaij, L.W. Van Laake, A.E. Tuinenburg, K.A. Jacob, E.E. van Aarnhem, M.I. Oerlemans Source Type: research
Acute Hepatitis After Lung Transplant in a Recipient from Hep C Donor: The Chicken or the Egg Phenomenon?
We present a case of acute hepatitis after lung transplant from an HCV positive donor confounded by amiodarone toxicity. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J.P. Braat, A. Arjuna Source Type: research
Amiodarone Association with PGD After Heart Transplant
Purpose: Amiodarone use prior to heart transplantation (HT) has been associated with primary graft dysfunction (PGD), although data are mixed. Our aim was to determine if amiodarone use was associated with severe PGD at our center. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: N. Stringer Dorsey, A. Biscopink, J. Atkins, S.K. O'Connor, A. Carnicelli, V. Rao, L. Witer, C. Inampudi, D. Silverman, A. Van Bakel, G. Jackson, , A. Kilic, R.J. Tedford, J.M. Griffin Source Type: research
