Cancers, Vol. 16, Pages 702: Pulmonary Metastasectomy for Adrenocortical Carcinoma & mdash;Not If, but When
Conclusions: PM appears to have a role in ACC patients. The number of nodules should not be an exclusion factor. Patients developing LM within a year of primary tumor resection may benefit from waiting before further surgeries, which may provide additional insight into who may benefit from PM. (Source: Cancers)
Source: Cancers - February 7, 2024 Category: Cancer & Oncology Authors: Shamus R. Carr Frank Villa Hernandez Diana Grace Varghese Hyoyoung Choo-Wosoba Seth M. Steinberg Martha E. Teke Jaydira Del Rivero David S. Schrump Chuong D. Hoang Tags: Article Source Type: research
Letter re: Impact of EDP-M on survival of patients with metastatic adrenocortical carcinoma: A population-based study
Dear Editor, (Source: European Journal of Cancer)
Source: European Journal of Cancer - February 5, 2024 Category: Cancer & Oncology Authors: Marta Lagan à, Deborah Cosentini, Guido Alberto Massimo Tiberio, Sandra Sigala, Alfredo Berruti Tags: Letter to the Editor Source Type: research
Diagnosis of adrenocortical carcinoma
Orv Hetil. 2024 Jan 28;165(4):123-131. doi: 10.1556/650.2024.32958. Print 2024 Jan 28.ABSTRACTA mellékvesekéreg-carcinoma ritka, rossz prognózisú megbetegedés. Az érintett betegek kórjóslatát döntően meghatározza, hogy a betegség korán, még lokoregionális stádiumban kerüljön felismerésre, amikor a sebészi tumoreltávolítással jelentősen növelhető a gyógyulás esélye. A mellékvese-daganatok dignitásának meghatározása gyakran jelent kihívást a preoperatív kivizsgálás során, a diagnózisalkotást hagyományos radiológiai és laboratóriumi vizsgálatok segítik. Újabban igen jó diagno...
Source: Orvosi Hetilap - January 28, 2024 Category: General Medicine Authors: Judit T őke Mikl ós Tóth Source Type: research
The European Network for the Study of Adrenal Tumors staging system (2015): a United States validation
CONCLUSION: The accuracy of mENSAT is virtually the same as that of AJCC in predicting CSM (74.7 vs. 74.5%) and OM (73.7 vs. 73.5%). However, calibration is lower for mENSAT than for AJCC. In consequence, no obvious benefit appears to be associated with the use of mENSAT relative to AJCC in United States ACC patients.PMID:38266758 | DOI:10.1210/clinem/dgae047 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - January 24, 2024 Category: Endocrinology Authors: Letizia Maria Ippolita Jannello Reha-Baris Incesu Simone Morra Lukas Scheipner Andrea Baudo Mario de Angelis Carolin Siech Zhe Tian Jordan A Goyal Stefano Luzzago Francesco A Mistretta Matteo Ferro Fred Saad Shahrokh F Shariat Felix K H Chun Alberto Briga Source Type: research
The European Network for the Study of Adrenal Tumors staging system (2015): a United States validation
CONCLUSION: The accuracy of mENSAT is virtually the same as that of AJCC in predicting CSM (74.7 vs. 74.5%) and OM (73.7 vs. 73.5%). However, calibration is lower for mENSAT than for AJCC. In consequence, no obvious benefit appears to be associated with the use of mENSAT relative to AJCC in United States ACC patients.PMID:38266758 | DOI:10.1210/clinem/dgae047 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - January 24, 2024 Category: Cancer & Oncology Authors: Letizia Maria Ippolita Jannello Reha-Baris Incesu Simone Morra Lukas Scheipner Andrea Baudo Mario de Angelis Carolin Siech Zhe Tian Jordan A Goyal Stefano Luzzago Francesco A Mistretta Matteo Ferro Fred Saad Shahrokh F Shariat Felix K H Chun Alberto Briga Source Type: research
Carney complex predisposes to breast cancer: prospective study of 50 women
CONCLUSIONS: As CNC could predispose to breast carcinoma, an adequate screening strategy and follow-up should be discussed in affected women.CLINICAL TRIAL REGISTRATION: ClinicalTrial.gov NCT00668291.PMID:38252880 | DOI:10.1093/ejendo/lvae010 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - January 22, 2024 Category: Endocrinology Authors: Patricia Vaduva Florian Violon Anne Jouinot Lucas Bouys St éphanie Espiard Fid éline Bonnet-Serrano Marie Odile North Catherine Cardot-Bauters Gerald Raverot Sylvie Hieronimus Herv é Lefebvre Marie-Laure Nunes Antoine Tabarin Lionel Groussin Guillaume Source Type: research
Recovery of adrenal function after stopping mitotane in patients with adrenocortical carcinoma
CONCLUSIONS: Our study demonstrates that adrenal recovery occurs in most patients after stopping mitotane, particularly when followed up in specialized centers, but not in all. Elimination time of mitotane after treatment discontinuation is very long but individually quite variable.PMID:38244214 | DOI:10.1093/ejendo/lvae007 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - January 20, 2024 Category: Endocrinology Authors: Barbara Altieri Otilia Kimpel Felix Megerle Mario Detomas Irina Chifu Carmina Teresa Fuss Marcus Quinkler Matthias Kroiss Martin Fassnacht Source Type: research
Hypogonadism and sexual function in men affected by adrenocortical carcinoma under mitotane therapy
ConclusionAMT was associated with hypergonatropic hypogonadism and ED, while ART led to a significant improvement of cFT levels and sexual function in the hypogonadal ACC patients. Therefore, we suggest to evaluate LH, SHBG, TT and cFT and sexual function during AMT, and start ART in the hypogonadal ACC patients with sexual dysfunction. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - January 10, 2024 Category: Endocrinology Source Type: research
Wnt/ β-catenin signaling pathway in the tumor progression of adrenocortical carcinoma
Adrenocortical carcinoma (ACC) is an uncommon, aggressive endocrine malignancy with a high rate of recurrence, a poor prognosis, and a propensity for metastasis. Currently, only mitotane has received certification from both the US Food and Drug Administration (FDA) and the European Medicines Agency for the therapy of advanced ACC. However, treatment in the advanced periods of the disorders is ineffective and has serious adverse consequences. Completely surgical excision is the only cure but has failed to effectively improve the survival of advanced patients. The aberrantly activated Wnt/β-catenin pathway is one of the cat...
Source: Frontiers in Endocrinology - January 9, 2024 Category: Endocrinology Source Type: research
Pan-Cancer Analysis of P3H1 and Experimental Validation in Renal Clear Cell Carcinoma
In this study, for the first time, aspects associated with P3H1, such as the mRNA expression, any mutation, promoter methylation, and prognostic significance, the relationship between P3H1 and clinicopathological parameters, drug sensitivity, and immune cell infiltration were investigated by searching several databases including The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), cBioPortal, and The Tumor Immune Evaluation Resource (TIMER2.0) using bioinformatics tools. The findings indicate significant differential expression of P3H1 in most tumors when compared to normal tissues, with a strong association ...
Source: Applied Biochemistry and Biotechnology - January 4, 2024 Category: Biochemistry Authors: Yongjie Li Ting Wang Feng Jiang Source Type: research
A pan-cancer analysis of the prognostic implication and oncogenic role of tubulin epsilon and delta complex 2 (TEDC2) in human tumors
In this study, we employed R software and various online bioinformatics analysis tools to investigate the functional attributes of TEDC2 in human tumours and its potential involvement in immune response. The status of TEDC2 expression was evaluated in samples from the TCGA and GEO datasets, as well as in tumour and corresponding normal samples from the TCGA database. Subsequently, Kaplan-Meier estimates, clinical correlations, and univariate Cox regressions were used to analyze the 33 types of tumors from TCGA and determine the prognostic significance of TEDC2. Moreover, nomogram models were formulated using three distinct...
Source: Frontiers in Immunology - January 4, 2024 Category: Allergy & Immunology Source Type: research
ASO Author Reflections: Surgical Decision-Making in Adrenocortical Carcinoma: When Less is More
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - January 3, 2024 Category: Cancer & Oncology Source Type: research
Current Evidence on Local Therapies in Advanced Adrenocortical
Carcinoma
Horm Metab Res 2024; 56: 91-98 DOI: 10.1055/a-2209-6022International guidelines emphasise the role of local therapies (LT) for the
treatment of advanced adrenocortical carcinoma (ACC). However, large studies are
lacking in this field. Therefore, we performed a review of the literature to
synthesise current evidence and develop clinical guidance. PubMed database was
searched for systematic literature. We identified 119 potentially relevant
articles, of which 21 could be included in our final analysis. All were
retrospective and reported on 374 patients treated with...
Source: Hormone and Metabolic Research - January 3, 2024 Category: Endocrinology Authors: Kimpel, Otilia Dischinger, Ulrich Altieri, Barbara Fuss, Carmina Teresa Polat, B ülent Kickuth, Ralph Kroiss, Matthias Fassnacht, Martin Tags: Review Source Type: research
A reappraisal of transcriptional regulation by NR5A1 and beta-catenin in adrenocortical carcinoma
CONCLUSION: Overall, my analysis suggests a model where NR5A1 overexpression and beta-catenin activation principally act independently, rather than functionally interacting, to drive ACC malignancy.PMID:38155952 | PMC:PMC10753177 | DOI:10.3389/fendo.2023.1303332 (Source: Cell Research)
Source: Cell Research - December 29, 2023 Category: Cytology Authors: Enzo Lalli Source Type: research
A reappraisal of transcriptional regulation by NR5A1 and beta-catenin in adrenocortical carcinoma
CONCLUSION: Overall, my analysis suggests a model where NR5A1 overexpression and beta-catenin activation principally act independently, rather than functionally interacting, to drive ACC malignancy.PMID:38155952 | PMC:PMC10753177 | DOI:10.3389/fendo.2023.1303332 (Source: Cell Research)
Source: Cell Research - December 29, 2023 Category: Cytology Authors: Enzo Lalli Source Type: research
