Hot Topics in Neuroscience: Is Electroconvulsive Therapy a Treatment for Depression Following Traumatic Brain Injury?

Conclusion TBI is a distinct and complex pathophysiological entity. Neurocognitive deficits and mood disorders are common sequelae of TBI. While nonmodifiable factors influence risk of developing post-TBI depression, there is also evidence that biological factors are involved. People who have suffered TBI are at increased risk for ictal events and cognitive impairment. ECT has been documented to successfully treat patients with post-TBI mood symptoms in only three published cases. While these vignettes suggest that ECT might be a safe and effective therapeutic option in treating individuals with post-TBI depression, more research is needed to establish its safety and beneficial clinical outcomes among this patient population. References  Dmirtas-Tatlidede A, Vahabzadeh-Hagh AM, Bernabeu M, et al. Noninvasive brain stimulation in traumatic brain injury. J Head Trauma Rehabil. 2012;27(4):274. Von Baumgarten L, Trabold R, Thal S, et al. Role of cortical spreading depressions for secondary brain damage after traumatic brain injury in mice. J Cereb Blood Flow Metab. 2008;28(7):1353–1360. Licastro F, Hrelia S, Porcellini E, et al. Peripheral inflammatory markers and antioxidant response during the post-acute and chronic phase after severe traumatic brain injury. Front Neurol. 2016. 7:189. Wang KK, Yang Z, Yue JK, et al. Plasma anti-glial fibrillary acidic protein autoantibody levels during the acute and chronic phases of traumatic brain injury: a transforming research and clini...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Hot Topics in Neuroscience depression ECT Electroconvulsive therapy mood disorders TBI traumatic brain injury treatments Source Type: research