A novel cuproptosis-related prognostic gene signature in adrenocortical carcinoma
CONCLUSIONS: CDKN2A and FDX1 are independent prognostic predictors of patients with ACC. Cuproptosis may play a role in the development of ACC, providing a new perspective on therapeutic strategies related to CRGs for cancer prevention and treatment.PMID:37997497 | DOI:10.1002/jcla.24981 (Source: Cancer Control)
Source: Cancer Control - November 24, 2023 Category: Cancer & Oncology Authors: Wenjun Gao Xiaoyan He Qi Huangfu Yanqi Xie Keliang Chen Chengfang Sun Jingchao Wei Bohan Wang Source Type: research
ASO Author Reflections: Surgical Decision-Making in Adrenocortical Carcinoma: When Less is More
Ann Surg Oncol. 2023 Nov 22. doi: 10.1245/s10434-023-14630-w. Online ahead of print.NO ABSTRACTPMID:37993746 | DOI:10.1245/s10434-023-14630-w (Source: Ann Oncol)
Source: Ann Oncol - November 22, 2023 Category: Cancer & Oncology Authors: Jesse E Passman Heather Wachtel Source Type: research
ASO Author Reflections: Surgical Decision-Making in Adrenocortical Carcinoma: When Less is More
Ann Surg Oncol. 2023 Nov 22. doi: 10.1245/s10434-023-14630-w. Online ahead of print.NO ABSTRACTPMID:37993746 | DOI:10.1245/s10434-023-14630-w (Source: Ann Oncol)
Source: Ann Oncol - November 22, 2023 Category: Cancer & Oncology Authors: Jesse E Passman Heather Wachtel Source Type: research
Case Report: Adrenocortical carcinoma in children —symptoms, diagnosis, and treatment
We report a rare case of adrenocortical carcinoma in a girl and a literature review using the PubMed database. A four-year-old girl presented with rapidly progressing precocious puberty and signs of Cushing’s syndrome. Imaging of the abdomen revealed a large heterogeneous solid mass. Histopathologic evaluation confirmed adrenocortical carcinoma with high mitotic activity, atypical mitoses, pleomorphism, necrosis, and vascular invasion. After tumourectomy, a decrease of previously elevated hormonal blood parameters was observed. Genetic tests confirmed Li Fraumeni syndrome. Adrenocortical carcinoma should be suspected in ...
Source: Frontiers in Endocrinology - November 21, 2023 Category: Endocrinology Source Type: research
Identification of key genes and pathways in adrenocortical carcinoma: evidence from bioinformatic analysis
In conclusion, the results in this study provided reliable key genes and pathways for ACC, which will be useful for ACC mechanisms, diagnosis and candidate targeted treatment. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - November 20, 2023 Category: Endocrinology Source Type: research
ASO Visual Abstract: Defining Optimal Management of Nonmetastatic Adrenocortical Carcinoma
Ann Surg Oncol. 2023 Nov 17. doi: 10.1245/s10434-023-14615-9. Online ahead of print.NO ABSTRACTPMID:37978113 | DOI:10.1245/s10434-023-14615-9 (Source: Ann Oncol)
Source: Ann Oncol - November 17, 2023 Category: Cancer & Oncology Authors: Jesse E Passman Wajid Amjad Jacqueline M Soegaard Ballester Sara P Ginzberg Heather Wachtel Source Type: research
ASO Visual Abstract: Defining Optimal Management of Nonmetastatic Adrenocortical Carcinoma
Ann Surg Oncol. 2023 Nov 17. doi: 10.1245/s10434-023-14615-9. Online ahead of print.NO ABSTRACTPMID:37978113 | DOI:10.1245/s10434-023-14615-9 (Source: Ann Oncol)
Source: Ann Oncol - November 17, 2023 Category: Cancer & Oncology Authors: Jesse E Passman Wajid Amjad Jacqueline M Soegaard Ballester Sara P Ginzberg Heather Wachtel Source Type: research
Discussion
Dr Priya Dedhia (Ohio State): Your team has filled a gap in the research that has been done on adrenocortical carcinoma and our ability to prognosticate the risk of occurrence. Adrenocortical carcinoma is a heterogeneous disease, and the clinical presentation and disease progression can be quite variable. Because of that, it is very difficult for us to predict what is going to happen to the patient. Being able to prognosticate the risk of recurrence is important. To that effect, the American Joint Committee on Cancer has developed a staging system, and that staging system involves the T-stage and all the things that Dr Zub...
Source: Surgery - November 10, 2023 Category: Surgery Source Type: research
Validated predictive model for treatment and prognosis of adrenocortical carcinoma
Adrenocortical carcinoma has a poor prognosis and multiple clinical, pathological, and treatment variables. Currently, we lack a prognostic and treatment calculator to determine the survival and efficacy of adjuvant chemoradiation. We aimed to validate a calculator to assess prognosis and treatment. (Source: Surgery)
Source: Surgery - November 10, 2023 Category: Surgery Authors: Samuel M. Zuber, Kristine Kuchta, Simon A. Holoubek, Amna Khokar, Tricia Moo-Young, Richard A. Prinz, David J. Winchester Source Type: research
Impact of EDP-M on Survival of Patients with Metastatic Adrenocortical Carcinoma: A population-based study
Historically, stage IV adrenocortical carcinoma (mACC) has a poor prognosis with a median overall survival (OS) of only 5 months. Based on the FIRM-ACT trial published in 2012, guidelines now advise first line systemic treatment with etoposide, cisplatin, doxorubicin and mitotane (EDP-M). The effect of EDP-M on patient survival in clinical practice in the Netherlands is unknown. (Source: European Journal of Cancer)
Source: European Journal of Cancer - November 9, 2023 Category: Cancer & Oncology Authors: Pien Debets, Koen M.A. Dreijerink, Anton Engelsman, Max Dahele, Harm R. Haak, Rebecca V. Steenaard, Ellen Kapiteijn, Eleonora Corssmit, C. Willemien Menke – van der Houven van Oordt Tags: Original Research Source Type: research
The effect of hormonal secretion on survival in adrenocortical carcinoma: A multi-center study
Current evidence suggests that cortisol secreting adrenocortical carcinoma has worse prognosis compared to non-secreting adrenocortical carcinoma. However, the effect of other secretory subtypes is unknown. (Source: Surgery)
Source: Surgery - November 8, 2023 Category: Surgery Authors: Alaa Sada, Trenton R. Foster, Ruaa Al-Ward, Sahar Sawani, HElaine Charchar, Reza Pishdad, Anat Ben-Shlomo, Benzon M. Dy, Melanie L. Lyden, Emily Bergsland, Sina Jasim, Nitya Raj, Jessica B. Shank, Oksana Hamidi, Amir H. Hamrahian, Jos é L. Chambô, Victo Source Type: research
Defining Optimal Management of Non-metastatic Adrenocortical Carcinoma
CONCLUSION: Tumor biology and surgical margins are the primary determinants of survival in non-metastatic ACC. Surgical extent and lymphadenectomy are not associated with overall survival. In advanced disease, the open approach is associated with improved survival.PMID:37925657 | DOI:10.1245/s10434-023-14533-w (Source: Ann Oncol)
Source: Ann Oncol - November 5, 2023 Category: Cancer & Oncology Authors: Jesse E Passman Wajid Amjad Jacqueline M Soegaard Ballester Sara P Ginzberg Heather Wachtel Source Type: research
Defining Optimal Management of Non-metastatic Adrenocortical Carcinoma
CONCLUSION: Tumor biology and surgical margins are the primary determinants of survival in non-metastatic ACC. Surgical extent and lymphadenectomy are not associated with overall survival. In advanced disease, the open approach is associated with improved survival.PMID:37925657 | DOI:10.1245/s10434-023-14533-w (Source: Ann Oncol)
Source: Ann Oncol - November 5, 2023 Category: Cancer & Oncology Authors: Jesse E Passman Wajid Amjad Jacqueline M Soegaard Ballester Sara P Ginzberg Heather Wachtel Source Type: research
Exploring the role of the disulfidptosis-related gene SLC7A11 in adrenocortical carcinoma: implications for prognosis, immune infiltration, and therapeutic strategies
Disulfidptosis and the disulfidptosis-related gene SLC7A11 have recently attracted significant attention for their role in tumorigenesis and tumour management. However, its association with adrenocortical carc... (Source: Cancer Cell International)
Source: Cancer Cell International - November 2, 2023 Category: Cancer & Oncology Authors: Tonghu Liu, Yilin Ren, Qixin Wang, Yu Wang, Zhiyuan Li, Weibo Sun, Dandan Fan, Yongkun Luan, Yukui Gao and Zechen Yan Tags: Research Source Type: research
