Gastrointestinal histoplasmosis with small intestinal perforation: 20-year experience
AbstractPostmortem studies show gastrointestinal tract involvement in as many as 70% of patients affected by disseminated histoplasmosis. Although gastrointestinal involvement is common in disseminated disease, the presentation of small intestinal perforation is exceedingly rare with few reported cases in the literature. Herein we present our institutional case series. The aim of the study is to describe small intestinal perforation in gastrointestinal histoplasmosis with attention to management and outcomes. This is a retrospective single-institution review of patients ≥ 18 years of age treated for small intestina...
Source: Updates in Surgery - March 20, 2024 Category: Surgery Source Type: research
Multifunctional Gold Nanozyme ‐Engineered Amphotericin B for Enhanced Antifungal Infection Therapy
Antifungal therapeutic drugs face significant obstacles in clinical application due to inherent toxicity and poor bioavailability. Using Amphotericin B (AmB) as an example, a new strategy is proposed to enhance the bioactivity of small-molecule antifungal drugs based on multifunctional metal nanozyme engineering, which significantly enhanced the antifungal properties of AmB at both in vitro and in vivo levels. AbstractChronic wounds of significant severity and acute injuries are highly vulnerable to fungal infections, drastically impeding the expected wound healing trajectory. The clinical use of antifungal therapeutic dru...
Source: Small - March 19, 2024 Category: Nanotechnology Authors: Chunmei Jiang,
Fangping Li,
Pei Song,
Mengyao Wen,
Saixue Yang,
Geng Tian,
Dongyan Shao,
Junling Shi,
Li Shang Tags: Research Article Source Type: research
Evaluation of the Vitek 2 system for antifungal susceptibility testing of Candida auris using a representative international panel of clinical isolates: overestimation of amphotericin B resistance and underestimation of fluconazole resistance
Journal of Clinical Microbiology, Ahead of Print. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - March 19, 2024 Category: Microbiology Authors: Maria SiopiIoannis PachoulisSevasti LeventakiBram SpruijtenburgJacques F. MeisSpyros PournarasGeorgia VrioniAthanasios TsakrisJoseph Meletiadis1Clinical Microbiology Laboratory, “Attikon” University General Hospital, Medical School, National and Kapod Source Type: research
Economic impact of managing invasive mold disease with isavuconazole compared with liposomal amphotericin B followed by posaconazole in Spain
CONCLUSION: According to the present model, the treatment of IFIs with ISAV would generate savings for the SNS compared to L-AMB→POSA. These savings are attributed to the shorter duration of IV treatment, reduced use of healthcare resources and lower costs associated with managing adverse effects when ISAV was employed.PMID:38494912 | DOI:10.1080/14787210.2024.2327517 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - March 18, 2024 Category: Infectious Diseases Authors: C Moya-Alarc ón J R Azanza J Barber án R Ferrer M Kwon A Moreno C Rubio-Terr és M G álvez-Santisteban Source Type: research
Antifungal therapy for the treatment of CNS infections
AbstractPurpose of reviewA review of existing and emerging therapies for the treatment of fungal infections of the CNS is presented, highlighting more recent studies. Newly authorized and emerging therapies and the data surrounding their use are also introduced.Recent findingsEarly data suggests Ibrexafungerp, a newly released antifungal for the treatment of vulvovaginal candidiasis, does not have a significant role in the treatment of CNS infections. Combination therapy including therapy with terbinafine appears promising for difficult-to-treat fungal infections of the CNS. Antifungal treatment remains pathogen-specific b...
Source: Current Fungal Infection Reports - March 16, 2024 Category: Infectious Diseases Source Type: research
Pulmonary surfactant impacts in vitro activity of selected antifungal drugs against Candida krusei and Candida albicans
ConclusionThis in-vitro study highlights the concentration-dependent inhibitory effect of surfactant on antifungal activity againstC. krusei and, to some extent,C. albicans, necessitating further clinical validation for invasive lung mycoses treatment. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - March 14, 2024 Category: Microbiology Source Type: research
Pediatric cutaneous mucormicosis
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662994.ABSTRACTA 9-year-old boy diagnosed with acute myeloblastic leukemia and undergoing chemotherapy, was admitted with febrile neutropenia. During his admission, several violaceous plaques appeared on the upper extremities and anterior left hemithorax, which worsened and acquired a necrotic center. We performed a biopsy and histology showed a cutaneous infarction at the dermoepidermal and subcutaneous level. We observed abundant wide hyphae with right-angled branching and a culture isolated Rhizopus oryzae. A plastic surgery consultant performed a surgical debrideme...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Mariana Claudia Matei Sandra Castejon Ramirez Sara Sanz Sanz Tamara Gracia Cazana Concepcion Lopez Gomez Neus Martinez Arnau Matilde Bustillo Alonso Isabel Bernad Alonso Source Type: research
Pediatric cutaneous mucormicosis
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662994.ABSTRACTA 9-year-old boy diagnosed with acute myeloblastic leukemia and undergoing chemotherapy, was admitted with febrile neutropenia. During his admission, several violaceous plaques appeared on the upper extremities and anterior left hemithorax, which worsened and acquired a necrotic center. We performed a biopsy and histology showed a cutaneous infarction at the dermoepidermal and subcutaneous level. We observed abundant wide hyphae with right-angled branching and a culture isolated Rhizopus oryzae. A plastic surgery consultant performed a surgical debrideme...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Mariana Claudia Matei Sandra Castejon Ramirez Sara Sanz Sanz Tamara Gracia Cazana Concepcion Lopez Gomez Neus Martinez Arnau Matilde Bustillo Alonso Isabel Bernad Alonso Source Type: research
Pediatric cutaneous mucormicosis
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662994.ABSTRACTA 9-year-old boy diagnosed with acute myeloblastic leukemia and undergoing chemotherapy, was admitted with febrile neutropenia. During his admission, several violaceous plaques appeared on the upper extremities and anterior left hemithorax, which worsened and acquired a necrotic center. We performed a biopsy and histology showed a cutaneous infarction at the dermoepidermal and subcutaneous level. We observed abundant wide hyphae with right-angled branching and a culture isolated Rhizopus oryzae. A plastic surgery consultant performed a surgical debrideme...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Mariana Claudia Matei Sandra Castejon Ramirez Sara Sanz Sanz Tamara Gracia Cazana Concepcion Lopez Gomez Neus Martinez Arnau Matilde Bustillo Alonso Isabel Bernad Alonso Source Type: research
Pediatric cutaneous mucormicosis
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662994.ABSTRACTA 9-year-old boy diagnosed with acute myeloblastic leukemia and undergoing chemotherapy, was admitted with febrile neutropenia. During his admission, several violaceous plaques appeared on the upper extremities and anterior left hemithorax, which worsened and acquired a necrotic center. We performed a biopsy and histology showed a cutaneous infarction at the dermoepidermal and subcutaneous level. We observed abundant wide hyphae with right-angled branching and a culture isolated Rhizopus oryzae. A plastic surgery consultant performed a surgical debrideme...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Mariana Claudia Matei Sandra Castejon Ramirez Sara Sanz Sanz Tamara Gracia Cazana Concepcion Lopez Gomez Neus Martinez Arnau Matilde Bustillo Alonso Isabel Bernad Alonso Source Type: research
Pediatric cutaneous mucormicosis
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662994.ABSTRACTA 9-year-old boy diagnosed with acute myeloblastic leukemia and undergoing chemotherapy, was admitted with febrile neutropenia. During his admission, several violaceous plaques appeared on the upper extremities and anterior left hemithorax, which worsened and acquired a necrotic center. We performed a biopsy and histology showed a cutaneous infarction at the dermoepidermal and subcutaneous level. We observed abundant wide hyphae with right-angled branching and a culture isolated Rhizopus oryzae. A plastic surgery consultant performed a surgical debrideme...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Mariana Claudia Matei Sandra Castejon Ramirez Sara Sanz Sanz Tamara Gracia Cazana Concepcion Lopez Gomez Neus Martinez Arnau Matilde Bustillo Alonso Isabel Bernad Alonso Source Type: research
Pediatric cutaneous mucormicosis
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662994.ABSTRACTA 9-year-old boy diagnosed with acute myeloblastic leukemia and undergoing chemotherapy, was admitted with febrile neutropenia. During his admission, several violaceous plaques appeared on the upper extremities and anterior left hemithorax, which worsened and acquired a necrotic center. We performed a biopsy and histology showed a cutaneous infarction at the dermoepidermal and subcutaneous level. We observed abundant wide hyphae with right-angled branching and a culture isolated Rhizopus oryzae. A plastic surgery consultant performed a surgical debrideme...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Mariana Claudia Matei Sandra Castejon Ramirez Sara Sanz Sanz Tamara Gracia Cazana Concepcion Lopez Gomez Neus Martinez Arnau Matilde Bustillo Alonso Isabel Bernad Alonso Source Type: research
Pediatric cutaneous mucormicosis
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662994.ABSTRACTA 9-year-old boy diagnosed with acute myeloblastic leukemia and undergoing chemotherapy, was admitted with febrile neutropenia. During his admission, several violaceous plaques appeared on the upper extremities and anterior left hemithorax, which worsened and acquired a necrotic center. We performed a biopsy and histology showed a cutaneous infarction at the dermoepidermal and subcutaneous level. We observed abundant wide hyphae with right-angled branching and a culture isolated Rhizopus oryzae. A plastic surgery consultant performed a surgical debrideme...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Mariana Claudia Matei Sandra Castejon Ramirez Sara Sanz Sanz Tamara Gracia Cazana Concepcion Lopez Gomez Neus Martinez Arnau Matilde Bustillo Alonso Isabel Bernad Alonso Source Type: research
