The role of long non-coding RNA AFAP1-AS1 in human malignant tumors
ConclusionsA series of studies provide detailed information to understand lncRNA AFAP1-AS1 role in various human cancers. LncRNA AFAP1-AS1 is an oncogene in tumors that have been studied so far, and it may act as a useful tumor biomarker and therapeutic target.
Publication date: Available online 3 June 2020Source: Journal of the American College of RadiologyAuthor(s): Ruth C. Carlos, Katy Lowry, Gelareh Sadigh
Conclusion. The proposed nomogram obtained more precision prognostic prediction for patients with initially-diagnosed primary spinal and pelvic tumors. Level of Evidence: 3
Study Design.. A meta-analysis. Objective.. The goal of this study was to accurately evaluate the risk ratio (RR) of recurrence in chordoma patients with wide margin after removing the tumors using surgery, compared with inadequate margin (intralesional or marginal). Summary of Background Data.. As a rare malignant bone cancer, the more effective treatment for sacral chordoma is still surgical resection. However, there is no convincing evidence and risk ratio about sacral chordoma patients would be benefit from which kind of surgical margin. Methods.. We searched the PubMed, Cochrane Library, Web of Science, and...
Conclusion. Patients with positive surgical margins benefit from adjuvant RT. Optimal OS is associated with adjuvant RT administered with advanced techniques and cumulative dose more than 65 Gy. Level of Evidence: 4
Authors: Carkic J, Nikolic N, Nisevic J, Lazarevic M, Kuzmanovic-Pficer J, Jelovac D, Milasin J Abstract Oral carcinoma is the sixth most common malignancy worldwide, with survival rates of approximately 50%. The major type of oral cancer, present in 90% of the cases, is oral squamous cell carcinoma (OSCC). The genetic background predisposing an individual to OSCC is complex and largely unknown. Studies have suggested that endothelial nitric oxide synthase (eNOS) gene polymorphisms modulate the cancer risk, prompting us to assess the impact of three functional eNOS gene polymorphisms on OSCC risk. The present study...
Purpose of review Genome instability has long been implicated as a primary causal factor in cancer and diseases of aging. The genome is constantly under attack from extrinsic and intrinsic damaging agents. Uracil misincorporation in DNA and its repair is an intrinsic factor resulting in genomic instability and DNA mutations. Additionally, the presence of uracil in DNA can modify gene expression by interfering with promoter binding and transcription inhibition or upregulation of apoptotic proteins. In immune cells, uracil in DNA drives beneficial genomic diversity for antigen-driven immunity. This review addresses disease...
Publication date: Available online 5 June 2020Source: Journal of the Formosan Medical AssociationAuthor(s): Po-Ting Lin, Wei Teng, Wen-Juei Jeng, Chun-Yen Lin
Conclusion: Both ESTD and ESD are safe and effective therapies for early-stage esophageal cancer wider than or equal to one half the esophageal circumference. The dissection speed of ESTD is faster than that of ESD.
CONCLUSION: A hybrid robotic transanal minimally invasive surgery approach allows for complete resection of very large polyps, which would otherwise be extremely challenging with standard transanal approaches. See Video at http://links.lww.com/DCR/B231.
No abstract available
More News: Academia | Adenocarcinoma | Bile Duct Cancer | Breast Cancer | Breast Carcinoma | Cancer | Cancer & Oncology | Carcinoma | Cholangiocarcinoma | Colorectal Cancer | Databases & Libraries | Esophagus Cancer | Eye Cancers | Gallbladder Cancer | Gastric (Stomach) Cancer | Gastroenterology | Genetics | Hepatocellular Carcinoma | Laryngeal Cancer | Liver Cancer | Lung Cancer | Molecular Biology | Nasopharyngeal Cancer | Ovarian Cancer | Ovaries | Pancreas | Pancreatic Cancer | Pathology | Retinoblastoma | Skin Cancer | Squamous Cell Carcinoma | Study | Thyroid | Thyroid Cancer