Unlocking the mystery behind skeletal aging

This study is the first in vivo research to demonstrate that the loss of an epigenetic factor promotes adult stem cell deterioration and exhaustion in skeletal aging.The findings, the researchers say, hold promise for the eventual development of strategies to reverse bone-fat imbalance, as well as for new prevention and treatment methods that address skeletal aging and osteoporosis by rejuvenating adult stem cells.“The work of Dr. Wang, his lab members and collaborators provides new molecular insight into the changes associated with skeletal aging,” said Dr. Paul Krebsbach, dean of the UCLA School of Dentistry.“These findings are an important step towards what may lead to more effective treatment for the millions of people who suffer from bone loss and osteoporosis. ”The work was supported by grants from the National Institute of Dental and Craniofacial Research (part of the National Institutes of Health), the UCLA Clinical and Translational Science Institute and the Hsien Family Foundation charitable funds.Dr. Wang is also a member of the UCLA Jonsson Comprehensive Cancer Center, the UCLA Samueli School of Engineering and Eli and Edyth Broad Center of Regenerative Medicine and Stem Cell Research at UCLA.Additional authors include Dr. Peng Deng, Quan Yuan, Yingduan Cheng, Jiong Li, Zhenqing Liu, Yan Liu, Mari Ekimyan Salvo and Ye Li, all of the Laboratory of Molecular Signaling at the UCLA School of Dentistry; Trent Su of the UCLA Department of Biological Chemistry; J...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news