Scedosporium boydii finding in an immunocompromised patient and review of the literature
CONCLUSIONS: Although the patient died due to complications of a Klebsiella pneumoniae sepsis refractory to treatment, the progression of the fungal disease, although slow, was favourable in the early phases of the treatment due to a correct diagnosis and the antifungal susceptibility test carried out. Clinical cases of this nature highlight the need to increase the epidemiological study of these microorganisms, as well as the proper treatment of the diseases caused, in order to achieve early diagnoses that reduce the morbidity and mortality of patients.PMID:38326154 | DOI:10.1016/j.riam.2023.10.001 (Source: Revista Iberoa...
Source: Revista Iberoamericana de Micologia - February 7, 2024 Category: Biology Authors: Silvana Ramad án Hern án Dalmaso Alicia Luque Maximiliano Sortino Mar ía Luján Cuestas Katherine Hermida Alava Diego Bertola Luc ía Bulacio Source Type: research
Scedosporium boydii finding in an immunocompromised patient and review of the literature
CONCLUSIONS: Although the patient died due to complications of a Klebsiella pneumoniae sepsis refractory to treatment, the progression of the fungal disease, although slow, was favourable in the early phases of the treatment due to a correct diagnosis and the antifungal susceptibility test carried out. Clinical cases of this nature highlight the need to increase the epidemiological study of these microorganisms, as well as the proper treatment of the diseases caused, in order to achieve early diagnoses that reduce the morbidity and mortality of patients.PMID:38326154 | DOI:10.1016/j.riam.2023.10.001 (Source: Revista Iberoa...
Source: Revista Iberoamericana de Micologia - February 7, 2024 Category: Biology Authors: Silvana Ramad án Hern án Dalmaso Alicia Luque Maximiliano Sortino Mar ía Luján Cuestas Katherine Hermida Alava Diego Bertola Luc ía Bulacio Source Type: research
Scedosporium boydii finding in an immunocompromised patient and review of the literature
CONCLUSIONS: Although the patient died due to complications of a Klebsiella pneumoniae sepsis refractory to treatment, the progression of the fungal disease, although slow, was favourable in the early phases of the treatment due to a correct diagnosis and the antifungal susceptibility test carried out. Clinical cases of this nature highlight the need to increase the epidemiological study of these microorganisms, as well as the proper treatment of the diseases caused, in order to achieve early diagnoses that reduce the morbidity and mortality of patients.PMID:38326154 | DOI:10.1016/j.riam.2023.10.001 (Source: Revista Iberoa...
Source: Revista Iberoamericana de Micologia - February 7, 2024 Category: Biology Authors: Silvana Ramad án Hern án Dalmaso Alicia Luque Maximiliano Sortino Mar ía Luján Cuestas Katherine Hermida Alava Diego Bertola Luc ía Bulacio Source Type: research
Scedosporium boydii finding in an immunocompromised patient and review of the literature
CONCLUSIONS: Although the patient died due to complications of a Klebsiella pneumoniae sepsis refractory to treatment, the progression of the fungal disease, although slow, was favourable in the early phases of the treatment due to a correct diagnosis and the antifungal susceptibility test carried out. Clinical cases of this nature highlight the need to increase the epidemiological study of these microorganisms, as well as the proper treatment of the diseases caused, in order to achieve early diagnoses that reduce the morbidity and mortality of patients.PMID:38326154 | DOI:10.1016/j.riam.2023.10.001 (Source: Revista Iberoa...
Source: Revista Iberoamericana de Micologia - February 7, 2024 Category: Biology Authors: Silvana Ramad án Hern án Dalmaso Alicia Luque Maximiliano Sortino Mar ía Luján Cuestas Katherine Hermida Alava Diego Bertola Luc ía Bulacio Source Type: research
Scedosporium boydii finding in an immunocompromised patient and review of the literature
CONCLUSIONS: Although the patient died due to complications of a Klebsiella pneumoniae sepsis refractory to treatment, the progression of the fungal disease, although slow, was favourable in the early phases of the treatment due to a correct diagnosis and the antifungal susceptibility test carried out. Clinical cases of this nature highlight the need to increase the epidemiological study of these microorganisms, as well as the proper treatment of the diseases caused, in order to achieve early diagnoses that reduce the morbidity and mortality of patients.PMID:38326154 | DOI:10.1016/j.riam.2023.10.001 (Source: Revista Iberoa...
Source: Revista Iberoamericana de Micologia - February 7, 2024 Category: Biology Authors: Silvana Ramad án Hern án Dalmaso Alicia Luque Maximiliano Sortino Mar ía Luján Cuestas Katherine Hermida Alava Diego Bertola Luc ía Bulacio Source Type: research
Scedosporium boydii finding in an immunocompromised patient and review of the literature
CONCLUSIONS: Although the patient died due to complications of a Klebsiella pneumoniae sepsis refractory to treatment, the progression of the fungal disease, although slow, was favourable in the early phases of the treatment due to a correct diagnosis and the antifungal susceptibility test carried out. Clinical cases of this nature highlight the need to increase the epidemiological study of these microorganisms, as well as the proper treatment of the diseases caused, in order to achieve early diagnoses that reduce the morbidity and mortality of patients.PMID:38326154 | DOI:10.1016/j.riam.2023.10.001 (Source: Revista Iberoa...
Source: Revista Iberoamericana de Micologia - February 7, 2024 Category: Biology Authors: Silvana Ramad án Hern án Dalmaso Alicia Luque Maximiliano Sortino Mar ía Luján Cuestas Katherine Hermida Alava Diego Bertola Luc ía Bulacio Source Type: research
Scedosporium boydii finding in an immunocompromised patient and review of the literature
CONCLUSIONS: Although the patient died due to complications of a Klebsiella pneumoniae sepsis refractory to treatment, the progression of the fungal disease, although slow, was favourable in the early phases of the treatment due to a correct diagnosis and the antifungal susceptibility test carried out. Clinical cases of this nature highlight the need to increase the epidemiological study of these microorganisms, as well as the proper treatment of the diseases caused, in order to achieve early diagnoses that reduce the morbidity and mortality of patients.PMID:38326154 | DOI:10.1016/j.riam.2023.10.001 (Source: Revista Iberoa...
Source: Revista Iberoamericana de Micologia - February 7, 2024 Category: Biology Authors: Silvana Ramad án Hern án Dalmaso Alicia Luque Maximiliano Sortino Mar ía Luján Cuestas Katherine Hermida Alava Diego Bertola Luc ía Bulacio Source Type: research
SAR study of N'-(Salicylidene)heteroarenecarbohydrazides as promising antifungal agents
Bioorg Med Chem. 2024 Jan 24;100:117610. doi: 10.1016/j.bmc.2024.117610. Online ahead of print.ABSTRACTClinically available antifungal drugs have therapeutic limitations due to toxicity, narrow spectrum of activity, and intrinsic or acquired drug resistance. Thus, there is an urgent need for new broad-spectrum antifungal agents with low toxicity and a novel mechanism of action. In this context, we have successfully identified several highly promising lead compounds, i.e., aromatic N'-(salicylidene)carbohydrazides, exhibiting excellent antifungal activities against Cryptococcus neoformans, Candida albicans, Aspergillus fumi...
Source: Bioorganic and Medicinal Chemistry - February 2, 2024 Category: Chemistry Authors: Yi Sun Saerom Kim SeungYoun Shin Kathryn Takemura Gabriel S Matos Cristina Lazzarini Krupanandan Haranahalli Julia Zambito Ashna Garg Maurizio Del Poeta Iwao Ojima Source Type: research
Mucormycosis-induced hypercalcemia: a case report
AbstractHypercalcemia is a vital laboratory marker because it can show underlying severe diseases like cancer and infections. Of all the causes of hypercalcemia, primary hyperparathyroidism, and malignancies are the most common, but granulomatous diseases, such as certain fungal infections, can also be the cause. Here we describe the case of a 29-year-old woman, an insulin-dependent diabetic, found unconscious and tachypneic at home. In the emergency room, the medical team diagnosed diabetic ketoacidosis (DKA) and acute kidney injury (AKI). During hospitalization, despite resolving acidemia, persistent hypercalcemia attrac...
Source: CEN Case Reports - February 1, 2024 Category: Urology & Nephrology Source Type: research
Distearoyl phosphatidylglycerol and dioleoyl phosphatidylglycerol increase the retention and reduce the toxicity of amphotericin B loaded in nanoemulsions
Nanomedicine, Ahead of Print. (Source: Future Medicine: Nanomedicine)
Source: Future Medicine: Nanomedicine - January 31, 2024 Category: Nanotechnology Authors: Gabriel Silva Marques Borges Thais Tunes Santos Cristiane Monteiro Pinto Fr édéric Frézard Ver ônica Freitas Blanco Roberta Ondei Stephen Rumbelow Lucas Ant ônio Miranda Ferreira Marta Marques Gontijo de Aguiar Gisele Assis Castro Goulart Source Type: research
Distearoyl phosphatidylglycerol and dioleoyl phosphatidylglycerol increase the retention and reduce the toxicity of amphotericin B loaded in nanoemulsions
Nanomedicine, Ahead of Print. (Source: Nanomedicine)
Source: Nanomedicine - January 31, 2024 Category: Nanotechnology Authors: Gabriel Silva Marques Borges Thais Tunes Santos Cristiane Monteiro Pinto Fr édéric Frézard Ver ônica Freitas Blanco Roberta Ondei Stephen Rumbelow Lucas Ant ônio Miranda Ferreira Marta Marques Gontijo de Aguiar Gisele Assis Castro Goulart Source Type: research
Treatment of < em > Candida auris < /em > during extracorporeal life support: A case report
We describe a case of C. auris in a VV-ECMO patient successfully managed with a combination of anidulafungin, amphotericin B, and flucytosine.PMID:38281934 | DOI:10.1177/03913988231226357 (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - January 28, 2024 Category: Transplant Surgery Authors: Paul Dobry Stephanie B Edwin Tsz Hin Ng Karey Dutcheshen Amir Kaki Theodore L Schreiber Source Type: research
Unveiling the role of serine o-acetyltransferase in drug resistance and oxidative stress tolerance in Leishmania donovani through the regulation of thiol-based redox metabolism
Free Radic Biol Med. 2024 Mar;213:371-393. doi: 10.1016/j.freeradbiomed.2024.01.039. Epub 2024 Jan 23.ABSTRACTUnderstanding the unique metabolic pathway of L. donovani is crucial for comprehending its biology under oxidative stress conditions. The de novo cysteine biosynthetic pathway of L. donovani is absent in humans and its product, cysteine regulates the downstream components of trypanothione-based thiol metabolism, important for maintaining cellular redox homeostasis. The role of serine o-acetyl transferase (SAT), the first enzyme of this pathway remains unexplored. In order to investigate the role of SAT protein, we ...
Source: Free Radical Biology and Medicine - January 25, 2024 Category: Biology Authors: Afreen Nawaz Bhawna Priya Kuljit Singh Vahab Ali Source Type: research
Early Experiences with Intrathecal Administration of Amphotericin B Liposomal Formulation at a Neurosurgical Center
ConclusionsLiposomal amphotericin B may be feasibly administered intrathecally for the adjunctive treatment of severe fungal meningitis. (Source: CNS Drugs)
Source: CNS Drugs - January 25, 2024 Category: Neurology Source Type: research
Exploration of Risk Factors of the Onset of Antibiotics-induced Acute Kidney Injury and Its Transfer to Chronic Kidney Disease Using the Medical Information Database
In this study, using the medical information database of Hamamatsu University Hospital, we investigated the risk factors that accelerate the onset of drug-induced AKI or its progression to CKD in patients who received aminoglycoside antibiotics (AGs) or glycopeptide antibiotics (GPs), which are strongly associated with drug-induced AKI and CKD. We performed logistic regression analysis using patients' background, laboratory test results, and concomitant drug use, among other such factors as explanatory variables and drug-induced AKI or CKD onset as objective variables to explore the risk factors for drug-induced AKI and CK...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 24, 2024 Category: Drugs & Pharmacology Authors: Masaya Ieda Yuka Kuroda Takahiro Matsumoto Ayaka Yamashita Takashi Watanabe Katsuhito Hori Michio Kimura Junichi Kawakami Masahiro Tohkin Source Type: research
