Correction for: ASXL1 promotes adrenocortical carcinoma and is associated with chemoresistance to EDP regimen
Aging (Albany NY). 2023 Oct 30;undefined. doi: 10.18632/aging.205255. Online ahead of print.NO ABSTRACTPMID:37906268 | DOI:10.18632/aging.205255 (Source: Aging)
Source: Aging - October 31, 2023 Category: Biomedical Science Authors: Liang Wang Yinfeng Lyu Yuqing Li Kunping Li Hui Wen Chenchen Feng Ning Li Source Type: research
Correction for: ASXL1 promotes adrenocortical carcinoma and is associated with chemoresistance to EDP regimen
Aging (Albany NY). 2023 Oct 30;undefined. doi: 10.18632/aging.205255. Online ahead of print.NO ABSTRACTPMID:37906268 | DOI:10.18632/aging.205255 (Source: Aging)
Source: Aging - October 31, 2023 Category: Biomedical Science Authors: Liang Wang Yinfeng Lyu Yuqing Li Kunping Li Hui Wen Chenchen Feng Ning Li Source Type: research
Giant adrenocortical carcinoma with androgen-producing causing male characteristics
Asian J Surg. 2023 Oct 28:S1015-9584(23)01617-2. doi: 10.1016/j.asjsur.2023.10.005. Online ahead of print.NO ABSTRACTPMID:37903692 | DOI:10.1016/j.asjsur.2023.10.005 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - October 30, 2023 Category: Surgery Authors: Changyi Jiang Li Yin Qingsong Pu Changxing Ke Source Type: research
Giant adrenocortical carcinoma with androgen-producing causing male characteristics
Asian J Surg. 2023 Oct 28:S1015-9584(23)01617-2. doi: 10.1016/j.asjsur.2023.10.005. Online ahead of print.NO ABSTRACTPMID:37903692 | DOI:10.1016/j.asjsur.2023.10.005 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - October 30, 2023 Category: Surgery Authors: Changyi Jiang Li Yin Qingsong Pu Changxing Ke Source Type: research
Pediatric adrenocortical carcinoma: clinical features and application of neoadjuvant chemotherapy
ConclusionIn the diagnosis and treatment of pediatric ACC, a comprehensive endocrine evaluation is necessary to facilitate early diagnosis. Surgery and chemotherapy are important components of ACC treatment, and neoadjuvant chemotherapy should be considered for children with ACC who meet certain criteria, such as a large tumor, distant metastases, or poor general condition. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - October 9, 2023 Category: Research Source Type: research
Inferior vena cava tumor thrombus: clinical outcomes at a canadian tertiary center
CONCLUSION: Different types of malignancy can affect the IVC and surgical intervention is usually indicated for these patients. Herein, we have reported the outcomes of IVC thrombectomy at our center.PMID:37774418 | DOI:10.1177/02676591231202682 (Source: Perfusion)
Source: Perfusion - September 29, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Ali Fatehi Hassanabad Chad G Ball William T Kidd Source Type: research
Inferior vena cava tumor thrombus: clinical outcomes at a canadian tertiary center
CONCLUSION: Different types of malignancy can affect the IVC and surgical intervention is usually indicated for these patients. Herein, we have reported the outcomes of IVC thrombectomy at our center.PMID:37774418 | DOI:10.1177/02676591231202682 (Source: Perfusion)
Source: Perfusion - September 29, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Ali Fatehi Hassanabad Chad G Ball William T Kidd Source Type: research
Single and mixture toxicity evaluation of avobenzone and homosalate to male zebrafish and H295R cells
In this study, the effect of the toxicity of a binary mixture comprising avobenzone (0.72 μg L-1) and homosalate (1.02 and 103 μg L-1) on steroid hormone biosynthesis were investigated using male zebrafish and human adrenocortical carcinoma (H295R) cells. In fish exposed to homosalate, a significant decrease in the gonadosomatic index, testosterone level, and transcription of several genes (e.g, hsd3b2, cyp17a1, and hsd17b1) and a significant increase in the hepatosomatic index, liver steatosis, 17β-estradiol level, and transcription of vtg gene were observed. These results suggest that estrogenic and anti-androgenic ef...
Source: Chemosphere - September 27, 2023 Category: Chemistry Authors: Sujin Lee Yujin Ka Bomi Lee Inhye Lee Ye Eun Seo Hyewon Shin Younglim Kho Kyunghee Ji Source Type: research
Single and mixture toxicity evaluation of avobenzone and homosalate to male zebrafish and H295R cells
In this study, the effect of the toxicity of a binary mixture comprising avobenzone (0.72 μg L-1) and homosalate (1.02 and 103 μg L-1) on steroid hormone biosynthesis were investigated using male zebrafish and human adrenocortical carcinoma (H295R) cells. In fish exposed to homosalate, a significant decrease in the gonadosomatic index, testosterone level, and transcription of several genes (e.g, hsd3b2, cyp17a1, and hsd17b1) and a significant increase in the hepatosomatic index, liver steatosis, 17β-estradiol level, and transcription of vtg gene were observed. These results suggest that estrogenic and anti-androgenic ef...
Source: Chemosphere - September 27, 2023 Category: Chemistry Authors: Sujin Lee Yujin Ka Bomi Lee Inhye Lee Ye Eun Seo Hyewon Shin Younglim Kho Kyunghee Ji Source Type: research
Single and mixture toxicity evaluation of avobenzone and homosalate to male zebrafish and H295R cells
In this study, the effect of the toxicity of a binary mixture comprising avobenzone (0.72 μg L-1) and homosalate (1.02 and 103 μg L-1) on steroid hormone biosynthesis were investigated using male zebrafish and human adrenocortical carcinoma (H295R) cells. In fish exposed to homosalate, a significant decrease in the gonadosomatic index, testosterone level, and transcription of several genes (e.g, hsd3b2, cyp17a1, and hsd17b1) and a significant increase in the hepatosomatic index, liver steatosis, 17β-estradiol level, and transcription of vtg gene were observed. These results suggest that estrogenic and anti-androgenic ef...
Source: Chemosphere - September 27, 2023 Category: Chemistry Authors: Sujin Lee Yujin Ka Bomi Lee Inhye Lee Ye Eun Seo Hyewon Shin Younglim Kho Kyunghee Ji Source Type: research
High-Dose Rate Brachytherapy Combined with PD-1 Blockade as a
Treatment for Metastatic Adrenocortical Carcinoma – A Single Center Case
Series
Horm Metab Res DOI: 10.1055/a-2150-3944The response rate of advanced adrenocortical carcinoma (ACC) to standard
chemotherapy with mitotane and etoposide/doxorubicin/cisplatin
(EDP-M) is unsatisfactory, and benefit is frequently short lived. Immune
checkpoint inhibitors (CPI) have been examined in patient’s refractory
to EDP-M, but objective response rates are only approximately 15%.
High-dose rate brachytherapy (HDR-BT) is a catheter-based internal radiotherapy
and expected to favorably combine with immunotherapies. Here we describe three
cases of pati...
Source: Hormone and Metabolic Research - September 25, 2023 Category: Endocrinology Authors: Schwarzlmueller, Paul Corradini, Stefanie Seidensticker, Max Zimmermann, Petra Schreiner, Jochen Maier, Tanja Triebig, Alexandra Kn ösel, Thomas Pazos, Montserrat Pfluger, Thomas Weigand, Isabel Belka, Claus Ricke, Jens Reincke, Martin Schmidmaier, Ralf Tags: Original Article: Endocrine Care Source Type: research
Two-dimensional chromatography for enantiomeric analysis of mitotane and its metabolite o,p'-DDA in patients with adrenocortical carcinoma indicates enantioselective metabolism
In this study, we analyzed the enantiomers of mitotane and o,p'-DDA in the plasma of patients by a newly developed chiral-phase method employed in two-dimensional chromatography. Important differences were observed in the ratio of (S)/(R)-mitotane, which varied substantially from 1:1.2 to 1:10 whereas the (S)/(R)-o,p'-DDA ratio was relatively conserved, at approximately 2:1. These findings provide evidence for the enantioselective metabolism and provide a method for further analyses of mitotane and metabolites, which can explain the variation in the therapeutic response.PMID:37713949 | DOI:10.1016/j.bioorg.2023.106835 (Sou...
Source: Bioorganic Chemistry - September 15, 2023 Category: Chemistry Authors: Gabriela Stadler Alan de Almeida Veiga Claudia Rita Corso Camila Bach de Assis Beatriz de Toledo Nogueira Lucia Regina Rocha Martins Beatriz Cruz Bonk Fl ávia Lada Degaut Pontes Bonald Cavalcante de Figueiredo Lauro Mera de Souza Source Type: research
Two-dimensional chromatography for enantiomeric analysis of mitotane and its metabolite o,p'-DDA in patients with adrenocortical carcinoma indicates enantioselective metabolism
In this study, we analyzed the enantiomers of mitotane and o,p'-DDA in the plasma of patients by a newly developed chiral-phase method employed in two-dimensional chromatography. Important differences were observed in the ratio of (S)/(R)-mitotane, which varied substantially from 1:1.2 to 1:10 whereas the (S)/(R)-o,p'-DDA ratio was relatively conserved, at approximately 2:1. These findings provide evidence for the enantioselective metabolism and provide a method for further analyses of mitotane and metabolites, which can explain the variation in the therapeutic response.PMID:37713949 | DOI:10.1016/j.bioorg.2023.106835 (Sou...
Source: Bioorganic Chemistry - September 15, 2023 Category: Chemistry Authors: Gabriela Stadler Alan de Almeida Veiga Claudia Rita Corso Camila Bach de Assis Beatriz de Toledo Nogueira Lucia Regina Rocha Martins Beatriz Cruz Bonk Fl ávia Lada Degaut Pontes Bonald Cavalcante de Figueiredo Lauro Mera de Souza Source Type: research
Cancers, Vol. 15, Pages 4491: Feasibility and Activity of Megestrol Acetate in Addition to Etoposide, Doxorubicin, Cisplatin, and Mitotane as First-Line Therapy in Patients with Metastatic/Unresectable Adrenocortical Carcinoma with Low Performance Status
Conclusions: The association of EDP-M + megestrol acetate in ACC pts with a low PS is feasible and well tolerated; its efficacy appeared to be non-inferior to EDP-M administered to pts with a good PS. (Source: Cancers)
Source: Cancers - September 9, 2023 Category: Cancer & Oncology Authors: Antonella Turla Marta Lagan à Andrea Abate Valentina Cremaschi Manuel Zamparini Matteo Chitt ò Francesca Consoli Andrea Alberti Roberta Ambrosini Mariangela Tamburello Salvatore Grisanti Guido Alberto Massimo Tiberio Sandra Sigala Deborah Cosentini Alfr Tags: Article Source Type: research
Case report: Remarkable response to a novel combination of mitotane, etoposide, paraplatin, and sintilimab in a patient with metastatic adrenocortical carcinoma
ConclusionThis case highlights the remarkable response of our patient’s ACC with MSI-H tumor, MLH1 spice mutation, and high TMB to treatment with a novel combination of EP-M and sintilimab. Our findings suggest a promising therapeutic option for patients with similar molecular profiles. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - September 8, 2023 Category: Endocrinology Source Type: research
