Local amphotericin B therapy for Cutaneous Leishmaniasis: A systematic review
ConclusionsDifferent AmB formulations and administration routes have been explored in preclinical and clinical studies. Developing therapeutic technologies is evident. Current findings might be interpreted as a favorable proof of concept for the local AmB administration which makes this intervention eligible to be explored in future well-designed studies towards less toxic treatments for leishmaniasis. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 16, 2024 Category: Tropical Medicine Authors: L índicy Leidicy Alves Source Type: research
Post-kala-azar dermal leishmaniasis (PKDL) drug efficacy study landscape: A systematic scoping review of clinical trials and observational studies to assess the feasibility of establishing an individual participant-level data (IPD) platform
ConclusionsOur review identified studies with very limited sample size for the three major drugs (miltefosine, L-AmB, and pentavalent antimony), while the number of patients combined across studies suggest that the IPD platform would be valuable. With the support of relevant stakeholders, the global PKDL community and sufficient financing, a PKDL IPD platform can be realised. This will allow for exploration of different aspects of treatment safety and efficacy, which can potentially guide future healthcare decisions and clinical practices. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 16, 2024 Category: Tropical Medicine Authors: Sauman Singh-Phulgenda Source Type: research
Redox homeostasis in human renal cells that had been treated with amphotericin B in combination with selected 1,3,4-thiadiazole derivatives
CONCLUSIONS: The results confirmed that thiadiazoles can stimulate the RPTEC cells to defend against the oxidative stress that is generated by AmB. In addition, together with the previously demonstrated synergistic antifungal activity, and low nephrotoxicity, these compounds have the potential to be used in new therapeutic strategies in the treatment of fungal infections.PMID:38587587 | DOI:10.1007/s43440-024-00592-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 8, 2024 Category: Drugs & Pharmacology Authors: Magdalena Kimsa-Dudek Celina Kruszniewska-Rajs Jolanta Adamska Barbara Strza łka-Mrozik Arkadiusz Matwijczuk Dariusz Karcz Mariusz Gago ś Joanna Magdalena Gola Source Type: research
Redox homeostasis in human renal cells that had been treated with amphotericin B in combination with selected 1,3,4-thiadiazole derivatives
CONCLUSIONS: The results confirmed that thiadiazoles can stimulate the RPTEC cells to defend against the oxidative stress that is generated by AmB. In addition, together with the previously demonstrated synergistic antifungal activity, and low nephrotoxicity, these compounds have the potential to be used in new therapeutic strategies in the treatment of fungal infections.PMID:38587587 | DOI:10.1007/s43440-024-00592-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 8, 2024 Category: Drugs & Pharmacology Authors: Magdalena Kimsa-Dudek Celina Kruszniewska-Rajs Jolanta Adamska Barbara Strza łka-Mrozik Arkadiusz Matwijczuk Dariusz Karcz Mariusz Gago ś Joanna Magdalena Gola Source Type: research
Redox homeostasis in human renal cells that had been treated with amphotericin B in combination with selected 1,3,4-thiadiazole derivatives
CONCLUSIONS: The results confirmed that thiadiazoles can stimulate the RPTEC cells to defend against the oxidative stress that is generated by AmB. In addition, together with the previously demonstrated synergistic antifungal activity, and low nephrotoxicity, these compounds have the potential to be used in new therapeutic strategies in the treatment of fungal infections.PMID:38587587 | DOI:10.1007/s43440-024-00592-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 8, 2024 Category: Drugs & Pharmacology Authors: Magdalena Kimsa-Dudek Celina Kruszniewska-Rajs Jolanta Adamska Barbara Strza łka-Mrozik Arkadiusz Matwijczuk Dariusz Karcz Mariusz Gago ś Joanna Magdalena Gola Source Type: research
Successful Treatment of Severe Aplastic Anemia with Hematopoietic Stem Cell Transplantation in the Setting of Active Mucormycosis
AbstractSevere aplastic anemia (SAA) is a life-threatening hematological disease characterized by the suppression of the bone marrow. Patients with SAA are predisposed to recurrent bacterial infections and invasive fungal infections (IFI) due to profound and persistent neutropenia. Mucorales are the second most common cause of IFI encountered in SAA. Here we present a pediatric case of SAA with active mucormycosis infection of the paranasal sinuses. In the first step, surgical debridement was performed and combined antifungal therapy (liposomal amphotericin B, posaconazole, caspofungin) was started. Due to severe neutropen...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 4, 2024 Category: ENT & OMF Source Type: research
Construction and docking studies of novel pyrimido[4,5-b]quinolines as antimicrobial agents
Chem Biodivers. 2024 Apr 3:e202400200. doi: 10.1002/cbdv.202400200. Online ahead of print.ABSTRACTIn order to develop novel antimicrobial agents, we prepared quinoline bearing pyrimidine analogues 2-7, 8a-d and 9a-d and their structures were elucidated by spectroscopic techniques. Furthermore, our second aim was to predict the interactions between the active compounds and enzymes (DNA gyrase and DHFR). In this work, fourteen pyrimido[4,5-b]quinoline derivatives were prepared and assessed for their antimicrobial potential by estimating zone of inhibition. All the screened candidates displayed antibacterial potential with zo...
Source: Chemistry and Biodiversity - April 3, 2024 Category: Biochemistry Authors: Rania Bakr Islam Helmy Nadia Elkanzi Source Type: research
Synergistic Action of Synthetic Peptides and Amphotericin B Causes Disruption of the Plasma Membrane and Cell Wall in Candida albicans
The objective of this work was to evaluate the combination of synthetic peptides based on the γ-core motif of defensin PvD1 with amphotericin B (AmB) at different concentrations against C. albicans. We applied the checkerboard assay using different concentrations of the commercial drug AmB and the synthetic peptides γ31-45PvD1++ and γ33-41PvD1++ against C. albicans, aiming to find combinations with synergistic interactions. Between these two interactions involving γ31-45PvD1++ and AmB, an additive effect was observed. One such interaction occurred at concentrations of 0.009 µM of peptide γ31-45PvD1++ and 13.23 µM of...
Source: Bioscience Reports - April 2, 2024 Category: Biomedical Science Authors: Thayna Souza Erica Mello Gabriel B Taveira Felipe Moreira S érgio Henrique Seabra Andr é O Carvalho Valdirene M Gomes Source Type: research
Synergistic Action of Synthetic Peptides and Amphotericin B Causes Disruption of the Plasma Membrane and Cell Wall in Candida albicans
The objective of this work was to evaluate the combination of synthetic peptides based on the γ-core motif of defensin PvD1 with amphotericin B (AmB) at different concentrations against C. albicans. We applied the checkerboard assay using different concentrations of the commercial drug AmB and the synthetic peptides γ31-45PvD1++ and γ33-41PvD1++ against C. albicans, aiming to find combinations with synergistic interactions. Between these two interactions involving γ31-45PvD1++ and AmB, an additive effect was observed. One such interaction occurred at concentrations of 0.009 µM of peptide γ31-45PvD1++ and 13.23 µM of...
Source: Bioscience Reports - April 2, 2024 Category: Biomedical Science Authors: Thayna Souza Erica Mello Gabriel B Taveira Felipe Moreira S érgio Henrique Seabra Andr é O Carvalho Valdirene M Gomes Source Type: research
Ibrexafungerp is efficacious in a neutropenic murine model of pulmonary mucormycosis as monotherapy and combined with liposomal amphotericin B
Antimicrob Agents Chemother. 2024 Apr 1:e0154523. doi: 10.1128/aac.01545-23. Online ahead of print.ABSTRACTIbrexafungerp (formerly SCY-078) is the first member of the triterpenoid class that prevents the synthesis of the fungal cell wall polymer β-(1,3)-D-glucan by inhibiting the enzyme glucan synthase. We evaluated the in vivo efficacy of ibrexafungerp against pulmonary mucormycosis using an established murine model. Neutropenic mice were intratracheally infected with either Rhizopus delemar or Mucor circinelloides. Treatment with placebo (diluent control), ibrexafungerp (30 mg/kg, PO BID), liposomal amphotericin B (LAMB...
Source: Antimicrobial Agents and Chemotherapy - April 1, 2024 Category: Microbiology Authors: Teclegiorgis Gebremariam Sondus Alkhazraji Yiyou Gu Laura K Najvar Katyna Borroto-Esoda Thomas F Patterson Scott G Filler Nathan P Wiederhold Ashraf S Ibrahim Source Type: research
Ibrexafungerp is efficacious in a neutropenic murine model of pulmonary mucormycosis as monotherapy and combined with liposomal amphotericin B
Antimicrob Agents Chemother. 2024 Apr 1:e0154523. doi: 10.1128/aac.01545-23. Online ahead of print.ABSTRACTIbrexafungerp (formerly SCY-078) is the first member of the triterpenoid class that prevents the synthesis of the fungal cell wall polymer β-(1,3)-D-glucan by inhibiting the enzyme glucan synthase. We evaluated the in vivo efficacy of ibrexafungerp against pulmonary mucormycosis using an established murine model. Neutropenic mice were intratracheally infected with either Rhizopus delemar or Mucor circinelloides. Treatment with placebo (diluent control), ibrexafungerp (30 mg/kg, PO BID), liposomal amphotericin B (LAMB...
Source: Antimicrobial Agents and Chemotherapy - April 1, 2024 Category: Microbiology Authors: Teclegiorgis Gebremariam Sondus Alkhazraji Yiyou Gu Laura K Najvar Katyna Borroto-Esoda Thomas F Patterson Scott G Filler Nathan P Wiederhold Ashraf S Ibrahim Source Type: research
Aerosolized Antifungals for the Treatment of Pulmonary Fungal Diseases
AbstractPurpose of ReviewInhaled antifungals achieve high lung concentrations with minimal systemic adverse events. Despite being available for over five decades, data supporting their use outside the mold-active prophylaxis setting are lacking. Herein, we review the recent evidence on inhaled antifungals in treating pulmonary aspergillosis (allergic, chronic, and invasive) and mucormycosis.Recent FindingsSeveral antifungals have recently been evaluated, including repurposed and newer inhaled agents (opelconazole). Inhaled amphotericin B deoxycholate (in pulmonary mucormycosis) and liposomal formulation (in invasive asperg...
Source: Current Fungal Infection Reports - April 1, 2024 Category: Infectious Diseases Source Type: research
Intrapleural Amphotericin B for Aspergillus Empyema After Lung Transplantation
Introduction: Aspergillus empyema occurs rarely after lung transplantation and there is no standard approach to treatment. Adequate drug penetration to the pleural space has been described for systemic voriconazole and micafungin. Clinical and microbiologic cure was achieved in 3 cases of non-transplant patients with systemic voriconazole plus caspofungin and intrapleural amphotericin. Here we present a case of aspergillus empyema treated with intrapleural amphotericin B post lung transplant. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: A. Driver, , R. Wright, N. Partovi, J. Choi, J. Costa, R. Levy, R. Nador, C. Bergeron, A. Kapasi, J. Samuels, J. Wilson, J. Yee Source Type: research
Antimicrobial activity of essential oils against biofilms formed in dental acrylic resin: a systematic review of < em > in vitro < /em > studies
In conclusion, the EOs of C. zeylanicum, C. citratus, C. nardus, and M. alternifolia showed antimicrobial activity to reduce biofilm on dental acrylic resin.PMID:38538551 | DOI:10.1080/08927014.2024.2332709 (Source: Biofouling)
Source: Biofouling - March 27, 2024 Category: Molecular Biology Authors: Jo ão Marcos Carvalho-Silva Ana Beatriz Vilela Teixeira Mariana Lima da Costa Valente Marcos Vinicius Wada Shimano Andr éa Cândido Dos Reis Source Type: research
Antimicrobial activity of essential oils against biofilms formed in dental acrylic resin: a systematic review of < em > in vitro < /em > studies
In conclusion, the EOs of C. zeylanicum, C. citratus, C. nardus, and M. alternifolia showed antimicrobial activity to reduce biofilm on dental acrylic resin.PMID:38538551 | DOI:10.1080/08927014.2024.2332709 (Source: Biofouling)
Source: Biofouling - March 27, 2024 Category: Molecular Biology Authors: Jo ão Marcos Carvalho-Silva Ana Beatriz Vilela Teixeira Mariana Lima da Costa Valente Marcos Vinicius Wada Shimano Andr éa Cândido Dos Reis Source Type: research
