Airway necrosis and granulation tissue formation caused by Rhizopus oryzae leading to severe upper airway obstruction: a case report
Pulmonary Mucormycosis is a fatal infectious disease with high mortality rate. The occurrence of Mucormycosis is commonly related to the fungal virulence and the host’s immunological defenses against pathogens. Mucormycosis infection and granulation tissue formation occurred in the upper airway was rarely reported. This patient was a 60-year-old male with diabetes mellitus, who was admitted to hospital due to progressive cough, sputum and dyspnea. High-resolution computed tomography (HRCT) and bronchoscopy revealed extensive tracheal mucosal necrosis, granulation tissue proliferation, and severe airway stenosis. The muco...
Source: Frontiers in cellular and infection microbiology - March 4, 2024 Category: Microbiology Source Type: research
Molecules, Vol. 29, Pages 1139: Antibacterial and Anticandidal Activity of the Nanostructural Composite of a Spirothiazolidine-Derivative Assembled on Silver Nanoparticles
I. Elsofany
Our aims in this work are the preparation of an ionic liquid based on heterocyclic compounds with Ag nanoparticles and the investigation of its application as an antibacterial and anticandidal agent. These goals were achieved through the fabrication of an ionic liquid based on Ag nanoparticles with 5-Amino-3-(4-fluorophenyl)-N-hexadecyl-7-(4-methylphenyl)-2-H spiro[cyclohexane1,2’-[1,3]thiazolo [4,5-b]pyridine]-6-carbonitrile (P16). The nanostructure of the prepared ionic liquid was characterized using techniques such as FTIR, 1HNMR, 13CNMR, UV, SEM, and TEM. The biological activity of the pre...
Source: Molecules - March 4, 2024 Category: Chemistry Authors: Odeh A. O. Alshammari Eid. M. S. Azzam Munirah S. Alhar Kaseb D. Alanazi Sara A. A. Aljuhani Walaa I. Elsofany Tags: Article Source Type: research
Unleashing the potential of vanillic acid: A new twist on nature's recipe to fight inflammation and circumvent azole-resistant fungal infections
Bioorg Chem. 2024 Mar 1;145:107254. doi: 10.1016/j.bioorg.2024.107254. Online ahead of print.ABSTRACTVanillic acid (VA) - a naturally occurring phenolic compound in plants - is not only used as a flavoring agent but also a prominent metabolite post tea consumption. VA and its associated compounds are believed to play a significant role in preventing diseases, underscoring the need for a systematic investigation. Herein, we report a 4-step synthesis employing the classical organic reactions, such as Willamson's alkylation, Fischer-Spier reaction, and Steglich esterification, complemented with a protection-deprotection strat...
Source: Bioorganic Chemistry - March 3, 2024 Category: Chemistry Authors: Farooq-Ahmad Khan Rimsha Irshad Nimra Tanveer Sana Yaqoob None Razaullah Raza Ali Nida Ali Jafar Saifullah Khwaja Ali Hasan Shahida Naz Abdul Qadir Almas Jabeen Yan Wang Source Type: research
Unleashing the potential of vanillic acid: A new twist on nature's recipe to fight inflammation and circumvent azole-resistant fungal infections
Bioorg Chem. 2024 Mar 1;145:107254. doi: 10.1016/j.bioorg.2024.107254. Online ahead of print.ABSTRACTVanillic acid (VA) - a naturally occurring phenolic compound in plants - is not only used as a flavoring agent but also a prominent metabolite post tea consumption. VA and its associated compounds are believed to play a significant role in preventing diseases, underscoring the need for a systematic investigation. Herein, we report a 4-step synthesis employing the classical organic reactions, such as Willamson's alkylation, Fischer-Spier reaction, and Steglich esterification, complemented with a protection-deprotection strat...
Source: Bioorganic Chemistry - March 3, 2024 Category: Chemistry Authors: Farooq-Ahmad Khan Rimsha Irshad Nimra Tanveer Sana Yaqoob None Razaullah Raza Ali Nida Ali Jafar Saifullah Khwaja Ali Hasan Shahida Naz Abdul Qadir Almas Jabeen Yan Wang Source Type: research
Structural determination and characterisation of the CYP105Q4 cytochrome P450 enzyme from Mycobacterium marinum
Arch Biochem Biophys. 2024 Feb 29:109950. doi: 10.1016/j.abb.2024.109950. Online ahead of print.ABSTRACTThe cytochrome P450 family of heme metalloenzymes (CYPs) catalyze important biological monooxygenation reactions. Mycobacterium marinum contains a gene encoding a CYP105Q4 enzyme of unknown function. Other members of the CYP105 CYP family have key roles in bacterial metabolism including the synthesis of secondary metabolites. We produced and purified the cytochrome P450 enzyme CYP105Q4 to enable its characterization. Several nitrogen-donor atom-containing ligands were found to bind to CYP105Q4 generating type II changes ...
Source: Archives of Biochemistry and Biophysics - March 2, 2024 Category: Biochemistry Authors: Hebatalla Mohamed Stella A Child Daniel Z Doherty John B Bruning Stephen G Bell Source Type: research
Disseminated Leishmaniasis, a Severe Form of Leishmania braziliensis Infection
Emerg Infect Dis. 2024 Mar;30(3):510-518. doi: 10.3201/eid3003.230786.ABSTRACTDisseminated leishmaniasis (DL) is an emergent severe disease manifesting with multiple lesions. To determine the relationship between immune response and clinical and therapeutic outcomes, we studied 101 DL and 101 cutaneous leishmaniasis (CL) cases and determined cytokines and chemokines in supernatants of mononuclear cells stimulated with leishmania antigen. Patients were treated with meglumine antimoniate (20 mg/kg) for 20 days (CL) or 30 days (DL); 19 DL patients were instead treated with amphotericin B, miltefosine, or miltefosine and meglu...
Source: Emerging Infectious Diseases - February 26, 2024 Category: Infectious Diseases Authors: Paulo R L Machado Alexsandro Lago Thiago M Cardoso Andr éa Magalhaes Lucas P Carvalho Tain ã Lago Augusto M Carvalho R úbia Costa Edgar M Carvalho Source Type: research
Disseminated Leishmaniasis, a Severe Form of Leishmania braziliensis Infection
Emerg Infect Dis. 2024 Mar;30(3):510-518. doi: 10.3201/eid3003.230786.ABSTRACTDisseminated leishmaniasis (DL) is an emergent severe disease manifesting with multiple lesions. To determine the relationship between immune response and clinical and therapeutic outcomes, we studied 101 DL and 101 cutaneous leishmaniasis (CL) cases and determined cytokines and chemokines in supernatants of mononuclear cells stimulated with leishmania antigen. Patients were treated with meglumine antimoniate (20 mg/kg) for 20 days (CL) or 30 days (DL); 19 DL patients were instead treated with amphotericin B, miltefosine, or miltefosine and meglu...
Source: Emerging Infectious Diseases - February 26, 2024 Category: Infectious Diseases Authors: Paulo R L Machado Alexsandro Lago Thiago M Cardoso Andr éa Magalhaes Lucas P Carvalho Tain ã Lago Augusto M Carvalho R úbia Costa Edgar M Carvalho Source Type: research
Dissecting the genome sequence of a clinical isolated Cunninghamella bertholletiae Z2 strain with rich cytochrome P450 enzymes (Article)
In this study, we isolated a Cunnignhamella bertholletiae Z2 strain from a skin lesion of a 14 year, 9 months old girl with acute lymphoblastic leukemia who die of infection from the Z2 strain. Genome sequencing was performed after isolation and amplification of the Z2 strain to reveal potential virulence factors and pathogenic mechanisms. The results showed that the genome size of the Z2 strain is 30.9 Mb with 9213 genes. Mucoral specific virulence factor genes found are ARF, CalN, and CoTH, while no gliotoxin biosynthesis gene cluster was found, which is a known virulence factor in Aspergillus fumigatus adapted to the en...
Source: Infection, Genetics and Evolution - February 25, 2024 Category: Genetics & Stem Cells Authors: En-Min Zhou Xin-Ai Chen Ming-Ming Zhou Li-Yao Xu Di Wang He-Ping Shen Wei-Qun Xu Source Type: research
Effectiveness, Tolerability, and Safety of Different Amphotericin B Formulations in Invasive Fungal Infections: A Multicenter, Retrospective, Observational Study
This study aimed to evaluate the effectiveness, tolerability, and safety of different amphotericin B (AMB) intravenously administered in the context of hospital practice for the treatment of invasive fungal infections (IFI) and to provide new insights into the profile of ABLC.METHODS: This is a multicenter, retrospective, observational study conducted at 10 tertiary Brazilian hospitals. Patients first exposed to any formulation of AMB for treating endemic and opportunistic IFI who had received at least 2 intravenous doses were screened. Retrospective data (from January 2014 to December 2019) were extracted from the patient...
Source: Clinical Therapeutics - February 25, 2024 Category: Drugs & Pharmacology Authors: Francelise Bridi Cavassin Marcello Mihailenko Chaves Magri Jose Ernesto Vidal Fabianne Altruda de Moraes Costa Carlesse Diego Rodrigues Falci Jo ão Luís Baú-Carneiro Giovanni Lu ís Breda F ábio de Araújo Motta C ássia Silva de Miranda Godoy Renata Source Type: research
Dissecting the genome sequence of a clinical isolated Cunninghamella bertholletiae Z2 strain with rich cytochrome P450 enzymes (Article)
In this study, we isolated a Cunnignhamella bertholletiae Z2 strain from a skin lesion of a 14 year, 9 months old girl with acute lymphoblastic leukemia who die of infection from the Z2 strain. Genome sequencing was performed after isolation and amplification of the Z2 strain to reveal potential virulence factors and pathogenic mechanisms. The results showed that the genome size of the Z2 strain is 30.9 Mb with 9213 genes. Mucoral specific virulence factor genes found are ARF, CalN, and CoTH, while no gliotoxin biosynthesis gene cluster was found, which is a known virulence factor in Aspergillus fumigatus adapted to the en...
Source: Infection, Genetics and Evolution - February 25, 2024 Category: Genetics & Stem Cells Authors: En-Min Zhou Xin-Ai Chen Ming-Ming Zhou Li-Yao Xu Di Wang He-Ping Shen Wei-Qun Xu Source Type: research
Effectiveness, Tolerability, and Safety of Different Amphotericin B Formulations in Invasive Fungal Infections: A Multicenter, Retrospective, Observational Study
This study aimed to evaluate the effectiveness, tolerability, and safety of different amphotericin B (AMB) intravenously administered in the context of hospital practice for the treatment of invasive fungal infections (IFI) and to provide new insights into the profile of ABLC.METHODS: This is a multicenter, retrospective, observational study conducted at 10 tertiary Brazilian hospitals. Patients first exposed to any formulation of AMB for treating endemic and opportunistic IFI who had received at least 2 intravenous doses were screened. Retrospective data (from January 2014 to December 2019) were extracted from the patient...
Source: Clinical Therapeutics - February 25, 2024 Category: Drugs & Pharmacology Authors: Francelise Bridi Cavassin Marcello Mihailenko Chaves Magri Jose Ernesto Vidal Fabianne Altruda de Moraes Costa Carlesse Diego Rodrigues Falci Jo ão Luís Baú-Carneiro Giovanni Lu ís Breda F ábio de Araújo Motta C ássia Silva de Miranda Godoy Renata Source Type: research
Effectiveness, Tolerability, and Safety of Different Amphotericin B Formulations in Invasive Fungal Infections: A Multicenter, Retrospective, Observational Study
This study aimed to evaluate the effectiveness, tolerability, and safety of different amphotericin B (AMB) intravenously administered in the context of hospital practice for the treatment of invasive fungal infections (IFI) and to provide new insights into the profile of ABLC.METHODS: This is a multicenter, retrospective, observational study conducted at 10 tertiary Brazilian hospitals. Patients first exposed to any formulation of AMB for treating endemic and opportunistic IFI who had received at least 2 intravenous doses were screened. Retrospective data (from January 2014 to December 2019) were extracted from the patient...
Source: Clinical Therapeutics - February 25, 2024 Category: Drugs & Pharmacology Authors: Francelise Bridi Cavassin Marcello Mihailenko Chaves Magri Jose Ernesto Vidal Fabianne Altruda de Moraes Costa Carlesse Diego Rodrigues Falci Jo ão Luís Baú-Carneiro Giovanni Lu ís Breda F ábio de Araújo Motta C ássia Silva de Miranda Godoy Renata Source Type: research
Effectiveness, Tolerability, and Safety of Different Amphotericin B Formulations in Invasive Fungal Infections: A Multicenter, Retrospective, Observational Study
This study aimed to evaluate the effectiveness, tolerability, and safety of different amphotericin B (AMB) intravenously administered in the context of hospital practice for the treatment of invasive fungal infections (IFI) and to provide new insights into the profile of ABLC.METHODS: This is a multicenter, retrospective, observational study conducted at 10 tertiary Brazilian hospitals. Patients first exposed to any formulation of AMB for treating endemic and opportunistic IFI who had received at least 2 intravenous doses were screened. Retrospective data (from January 2014 to December 2019) were extracted from the patient...
Source: Clinical Therapeutics - February 25, 2024 Category: Drugs & Pharmacology Authors: Francelise Bridi Cavassin Marcello Mihailenko Chaves Magri Jose Ernesto Vidal Fabianne Altruda de Moraes Costa Carlesse Diego Rodrigues Falci Jo ão Luís Baú-Carneiro Giovanni Lu ís Breda F ábio de Araújo Motta C ássia Silva de Miranda Godoy Renata Source Type: research
New synthetic molecules incorporated into polymeric micelles used for treatment against visceral leishmaniasis
In conclusion, preliminary data suggest that 3 s/M and 3 t/M could be considered for future studies as therapeutic agents against VL.PMID:38373365 | DOI:10.1016/j.cyto.2024.156543 (Source: Cytokine)
Source: Cytokine - February 19, 2024 Category: Molecular Biology Authors: Camila S Freitas Isabela A G Pereira Daniela P Lage Danniele L Vale Breno L Pimenta N ícia P Soares Samira S Santiago V ívian T Martins Raquel S B C âmara Marcelo M Jesus Grasiele S V Tavares Fernanda F Ramos Fernanda Ludolf L ícia N D Magalhães Fabr Source Type: research
New synthetic molecules incorporated into polymeric micelles used for treatment against visceral leishmaniasis
In conclusion, preliminary data suggest that 3 s/M and 3 t/M could be considered for future studies as therapeutic agents against VL.PMID:38373365 | DOI:10.1016/j.cyto.2024.156543 (Source: Cytokine)
Source: Cytokine - February 19, 2024 Category: Molecular Biology Authors: Camila S Freitas Isabela A G Pereira Daniela P Lage Danniele L Vale Breno L Pimenta N ícia P Soares Samira S Santiago V ívian T Martins Raquel S B C âmara Marcelo M Jesus Grasiele S V Tavares Fernanda F Ramos Fernanda Ludolf L ícia N D Magalhães Fabr Source Type: research
