Case Report: Disseminated Paracoccidioidomycosis and Strongyloides Hyperinfection in a Patient with Human T-Lymphotropic Virus Type 1/2 Infection
We describe the case of a Peruvian farmer from the central jungle with human T-lymphotropic virus type 1/2 infection, with 2 months of illness characterized by respiratory and gastrointestinal symptoms associated with fever, weight loss, and enlarged lymph nodes. Strongyloides stercoralis and Paracoccidioides brasiliensis were isolated in sputum and bronchoalveolar lavage samples, respectively. The clinical evolution was favorable after the patient received ivermectin and amphotericin B. We hypothesize that autoinfestation by S. stercoralis in human T-lymphotropic virus type 1/2-infected patients may contribute to the diss...
Source: Am J Trop Med Hyg - March 26, 2024 Category: Infectious Diseases Authors: Juan Montenegro-Idrogo Alfredo Chiappe-Gonzalez Esperanza Vicente-Lozano Gonzalo Cornejo-Venegas Cristhian Resurrecci ón-Delgado Source Type: research
Case Report: Disseminated Paracoccidioidomycosis and Strongyloides Hyperinfection in a Patient with Human T-Lymphotropic Virus Type 1/2 Infection
We describe the case of a Peruvian farmer from the central jungle with human T-lymphotropic virus type 1/2 infection, with 2 months of illness characterized by respiratory and gastrointestinal symptoms associated with fever, weight loss, and enlarged lymph nodes. Strongyloides stercoralis and Paracoccidioides brasiliensis were isolated in sputum and bronchoalveolar lavage samples, respectively. The clinical evolution was favorable after the patient received ivermectin and amphotericin B. We hypothesize that autoinfestation by S. stercoralis in human T-lymphotropic virus type 1/2-infected patients may contribute to the diss...
Source: The American Journal of Tropical Medicine and Hygiene - March 26, 2024 Category: Tropical Medicine Authors: Juan Montenegro-Idrogo Alfredo Chiappe-Gonzalez Esperanza Vicente-Lozano Gonzalo Cornejo-Venegas Cristhian Resurrecci ón-Delgado Source Type: research
Case Report: Disseminated Paracoccidioidomycosis and Strongyloides Hyperinfection in a Patient with Human T-Lymphotropic Virus Type 1/2 Infection
We describe the case of a Peruvian farmer from the central jungle with human T-lymphotropic virus type 1/2 infection, with 2 months of illness characterized by respiratory and gastrointestinal symptoms associated with fever, weight loss, and enlarged lymph nodes. Strongyloides stercoralis and Paracoccidioides brasiliensis were isolated in sputum and bronchoalveolar lavage samples, respectively. The clinical evolution was favorable after the patient received ivermectin and amphotericin B. We hypothesize that autoinfestation by S. stercoralis in human T-lymphotropic virus type 1/2-infected patients may contribute to the diss...
Source: Am J Trop Med Hyg - March 26, 2024 Category: Infectious Diseases Authors: Juan Montenegro-Idrogo Alfredo Chiappe-Gonzalez Esperanza Vicente-Lozano Gonzalo Cornejo-Venegas Cristhian Resurrecci ón-Delgado Source Type: research
Case Report: Disseminated Paracoccidioidomycosis and Strongyloides Hyperinfection in a Patient with Human T-Lymphotropic Virus Type 1/2 Infection
We describe the case of a Peruvian farmer from the central jungle with human T-lymphotropic virus type 1/2 infection, with 2 months of illness characterized by respiratory and gastrointestinal symptoms associated with fever, weight loss, and enlarged lymph nodes. Strongyloides stercoralis and Paracoccidioides brasiliensis were isolated in sputum and bronchoalveolar lavage samples, respectively. The clinical evolution was favorable after the patient received ivermectin and amphotericin B. We hypothesize that autoinfestation by S. stercoralis in human T-lymphotropic virus type 1/2-infected patients may contribute to the diss...
Source: The American Journal of Tropical Medicine and Hygiene - March 26, 2024 Category: Tropical Medicine Authors: Juan Montenegro-Idrogo Alfredo Chiappe-Gonzalez Esperanza Vicente-Lozano Gonzalo Cornejo-Venegas Cristhian Resurrecci ón-Delgado Source Type: research
Case Report: Disseminated Paracoccidioidomycosis and Strongyloides Hyperinfection in a Patient with Human T-Lymphotropic Virus Type 1/2 Infection
We describe the case of a Peruvian farmer from the central jungle with human T-lymphotropic virus type 1/2 infection, with 2 months of illness characterized by respiratory and gastrointestinal symptoms associated with fever, weight loss, and enlarged lymph nodes. Strongyloides stercoralis and Paracoccidioides brasiliensis were isolated in sputum and bronchoalveolar lavage samples, respectively. The clinical evolution was favorable after the patient received ivermectin and amphotericin B. We hypothesize that autoinfestation by S. stercoralis in human T-lymphotropic virus type 1/2-infected patients may contribute to the diss...
Source: Am J Trop Med Hyg - March 26, 2024 Category: Infectious Diseases Authors: Juan Montenegro-Idrogo Alfredo Chiappe-Gonzalez Esperanza Vicente-Lozano Gonzalo Cornejo-Venegas Cristhian Resurrecci ón-Delgado Source Type: research
Nanoemulsions containing amphotericin b and paromomycin for the treatment of cutaneous leishmaniasis
CONCLUSION: It is possible to develop a NE for the treatment of CL; however, complementary studies regarding the antileishmanial activity of NE should be carried out.PMID:38522630 | DOI:10.1016/j.actatropica.2024.107189 (Source: Acta Tropica)
Source: Acta Tropica - March 24, 2024 Category: Infectious Diseases Authors: Nicolas Fontenele Callipo Cunha Luciana Betzler de Oliveira de Siqueira Andreza Raposo Garcia Igor Almeida Rodrigues Ana Paula Dos Santos Matos Eduardo Ricci J únior Mariana Sato de Souza Bustamante Monteiro Source Type: research
Nanoemulsions containing amphotericin b and paromomycin for the treatment of cutaneous leishmaniasis
CONCLUSION: It is possible to develop a NE for the treatment of CL; however, complementary studies regarding the antileishmanial activity of NE should be carried out.PMID:38522630 | DOI:10.1016/j.actatropica.2024.107189 (Source: Acta Tropica)
Source: Acta Tropica - March 24, 2024 Category: Infectious Diseases Authors: Nicolas Fontenele Callipo Cunha Luciana Betzler de Oliveira de Siqueira Andreza Raposo Garcia Igor Almeida Rodrigues Ana Paula Dos Santos Matos Eduardo Ricci J únior Mariana Sato de Souza Bustamante Monteiro Source Type: research
Nanoemulsions containing amphotericin b and paromomycin for the treatment of cutaneous leishmaniasis
CONCLUSION: It is possible to develop a NE for the treatment of CL; however, complementary studies regarding the antileishmanial activity of NE should be carried out.PMID:38522630 | DOI:10.1016/j.actatropica.2024.107189 (Source: Acta Tropica)
Source: Acta Tropica - March 24, 2024 Category: Infectious Diseases Authors: Nicolas Fontenele Callipo Cunha Luciana Betzler de Oliveira de Siqueira Andreza Raposo Garcia Igor Almeida Rodrigues Ana Paula Dos Santos Matos Eduardo Ricci J únior Mariana Sato de Souza Bustamante Monteiro Source Type: research
Treatment using vanillin-derived synthetic molecules incorporated into polymeric micelles is effective against infection caused by Leishmania amazonensis species
In conclusion, results suggest that 3s/Mic and 3t/Mic could be considered as therapeutic candidates to treat against L. amazonensis infection.PMID:38513973 | DOI:10.1016/j.exppara.2024.108743 (Source: Experimental Parasitology)
Source: Experimental Parasitology - March 21, 2024 Category: Parasitology Authors: Isabela A G Pereira Camila S Freitas Raquel S B C âmara Marcelo M Jesus Daniela P Lage Grasiele S V Tavares Tauane G Soyer Fernanda F Ramos N ícia P Soares Samira S Santiago V ívian T Martins Danniele L Vale Breno L Pimenta Fernanda Ludolf Fabr ício M Source Type: research
Treatment using vanillin-derived synthetic molecules incorporated into polymeric micelles is effective against infection caused by Leishmania amazonensis species
In conclusion, results suggest that 3s/Mic and 3t/Mic could be considered as therapeutic candidates to treat against L. amazonensis infection.PMID:38513973 | DOI:10.1016/j.exppara.2024.108743 (Source: Experimental Parasitology)
Source: Experimental Parasitology - March 21, 2024 Category: Parasitology Authors: Isabela A G Pereira Camila S Freitas Raquel S B C âmara Marcelo M Jesus Daniela P Lage Grasiele S V Tavares Tauane G Soyer Fernanda F Ramos N ícia P Soares Samira S Santiago V ívian T Martins Danniele L Vale Breno L Pimenta Fernanda Ludolf Fabr ício M Source Type: research
Molecules, Vol. 29, Pages 1396: Characterisation of Modular Polyketide Synthases Designed to Make Pentaene Analogues of Amphotericin B
k Caffrey
Glycosylated polyene macrolides are important antifungal agents that are produced by many actinomycete species. Development of new polyenes may deliver improved antibiotics. Here, Streptomyces nodosus was genetically re-programmed to synthesise pentaene analogues of the heptaene amphotericin B. These pentaenes are of interest as surrogate substrates for enzymes catalysing unusual, late-stage biosynthetic modifications. The previous deletion of amphotericin polyketide synthase modules 5 and 6 generated S. nodosus M57, which produces an inactive pentaene. Here, the chain-terminating thioesterase was fused to mo...
Source: Molecules - March 21, 2024 Category: Chemistry Authors: Yuhao Song Mark Hogan Jimmy Muldoon Paul Evans Patrick Caffrey Tags: Article Source Type: research
Gastrointestinal histoplasmosis with small intestinal perforation: 20-year experience
AbstractPostmortem studies show gastrointestinal tract involvement in as many as 70% of patients affected by disseminated histoplasmosis. Although gastrointestinal involvement is common in disseminated disease, the presentation of small intestinal perforation is exceedingly rare with few reported cases in the literature. Herein we present our institutional case series. The aim of the study is to describe small intestinal perforation in gastrointestinal histoplasmosis with attention to management and outcomes. This is a retrospective single-institution review of patients ≥ 18 years of age treated for small intestina...
Source: Updates in Surgery - March 20, 2024 Category: Surgery Source Type: research
Multifunctional Gold Nanozyme ‐Engineered Amphotericin B for Enhanced Antifungal Infection Therapy
Antifungal therapeutic drugs face significant obstacles in clinical application due to inherent toxicity and poor bioavailability. Using Amphotericin B (AmB) as an example, a new strategy is proposed to enhance the bioactivity of small-molecule antifungal drugs based on multifunctional metal nanozyme engineering, which significantly enhanced the antifungal properties of AmB at both in vitro and in vivo levels. AbstractChronic wounds of significant severity and acute injuries are highly vulnerable to fungal infections, drastically impeding the expected wound healing trajectory. The clinical use of antifungal therapeutic dru...
Source: Small - March 19, 2024 Category: Nanotechnology Authors: Chunmei Jiang,
Fangping Li,
Pei Song,
Mengyao Wen,
Saixue Yang,
Geng Tian,
Dongyan Shao,
Junling Shi,
Li Shang Tags: Research Article Source Type: research
Evaluation of the Vitek 2 system for antifungal susceptibility testing of Candida auris using a representative international panel of clinical isolates: overestimation of amphotericin B resistance and underestimation of fluconazole resistance
Journal of Clinical Microbiology, Ahead of Print. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - March 19, 2024 Category: Microbiology Authors: Maria SiopiIoannis PachoulisSevasti LeventakiBram SpruijtenburgJacques F. MeisSpyros PournarasGeorgia VrioniAthanasios TsakrisJoseph Meletiadis1Clinical Microbiology Laboratory, “Attikon” University General Hospital, Medical School, National and Kapod Source Type: research
Economic impact of managing invasive mold disease with isavuconazole compared with liposomal amphotericin B followed by posaconazole in Spain
CONCLUSION: According to the present model, the treatment of IFIs with ISAV would generate savings for the SNS compared to L-AMB→POSA. These savings are attributed to the shorter duration of IV treatment, reduced use of healthcare resources and lower costs associated with managing adverse effects when ISAV was employed.PMID:38494912 | DOI:10.1080/14787210.2024.2327517 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - March 18, 2024 Category: Infectious Diseases Authors: C Moya-Alarc ón J R Azanza J Barber án R Ferrer M Kwon A Moreno C Rubio-Terr és M G álvez-Santisteban Source Type: research
