Visceral Leishmaniasis Masquerading as Drug-Induced Pancytopenia in Lung Cancer Patients
Curr Oncol. 2024 Apr 17;31(4):2274-2277. doi: 10.3390/curroncol31040168.ABSTRACTMaintenance chemotherapy is a standard treatment in patients with non-progressive advance staged IV non-squamous non-small cell lung cancer after induction therapy. Here, we report the case of a 53-year-old man undergoing a maintenance monotherapy with pemetrexed who presented prolonged pancytopenia despite filgrastim injections. A bone marrow aspiration revealed a macrophage activation syndrome with Leishmania amastigotes. A Polymerase Chest Reaction testing confirmed the diagnosis of visceral leishmaniasis. Treatment with liposomal amphoteric...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Sophie Laroumagne Julie Tronchetti Herv é Dutau Philippe Astoul Source Type: research
Successful treatment of recurrent visceral leishmaniasis relapse in an immunocompetent adult female with functional hypopituitarism in Bangladesh
ConclusionIn the absence of protective vaccines againstLeishmania species and standard treatment regimen, this modified treatment regimen could help the management of recurrent relapse cases. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 26, 2024 Category: Tropical Medicine Authors: Tabiha Binte Hannan Source Type: research
Intraorbital amphotericin B for mucormycosis in an Allo-HSCT recipient
Bone Marrow Transplantation, Published online: 25 April 2024; doi:10.1038/s41409-024-02287-2Intraorbital amphotericin B for mucormycosis in an Allo-HSCT recipient (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - April 25, 2024 Category: Hematology Authors: Wyatt Schwartz Adam C. Christiansen Sagar S. Patel Source Type: research
Visceral Leishmaniasis (VL) Clinical Presentation, Laboratory Findings, Treatment Options and Outcome
CONCLUSION: VL should be included in the differential diagnosis of any child who presents with fever, splenomegaly, and anemia. Concerning the treatment strategy in this study, liposomal amphotericin B had more efficiency and shorter hospitalization duration.PMID:38654944 | PMC:PMC11033536 | DOI:10.18502/ijpa.v19i1.15190 (Source: Iranian Journal of Parasitology)
Source: Iranian Journal of Parasitology - April 24, 2024 Category: Parasitology Authors: Mahmoud Khodabandeh Elham Moradian Maedeh Sarvari Mahsa Soti Khiabani Source Type: research
< i > Leishmania < /i > blood parasite dynamics during and after treatment of visceral leishmaniasis in Eastern Africa: A pharmacokinetic-pharmacodynamic model
ConclusionThis semi-mechanistic pharmacokinetic-pharmacodynamic model adequately captured the blood parasite dynamics during and after treatment, and revealed that high blood parasite loads on Day 28 and Day 56 after start of treatment are an early indication for VL relapse, which could be a useful biomarker to assess treatment efficacy of a treatment regimen in a clinical trial setting. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 19, 2024 Category: Tropical Medicine Authors: Luka Verrest Source Type: research
Local amphotericin B therapy for Cutaneous Leishmaniasis: A systematic review
ConclusionsDifferent AmB formulations and administration routes have been explored in preclinical and clinical studies. Developing therapeutic technologies is evident. Current findings might be interpreted as a favorable proof of concept for the local AmB administration which makes this intervention eligible to be explored in future well-designed studies towards less toxic treatments for leishmaniasis. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 16, 2024 Category: Tropical Medicine Authors: L índicy Leidicy Alves Source Type: research
Post-kala-azar dermal leishmaniasis (PKDL) drug efficacy study landscape: A systematic scoping review of clinical trials and observational studies to assess the feasibility of establishing an individual participant-level data (IPD) platform
ConclusionsOur review identified studies with very limited sample size for the three major drugs (miltefosine, L-AmB, and pentavalent antimony), while the number of patients combined across studies suggest that the IPD platform would be valuable. With the support of relevant stakeholders, the global PKDL community and sufficient financing, a PKDL IPD platform can be realised. This will allow for exploration of different aspects of treatment safety and efficacy, which can potentially guide future healthcare decisions and clinical practices. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 16, 2024 Category: Tropical Medicine Authors: Sauman Singh-Phulgenda Source Type: research
Redox homeostasis in human renal cells that had been treated with amphotericin B in combination with selected 1,3,4-thiadiazole derivatives
CONCLUSIONS: The results confirmed that thiadiazoles can stimulate the RPTEC cells to defend against the oxidative stress that is generated by AmB. In addition, together with the previously demonstrated synergistic antifungal activity, and low nephrotoxicity, these compounds have the potential to be used in new therapeutic strategies in the treatment of fungal infections.PMID:38587587 | DOI:10.1007/s43440-024-00592-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 8, 2024 Category: Drugs & Pharmacology Authors: Magdalena Kimsa-Dudek Celina Kruszniewska-Rajs Jolanta Adamska Barbara Strza łka-Mrozik Arkadiusz Matwijczuk Dariusz Karcz Mariusz Gago ś Joanna Magdalena Gola Source Type: research
Redox homeostasis in human renal cells that had been treated with amphotericin B in combination with selected 1,3,4-thiadiazole derivatives
CONCLUSIONS: The results confirmed that thiadiazoles can stimulate the RPTEC cells to defend against the oxidative stress that is generated by AmB. In addition, together with the previously demonstrated synergistic antifungal activity, and low nephrotoxicity, these compounds have the potential to be used in new therapeutic strategies in the treatment of fungal infections.PMID:38587587 | DOI:10.1007/s43440-024-00592-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 8, 2024 Category: Drugs & Pharmacology Authors: Magdalena Kimsa-Dudek Celina Kruszniewska-Rajs Jolanta Adamska Barbara Strza łka-Mrozik Arkadiusz Matwijczuk Dariusz Karcz Mariusz Gago ś Joanna Magdalena Gola Source Type: research
Redox homeostasis in human renal cells that had been treated with amphotericin B in combination with selected 1,3,4-thiadiazole derivatives
CONCLUSIONS: The results confirmed that thiadiazoles can stimulate the RPTEC cells to defend against the oxidative stress that is generated by AmB. In addition, together with the previously demonstrated synergistic antifungal activity, and low nephrotoxicity, these compounds have the potential to be used in new therapeutic strategies in the treatment of fungal infections.PMID:38587587 | DOI:10.1007/s43440-024-00592-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 8, 2024 Category: Drugs & Pharmacology Authors: Magdalena Kimsa-Dudek Celina Kruszniewska-Rajs Jolanta Adamska Barbara Strza łka-Mrozik Arkadiusz Matwijczuk Dariusz Karcz Mariusz Gago ś Joanna Magdalena Gola Source Type: research
Successful Treatment of Severe Aplastic Anemia with Hematopoietic Stem Cell Transplantation in the Setting of Active Mucormycosis
AbstractSevere aplastic anemia (SAA) is a life-threatening hematological disease characterized by the suppression of the bone marrow. Patients with SAA are predisposed to recurrent bacterial infections and invasive fungal infections (IFI) due to profound and persistent neutropenia. Mucorales are the second most common cause of IFI encountered in SAA. Here we present a pediatric case of SAA with active mucormycosis infection of the paranasal sinuses. In the first step, surgical debridement was performed and combined antifungal therapy (liposomal amphotericin B, posaconazole, caspofungin) was started. Due to severe neutropen...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 4, 2024 Category: ENT & OMF Source Type: research
