MEN2B syndrome - paediatric case report.
We present a case of a 16-year-old girl diagnosed with MEN 2B syndrome with an atypical course of the disease. Our patient had no family history of MTC and presented short stature instead of marfanoid features. Rare ophthalmological manifestations also occurred. The example of this patient proves that rare endocrinological syndromes should be taken into consideration when diagnosing unclear symptoms, even if not all of the typical manifestations are present. PMID: 33191720 [PubMed - as supplied by publisher] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 16, 2020 Category: Endocrinology Authors: Zendran I, Szlasa W, Bis G, Sondaj K, Barg E Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Metformin and proliferation of cancer cell lines.
CONCLUSIONS: The results of our study showed beneficial effects of metformin on decreasing proliferation of cancer cells. Percentage of vivid popula-tions were lowering and we confirmed anti-cancer effect of this drug. PMID: 33191721 [PubMed - as supplied by publisher] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 16, 2020 Category: Endocrinology Authors: Tądel K, Wiatrak B, Bodetko D, Barg E Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Ten-year use of recombinant parathyroid hormone for the treatment of hypoparathyroidism in a boy with partial Jacobsen syndrome.
In conclusion, our single-case experience indicates that long-term therapy of chronic HPT with rhPTH1-34 is safe and reduces the need for additional therapies. PMID: 33191722 [PubMed - as supplied by publisher] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 16, 2020 Category: Endocrinology Authors: Dayal D, Panigrahi I, Varma T, Gupta S, Gupta A, Kumar R, Sachdeva N Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Congenital chloride diarrhea in patient with SLC26A2 mutation - analysis of the clinical phenotype and differential diagnosis.
CONCLUSIONS: Persistent diarrhea and electrolyte disorder in pediatrics are easy to misdiagnose as CLD. Furthermore, it is difficult to identify Batter syndrome, Gitelman syndrome, renal tubular acidosis and CLD. Blood and stool electrolyte detection and SLC26A3 genetic tests are helpful for diagnosis, and sodium chloride and potassium chloride replacement therapy are critical for the patient prognosis. PMID: 33191723 [PubMed - as supplied by publisher] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 16, 2020 Category: Endocrinology Authors: Sun M, Tao N, Liu X, Yang Y, Su Y, Xu F Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

[In memoriam of Professor Maria Rybakowa].
PMID: 33044053 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - October 14, 2020 Category: Endocrinology Authors: Starzyk J Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Do the intervals in growth hormone therapy positively affect the growth velocity?
CONCLUSIONS: Re-introduction of rhGH treatment after short-term therapy cessation leads to the re-occurrence of catch- up growth in patients with GHD. PMID: 32901467 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 11, 2020 Category: Endocrinology Authors: Kędzia A, Majewska K, Korcz M Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Treatment of classic phenylketonuria in Poland in the years 2009-2015 based on the database of the Polish National Health Fund.
CONCLUSIONS: Adult patients with PKU do not receive sufficient healthcare. The discontinuation of healthcare by adults with PKU can result from the lack of an adequate transition process from paediatric to adult care. PMID: 32901468 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 11, 2020 Category: Endocrinology Authors: Szypowska A, Franek E, J Grzeszczak W, Zięba M, Filipow W, Kabicz P, Więckowska B, Sykut-Cegielska J, Taybert J Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Serum vitamin D level may be associated with body weight and body composition in male adolescents; a longitudinal study.
This study aimed to investigate the association between vitamin D serum level and anthropometric indices of overweight and obese male adolescents at baseline and after 18 weeks of a weight reduction intervention. MATERIAL AND METHODS: This study was carried out on 90 male students aged 12 to 16 years who were randomly selected from two schools in Tehran, Iran. The participants were assigned to two groups with high and low vitamin D level based on their serum vitamin D levels at baseline. Five ml blood samples were collected at the baseline and after the 18 weeks of a weight reduction intervention. Height, weight, body...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 11, 2020 Category: Endocrinology Authors: Doaei S, Jarrahi S, Torki S, Haghshenas R, Jamshidi Z, Rezaei S, Moslem A, Ghorat F, Khodabakhshi A, Gholamalizadeh M Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Pediatric type 1 diabetes research in the 21st century: a scientometric review.
CONCLUSIONS: The USA and Finland are the most productive and the most impactful countries respectively in global pediatric T1D research. The contribution from developing countries especially from Southeast Asia is meager despite a large disease burden. PMID: 32901470 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 11, 2020 Category: Endocrinology Authors: M Gupta B, Dayal D Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Cushing's syndrome due to primary pigmented nodular adrenal disease in two brothers with Carney complex.
Abstract Two brothers (19 and 18 years old, respectively) presented with weight gain and stunted growth since the age of 10 years. They had spotty skin pigmentation over the face along with florid features of Cushing's syndrome with low bone density, renal calculi, dyslipidaemia, hypertension, and dilated cardiomyopathy. They underwent evaluation of the hypothalamic-pituitary-adrenals axis, which suggested ACTH-independent Cushing's syndrome, and the abdominal CT imaging revealed normal adrenals. The diagnosis of Familial Cushing's syndrome with primary pigmented nodular adrenal disease and Carney complex was made...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 11, 2020 Category: Endocrinology Authors: Attri B, Aggarwal A, Mattoo S, Kulshreshtha B Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Growth hormone deficiency as a complication of haemophilia - a case report and literature data.
We report the case of isolated growth hormone deficiency in a boy with severe haemophilia A. He experienced several intracranial haemorrhages in early childhood. At the age of seven years, growth hormone deficiency was diagnosed. The MRI scan of the pituitary gland was normal, but many focal changes in brain tissue were found. The function of pituitary-dependent hormonal axes beyond GH/IGF1 axis was sufficient. Therapy with rhGH was introduced and continued for over nine years. Growth velocity increased and the height normalised appropriately to parental height. We did not observe any complications besides sporadic subcuta...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 29, 2020 Category: Endocrinology Authors: Kucharska A, Łaguna P, Adamowicz-Salach A, Witkowska-Sędek E, Klukowska A Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

[In memoriam of Professor Maria Rybakowa].
PMID: 32564581 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - June 23, 2020 Category: Endocrinology Authors: Starzyk J Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Growth hormone therapy in children with partial growth hormone deficiency. Are we treating the right patients?
Abstract INTRODUCTION: Diagnosis of growth hormone deficiency (GHD) in children with short stature, whose height is below -2SD for the population norm, is based on the assessment of growth hormone (GH) peaks in stimulation tests. However, cut-off values for GH secretion are arbitrary and vary in different centres. Indications for recombinant GH therapy remain disputable in children with GH concentrations between 5 and 10 ng/ml (pGHD). AIM OF THE STUDY: The aim of our study was to assess the effects of rhGH therapy in children with transient pGHD deficiency compared to untreated children with idiopathic short ...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - June 23, 2020 Category: Endocrinology Authors: Krukowska-Andrzejczyk B, Kalina M, Kalina-Faska B, Małecka-Tendera E Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Low serum copper and zinc concentrations in North Indian children with overweight and obesit.
Authors: Abstract INTRODUCTION: There are limited data on the alterations of serum copper and zinc, which have been proposed to have associations among children with obesity. MATERIAL AND METHODS: A total of 173 children were enrolled and grouped into overweight/obese (n = 69) and non-obese (n = 104) according to CDC 2000 growth charts. Serum and whole blood zinc and copper concentrations were measured by validated ICP-MS method, and copper/zinc ratios were calculated and correlated to various anthropometric parameters. RESULTS: Mean BMI in obese (24.78 ±3.93) was significantl...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - June 23, 2020 Category: Endocrinology Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Possible association between haemostasis dysfunction and early onset of microvascular complications in patients with type 1 diabetes.
Authors: Abstract Chronic hyperglycaemia, the effect of which is enhanced with diabetes duration and poor compensation, has a great impact on the complex aetiopathogenesis of microvascular diabetic complications. However, other factors are particularly likely in young patients with early onset of chronic complications. One of the possible risk factors is procoagulant condition, which can lead to small vessel microthromboses, endothelial damage, and ultimately specific organ manifestations. While these changes are well described in a group of adult patients with type 2 diabetes, similar information is le...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - June 23, 2020 Category: Endocrinology Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Can athletes with type 1 diabetes use supplementation?
Abstract From year to year, we observe constantly growing revenue from the sale of supplements and functional food for athletes. The increased interest in their use raises many questions concerning the choice of products, portions, in addition in the case of athletes with type 1 diabetes - how they affect the level of glycaemia. In the group of people under 18 with diagnosed type 1 diabetes, the properly selected supplementation, which will not cause undesirable effects, is even more important. This publication aims to summarize the current reports on nutrients that come from: the present scientific knowledge, inf...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - June 23, 2020 Category: Endocrinology Authors: Lejk A, Myśliwiec M, Myśliwiec A Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Acute hypoxic hepatitis as a  complication of diabetic ketoacidosis in a boy with newly diagnosed diabetes.
CONCLUSIONS: Severe diabetic ketoacidosis with significant dehydration and hypovolaemic shock may lead to hypoxic hepatitis, also in small children. PMID: 32564586 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - June 23, 2020 Category: Endocrinology Authors: Zubkiewicz-Kucharska A, Gorlo A, Noczyńska A Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

HLA-A gene variation modulates residual function of the pancreatic β-cells in children with type 1 diabetes.
HLA-A gene variation modulates residual function of the pancreatic β-cells in children with type 1 diabetes. Pediatr Endocrinol Diabetes Metab. 2020 May 28;: Authors: Hogendorf A, Abel M, Wyka K, Bodalski J, Młynarski W Abstract AIM OF THE STUDY: The study aimed to analyze an association between the HLA-A gene variation and a risk of type 1 diabetes development and to evaluate the association of HLA class I and class II alleles with β-cell destruction. MATERIAL AND METHODS: A group of 108 children with type 1 diabetes were genotyped in HLA-A, -DRB1, and -DQB1 genes using hybridization ...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - May 27, 2020 Category: Endocrinology Authors: Hogendorf A, Abel M, Wyka K, Bodalski J, Młynarski W Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Anti-tumour necrosis factor α therapy - Does it increase the risk of thyroid disease or protect against its development?
CONCLUSIONS: The real impact of anti-TNF-α therapy on the development of AITD remains an open question. The available studies concern the adult population; there are no data regarding this problem in children. Due to the increasing use of anti-TNF-α therapy also in the paediatric population, it seems reasonable to evaluate this subject in this group of patients. PMID: 32462852 [PubMed - as supplied by publisher] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - May 27, 2020 Category: Endocrinology Authors: Furtak A, Wedrychowicz A, Starzyk J Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Diagnostic challenges and considerations of cyclical Cushing's syndrome in a 15-year-old female.
Abstract Cyclical Cushing's syndrome (CS) is a rare disorder in which cortisol secretion is cyclical and intermittent. This phenomenon makes for a challenging diagnosis, as patterns of cycling can vary widely among patients and as patients with cyclical CS do not exhibit unique clinical features compared to those without cycling. Current research suggests that cyclical CS may be present in approximately 15% of adult cases, with an even lower reported prevalence in the pediatric population. In this case study, we describe a 15-year-old female with obesity and hypertension who was then diagnosed with cyclical CS aft...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - May 27, 2020 Category: Endocrinology Authors: An M, Hendricks L, Bachrach B Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

The Nightscout system - description of the system and its evaluation in scientific publications.
This article describes the Nightscout system - required components, operating costs, and other usage options. It also presents the current evaluation of the Nightscout system in scientific publications. PMID: 32462854 [PubMed - as supplied by publisher] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - May 27, 2020 Category: Endocrinology Authors: Kublin O, Stępień M Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Evaluation of the usefulness of antym üllerian hormone and inhibin B as markers of ovarian activity in patients with Turner syndrome - preliminary results.
Evaluation of the usefulness of antymüllerian hormone and inhibin B as markers of ovarian activity in patients with Turner syndrome - preliminary results. Pediatr Endocrinol Diabetes Metab. 2020 May 28;: Authors: Ruszała A, Wójcik M, Starzyk J Abstract INTRODUCTION: Spontaneous puberty occurs in 30% of patients with Turner Syndrome. Its absence is an indication for hormone replacement therapy (HRT). No reliable markers of spontaneous puberty have been defined to date. AIM OF THE STUDY: To evaluate the usefulness of antymüllerian hormone (AMH) and inhibin B assessment in predicti...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - May 27, 2020 Category: Endocrinology Authors: Ruszała A, Wójcik M, Starzyk J Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Evaluation of skin autofluorescence as a surrogate of advanced glycation end products accumulation in children and adolescents with normal haemoglobin A1c values.
Abstract INTRODUCTION: Skin autofluorescence (sAF) represents tissue accumulation of advanced glycation end products (AGEs) and correlates with cardiovas-cular morbidity and diabetes risk. THE AIM: To assess sAF in Polish children without diabetes and to investigate whether sAF values in children with chronic diseases (but without glucose metabolism disorders) differ from sAF in healthy children. MATERIAL AND METHODS: Children without diseases known to influence sAF results (diabetes, renal failure) and with HbA1c
Source: Pediatric Endocrinology, Diabetes, and Metabolism - May 20, 2020 Category: Endocrinology Authors: Jankowska M, Bobeff K, Baranowska-Jaźwiecka A, Mianowska M, Lubnauer A, Michalak A, Młynarski W, Szadkowska A, Mianowska B Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Metabolic bone markers can be related to preserved insulin secretion in children with newly diagnosed type 1 diabetes.
ska A Abstract INTRODUCTION: Type 1 diabetes (T1D) may be associated with numerous complications including bone metabolism disorders. The aim of the study was to evaluate the bone metabolism markers twice in children with a newly diagnosed T1D and after an average of seven months of its duration in relation to parameters of the clinical course of diabetes. MATERIAL AND METHODS: In 100 T1D patients and 52 control subjects, the following bone turnover markers were evaluated: osteocalcin - OC, osteoprotegerin - OPG, sRANKL, and deoxypyridoline in urine - DPD and DXA examination was also performed. RESULTS: ...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - May 20, 2020 Category: Endocrinology Authors: Szymańska M, Michałus I, Kaszkowiak M, Wyka K, Chlebna-Sokół D, Fendler W, Jakubowska-Pietkiewicz E, Młynarski W, Szadkowska A, Zmysłowska A Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Comparison of sirtuin 1 level and related blood factors in diabetic and healthy subjects.
Abstract INTRODUCTION: Diabetes (II) is a chronic metabolic disease with many side effects. Sirtuin 1 (SIRT1) regulates prominent cellular processes such as apoptosis, aging, and metabolism of the cell, and it seems to play an important role in type 2 diabetes. THE AIM OF THE STUDY: was to compare the serum level of SIRT1 and related biochemical factors in patients with controlled and uncontrolled diabetes with healthy subjects. METHODS: Type 2 diabetic patients were randomly divided into controlled and uncontrolled fasting blood glucose (FBG) and healthy individuals as the control group (n = 50/group). ...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - May 20, 2020 Category: Endocrinology Authors: Rahimi M, Ghanbari S, Khazaei M, Niroman E Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

"PoZdro!" as an example of a successful multicenter programme for obesity management and healthy lifestyle promotion in children and adolescents - programme protocol and preliminary results from the first intervention site.
CONCLUSIONS: "PoZdro!" is a unique obesity prevention and management programme in Poland operating simultaneously in several Polish big cities. The programme incorporates parental engagement and long-term behavioral intervention. Preliminary results show that it may result in meaningful decrease in BMI in two following years. Further data analyses are necessary to show the influence of the programme on metabolic risk in studied group. PMID: 32418419 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - May 20, 2020 Category: Endocrinology Authors: Brzeziński M, Korzeniowska K, Szarejko K, Radziwiłł M, Myśliwiec M, Anyszek T, Czupryniak L, Berggren PO, Soszyński P Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Nasal glucagon - a new way to treat severe hypoglycemia in patients with diabetes.
Abstract Hypoglycaemia is the most frequent acute complication of diabetes in patients treated with insulin. Severe hypoglycaemia can lead to life-threatening disorders. In addition, fear of hypoglycaemia remains a major obstacle to achieving therapeutic goals in diabetics, espe-cially with type 1. As such, both the prevention and treatment of hypoglycemia are so important in diabetes care. Treatment of hypoglycemia is still based on administration of glucose (oral or parenteral depending on the level of consciousness) or of glucagon injected intramuscularly or subcutaneously. In 1983, it was shown for the first t...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - May 17, 2020 Category: Endocrinology Authors: Pietrzak I, Szadkowska A Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Simple virilising congenital adrenal hyperplasia in monozygotic twins: A rare report and review of previous cases.
In this report, we describe a pair of monozygotic twins with classic simple virilising form of CAH, who had a simultaneous onset and similar severity of clinical manifestations. Genetic analysis of the CYP21A2 gene in twin 1 showed the pres-ence of two heterozygous pathogenic sequence variants, c.518T>A and c.955C>T in the CYP21A2 gene, consistent with a diagnosis of CAH due to 21-hydroxylase deficiency. We also present a brief review of previous cases of twins with CAH. PMID: 32272826 [PubMed - as supplied by publisher] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - April 9, 2020 Category: Endocrinology Authors: Muthuvel B, Gautam A, Pal R, Panigrahi I, Dayal D Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Dental caries and periodontal status in children with type 1 diabetes mellitus.
Abstract INTRODUCTION: Type 1 diabetes mellitus (T1DM) is a chronic metabolic disease that strongly affects the health of individuals. Some studies have sug-gested that it affects oral health, thus indicating a higher-than-average predisposition of patients with diabetes to caries and periodontal diseases. AIM OF THE STUDY: We aimed at investigating the association between caries, periodontal diseases, and diabetes among children using dental indices. MATERIAL AND METHODS: The study included 50 children (aged 10-18 years) who had type 1 diabetes for at least years. The participants were divided into well...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - April 9, 2020 Category: Endocrinology Authors: Pachoński M, Jarosz-Chobot P, Koczor-Rozmus A, Łanowy P, Mocny-Pachońska K Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Assessment of diet quality, nutrient intake, and dietary behaviours in obese children compared to healthy children.
Abstract INTRODUCTION: Obesity has been recognised by the World Health Organisation as the most common chronic disease in the world. An increase in the prevalence of childhood obesity has been seen in Poland. PURPOSE: The aim of this study was to compare the dietary behaviours, quality of diet, and nutrient intake in a group of obese children compared to children with normal body weight. MATERIAL AND METHODS: A total of 105 children aged between seven and 15 years were surveyed. The test group consisted of 52 obese patients from a Dietary Clinic in the Children's University Hospital in Cracow, without ac...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - April 9, 2020 Category: Endocrinology Authors: Kozioł-Kozakowska A, Kozłowska M, Jagielski P Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Levothyroxine supplementation for obesity-associated thyroid dysfunction in children: a prospective, randomized, case control study.
CONCLUSIONS: Addition of levothyroxine to weight management interventions has no beneficial effect on BMI reduction as well as parameters of lipid and thyroid profiles, and should not be prescribed to children with obesity associated thyroid dysfunction. PMID: 31769268 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 28, 2019 Category: Endocrinology Authors: Kumar S, Dayal D, Attri S, Gupta A, Bhalla A Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Extrathyroidal congenital defects in children with congenital hypothyroidism - observations from a single paediatric centre in Central Europe with a review of literature.
CONCLUSIONS: The analysis of our data and current literature suggests that genetic factors play the most important role in the development of extrathy-roidal abnormalities in newborns with CH. Identifying the mutation causing CH, the potential defects that can accompany newborns with CH, screening could be offered for these patients in order to obtain an earlier diagnosis and implement early and appropriate treat-ment. PMID: 31769269 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 28, 2019 Category: Endocrinology Authors: Wędrychowicz A, Furtak A, Prośniak A, Żuberek M, Szczerkowska M, Pacut P, Lemańska D, Słuszniak A, Starzyk J Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Difficulties in diagnostics of polycystic ovary syndrome in adolescents - a preliminary study.
CONCLUSIONS: In our study 27% of patients suspected of PCOS met all Rotterdam criteria. The co-occurrence of symptoms increases the probability of hyperandrogenaemia. PMID: 31769270 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 28, 2019 Category: Endocrinology Authors: Milczarek M, Kucharska A, Borowiec A Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Cushing disease in children and adolescents - assessment of the clinical course, diagnostic process, and effects of the treatment - experience from a single paediatric centre.
CONCLUSIONS: In each case of the coexistence of growth velocity inhibition (not necessarily short stature) with the weight gain (not necessarily obesity) and the appearance of hyperandrogenism and depressive-anxiety disorders, biochemical diagnostics of CS should be performed. Obesi-ty could be a chronic complication of CD in childhood, even after effective neurosurgery treatment. PMID: 31769271 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 28, 2019 Category: Endocrinology Authors: Wędrychowicz A, Hull B, Tyrawa K, Kalicka-Kasperczyk A, Zieliński G, Starzyk J Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

"Oncofertility" procedures in children and adolescents.
"Oncofertility" procedures in children and adolescents. Pediatr Endocrinol Diabetes Metab. 2019;25(3):144-149 Authors: Tarasiewicz M, Martynowicz I, Knapp P, Sieczyński P Abstract One of the most important elements associated with increase in oncological outcome in children is fertility preservation for future. It is obvious that chemo and radio therapy used in cancer treatment aim to destroy tumor cells, but they also impact healthy tissues. The nega-tive influence of these types of therapy can be observed in every patient's organ. One of the most serious complication of oncological treatm...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 28, 2019 Category: Endocrinology Authors: Tarasiewicz M, Martynowicz I, Knapp P, Sieczyński P Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Food neophobia in children.
Abstract Eating habits are formed from the early childhood through experience gained from the contact with foods and as a result of observation of the environment. One of the feeding disorders, specific for the childhood, is food neophobia, defined as an attitude towards food, which manifests as a persistent reluctance to eat new foods, avoiding tasting unknown products and unwillingness to accept newly in-troduced flavours or unknown consistency of food. It should be differentiated from pickiness, which are a typical stage of children's development. Food neophobia is a significant problem from both psychological ...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 28, 2019 Category: Endocrinology Authors: Łoboś P, Januszewicz A Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Distinguishing between post-trauma pituitary stalk disruption and genetic pituitary stalk interruption syndrome - case presentation and literature overview.
CONCLUSIONS: MRI image together with medical history of the head trauma and its strict temporal relation with transient diabetes insipidus and the occurrence of CPHD signs, as well as the lack of extrapituitary midline defects differentiate posttraumatic pituitary stalk transection syndrome (PSTS) from genetic PSIS. In every case of severe traumatic head injury hormonal evaluation and MRI of hypothalamic-pituitary axis should be performed. PMID: 31769274 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 28, 2019 Category: Endocrinology Authors: Ruszała A, Wójcik M, Krystynowicz A, Starzyk J Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Acquired autoimmune hypothyroidism as a cause of severe growth deficiency in one of the twin sisters.
We report on the case of full clinical picture of severe hypothyroidism in one of the twins. Thyroid function deteriorated in one of the sisters, resulting in mental, motor and growth slowdown, remaining undiagnosed for about 2 years, while the other sister developed normally. In the reported case, severe hypothy-roidism and growth deficiency were accompanied by celiac disease. Initiation of L-thyroxine therapy resulted in an immediate response that increased the growth velocity by more than 2.2 times. This confirms the dominant role of thyroid hormones over celiac disease in the growth process, as the catch up effect star...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 28, 2019 Category: Endocrinology Authors: Kędzia A, Majewska K Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

The impact of thyroid function on the occurrence of metabolic syndrome in obese children and adolescents.
CONCLUSIONS: Isolated increased TSH level is common in obese adolescents, although there is no correlation between TSH, fT3, and fT4 levels and BMI SDS value. Isolated increased TSH level is not associated with the occurrence of MS in obese adolescents. The occurrence of asymptomatic autoimmune thyroiditis (AITD) in obese adolescents is more common than in the general population. PMID: 31343126 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Ruszała A, Wójcik M, Starzyk JB Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Clinical determinants of the remission phase in children with new-onset type 1 diabetes mellitus in two years of observation.
PMID: 31343127 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Rydzewska M, Kulesza M, Olszewska M, Jamiołkowska M, Łuczyński W, Głowińska-Olszewska B, Bossowski A Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Usefulness of the metabolic syndrome diagnosis in obese children in clinical practice.
sik P Abstract INTRODUCTION: In the light of recent studies, the usefulness of the metabolic syndrome diagnosis in obese pediatric patients seems to be controversial. It leads to the pressing questions, if the metabolic syndrome diagnosis is reflecting risk of the cardiovascular complications in obese chil-dren. AIM OF THE STUDY: To evaluate the incidence of metabolic syndrome in obese children, asses the role of insulin resistance in the metabolic complications and investigate if the diagnosis of MS has a clinical value in that group of patients. MATERIAL AND METHODS: After the retrospective analysis of...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Springwald A, Różana-Kowalska P, Gibała P, Zajdel-Cwynar O, Małecka-Tendera E, Matusik P Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Alterations in postural control, gait pattern, and muscle function in diabetes mellitus: does it matter in children and adolescents with type 1 diabetes?
Abstract Diabetes mellitus (DM) is associated with chronic microvascular complications such as neuropathy. The most frequent is diabetic pe-ripheral neuropathy (DPN) which is related to chronic disability and decrease in quality of life. Alterations in postural control, gait per-formance, and muscle function are widely described in the literature. However, the role of other non-neuropathic factors in these altera-tions remains unclear. Although neuropathy is rather rare in children and adolescents with type 1 DM, there is evidence that early chang-es and symptoms might have their onset in the early stages of the d...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Ławnicki J, Hansdorfer-Korzon R, Myśliwiec M Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

The prognostic value of inflammatory and vascular endothelial dysfunction biomarkers in microvascular and macrovascular complications in type 1 diabetes.
Abstract Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterised by a destruction of pancreatic  cells, which leads to absolute insulin deficiency. Persistently high glycaemia causes vascular damage throughout the body. Microvascular complications com-prise the following: nephropathy, retinopathy, and neuropathy. Macrovascular complications include coronary heart disease (CHD), which may result in myocardial infarction, cerebrovascular disease (leading to strokes), and peripheral vascular disease. The pathogene-sis of vascular complications is multifactorial and is probably the combination...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Wołoszyn-Durkiewicz A, Myśliwiec M Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Health educators as assistants for disabled people in universal teaching institutions in Poland.
Abstract Education dedicated to the health needs of pupils disabled because of chronic diseases in Poland remains an empty term, a chair without a backrest. In this article, suggestions of changes in the educational system are presented. These suggestions, thanks to support from interested therapeutic teams, have a chance to fulfil the educational gap in the area of chronic diseases and proceeding with disabled pu-pils at universal teaching institutions in Poland due to the introduction of health educators. A health educator is a person suffering from type 1 diabetes, educated during specialised postgraduate studi...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Kucharska B Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Trichorhinophalangeal syndrome as a diagnostic and therapeutic challenge for paediatric endocrinologists.
This report presents four cases of TRPS (three sporadic and one familial). Clinical presentation included typical facial features and vari-ous skeletal abnormalities. Some TRPS symptoms may mimic growth hormone deficiency and other endocrine disturbances. The aim of this article is to deliver TRPS symptomatology. The treatment of TRPS is symptomatic and supportive and requires the coordination of several specialists, including paediatricians, endocrinologists, orthopaedic surgeons, dermatologists, and medical rehabilitation and den-tal specialists. In some cases, recombinant growth hormone therapy may be necessary. Genetic...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Foryś-Dworniczak E, Zajdel-Cwynar O, Kalina-Faska B, Małecka-Tendera E, Matusik P Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Symptomatic hyponatremia during the diabetic ketoacidosis in 5 years old child with new onset diabetes - own experience.
In this report we present a patient with symptomatic hyponatremia in the new diagnosed patient with type 1 diabetes mellitus. PMID: 31343133 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Kącka A, Banach A, Jabłońska J, Charemska D, Klonowska B, Głowińska-Olszewska B Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

[Dr hab. n. med. Maria Kalina (1975-2019)].
PMID: 31343134 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Małecka-Tendera E Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Seasonality of vitamin D concentrations and the incidence of vitamin D deficiency in children and adolescents from central Poland.
CONCLUSIONS: Our results are consistent with previous reports on inadequate vitamin D supplementation in Polish children and adolescents, pointing out the necessity to implement current recommendations concerning vitamin D supplementation and the need for further studies on the consequences vitamin D deficiency for health of children and adolescents, with special attention to the pleiotropic effects of vitamin D. PMID: 31343135 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Smyczyńska J, Smyczyńska U, Stawerska R, Domagalska-Nalewajek H, Lewiński A, Hilczer M Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

The degree of fathers' involvement in taking care of children with diabetesand its implications in family functioning in the assessment of diabetic children's mothers.
CONCLUSIONS: It is necessary to support families affected by diabetes. Their personal and social skills should be developed so that they can cope with chronic disease and the duties related to managing diabetes. The responsibility should be shared by both parents. PMID: 31343136 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Zamarlik MA Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Ex vivo model for the assessment of the cytotoxicity of biological materialfrom patients with carbohydrate metabolism disturbances.
CONCLUSIONS: Blood serum, as multicompound biological material, influences negatively PC12 cell line but in a variety of ways. Increasing hyperinsulinaemia has a higher cytotoxic effect on the cells than hyperglycaemia, which probably results from the fact that it is compensated by other components of biological material; however, further studies are necessary to obtain more detailed characteristics of these processes. PMID: 31343137 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Piwowar A, Rorbach-Dolata A, Głogowska N, Bednarska-Chabowska D Tags: Pediatr Endocrinol Diabetes Metab Source Type: research