Viruses, Vol. 15, Pages 2416: Phenotypical Screening of an MMV Open Box Library and Identification of Compounds with Antiviral Activity against St. Louis Encephalitis Virus
l Elias Marques
St. Louis encephalitis virus (SLEV) is a neglected mosquito-borne Flavivirus that may cause severe neurological disease in humans and other animals. There are no specific treatments against SLEV infection or disease approved for human use, and drug repurposing may represent an opportunity to accelerate the development of treatments against SLEV. Here we present a scalable, medium-throughput phenotypic cell culture-based screening assay on Vero CCL81 cells to identify bioactive compounds that could be repurposed against SLEV infection. We screened eighty compounds from the Medicines for Malaria Venture (...
Source: Viruses - December 13, 2023 Category: Virology Authors: Giuliana Eboli Sotorilli Humberto Doriguetto Gravina Ana Carolina de Carvalho Jacqueline Farinha Shimizu Marina Alves Fontoura Talita Diniz Melo-Hanchuk Artur Torres Cordeiro Rafael Elias Marques Tags: Article Source Type: research
The role of melatonin in preventing amiodarone induced rat liver damage
In conclusion the application of melatonin together with amiodarone prevented an increase in tissue oxidative damage parameters and moderately prevented liver cell apoptosis, indicating that the damage of hepatocytes provoked by amiodarone supersedes the protective properties of melatonin in a given dose.PMID:38079620 | DOI:10.1139/cjpp-2023-0253 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Dejan Petrovi ć Marina Deljanin Ili ć Dejan Simonovi ć Milovan Stojanovi ć Milica Stankovi ć Slavi ša Stanišić Sanja Stojanovi ć Neboj ša Arsić Dusan Sokolovic Source Type: research
The role of melatonin in preventing amiodarone induced rat liver damage
In conclusion the application of melatonin together with amiodarone prevented an increase in tissue oxidative damage parameters and moderately prevented liver cell apoptosis, indicating that the damage of hepatocytes provoked by amiodarone supersedes the protective properties of melatonin in a given dose.PMID:38079620 | DOI:10.1139/cjpp-2023-0253 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Dejan Petrovi ć Marina Deljanin Ili ć Dejan Simonovi ć Milovan Stojanovi ć Milica Stankovi ć Slavi ša Stanišić Sanja Stojanovi ć Neboj ša Arsić Dusan Sokolovic Source Type: research
The role of melatonin in preventing amiodarone induced rat liver damage
In conclusion the application of melatonin together with amiodarone prevented an increase in tissue oxidative damage parameters and moderately prevented liver cell apoptosis, indicating that the damage of hepatocytes provoked by amiodarone supersedes the protective properties of melatonin in a given dose.PMID:38079620 | DOI:10.1139/cjpp-2023-0253 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Dejan Petrovi ć Marina Deljanin Ili ć Dejan Simonovi ć Milovan Stojanovi ć Milica Stankovi ć Slavi ša Stanišić Sanja Stojanovi ć Neboj ša Arsić Dusan Sokolovic Source Type: research
The role of melatonin in preventing amiodarone induced rat liver damage
In conclusion the application of melatonin together with amiodarone prevented an increase in tissue oxidative damage parameters and moderately prevented liver cell apoptosis, indicating that the damage of hepatocytes provoked by amiodarone supersedes the protective properties of melatonin in a given dose.PMID:38079620 | DOI:10.1139/cjpp-2023-0253 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Dejan Petrovi ć Marina Deljanin Ili ć Dejan Simonovi ć Milovan Stojanovi ć Milica Stankovi ć Slavi ša Stanišić Sanja Stojanovi ć Neboj ša Arsić Dusan Sokolovic Source Type: research
The role of melatonin in preventing amiodarone induced rat liver damage
In conclusion the application of melatonin together with amiodarone prevented an increase in tissue oxidative damage parameters and moderately prevented liver cell apoptosis, indicating that the damage of hepatocytes provoked by amiodarone supersedes the protective properties of melatonin in a given dose.PMID:38079620 | DOI:10.1139/cjpp-2023-0253 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Dejan Petrovi ć Marina Deljanin Ili ć Dejan Simonovi ć Milovan Stojanovi ć Milica Stankovi ć Slavi ša Stanišić Sanja Stojanovi ć Neboj ša Arsić Dusan Sokolovic Source Type: research
The role of melatonin in preventing amiodarone induced rat liver damage
In conclusion the application of melatonin together with amiodarone prevented an increase in tissue oxidative damage parameters and moderately prevented liver cell apoptosis, indicating that the damage of hepatocytes provoked by amiodarone supersedes the protective properties of melatonin in a given dose.PMID:38079620 | DOI:10.1139/cjpp-2023-0253 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Dejan Petrovi ć Marina Deljanin Ili ć Dejan Simonovi ć Milovan Stojanovi ć Milica Stankovi ć Slavi ša Stanišić Sanja Stojanovi ć Neboj ša Arsić Dusan Sokolovic Source Type: research
The role of melatonin in preventing amiodarone induced rat liver damage
In conclusion the application of melatonin together with amiodarone prevented an increase in tissue oxidative damage parameters and moderately prevented liver cell apoptosis, indicating that the damage of hepatocytes provoked by amiodarone supersedes the protective properties of melatonin in a given dose.PMID:38079620 | DOI:10.1139/cjpp-2023-0253 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Dejan Petrovi ć Marina Deljanin Ili ć Dejan Simonovi ć Milovan Stojanovi ć Milica Stankovi ć Slavi ša Stanišić Sanja Stojanovi ć Neboj ša Arsić Dusan Sokolovic Source Type: research
The role of melatonin in preventing amiodarone induced rat liver damage
In conclusion the application of melatonin together with amiodarone prevented an increase in tissue oxidative damage parameters and moderately prevented liver cell apoptosis, indicating that the damage of hepatocytes provoked by amiodarone supersedes the protective properties of melatonin in a given dose.PMID:38079620 | DOI:10.1139/cjpp-2023-0253 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Dejan Petrovi ć Marina Deljanin Ili ć Dejan Simonovi ć Milovan Stojanovi ć Milica Stankovi ć Slavi ša Stanišić Sanja Stojanovi ć Neboj ša Arsić Dusan Sokolovic Source Type: research
State-independent inhibition of the oncogenic Kv10.1 channel by desethylamiodarone, a comparison with amiodarone
Pflugers Arch. 2023 Dec 8. doi: 10.1007/s00424-023-02893-x. Online ahead of print.ABSTRACTKv10.1 is a voltage-dependent K channel whose ectopic expression is associated with several human cancers. Additionally, Kv10.1 has structure-function properties which are not yet well understood. We are using drugs of clinical importance in an attempt to gain insight on the relationship between pharmacology and characteristic functional properties of this channel. Herein, we report the interaction of desethylamiodarone (desAd), the active metabolic product of the antiarrhythmic amiodarone with Kv10.1: desAd binds to both closed and o...
Source: Pflugers Archiv : European Journal of Physiology - December 8, 2023 Category: Physiology Authors: F Gomez-Lagunas C Barriga-Montoya J P Pardo Source Type: research
