Pediatric cutaneous mucormicosis
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662994.ABSTRACTA 9-year-old boy diagnosed with acute myeloblastic leukemia and undergoing chemotherapy, was admitted with febrile neutropenia. During his admission, several violaceous plaques appeared on the upper extremities and anterior left hemithorax, which worsened and acquired a necrotic center. We performed a biopsy and histology showed a cutaneous infarction at the dermoepidermal and subcutaneous level. We observed abundant wide hyphae with right-angled branching and a culture isolated Rhizopus oryzae. A plastic surgery consultant performed a surgical debrideme...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Mariana Claudia Matei Sandra Castejon Ramirez Sara Sanz Sanz Tamara Gracia Cazana Concepcion Lopez Gomez Neus Martinez Arnau Matilde Bustillo Alonso Isabel Bernad Alonso Source Type: research
Pediatric cutaneous mucormicosis
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662994.ABSTRACTA 9-year-old boy diagnosed with acute myeloblastic leukemia and undergoing chemotherapy, was admitted with febrile neutropenia. During his admission, several violaceous plaques appeared on the upper extremities and anterior left hemithorax, which worsened and acquired a necrotic center. We performed a biopsy and histology showed a cutaneous infarction at the dermoepidermal and subcutaneous level. We observed abundant wide hyphae with right-angled branching and a culture isolated Rhizopus oryzae. A plastic surgery consultant performed a surgical debrideme...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Mariana Claudia Matei Sandra Castejon Ramirez Sara Sanz Sanz Tamara Gracia Cazana Concepcion Lopez Gomez Neus Martinez Arnau Matilde Bustillo Alonso Isabel Bernad Alonso Source Type: research
Pediatric cutaneous mucormicosis
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662994.ABSTRACTA 9-year-old boy diagnosed with acute myeloblastic leukemia and undergoing chemotherapy, was admitted with febrile neutropenia. During his admission, several violaceous plaques appeared on the upper extremities and anterior left hemithorax, which worsened and acquired a necrotic center. We performed a biopsy and histology showed a cutaneous infarction at the dermoepidermal and subcutaneous level. We observed abundant wide hyphae with right-angled branching and a culture isolated Rhizopus oryzae. A plastic surgery consultant performed a surgical debrideme...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Mariana Claudia Matei Sandra Castejon Ramirez Sara Sanz Sanz Tamara Gracia Cazana Concepcion Lopez Gomez Neus Martinez Arnau Matilde Bustillo Alonso Isabel Bernad Alonso Source Type: research
Pediatric cutaneous mucormicosis
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662994.ABSTRACTA 9-year-old boy diagnosed with acute myeloblastic leukemia and undergoing chemotherapy, was admitted with febrile neutropenia. During his admission, several violaceous plaques appeared on the upper extremities and anterior left hemithorax, which worsened and acquired a necrotic center. We performed a biopsy and histology showed a cutaneous infarction at the dermoepidermal and subcutaneous level. We observed abundant wide hyphae with right-angled branching and a culture isolated Rhizopus oryzae. A plastic surgery consultant performed a surgical debrideme...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Mariana Claudia Matei Sandra Castejon Ramirez Sara Sanz Sanz Tamara Gracia Cazana Concepcion Lopez Gomez Neus Martinez Arnau Matilde Bustillo Alonso Isabel Bernad Alonso Source Type: research
Antimicrobial peptides: A new alternative for the treatment of aspergillosis
Rev Mal Respir. 2024 Mar 7:S0761-8425(24)00141-4. doi: 10.1016/j.rmr.2024.02.011. Online ahead of print.ABSTRACTAspergillus fumigatus is the predominant fungal species causing pulmonary aspergillosis. The present-day anti-aspergillosis arsenal is limited, with a number of molecules occasioning severe side effects (amphotericin B) or provoking significant drug interactions (azole derivatives). Moreover, the recent emergence of azole-resistant A. fumigatus strains is a cause for concern. In this context, antimicrobial peptides (AMPs) are emerging as a promising therapeutic approach and alternative or complement to convention...
Source: Revue des Maladies Respiratoires - March 8, 2024 Category: Respiratory Medicine Authors: C Rochard J Bigot V Balloy C Hennequin J Guitard Source Type: research
Aspergillus niger pneumonia as superinfection in a patient with pulmonary tuberculosis
We report a patient with severe cavitary pulmonary tuberculosis and Aspergillus niger superinfection, whose only comorbidity was untreated diabetes mellitus. A. niger pneumonia was proven by PCR, sequencing and culture of pleural and respiratory secretions. The patient was successfully treated with a four-drug antituberculous regimen, liposomal amphotericin B (up to 5 mg/kg/d) and pleuro-pneumonectomy. Histology of the resected lung revealed destroyed lung tissue with inflammatory cells and fungal conidia. There were large deposits of polarising material, which was found to be calcium oxalate. There was also nodular caseat...
Source: Pneumologie - March 7, 2024 Category: Respiratory Medicine Authors: Santiago Ewig S ören Gatermann Stathis Phillipou Christian Giesa Erich Hecker Source Type: research
Cryptococcal meningitis associated with hydrocephalus in an immunocompetent patient
We present the case of a 67-year-old male who was admitted for subacute symptoms of gait disturbance and urinary incontinence. Neurological examination revealed inability to stand and memory impairment. Cranial imaging showed obstructive tetraventricular hydrocephalus with areas of gliosis in the cerebellar peduncles. Endoscopic treatment of hydrocephalus was performed and cerebrospinal fluid samples taken revealing the growth of Cryptococcus neoformans. The patient improved with the endoscopic treatment and after completing intravenous antifungal therapy with liposomal amphotericin B and fluconazole for ten weeks. Antifun...
Source: Anales del Sistema Sanitario de Navarra - March 7, 2024 Category: General Medicine Authors: Juli án Castro Castro Mar ía Dolores Díaz López Source Type: research
Aspergillus niger pneumonia as superinfection in a patient with pulmonary tuberculosis
We report a patient with severe cavitary pulmonary tuberculosis and Aspergillus niger superinfection, whose only comorbidity was untreated diabetes mellitus. A. niger pneumonia was proven by PCR, sequencing and culture of pleural and respiratory secretions. The patient was successfully treated with a four-drug antituberculous regimen, liposomal amphotericin B (up to 5 mg/kg/d) and pleuro-pneumonectomy. Histology of the resected lung revealed destroyed lung tissue with inflammatory cells and fungal conidia. There were large deposits of polarising material, which was found to be calcium oxalate. There was also nodular caseat...
Source: Pneumologie - March 7, 2024 Category: Respiratory Medicine Authors: Santiago Ewig S ören Gatermann Stathis Phillipou Christian Giesa Erich Hecker Source Type: research
Cryptococcal meningitis associated with hydrocephalus in an immunocompetent patient
We present the case of a 67-year-old male who was admitted for subacute symptoms of gait disturbance and urinary incontinence. Neurological examination revealed inability to stand and memory impairment. Cranial imaging showed obstructive tetraventricular hydrocephalus with areas of gliosis in the cerebellar peduncles. Endoscopic treatment of hydrocephalus was performed and cerebrospinal fluid samples taken revealing the growth of Cryptococcus neoformans. The patient improved with the endoscopic treatment and after completing intravenous antifungal therapy with liposomal amphotericin B and fluconazole for ten weeks. Antifun...
Source: Anales del Sistema Sanitario de Navarra - March 7, 2024 Category: General Medicine Authors: Juli án Castro Castro Mar ía Dolores Díaz López Source Type: research
Aspergillus niger pneumonia as superinfection in a patient with pulmonary tuberculosis
We report a patient with severe cavitary pulmonary tuberculosis and Aspergillus niger superinfection, whose only comorbidity was untreated diabetes mellitus. A. niger pneumonia was proven by PCR, sequencing and culture of pleural and respiratory secretions. The patient was successfully treated with a four-drug antituberculous regimen, liposomal amphotericin B (up to 5 mg/kg/d) and pleuro-pneumonectomy. Histology of the resected lung revealed destroyed lung tissue with inflammatory cells and fungal conidia. There were large deposits of polarising material, which was found to be calcium oxalate. There was also nodular caseat...
Source: Pneumologie - March 7, 2024 Category: Respiratory Medicine Authors: Santiago Ewig S ören Gatermann Stathis Phillipou Christian Giesa Erich Hecker Source Type: research
Cryptococcal meningitis associated with hydrocephalus in an immunocompetent patient
We present the case of a 67-year-old male who was admitted for subacute symptoms of gait disturbance and urinary incontinence. Neurological examination revealed inability to stand and memory impairment. Cranial imaging showed obstructive tetraventricular hydrocephalus with areas of gliosis in the cerebellar peduncles. Endoscopic treatment of hydrocephalus was performed and cerebrospinal fluid samples taken revealing the growth of Cryptococcus neoformans. The patient improved with the endoscopic treatment and after completing intravenous antifungal therapy with liposomal amphotericin B and fluconazole for ten weeks. Antifun...
Source: Anales del Sistema Sanitario de Navarra - March 7, 2024 Category: General Medicine Authors: Juli án Castro Castro Mar ía Dolores Díaz López Source Type: research
Aspergillus niger pneumonia as superinfection in a patient with pulmonary tuberculosis
We report a patient with severe cavitary pulmonary tuberculosis and Aspergillus niger superinfection, whose only comorbidity was untreated diabetes mellitus. A. niger pneumonia was proven by PCR, sequencing and culture of pleural and respiratory secretions. The patient was successfully treated with a four-drug antituberculous regimen, liposomal amphotericin B (up to 5 mg/kg/d) and pleuro-pneumonectomy. Histology of the resected lung revealed destroyed lung tissue with inflammatory cells and fungal conidia. There were large deposits of polarising material, which was found to be calcium oxalate. There was also nodular caseat...
Source: Pneumologie - March 7, 2024 Category: Respiratory Medicine Authors: Santiago Ewig S ören Gatermann Stathis Phillipou Christian Giesa Erich Hecker Source Type: research
