Effect of Superior Ovarian Nerve and Plexus Nerve Sympathetic Denervation on Ovarian-Derived Infertility Provoked by Estradiol Exposure to Rats

This study was supported by grants from GSK/Galvani Bioelectronics to AS and HL and Fondecyt 1170291 (to HL). Conflict of Interest Statement AS and JW are employees of Galvani Bioelectronics, a for-profit company. The authors declare that the study was funded by Galvani Bioelectronics and Fondecyt 1170291. HL along with AS and JW (employees of Galvani Bioelectronics) were involved in the design of the study, interpretation of the results. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. References Barria, A., Leyton, V., Ojeda, S. R., and Lara, H. E. (1993). Ovarian steroidal response to gonadotropins and beta-adrenergic stimulation is enhanced in polycystic ovary syndrome: role of sympathetic innervation. Endocrinology 133, 2696–2703. doi: 10.1210/endo.133.6.8243293 PubMed Abstract | CrossRef Full Text | Google Scholar Bernuci, M. P., Szawka, R. E., Helena, C. V., Leite, C. M., Lara, H. E., and Anselmo-Franci, J. A. (2008). Locus coeruleus mediates cold stress-induced polycystic ovary in rats. Endocrinology 149, 2907–2916. doi: 10.1210/en.2007-1254 PubMed Abstract | CrossRef Full Text | Google Scholar Brawer, J. R., Munoz, M., and Farookhi, R. (1986). Development of the polycystic ovarian condition (PCO) in the estradiol valerate-treated rat. Biol. Reprod. 35, 647–655. doi: 10.1095/biolreprod35.3.647 Pu...
Source: Frontiers in Physiology - Category: Physiology Source Type: research