New synthetic molecules incorporated into polymeric micelles used for treatment against visceral leishmaniasis
In conclusion, preliminary data suggest that 3 s/M and 3 t/M could be considered for future studies as therapeutic agents against VL.PMID:38373365 | DOI:10.1016/j.cyto.2024.156543 (Source: Cytokine)
Source: Cytokine - February 19, 2024 Category: Molecular Biology Authors: Camila S Freitas Isabela A G Pereira Daniela P Lage Danniele L Vale Breno L Pimenta N ícia P Soares Samira S Santiago V ívian T Martins Raquel S B C âmara Marcelo M Jesus Grasiele S V Tavares Fernanda F Ramos Fernanda Ludolf L ícia N D Magalhães Fabr Source Type: research
< em > Candida glabrata < /em > oropharyngeal infection in a patient with oral squamous cell carcinoma after COVID-19 infection
CONCLUSION: Risk of fungal infections, such as Candida seems to be high in patients with severe COVID-19, mainly affecting the oral mucosa. However, whether they are directly attributed to COVID-19 or other surrounding factors is unknown.PMID:38361958 | PMC:PMC10864745 | DOI:10.22034/cmm.2023.345120.1478 (Source: Pain Physician)
Source: Pain Physician - February 16, 2024 Category: Anesthesiology Authors: Jalal Jafarzadeh Javad Javidnia Seyed Ali Jeddi Mahshid Vakili Mojtaba Taghizadeh Armaki Mahin Tavakoli Source Type: research
In vitro conversion of ellagic acid to urolithin A by different gut microbiota of urolithin metabotype A
In conclusion, the study revealed unique interactions between polyphenols and gut microbiota, deepening our understanding of the relationship between phenolic compounds like EA and the gut microbiota. These findings may contribute to the development of gut bacteria as potential probiotics for further development. KEY POINTS: • Intestinal microbiome involved in ellagic acid metabolism. • Gram-positive bacteria in the intestinal microbiome are crucial for ellagic acid metabolism. • Bifidobacterium longum, Bifidobacterium adolescentis, and Bifidobacterium bifidum participate in ellagic acid metabolism.PMID:38363367 | DO...
Source: Applied Microbiology and Biotechnology - February 16, 2024 Category: Microbiology Authors: Fuxiang He Yingying Bian Yaling Zhao Mengjie Xia Shu Liu Jiajin Gui Xiaoyue Hou Yaowei Fang Source Type: research
< em > Candida glabrata < /em > oropharyngeal infection in a patient with oral squamous cell carcinoma after COVID-19 infection
CONCLUSION: Risk of fungal infections, such as Candida seems to be high in patients with severe COVID-19, mainly affecting the oral mucosa. However, whether they are directly attributed to COVID-19 or other surrounding factors is unknown.PMID:38361958 | PMC:PMC10864745 | DOI:10.22034/cmm.2023.345120.1478 (Source: Pain Physician)
Source: Pain Physician - February 16, 2024 Category: Anesthesiology Authors: Jalal Jafarzadeh Javad Javidnia Seyed Ali Jeddi Mahshid Vakili Mojtaba Taghizadeh Armaki Mahin Tavakoli Source Type: research
In vitro conversion of ellagic acid to urolithin A by different gut microbiota of urolithin metabotype A
In conclusion, the study revealed unique interactions between polyphenols and gut microbiota, deepening our understanding of the relationship between phenolic compounds like EA and the gut microbiota. These findings may contribute to the development of gut bacteria as potential probiotics for further development. KEY POINTS: • Intestinal microbiome involved in ellagic acid metabolism. • Gram-positive bacteria in the intestinal microbiome are crucial for ellagic acid metabolism. • Bifidobacterium longum, Bifidobacterium adolescentis, and Bifidobacterium bifidum participate in ellagic acid metabolism.PMID:38363367 | PM...
Source: Applied Microbiology and Biotechnology - February 16, 2024 Category: Microbiology Authors: Fuxiang He Yingying Bian Yaling Zhao Mengjie Xia Shu Liu Jiajin Gui Xiaoyue Hou Yaowei Fang Source Type: research
In vitro conversion of ellagic acid to urolithin A by different gut microbiota of urolithin metabotype A
In conclusion, the study revealed unique interactions between polyphenols and gut microbiota, deepening our understanding of the relationship between phenolic compounds like EA and the gut microbiota. These findings may contribute to the development of gut bacteria as potential probiotics for further development. KEY POINTS: • Intestinal microbiome involved in ellagic acid metabolism. • Gram-positive bacteria in the intestinal microbiome are crucial for ellagic acid metabolism. • Bifidobacterium longum, Bifidobacterium adolescentis, and Bifidobacterium bifidum participate in ellagic acid metabolism.PMID:38363367 | PM...
Source: Applied Microbiology and Biotechnology - February 16, 2024 Category: Microbiology Authors: Fuxiang He Yingying Bian Yaling Zhao Mengjie Xia Shu Liu Jiajin Gui Xiaoyue Hou Yaowei Fang Source Type: research
Treatment of Cutaneous Leishmaniasis lesion caused by Leishmania major Using Leech Therapy in BALB/c Mice
CONCLUSION: Considering the fact that the standard drugs for the treatment of leishmaniasis have many side effects, alternative therapies such as leech therapy can be effectively used to treat these chronic wounds. There are about 20 active substances in leech saliva. These substances include antistasin, eglins, guamerin, hirudin, saratin, bdellins, complement, and carboxypeptidase inhibitors. Leech saliva is an anticoagulant, anti-inflammation and prevents the platelet. Leech therapy was effective in treating leishmaniasis wounds in BALB/c mice. In this study, there was complete wound healing in 56% of the mice models.PMI...
Source: Journal of Vector Borne Diseases - February 15, 2024 Category: Infectious Diseases Authors: Leila Shirani-Bidabadi Source Type: research
A potent candicidal peptide designed based on an encrypted peptide from a proteinase inhibitor
This study extends our knowledge on how AMPs can be engineered from peptides encrypted in larger proteins and their potential as candicidal agents.PMID:38360076 | DOI:10.1016/j.bbagen.2024.130583 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - February 15, 2024 Category: Biochemistry Authors: Lu ís Henrique de Oliveira Almeida Suellen Rodrigues Ramalho Claudiane Vilharroel Almeida Camila de Oliveira Gutierrez Jana ína de Cassia Orlandi Sardi Antonio de Miranda Ricardo Abreu de Oliveira Samilla Beatriz de Rezende Edson Crusca Oct ávio Luiz F Source Type: research
Treatment of Cutaneous Leishmaniasis lesion caused by Leishmania major Using Leech Therapy in BALB/c Mice
CONCLUSION: Considering the fact that the standard drugs for the treatment of leishmaniasis have many side effects, alternative therapies such as leech therapy can be effectively used to treat these chronic wounds. There are about 20 active substances in leech saliva. These substances include antistasin, eglins, guamerin, hirudin, saratin, bdellins, complement, and carboxypeptidase inhibitors. Leech saliva is an anticoagulant, anti-inflammation and prevents the platelet. Leech therapy was effective in treating leishmaniasis wounds in BALB/c mice. In this study, there was complete wound healing in 56% of the mice models.PMI...
Source: Journal of Vector Borne Diseases - February 15, 2024 Category: Infectious Diseases Authors: Leila Shirani-Bidabadi Source Type: research
A potent candicidal peptide designed based on an encrypted peptide from a proteinase inhibitor
This study extends our knowledge on how AMPs can be engineered from peptides encrypted in larger proteins and their potential as candicidal agents.PMID:38360076 | DOI:10.1016/j.bbagen.2024.130583 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - February 15, 2024 Category: Biochemistry Authors: Lu ís Henrique de Oliveira Almeida Suellen Rodrigues Ramalho Claudiane Vilharroel Almeida Camila de Oliveira Gutierrez Jana ína de Cassia Orlandi Sardi Antonio de Miranda Ricardo Abreu de Oliveira Samilla Beatriz de Rezende Edson Crusca Oct ávio Luiz F Source Type: research
Treatment of Cutaneous Leishmaniasis lesion caused by Leishmania major Using Leech Therapy in BALB/c Mice
CONCLUSION: Considering the fact that the standard drugs for the treatment of leishmaniasis have many side effects, alternative therapies such as leech therapy can be effectively used to treat these chronic wounds. There are about 20 active substances in leech saliva. These substances include antistasin, eglins, guamerin, hirudin, saratin, bdellins, complement, and carboxypeptidase inhibitors. Leech saliva is an anticoagulant, anti-inflammation and prevents the platelet. Leech therapy was effective in treating leishmaniasis wounds in BALB/c mice. In this study, there was complete wound healing in 56% of the mice models.PMI...
Source: Journal of Vector Borne Diseases - February 15, 2024 Category: Infectious Diseases Authors: Leila Shirani-Bidabadi Source Type: research
Risk factors for short-term prognosis of end-stage liver disease complicated by invasive pulmonary aspergillosis
ConclusionsGlucocorticoid exposure, invasive procedures, and broad-spectrum antibiotic exposure increased the risk of IPA in ESLD patients. AmB alone or combined with other antifungals may serve as an economical, safe, and effective treatment option for ESLD-IPA. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 12, 2024 Category: Microbiology Source Type: research
Quinine and chloroquine: potential preclinical candidates for the treatment of tegumentary leishmaniasis
This study aimed at evaluating the susceptibility of Leishmania (L.) amazonensis to chloroquine (CQ) and quinine (QN), alone or in combination with amphotericin B (AFT) and pentamidine (PTN). In the in vitro tests, first, we evaluated the growth inhibition of 50% of promastigotes (IC50) and cytotoxicity for HepG2 and THP-1 cells (CC50). The IC50 values of AFT and PNT were below 1 µM, while the IC50 values of CQ and QN ranged between 4 - 13 µM. Concerning cytotoxicity, CC50 values ranged between 7 and 30 µM for AFT and PNT, and between 22 to 157 µM for the antimalarials. We also calculated the Selectivity Index (SI), wh...
Source: Acta Tropica - February 8, 2024 Category: Infectious Diseases Authors: Norton Rubens Diunior Lucas Pejara Rossi Saara Neri Fialho Aurileya de Jesus Gouveia Am ália Santos Ferreira Minelly Azevedo da Silva Leandro Do Nascimento Martinez Welington da Silva Paula do Nascimento Arlindo Gonzaga Daniel Sol Sol de Medeiros Neuza B Source Type: research
