Levothyroxine supplementation for obesity-associated thyroid dysfunction in children: a prospective, randomized, case control study.
CONCLUSIONS: Addition of levothyroxine to weight management interventions has no beneficial effect on BMI reduction as well as parameters of lipid and thyroid profiles, and should not be prescribed to children with obesity associated thyroid dysfunction. PMID: 31769268 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 28, 2019 Category: Endocrinology Authors: Kumar S, Dayal D, Attri S, Gupta A, Bhalla A Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Extrathyroidal congenital defects in children with congenital hypothyroidism - observations from a single paediatric centre in Central Europe with a review of literature.
CONCLUSIONS: The analysis of our data and current literature suggests that genetic factors play the most important role in the development of extrathy-roidal abnormalities in newborns with CH. Identifying the mutation causing CH, the potential defects that can accompany newborns with CH, screening could be offered for these patients in order to obtain an earlier diagnosis and implement early and appropriate treat-ment. PMID: 31769269 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 28, 2019 Category: Endocrinology Authors: Wędrychowicz A, Furtak A, Prośniak A, Żuberek M, Szczerkowska M, Pacut P, Lemańska D, Słuszniak A, Starzyk J Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Difficulties in diagnostics of polycystic ovary syndrome in adolescents - a preliminary study.
CONCLUSIONS: In our study 27% of patients suspected of PCOS met all Rotterdam criteria. The co-occurrence of symptoms increases the probability of hyperandrogenaemia. PMID: 31769270 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 28, 2019 Category: Endocrinology Authors: Milczarek M, Kucharska A, Borowiec A Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Cushing disease in children and adolescents - assessment of the clinical course, diagnostic process, and effects of the treatment - experience from a single paediatric centre.
CONCLUSIONS: In each case of the coexistence of growth velocity inhibition (not necessarily short stature) with the weight gain (not necessarily obesity) and the appearance of hyperandrogenism and depressive-anxiety disorders, biochemical diagnostics of CS should be performed. Obesi-ty could be a chronic complication of CD in childhood, even after effective neurosurgery treatment. PMID: 31769271 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 28, 2019 Category: Endocrinology Authors: Wędrychowicz A, Hull B, Tyrawa K, Kalicka-Kasperczyk A, Zieliński G, Starzyk J Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

"Oncofertility" procedures in children and adolescents.
"Oncofertility" procedures in children and adolescents. Pediatr Endocrinol Diabetes Metab. 2019;25(3):144-149 Authors: Tarasiewicz M, Martynowicz I, Knapp P, Sieczyński P Abstract One of the most important elements associated with increase in oncological outcome in children is fertility preservation for future. It is obvious that chemo and radio therapy used in cancer treatment aim to destroy tumor cells, but they also impact healthy tissues. The nega-tive influence of these types of therapy can be observed in every patient's organ. One of the most serious complication of oncological treatm...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 28, 2019 Category: Endocrinology Authors: Tarasiewicz M, Martynowicz I, Knapp P, Sieczyński P Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Food neophobia in children.
Abstract Eating habits are formed from the early childhood through experience gained from the contact with foods and as a result of observation of the environment. One of the feeding disorders, specific for the childhood, is food neophobia, defined as an attitude towards food, which manifests as a persistent reluctance to eat new foods, avoiding tasting unknown products and unwillingness to accept newly in-troduced flavours or unknown consistency of food. It should be differentiated from pickiness, which are a typical stage of children's development. Food neophobia is a significant problem from both psychological ...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 28, 2019 Category: Endocrinology Authors: Łoboś P, Januszewicz A Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Distinguishing between post-trauma pituitary stalk disruption and genetic pituitary stalk interruption syndrome - case presentation and literature overview.
CONCLUSIONS: MRI image together with medical history of the head trauma and its strict temporal relation with transient diabetes insipidus and the occurrence of CPHD signs, as well as the lack of extrapituitary midline defects differentiate posttraumatic pituitary stalk transection syndrome (PSTS) from genetic PSIS. In every case of severe traumatic head injury hormonal evaluation and MRI of hypothalamic-pituitary axis should be performed. PMID: 31769274 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 28, 2019 Category: Endocrinology Authors: Ruszała A, Wójcik M, Krystynowicz A, Starzyk J Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Acquired autoimmune hypothyroidism as a cause of severe growth deficiency in one of the twin sisters.
We report on the case of full clinical picture of severe hypothyroidism in one of the twins. Thyroid function deteriorated in one of the sisters, resulting in mental, motor and growth slowdown, remaining undiagnosed for about 2 years, while the other sister developed normally. In the reported case, severe hypothy-roidism and growth deficiency were accompanied by celiac disease. Initiation of L-thyroxine therapy resulted in an immediate response that increased the growth velocity by more than 2.2 times. This confirms the dominant role of thyroid hormones over celiac disease in the growth process, as the catch up effect star...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - November 28, 2019 Category: Endocrinology Authors: Kędzia A, Majewska K Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

The impact of thyroid function on the occurrence of metabolic syndrome in obese children and adolescents.
CONCLUSIONS: Isolated increased TSH level is common in obese adolescents, although there is no correlation between TSH, fT3, and fT4 levels and BMI SDS value. Isolated increased TSH level is not associated with the occurrence of MS in obese adolescents. The occurrence of asymptomatic autoimmune thyroiditis (AITD) in obese adolescents is more common than in the general population. PMID: 31343126 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Ruszała A, Wójcik M, Starzyk JB Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Clinical determinants of the remission phase in children with new-onset type 1 diabetes mellitus in two years of observation.
PMID: 31343127 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Rydzewska M, Kulesza M, Olszewska M, Jamiołkowska M, Łuczyński W, Głowińska-Olszewska B, Bossowski A Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Usefulness of the metabolic syndrome diagnosis in obese children in clinical practice.
sik P Abstract INTRODUCTION: In the light of recent studies, the usefulness of the metabolic syndrome diagnosis in obese pediatric patients seems to be controversial. It leads to the pressing questions, if the metabolic syndrome diagnosis is reflecting risk of the cardiovascular complications in obese chil-dren. AIM OF THE STUDY: To evaluate the incidence of metabolic syndrome in obese children, asses the role of insulin resistance in the metabolic complications and investigate if the diagnosis of MS has a clinical value in that group of patients. MATERIAL AND METHODS: After the retrospective analysis of...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Springwald A, Różana-Kowalska P, Gibała P, Zajdel-Cwynar O, Małecka-Tendera E, Matusik P Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Alterations in postural control, gait pattern, and muscle function in diabetes mellitus: does it matter in children and adolescents with type 1 diabetes?
Abstract Diabetes mellitus (DM) is associated with chronic microvascular complications such as neuropathy. The most frequent is diabetic pe-ripheral neuropathy (DPN) which is related to chronic disability and decrease in quality of life. Alterations in postural control, gait per-formance, and muscle function are widely described in the literature. However, the role of other non-neuropathic factors in these altera-tions remains unclear. Although neuropathy is rather rare in children and adolescents with type 1 DM, there is evidence that early chang-es and symptoms might have their onset in the early stages of the d...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Ławnicki J, Hansdorfer-Korzon R, Myśliwiec M Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

The prognostic value of inflammatory and vascular endothelial dysfunction biomarkers in microvascular and macrovascular complications in type 1 diabetes.
Abstract Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterised by a destruction of pancreatic  cells, which leads to absolute insulin deficiency. Persistently high glycaemia causes vascular damage throughout the body. Microvascular complications com-prise the following: nephropathy, retinopathy, and neuropathy. Macrovascular complications include coronary heart disease (CHD), which may result in myocardial infarction, cerebrovascular disease (leading to strokes), and peripheral vascular disease. The pathogene-sis of vascular complications is multifactorial and is probably the combination...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Wołoszyn-Durkiewicz A, Myśliwiec M Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Health educators as assistants for disabled people in universal teaching institutions in Poland.
Abstract Education dedicated to the health needs of pupils disabled because of chronic diseases in Poland remains an empty term, a chair without a backrest. In this article, suggestions of changes in the educational system are presented. These suggestions, thanks to support from interested therapeutic teams, have a chance to fulfil the educational gap in the area of chronic diseases and proceeding with disabled pu-pils at universal teaching institutions in Poland due to the introduction of health educators. A health educator is a person suffering from type 1 diabetes, educated during specialised postgraduate studi...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Kucharska B Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Trichorhinophalangeal syndrome as a diagnostic and therapeutic challenge for paediatric endocrinologists.
This report presents four cases of TRPS (three sporadic and one familial). Clinical presentation included typical facial features and vari-ous skeletal abnormalities. Some TRPS symptoms may mimic growth hormone deficiency and other endocrine disturbances. The aim of this article is to deliver TRPS symptomatology. The treatment of TRPS is symptomatic and supportive and requires the coordination of several specialists, including paediatricians, endocrinologists, orthopaedic surgeons, dermatologists, and medical rehabilitation and den-tal specialists. In some cases, recombinant growth hormone therapy may be necessary. Genetic...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Foryś-Dworniczak E, Zajdel-Cwynar O, Kalina-Faska B, Małecka-Tendera E, Matusik P Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Symptomatic hyponatremia during the diabetic ketoacidosis in 5 years old child with new onset diabetes - own experience.
In this report we present a patient with symptomatic hyponatremia in the new diagnosed patient with type 1 diabetes mellitus. PMID: 31343133 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Kącka A, Banach A, Jabłońska J, Charemska D, Klonowska B, Głowińska-Olszewska B Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

[Dr hab. n. med. Maria Kalina (1975-2019)].
PMID: 31343134 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Małecka-Tendera E Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Seasonality of vitamin D concentrations and the incidence of vitamin D deficiency in children and adolescents from central Poland.
CONCLUSIONS: Our results are consistent with previous reports on inadequate vitamin D supplementation in Polish children and adolescents, pointing out the necessity to implement current recommendations concerning vitamin D supplementation and the need for further studies on the consequences vitamin D deficiency for health of children and adolescents, with special attention to the pleiotropic effects of vitamin D. PMID: 31343135 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Smyczyńska J, Smyczyńska U, Stawerska R, Domagalska-Nalewajek H, Lewiński A, Hilczer M Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

The degree of fathers' involvement in taking care of children with diabetesand its implications in family functioning in the assessment of diabetic children's mothers.
CONCLUSIONS: It is necessary to support families affected by diabetes. Their personal and social skills should be developed so that they can cope with chronic disease and the duties related to managing diabetes. The responsibility should be shared by both parents. PMID: 31343136 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Zamarlik MA Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Ex vivo model for the assessment of the cytotoxicity of biological materialfrom patients with carbohydrate metabolism disturbances.
CONCLUSIONS: Blood serum, as multicompound biological material, influences negatively PC12 cell line but in a variety of ways. Increasing hyperinsulinaemia has a higher cytotoxic effect on the cells than hyperglycaemia, which probably results from the fact that it is compensated by other components of biological material; however, further studies are necessary to obtain more detailed characteristics of these processes. PMID: 31343137 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Piwowar A, Rorbach-Dolata A, Głogowska N, Bednarska-Chabowska D Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Nutrition of children and adolescents with type 1 diabetes in the recommendations of the Mediterranean diet.
CONCLUSIONS: Żywienie dzieci i młodzieży istotnie wpływa na rozwój fizyczny i psychiczny dziecka - zarówno chorego na cukrzycę typu 1, jak i zdrowego. Zasady odżywiania dzieci i młodzieży z cukrzycą typu 1 nie różnią się od zasad żywienia ich zdrowych rówieśników. Dlatego też zapotrzebowanie na poszczególne składniki pokarmowe u dzieci chorych na cukrzycę typu 1 oraz dla zdrowych jest takie samo. Sposób odżywiania dzieci i młodzieży powinien spełniać zalecenia Instytutu Żywności i Żywienia oraz Polskiego Towarzystwa Diabetologicznego. PMID: 3134...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Mańkiewicz-Żurawska I, Jarosz-Chobot P Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Effect of eating resistant starch on the development of overweight, obesity,and disorders of carbohydrate metabolism in children.
Abstract Overweight and obesity in children is becoming an increasingly common problem due to the increased access to processed food, overly high energy density diet, and limitation of physical activity in children. Such trends in today's society lead to health consequences that can be observed in the early stages of carbohydrate metabolism disorders. Reduction of body weight and changes in eating habits can prevent the onset of type 2 diabetes. Recently, the benefits of consuming products containing resistant starch, which has the main advantage of influencing the metabolic pathway of glucose, have been increasin...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Lejk A, Myśliwiec M, Myśliwiec A Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Hyperosmolar hyperglycaemic state (HHS) as the first manifestationof type 2 diabetes in a child.
We describe the case of a 13-year-old patient with severe obesity (at presentation body mass> 120 kg, BMI> 40 kg/m2), who developed HHS (glycaemia 647 mg/dl, pH 7.18, pCO2 96.5 mmHg, BE - 5.0 mmol/l, HCO3 35.2 mmol/l; Na 167 mmol/l, plasma osmolarity 370 mOsm/kg) in the course of pneumonia and newly diagnosed type 2 diabetes (HbA1c 15.5%, C-peptide 2.63 ng/ml). In the follow-up, due to the hypoglycaemia, insulin was discontinued, metformin was administered at a dose of 2 g/day, with a further reduction to 500 mg/day, together with physical rehabilitation and a low-calorie diet. Weight reducti...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Zubkiewicz-Kucharska A, Chrzanowska J, Noczyńska A Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

An intriguing case of precocious puberty due to an ovarian mass in an infant.
We present a rare occurrence of precocious puberty (PP) probably due to an autonomous ovarian cyst in a 15-month-old girl who presented to us with growth spurt, breast and pubic hair development, and vaginal bleeding over the last few months. The clinical presentation was suggestive of central precocious puberty (CPP). However, the rapid progression of pubertal changes and occurrence of menarche at breast Tanner stage 2 indicated peripheral precocious puberty (PPP). Due to uncertainty of clinical diagnosis, investigations were conducted for CPP as well as PPP. The basal and peak stimulated LH concentrations were
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Dayal D, Seetharaman K, Menon P, Aggarwal A, Das G, Srinivasan R Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

X-linked adrenoleukodystrophy diagnosed in three brothers.
Abstract Adrenoleukodystrophy is a genetic diseases classified in the group of peroxisomal disorders caused by mutations in ABCD1, gene located on the X chromosome (Xq28). It demonstrates X-linked recessive inheritance. There is an accumulation of very long-chain fatty acids (VLCFA) in plasma and all tissues in the process of ALD. No causal treatment for ALD is known, although hematopoietic stem cell transplantation (HSCT) and gene therapy are allowed for early diagnosis in childhood cerebral form. The case report describes three of the brothers suffering from ALD, diagnosed in different stages of disease. Th...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Herman M, Jura M, Krakowska K, Barg E Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

[What was discussed during the 44th ISPAD - International Society for Pediatric and Adolescent Diabetes?]
PMID: 31343143 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Jarosz-Chobot P, Buczkowska E Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Real-world experience of using basal insulin analogues in children with type 1 diabetes: is twice-daily dosing of insulin detemir justified?
PMID: 31343144 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - July 27, 2019 Category: Endocrinology Authors: Dayal D, Rohilla L Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Initial Fluid Therapy in Pediatric Diabetic Ketoacidosis: A comparison of Hypertonic Saline Solution and Normal Saline Solution.
CONCLUSIONS: Both 0.9% saline and 3% saline were equally effective as initial fluid in children with DKA with respect to hemodynamic improvement, the resolution of acidosis and the correction of hyperglycemia, but the use of 3% saline solution did not preclude the development of cerebral edema and has the potential to cause hypernatremia, hyperchloremia and hyperchloremic metabolic acidosis. PMID: 30300426 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - October 11, 2018 Category: Endocrinology Authors: Shafi O, Kumar V Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Assessment pf physical fitness of 8 and 9-year-old children from Szczecin,Poland, involved in the obesity prevention program - pilot study.
CONCLUSION: The fact of unsatisfactory physical fitness and excess body weight in children from Szczecin is unsettling. There is ceratainly a need for preventive measures in the broad sense. PMID: 30300427 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - October 11, 2018 Category: Endocrinology Authors: Ratajczak J, Raducha D, Horodnicka-Józwa A, Kilian A, Demiaszkiewicz M, Bartoszewicz K, Jackowski T, Szmit-Domagalska J, Biczysko-Mokosa A, Marcinkiewicz K, Adamczyk T, Gapińska I, Walczak M, Petriczko E Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

[Nutritional habits of 11-12-year-old swimmers against non-athlete peers - a pilot study].
CONCLUSIONS: Results of this study revealed insufficient number of consumed meal portions in both groups. There is a need of permanent nutritional education, provided by parents, teachers at school and sports coaches. PMID: 30300428 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - October 11, 2018 Category: Endocrinology Authors: Bielec G, Goździejewska A Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

[Body fat measurements using bioelectrical impedance in pediatric patientstreated with hematopoietic cell transplantation].
CONCLUSION: Significant differences in BF and BF% in the patients after HCT compared with healthy controls suggest that BIA may be useful in screening for body fat abnormalities in patients after HCT. PMID: 30300429 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - October 11, 2018 Category: Endocrinology Authors: Strojny W, Drożdż D, Klus-Kwiecińska K, Pietrys D, Balwierz W, Skoczeń S Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Endocrine disruptor compounds in environment: As a danger for children health.
Abstract Endocrine disrupting compounds (EDCs) are heterogenous in structure and include synthetic organic compounds such as pharmaceutical agents, plant protection products, plastics, plasticizers, polychlorinated biphenyls, dioxins, flame-retardants, and antifoulant paint additive, as well, as natural plant-derived EDCs termed phytoestrogens and mycoestrogens. Children and adults are exposed daily to EDCs during drinking contaminated water, eating, breathing polluted air or direct contact with chemicals. Prenatal and perinatal period, infancy, childhood, and puberty are critical time of development during which ...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - October 11, 2018 Category: Endocrinology Authors: Beszterda M, Frański R Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

[The impact of VDR gene polymorphisms on obesity, metabolic changes, bone mass disorders and neoplastic processes].
Abstract Vitamin D activity is controlled by its receptor (VDR) located in many cells of the body. The presence of VDR in numerous cellular pathways suggests its important role in the etiology and development of many diseases. Increased risk of obesity, metabolic disturbances, bone mass disturbances and neoplasia among certain VDR alleles has been proven. The importance of VDR in the etiopathology of obesity is associated with the occurrence of polymorphisms: Fok1, Bsm1, Apa1, Taq1. VDR expression in adipocytes plays a role in the regulation of energy metabolism and the induction of obesity. Vitamin D and VDR poly...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - October 11, 2018 Category: Endocrinology Authors: Wysoczańska-Klaczyńska A, Ślęzak A, Hetman M, Barg E Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Oral prednisolone for management of persistent hypercalcemia afterhypercalcemic crisis in the Williams-Beuren syndrome.
In this report, we describe our experience of conducting oral corticosteroid therapy in a child with the Williams-Beuren syndrome who continued to have hypercalcemia after the resolution of the hypercalcemic crisis. PMID: 30300432 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - October 11, 2018 Category: Endocrinology Authors: Varma TH, Sahitya DSK, Dusad S, Agarwal A, Dayal D Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Assessment of diabetes control in insulin pump therapy in late adolescentsand young adults with type 1 diabetes.
ska L Abstract OBJECTIVES: The aim of the study was to evaluate metabolic control in insulin pump therapy (IPT) in late adolescents and young adults with type 1 diabetes mellitus. MATERIAL AND METHODS: The study was conducted in 86 subjects with type 1 diabetes, and included 45 patients aged 16-19 years (mean 17.6±1.2) treated in a pediatric outpatient clinic and 41 subjects aged 19-26 years (mean 22.8±2.2) treated in an adult outpatient clinic of the same university hospital, who received the same refund of IPT. RESULTS: Late adolescents had a lower BMI (22.7±2.9 kg/m2 vs. 24.2±3.2 kg/m2; P
Source: Pediatric Endocrinology, Diabetes, and Metabolism - August 12, 2018 Category: Endocrinology Authors: Bielińska A, Niemiec A, Bryśkiewicz M, Wójcik K, Majkowska L Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

The usefulness of the FlashStyle Libre system in glycemic control in children with type 1 diabetes during summer camp.
CONCLUSION: Libre user's satisfaction survey revealed that most of the respondents rated the cooperation with Flash FreeStyle Libre positively. The relatively good results of Libre in comparison with glucose meters have confirmed the usefulness of this method of monitoring glucose in summer camps for children with diabetes. PMID: 30083658 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - August 12, 2018 Category: Endocrinology Authors: Deja G, Kłeczek M, Chumięcki M, Strzała-Kłeczek A, Deja R, Jarosz-Chobot P Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Trends of underweight and obesity prevalence among adolescent girls in the selected population of the Silesian Agglomeration.
CONCLUSIONS: 1. Most girls in the examined population at 14 and 18 years of age demonstrate a normal nutrition state. Obesity was observed in 15% of the examined females at the age of 14 and in 17% at the age of 18, whereas 5% of girls aged 14 and 6% of girls aged 18 are underweight. 2. From early to late adolescence a tendency to persistent abnormalities of the nutritional status is observed in girls. 3. Obesity in girls aged 14 is a predictor for obesity at the age of 18 and perhaps in the adult life. PMID: 30083659 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - August 12, 2018 Category: Endocrinology Authors: Pałasz W, Ziora-Jakutowicz K, Oświęcimska J, Gorczyca P, Ziora K Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Polycystic ovary syndrome (PCOS) and the accompanying disorders of glucose homeostasis among girls at the time of puberty.
Abstract Polycystic ovary syndrome (PCOS) usually arises during puberty and is marked by insulin resistance, hyperinsulinemia, and hyperandrogenism. The principle is that the diagnosis of PCOS must be based on the presence of at least two of the following three criteria: chronic anovulation, hyperandrogenism (clinical or biological), and polycystic ovaries. The diagnosis of PCOS in adolescents is particularly difficult due to developmental problems in this group. Many symptoms of PCOS, including acne, menstrual irregularities, and hyperinsulinemia, are common in normal puberty. Adolescents with PCOS are at an incr...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - August 12, 2018 Category: Endocrinology Authors: Otto-Buczkowska E, Grzyb K, Jainta N Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

[Chemerin as an early marker of metabolic syndrome].
Abstract Chemerin (CHEM) is a protein synthesized primarily by adiposse tissue and liver. CHEM acts both paracrine and autocrine, stimulating adipocytes maturation and differentiation. In addition to its hormonal function, CHEM acts as a chemoattractant for immune cells, regulating the innate and acquired inflammatory response. Its pleiotropic properties also affect the carbohydrates and lipids metabolism. High concentrations of CHEM are observed in people with obesity, type 2 diabetes, hypertension, and hyperlipidemia - components of the metabolic syndrome. Therefore CHEM also may be considered as an early predic...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - August 12, 2018 Category: Endocrinology Authors: Roguska J, Zubkiewicz-Kucharska A Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Estimates of insulin sensitivity and β-cell function in children and adolescents with and without components of the metabolic syndrome.
Estimates of insulin sensitivity and β-cell function in children and adolescents with and without components of the metabolic syndrome. Pediatr Endocrinol Diabetes Metab. 2017;23(3):122-129 Authors: Frithioff-Bøjsøe C, Trier C, Esmann Fonvig C, Nissen A, Kloppenborg JT, Mollerup PM, Bjerrum PJ, Pedersen O, Hansen T, Holm JC Abstract INTRODUCTION: The accumulation of components of the metabolic syndrome (MetS) is associated with a disturbed glucose metabolism in obese children. AIM OF STUDY: The aim of the present study was to evaluate the association between MetS and estimates ...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - December 20, 2017 Category: Endocrinology Authors: Frithioff-Bøjsøe C, Trier C, Esmann Fonvig C, Nissen A, Kloppenborg JT, Mollerup PM, Bjerrum PJ, Pedersen O, Hansen T, Holm JC Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Assessment of preservation of beta-cell function in children with long-standing type 1 diabetes with "ultrasensitive c-peptide" method.
CONCLUSIONS: Our observation shows that 34% of young patients with long-standing type 1 diabetes have prolonged c-peptide secretion. We confirm the long-standing assumption that residual beta-cell function is beneficial for metabolic control of the patients. Classic method of the c-peptide measurement can be just as useful in clinical practice as the ultrasensitive one. PMID: 29253033 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - December 20, 2017 Category: Endocrinology Authors: Kalinowska A, Orlińska B, Panasiuk M, Jamiołkowska M, Zasim A, Florys B, Wojtkielewicz K, Łuczyński W, Głowińska-Olszewska B, Bossowski A Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Coexisting psoriasis affects the clinical course of type 1 diabetes in children.
CONCLUSIONS: Patients with T1D and psoriasis present higher endogenous insulin secretion at T1D onset and a tendency for better glycemic control during the first 6 months. PMID: 29253034 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - December 20, 2017 Category: Endocrinology Authors: Michalak A, Koptas M, Świercz A, Wyka K, Hogendorf A, Szadkowska A, Młynarski W, Fendler W Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

History of endocrinology in the world and in Poland.
Abstract Endocrinology is a branch of medicine dealing with the functioning of endocrine glands. Theain role of the endocrine glands is to control various functions and to adopt internal environment to changes in the external environment. Glands manage to do this by regulating the metabolism of target cells by hormones. One of the earliest connections with endocrinology is found in theHippocratic humoral hypothesis dating about 400 years BC. The author of the first endocrinological observations was Aristotle, who noticed changes in behavior and appearance in castrated roosters. In the Middle Ages winners of battle...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - December 20, 2017 Category: Endocrinology Authors: Dittfeld A, Gwizdek K, Brończyk-Puzoń A Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

[Prevention of overweight and obesity in children and adolescents in European countries].
Abstract In the 21st century the occurrence of overweight and obesity in children and adolescents reaches the size of a global epidemic. It is recommended to promote a healthy lifestyle and, above all, to educate children, adolescents and adults about the dangerous consequences of being overweight or obese. It is crucial for prevention programs to comprise educational activities so that the participants are encouraged to change their lifestyle for better. However, it must be borne in mind that the overall effectiveness of such activities is determined by the commitment of both the obese child and the environment -...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - December 20, 2017 Category: Endocrinology Authors: Drewa A, Zorena K Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

[Myasthenia gravis, Graves-Basedow disease and other autoimmune diseases in patient with diabetes type 1 - APS-3 case report, therapeutic complications].
We report the case of the patient, who presents coincidence of T1D with other rare autoimmune diseases such as: Graves - Basedow disease, myasthenia gravis, vitiligo and IgA deficiency. All mentioned diseases significantly complicated both endocrine and diabetic treatment of our patient and they negatively contributed her quality of life. The clinical picture of the case allows to recognize one of the autoimmune polyendocrine syndromes: APS-3 and is associated with still high risk of developing another autoimmune disease. PMID: 29253037 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - December 20, 2017 Category: Endocrinology Authors: Klenczar K, Deja G, Kalina-Faska B, Jarosz-Chobot P Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

[Difficulties of the therapy in a boy with coexisting type 1 diabetes mellitus and idiopathic thrombocytopenic purpura].
Abstract Idiopathic thrombocytopenic purpura (ITP) is an acquired autoimmune disease, caused by antibodies against platelet glycoproteins, which provoke platelet destruction and inhibit platelet production in bone marrow. Type 1 Diabetes Mellitus (T1DM) is an acquired autoimmune disease in witch beta cells are destroyed by autoantibodies. Patient with T1DM since the age of 6, was treated by intensive functional insulin therapy by insulin pump. At the age of 14,5 he was also diagnosed with ITP. Due to the short effect of immunoglobulin therapy, glucocorticoids were introduced. After 3 months of glucocorticotherapy ...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - December 20, 2017 Category: Endocrinology Authors: Zarębska J, Musioł K, Brożek P, Zybała A, Szerląg P, Sobol-Milejska G, Jarosz-Chobot P Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Complementary and alternative medicine in Brazilian children and adolescents with type 1 diabetes mellitus.
CONCLUSIONS: The construction of the profile revealed a group of patients that deserve a special attention by health professionals because they are more prone to adopt behaviors that impair the success of the treatment, such as not counting carbohydrates and not informing the doctor about the use of CAM. PMID: 29073288 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - October 28, 2017 Category: Endocrinology Authors: Machado LCB, Alves C Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

PM10 concentration and microbiological assessment of air in relation to the number of acute cases of type 1 diabetes mellitus in the Lubelskie Voivodeship. Preliminary report.
Abstract INTRODUCTION: The aim of our study was to evaluate the relation between the concentration of particulate matter of less than 10 μm in diameter (PM10) in air and the effect of psychrophilic bacteria, mesophilic bacteria and mould fungi on the number of new cases of type 1 diabetes mellitus in children and adolescents in the Lubelskie Voivodeship in the years 2015-2016. PATIENTS AND METHODS: Epidemiological data on the number of new cases of T1DM was obtained from the Department of Paediatric Endocrinology and Diabetology of the Medical University in Lublin. The number of births for the year 2015 an...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - October 28, 2017 Category: Endocrinology Authors: Michalska M, Bartoszewicz M, Wąż P, Kozaczuk S, Beń-Skowronek I, Zorena K Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Nutritional status at the moment of diagnosis in childhood cancer patients.
Abstract INTRODUCTION: Children with a neoplastic disease are highly susceptible to malnutrition. The main objective of the study was to assess the frequency of undernourishment and obesity at the time of the diagnosis of the neoplastic disease at children. MATERIALS AND METHODS: The study included 734 patients (58% males) at the age 1-20,25, with the diagnosis of neoplasm in the years 1986-2014. The patients were divided into groups depending on the type of the diagnosis: 1) ALL, 2) ANLL, 3) HL, 4) NHL, 5) NBL, 6) Wilms tumor, 7) mesenchymal malignant tumor. The BMI SDS and the height SDS were evaluated. The...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - October 28, 2017 Category: Endocrinology Authors: Połubok J, Malczewska A, Rąpała M, Szymocha J, Kozicka M, Dubieńska K, Duczek M, Kazanowska B, Barg E Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

[Direction of change in the somatic development in children and adolescents with type 1 diabetes].
CONCLUSIONS: Changes in body build in patients with diabetes type 1 are associated with chronological age, duration of disease and metabolic control. It has been observed that the increase of weight and waist circumference concern girls. Patients with overweight and obesity represent a risk of early development of complications and require special care. PMID: 29073291 [PubMed - in process] (Source: Pediatric Endocrinology, Diabetes, and Metabolism)
Source: Pediatric Endocrinology, Diabetes, and Metabolism - October 28, 2017 Category: Endocrinology Authors: Kołodziejczyk H, Wajda-Cuszlag M, Świercz A, Szalecki M Tags: Pediatr Endocrinol Diabetes Metab Source Type: research