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Antimicrobial activity of essential oils against biofilms formed in dental acrylic resin: a systematic review of in vitro studies
In conclusion, the EOs of C. zeylanicum, C. citratus, C. nardus, and M. alternifolia showed antimicrobial activity to reduce biofilm on dental acrylic resin.PMID:38538551 | DOI:10.1080/08927014.2024.2332709 (Source: Biofouling)
Source: Biofouling - March 27, 2024 Category: Molecular Biology Authors: Jo ão Marcos Carvalho-Silva Ana Beatriz Vilela Teixeira Mariana Lima da Costa Valente Marcos Vinicius Wada Shimano Andr éa Cândido Dos Reis Source Type: research

Pore-forming peptide C14R exhibits potent antifungal activity against clinical isolates of Candida albicans and Candida auris
DiscussionC14R has a potent antifungal activity against a large set of clinical isolates of both C. albicans and C. auris, showing its capacity to disrupt Candida membranes. This antifungal activity remains consistent across isolates regardless of their clinical source. Furthermore, the absence of correlation between MICs to C14R and resistance to fluconazole indicates the peptide’s potential effectiveness against fluconazole-resistant strains. Our results suggest the potential of C14R, a pore-forming peptide, as a treatment option for fungal infections, such as invasive candidiasis, including fluconazole and amphoterici...
Source: Frontiers in cellular and infection microbiology - March 27, 2024 Category: Microbiology Source Type: research

Synthesis and antifungal activity of hexahydropyrrolidoindole alkaloids
Nat Prod Res. 2024 Mar 26:1-9. doi: 10.1080/14786419.2024.2333047. Online ahead of print.ABSTRACTTwenty-one hexahydropyrrolidoindole alkaloids were designed and synthesised via acylation reaction at the 3-N position from the commercially available indole-3-acetonitrile as the starting material in excellent yields. The effects of all target compounds against Verticillium dahlia, Fusarium oxysperium sp., Cytospora juglandis, Aspergillu sflavu, Aspergillus niger and Fusarium oxysporum were determined. The results of bioassays indicated that the majority of tested compounds displayed comparable or better in vitro bioactivity t...
Source: Natural Product Research - March 26, 2024 Category: Biochemistry Authors: Yujie Zhou Shoude Ma Xiaohan Li Xinye Liu Jie Gao Dingding L ü Ya Wang Shaojun Zheng Source Type: research

Anthraquinones against Cryptococcus neoformans sensu stricto : antifungal interaction, biofilm inhibition and pathogenicity in the Caenorhabditis elegans model
Conclusion. These results highlight the potential activity of anthraquinones to increase the effectiveness of antifungal drugs against cryptococcal biofilms.PMID:38530134 | DOI:10.1099/jmm.0.001815 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 26, 2024 Category: Microbiology Authors: G éssica Dos Santos Araújo Raimunda S âmia Nogueira Brilhante Maria Gleiciane da Rocha Lara de Aguiar D ébora de Souza Collares Maia Castelo-Branco Glaucia Morgana de Melo Guedes Jos é Júlio Costa Sidrim Waldemiro Aquino Pereira Neto Marcos F ábio Source Type: research

Case Report: Disseminated Paracoccidioidomycosis and Strongyloides Hyperinfection in a Patient with Human T-Lymphotropic Virus Type 1/2 Infection
We describe the case of a Peruvian farmer from the central jungle with human T-lymphotropic virus type 1/2 infection, with 2 months of illness characterized by respiratory and gastrointestinal symptoms associated with fever, weight loss, and enlarged lymph nodes. Strongyloides stercoralis and Paracoccidioides brasiliensis were isolated in sputum and bronchoalveolar lavage samples, respectively. The clinical evolution was favorable after the patient received ivermectin and amphotericin B. We hypothesize that autoinfestation by S. stercoralis in human T-lymphotropic virus type 1/2-infected patients may contribute to the diss...
Source: The American Journal of Tropical Medicine and Hygiene - March 26, 2024 Category: Tropical Medicine Authors: Juan Montenegro-Idrogo Alfredo Chiappe-Gonzalez Esperanza Vicente-Lozano Gonzalo Cornejo-Venegas Cristhian Resurrecci ón-Delgado Source Type: research

Case Report: Disseminated Paracoccidioidomycosis and Strongyloides Hyperinfection in a Patient with Human T-Lymphotropic Virus Type 1/2 Infection
We describe the case of a Peruvian farmer from the central jungle with human T-lymphotropic virus type 1/2 infection, with 2 months of illness characterized by respiratory and gastrointestinal symptoms associated with fever, weight loss, and enlarged lymph nodes. Strongyloides stercoralis and Paracoccidioides brasiliensis were isolated in sputum and bronchoalveolar lavage samples, respectively. The clinical evolution was favorable after the patient received ivermectin and amphotericin B. We hypothesize that autoinfestation by S. stercoralis in human T-lymphotropic virus type 1/2-infected patients may contribute to the diss...
Source: Am J Trop Med Hyg - March 26, 2024 Category: Infectious Diseases Authors: Juan Montenegro-Idrogo Alfredo Chiappe-Gonzalez Esperanza Vicente-Lozano Gonzalo Cornejo-Venegas Cristhian Resurrecci ón-Delgado Source Type: research