A reappraisal of transcriptional regulation by NR5A1 and beta-catenin in adrenocortical carcinoma
CONCLUSION: Overall, my analysis suggests a model where NR5A1 overexpression and beta-catenin activation principally act independently, rather than functionally interacting, to drive ACC malignancy.PMID:38155952 | PMC:PMC10753177 | DOI:10.3389/fendo.2023.1303332 (Source: Cell Research)
Source: Cell Research - December 29, 2023 Category: Cytology Authors: Enzo Lalli Source Type: research
Identification of Key Genes and Related Drugs of Adrenocortical
Carcinoma by Integrated Bioinformatics Analysis
This study aims to discover biomarkers and potential
therapeutic agents for ACC through bioinformatics, enhancing clinical diagnosis
and treatment strategies. Differentially expressed genes (DEGs) between ACC and
normal adrenal cortex were screened out from the GSE19750 and GSE90713 datasets
available in the GEO database. An online Venn diagram tool was utilized to
identify the common DEGs between the two datasets. The identified DEGs were
subjected to functional assessment, pathway enrichment, and identification of
hub genes by performing the protein-pr...
Source: Hormone and Metabolic Research - December 18, 2023 Category: Endocrinology Authors: Wei, Jian-bin Zeng, Xiao-chun Ji, Kui-rong Zhang, Ling-yi Chen, Xiao-min Tags: Original Article: Endocrine Research Source Type: research
Identification of ACBD3 as a new molecular biomarker in pan-cancers through bioinformatic analysis: a preclinical study
CONCLUSION: According to our pan-cancer analysis, ACBD3 may serve as a remarkable prognostic and diagnostic biomarker of pan-cancers as well as contribute to tumor development. ACBD3 may also provide new directions for cancer treatment targets in the future.PMID:38098097 | DOI:10.1186/s40001-023-01576-8 (Source: Cell Research)
Source: Cell Research - December 15, 2023 Category: Cytology Authors: Xinyue Ma Shu Huang Huiqin Shi Rui Luo Bei Luo Zhenju Tan Lei Shi Wei Zhang Weixing Yang Xiaolin Zhong Muhan L ü Xia Chen Xiaowei Tang Source Type: research
Identification of ACBD3 as a new molecular biomarker in pan-cancers through bioinformatic analysis: a preclinical study
ConclusionAccording to our pan-cancer analysis,ACBD3 may serve as a remarkable prognostic and diagnostic biomarker of pan-cancers as well as contribute to tumor development.ACBD3 may also provide new directions for cancer treatment targets in the future. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 14, 2023 Category: Research Source Type: research
Adrenal Cushing ’s syndrome in children
Adrenal Cushing’s syndrome is a rare cause of endogenous hypercortisolism in neonatal and early childhood stages. The most common causes of adrenal CS are hyperfunctioning adrenal tumours, adenoma or carcinoma. Rarer causes are primary bilateral macronodular adrenal hyperplasia (PBAMH), primary pigmented adrenocortical disease (PPNAD) and McCune Albright syndrome. The diagnosis represents a challenge for clinicians. In cases of clinical suspicion, confirmatory tests of hypercortisolism should be performed, similarly to those performed in adults. Radiological imaging should be always combined with biochemical confirmatory...
Source: Frontiers in Endocrinology - December 12, 2023 Category: Endocrinology Source Type: research
CXCR4-directed PET/CT with [68 Ga]Ga-pentixafor in solid tumors—a comprehensive analysis of imaging findings and comparison with histopathology
ConclusionsIn a whole-body tumor read-out, a substantial portion of prevalent solid tumors demonstrated increased and uniform [68 Ga]Ga-pentixafor uptake, along with high image contrast. We also observed a respective link between in- and ex-vivo CXCR4 expression, suggesting high specificity of the PET agent. Last, a fraction of patients with [68 Ga]Ga-pentixafor-positive tumor burden were rendered potentially suitable for CXCR4-directed therapy. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - December 12, 2023 Category: Nuclear Medicine Source Type: research
CXCR4-directed PET/CT with [ < sup > 68 < /sup > Ga]Ga-pentixafor in solid tumors-a comprehensive analysis of imaging findings and comparison with histopathology
CONCLUSIONS: In a whole-body tumor read-out, a substantial portion of prevalent solid tumors demonstrated increased and uniform [68 Ga]Ga-pentixafor uptake, along with high image contrast. We also observed a respective link between in- and ex-vivo CXCR4 expression, suggesting high specificity of the PET agent. Last, a fraction of patients with [68 Ga]Ga-pentixafor-positive tumor burden were rendered potentially suitable for CXCR4-directed therapy.PMID:38082196 | DOI:10.1007/s00259-023-06547-z (Source: Molecular Medicine)
Source: Molecular Medicine - December 11, 2023 Category: Molecular Biology Authors: Niklas Dreher Stefanie Hahner Carmina T Fu ß Wiebke Schl ötelburg Philipp E Hartrampf Sebastian E Serfling Andreas Schirbel Samuel Samnick Takahiro Higuchi Alexander Weich Constantin Lapa Andreas Rosenwald Andreas K Buck Stefan Kircher Rudolf A Werner Source Type: research
A reappraisal of transcriptional regulation by NR5A1 and beta-catenin in adrenocortical carcinoma
ConclusionOverall, my analysis suggests a model where NR5A1 overexpression and beta-catenin activation principally act independently, rather than functionally interacting, to drive ACC malignancy. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - December 8, 2023 Category: Endocrinology Source Type: research
Adrenocortical carcinoma - 12-year observation period in a single centre. Case report with literature review
CONCLUSIONS: A patient after ACC treatment requires regular check-ups and long-term observation. Constant supervision enables early diagnosis of disease recurrence, and the use of treatment improves the prognosis.PMID:38031835 | DOI:10.5114/pedm.2023.132131 (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 30, 2023 Category: Endocrinology Authors: Patrycja Dasiewicz El żbieta Moszczyńska Danuta Perek Dariusz Polnik Maria Stepaniuk Joanna Trubicka Wies ława Grajkowska Source Type: research
Adrenocortical carcinoma - 12-year observation period in a single centre. Case report with literature review
CONCLUSIONS: A patient after ACC treatment requires regular check-ups and long-term observation. Constant supervision enables early diagnosis of disease recurrence, and the use of treatment improves the prognosis.PMID:38031835 | PMC:PMC10679906 | DOI:10.5114/pedm.2023.132131 (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 30, 2023 Category: Endocrinology Authors: Patrycja Dasiewicz El żbieta Moszczyńska Danuta Perek Dariusz Polnik Maria Stepaniuk Joanna Trubicka Wies ława Grajkowska Source Type: research
Adrenocortical carcinoma - 12-year observation period in a single centre. Case report with literature review
CONCLUSIONS: A patient after ACC treatment requires regular check-ups and long-term observation. Constant supervision enables early diagnosis of disease recurrence, and the use of treatment improves the prognosis.PMID:38031835 | PMC:PMC10679906 | DOI:10.5114/pedm.2023.132131 (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 30, 2023 Category: Endocrinology Authors: Patrycja Dasiewicz El żbieta Moszczyńska Danuta Perek Dariusz Polnik Maria Stepaniuk Joanna Trubicka Wies ława Grajkowska Source Type: research
Adrenocortical carcinoma - 12-year observation period in a single centre. Case report with literature review
CONCLUSIONS: A patient after ACC treatment requires regular check-ups and long-term observation. Constant supervision enables early diagnosis of disease recurrence, and the use of treatment improves the prognosis.PMID:38031835 | PMC:PMC10679906 | DOI:10.5114/pedm.2023.132131 (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 30, 2023 Category: Endocrinology Authors: Patrycja Dasiewicz El żbieta Moszczyńska Danuta Perek Dariusz Polnik Maria Stepaniuk Joanna Trubicka Wies ława Grajkowska Source Type: research
Adrenocortical carcinoma - 12-year observation period in a single centre. Case report with literature review
CONCLUSIONS: A patient after ACC treatment requires regular check-ups and long-term observation. Constant supervision enables early diagnosis of disease recurrence, and the use of treatment improves the prognosis.PMID:38031835 | PMC:PMC10679906 | DOI:10.5114/pedm.2023.132131 (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 30, 2023 Category: Endocrinology Authors: Patrycja Dasiewicz El żbieta Moszczyńska Danuta Perek Dariusz Polnik Maria Stepaniuk Joanna Trubicka Wies ława Grajkowska Source Type: research
Adrenocortical carcinoma - 12-year observation period in a single centre. Case report with literature review
CONCLUSIONS: A patient after ACC treatment requires regular check-ups and long-term observation. Constant supervision enables early diagnosis of disease recurrence, and the use of treatment improves the prognosis.PMID:38031835 | PMC:PMC10679906 | DOI:10.5114/pedm.2023.132131 (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 30, 2023 Category: Endocrinology Authors: Patrycja Dasiewicz El żbieta Moszczyńska Danuta Perek Dariusz Polnik Maria Stepaniuk Joanna Trubicka Wies ława Grajkowska Source Type: research
