Relapse prevention interventions for smoking cessation
Updated review found that behavioural interventions provided no worthwhile benefit in preventing relapse in assisted abstainers. Moderate certainty evidence suggests that extended treatment with varenicline but not bupropion helped to prevent relapse. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 21, 2020 Category: Consumer Health News Source Type: news

Contrave Boosts Weight Loss in Diabetes Patients on Incretins Contrave Boosts Weight Loss in Diabetes Patients on Incretins
Naltrexone/bupropion added to a GLP-1 agonist or a DPP-4 inhibitor is a reasonable option for weight loss in patients with obesity and type 2 diabetes, a study suggests.Medscape Medical News (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - June 30, 2020 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news

Antidepressant Fails to Improve Apathy in Dementia Patients Antidepressant Fails to Improve Apathy in Dementia Patients
The antidepressant bupropion was no better than placebo in reducing apathy in nondepressed patients with Alzheimer-type dementia in a randomized controlled trial.Medscape Medical News (Source: Medscape FamilyMedicine Headlines)
Source: Medscape FamilyMedicine Headlines - May 29, 2020 Category: Primary Care Tags: Psychiatry News Source Type: news

International Laboratories, LLC Issues Voluntary Nationwide Recall of One (1) Lot of Pravastatin Sodium Tablets USP, 40mg Packaged in Bottles of 30 Tablets Due to Mislabeling NDC # 54458-925-16; Lot # 115698A
International Laboratories, LLC is voluntarily recalling one (1) Lot of Pravastatin Sodium Tablets USP 40 mg packaged in bottles of 30 tablets, to the consumer level due to mislabeling. The product is labeled as Pravastatin Sodium Tablets USP 40 mg but contained Bupropion Hydrochloride XL 300 mg tablets. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - May 21, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Serotonin toxicity from isolated bupropion overdoses - Sidlak AM, Koivisto KO, Marino RT, Abesamis MG.
Background: Bupropion is a synthetic cathinone, which acts therapeutically through norepinephrine and dopamine reuptake inhibition. Recent evidence suggests that serotonin receptor activation occurs with high doses of bupropion and severe serotonin ... (Source: SafetyLit)
Source: SafetyLit - April 21, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Buproprion associated seizures following acute overdose: who develops late seizures - Offerman S, Gosen J, Thomas SH, Padilla-Jones A, Ruha AM, Levine M.
Objectives: Bupropion is an antidepressant that is commonly known to cause seizures in overdose. Because of concern for delayed onset of seizures, patients are frequently observed for prolonged periods after overdose. The primary objective is to eva... (Source: SafetyLit)
Source: SafetyLit - March 30, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Wellbutrin (bupropion)
Title: Wellbutrin (bupropion)Category: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 2/12/2020 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - February 12, 2020 Category: Drugs & Pharmacology Source Type: news

Clinical characteristics and outcomes associated with bupropion overdose: a Canadian perspective - Stewart E, Grewal K, Hudson H, Thompson M, Godwin J.
Background: Therapeutic use, overdose and recreational abuse of bupropion are increasing. The purpose of this study was to describe the incidence and outcomes of bupropion exposures reported to the Ontario Poison Centre in Canada, and to identify pr... (Source: SafetyLit)
Source: SafetyLit - December 16, 2019 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Drug safety update: Naltrexone/bupropion (Mysimba)
The Medicines and Healthcare products Regulatory Agency (MHRA) has issued a drug safety update that patients should be advised that naltrexone/bupropion has been associated with adverse reactions such (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - August 20, 2019 Category: Drugs & Pharmacology Source Type: news

Toxicity of bupropion overdose compared with selective serotonin reuptake inhibitors - Overberg A, Morton S, Wagner E, Froberg B.
OBJECTIVES: Adolescent depression and attempted and completed suicide are increasing in the United States. Because suicide is often impulsive, the means of self-harm are frequently items of convenience like medication. Authors of a recent study compared tr... (Source: SafetyLit)
Source: SafetyLit - July 8, 2019 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Zoloft (sertraline) vs. Wellbutrin (bupropion)
Title: Zoloft (sertraline) vs. Wellbutrin (bupropion)Category: MedicationsCreated: 6/27/2019 12:00:00 AMLast Editorial Review: 6/27/2019 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - June 27, 2019 Category: Drugs & Pharmacology Source Type: news

Methaemoglobinemia induced by poppers and bupropion intoxication in the emergency department - Batista F, Alves C, Trindade M, Duarte JA, Marques R.
A 40-year-old man presented to the emergency department with dyspnoea and fatigue after bupropion and popper consumption. Clinical examination was remarkable for central cyanosis not responding to supplementary oxygen. Arterial blood gas analysis showed a ... (Source: SafetyLit)
Source: SafetyLit - April 3, 2019 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

bupropion extended release (Forfivo XL)
Title: bupropion extended release (Forfivo XL)Category: MedicationsCreated: 10/16/2013 12:00:00 AMLast Editorial Review: 3/13/2019 12:00:00 AM (Source: MedicineNet Depression General)
Source: MedicineNet Depression General - March 13, 2019 Category: Psychiatry Source Type: news

Smoking During Pregnancy Doubles Risk Of Sudden Death For Baby, Study Says
(CNN) — Smoking even one cigarette a day during pregnancy can double the chance of sudden unexpected death for your baby, according to a new study analyzing over 20 million births, including over 19,000 unexpected infant deaths. The study, published Monday in the journal Pediatrics, analyzed data on smoking during pregnancy from the US Centers for Disease Control and Prevention’s birth/infant death data set between 2007 and 2011 and found that the risk of death rises by .07 for each additional cigarette smoked, up to 20 a day, a typical pack of cigarettes. By the time you smoke a pack a day, the study found, yo...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - March 11, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Cigarettes Pregnancy Smoking Source Type: news

Antidepressant shortage alarms Saskatchewan patients with mental illnesses
The shortage in Canada of bupropion, a popular prescription antidepressant, has been stressful for patients with mental illnesses and the people who care for them. (Source: CBC | Health)
Source: CBC | Health - November 18, 2018 Category: Consumer Health News Tags: News/Canada/Saskatchewan Source Type: news

Shortage of antidepressant 'in a class all on its own' alarms patients with mental illnesses
The shortage in Canada of bupropion, a popular prescription antidepressant, has been stressful for patients with mental illnesses and the people who care for them. (Source: CBC | Health)
Source: CBC | Health - November 18, 2018 Category: Consumer Health News Tags: News/Canada/Saskatchewan Source Type: news

Which Drugs Work Best for ADHD? Large Study Zeroes in on Two
The researchers compared seven ADHD drugs -- amphetamines (including lisdexamfetamine), atomoxetine, bupropion, clonidine, guanfacine, methylphenidate and modafinil -- and a placebo over 12 weeks of treatment. (Source: WebMD Health)
Source: WebMD Health - August 8, 2018 Category: Consumer Health News Source Type: news

Rapid Bupropion-induced Hepatotoxicity Rapid Bupropion-induced Hepatotoxicity
This case demonstrates the rare, but potentially serious possibility of idiosyncratic bupropion-induced hepatotoxicity.Journal of Medical Case Reports (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 23, 2018 Category: Consumer Health News Tags: Internal Medicine Journal Article Source Type: news

La FDA revisa la descripci ón de los efectos secundarios para la salud mental de los medicamentos para dejar de fumar Chantix (vareniclina) y Zyban (bupropión) para reflejar las conclusiones de estudio clínico
FDA revises description of mental health side effects of the stop-smoking medicines Chantix (varenicline) and Zyban (bupropion) to reflect clinical trial findings (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - March 8, 2018 Category: Drugs & Pharmacology Source Type: news

La FDA revisa la descripci ó n de los efectos secundarios para la salud mental de los medicamentos para dejar de fumar Chantix (vareniclina) y Zyban (bupropi ó n) para reflejar las conclusiones de estudio cl í nico
FDA revises description of mental health side effects of the stop-smoking medicines Chantix (varenicline) and Zyban (bupropion) to reflect clinical trial findings (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - March 8, 2018 Category: Drugs & Pharmacology Source Type: news

FDA Drug Safety Communication: FDA revises description of mental health side effects of the stop-smoking medicines Chantix (varenicline) and Zyban (bupropion) to reflect clinical trial findings
An FDA review found the side effects on mood, behavior, or thinking with the stop-smoking medicines Chantix (varenicline) and Zyban (bupropion) are lower than previously suspected. These risks still exist, but we believe the benefits of quitting smoking outweigh them. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - March 8, 2018 Category: Drugs & Pharmacology Source Type: news

bupropion (Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zyban, Aplenzin, Fortivo XL, Zyban)
Title: bupropion (Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zyban, Aplenzin, Fortivo XL, Zyban)Category: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 11/7/2017 12:00:00 AM (Source: MedicineNet Depression General)
Source: MedicineNet Depression General - November 7, 2017 Category: Psychiatry Source Type: news

Suicidal bupropion ingestions in adolescents: increased morbidity compared with other antidepressants - Sheridan DC, Lin A, Zane Horowitz B.
The objective of this study was to compare outcomes in adolescent su... (Source: SafetyLit)
Source: SafetyLit - September 30, 2017 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Pravastatin Recalled Over Bupropion Mix-Up (FREE)
By the Editors One lot of pravastatin tablets (40 mg, 30-tablet bottles) manufactured by International Laboratories, LLC has … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - August 14, 2017 Category: Primary Care Source Type: news

International Laboratories, LLC Issues Voluntary Nationwide Recall of One (1) Lot of Pravastatin Sodium Tablets USP, 40mg Packaged in Bottles of 30 Tablets Due to Mislabeling NDC # 54458-925-16; Lot # 115698A
International Laboratories, LLC is voluntarily recalling one (1) Lot of Pravastatin Sodium Tablets USP 40 mg packaged in bottles of 30 tablets, to the consumer level due to mislabeling. The product is labeled as Pravastatin Sodium Tablets USP 40 mg but contained Bupropion Hydrochloride XL 300 mg tablets. (Source: Food and Drug Administration)
Source: Food and Drug Administration - August 10, 2017 Category: Food Science Source Type: news

For Treatment-Resistant Depression, Add an Antipsychotic or Switch Antidepressants? (FREE)
By Amy Orciari Herman Edited by David G. Fairchild, MD, MPH, and Lorenzo Di Francesco, MD, FACP, FHM For patients with depression unresponsive to antidepressants, adding the antipsychotic aripiprazole seems modestly better than switching to the antidepressant bupropion, a JAMA study … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - July 12, 2017 Category: Primary Care Source Type: news

Study compares switching meds vs. an additional med for patients unresponsive to an antidepressant
(The JAMA Network Journals) Among patients unresponsive to an antidepressant medication, adding the antipsychotic aripiprazole modestly increased the likelihood of remission from depression compared to switching to the antidepressant bupropion, according to a study published by JAMA. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - July 11, 2017 Category: International Medicine & Public Health Source Type: news

Cocaine abuse, traumatic brain injury, and preexisting brain lesions as risk factors for bupropion-associated psychosis - Barman R, Kumar S, Pagadala B, Detweiler MB.
BACKGROUND AND OBJECTIVE: Bupropion is generally considered safe and is widely used both as a monotherapy and as an augmentation agent for the treatment of major depression. Concerns have been raised about bupropion's propensity to precipitate new psychosi... (Source: SafetyLit)
Source: SafetyLit - June 9, 2017 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Orexigen Therapeutics Announces Commercialization and Distributorship Arrangement with Navamedic ASA for Mysimba(R) (naltrexone HCl / bupropion HCl prolonged release) in Five Nordic Countries
SAN DIEGO, May 2, 2017 -- (Healthcare Sales & Marketing Network) -- Orexigen Therapeutics, Inc. (NASDAQ: OREX) today announced that its wholly owned subsidiary, Orexigen Therapeutics Ireland Ltd., and Navamedic AB, an affiliate of Navamedic ASA (Oslo:NAVA... Biopharmaceuticals, Distribution Orexigen Therapeutics, Navamedic AB, Mysimba, naltrexone, bupropion (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - May 2, 2017 Category: Pharmaceuticals Source Type: news

Budeprion XL (Bupropion Hydrochloride Extended-Release Tablets) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - February 8, 2017 Category: Drugs & Pharmacology Source Type: news

Smoking-Cessation Meds, Counseling Work in Patients With CVD Smoking-Cessation Meds, Counseling Work in Patients With CVD
In contrast with some earlier research, a meta-analysis found that varenicline and bupropion along with counseling by phone or in person all seem effective in patients with cardiovascular disease.Heartwire from Medscape (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 24, 2017 Category: Consumer Health News Tags: Cardiology News Source Type: news

Aplenzin (Bupropion Hydrobromide Tablet) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - January 11, 2017 Category: Drugs & Pharmacology Source Type: news

Contrave (Naltrexone HCl and Bupropion HCl Extended-Release Tablets) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - January 11, 2017 Category: Drugs & Pharmacology Source Type: news

La FDA revisa la descripci ó n de los efectos secundarios para la salud mental de los medicamentos para dejar de fumar Chantix (vareniclina) y Zyban (bupropi ó n) para reflejar las conclusiones de estudio cl í nico
FDA revises description of mental health side effects of the stop-smoking medicines Chantix (varenicline) and Zyban (bupropion) to reflect clinical trial findings (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - January 5, 2017 Category: Drugs & Pharmacology Source Type: news

La FDA revisa la descripci ón de los efectos secundarios para la salud mental de los medicamentos para dejar de fumar Chantix (vareniclina) y Zyban (bupropión) para reflejar las conclusiones de estudio clínico
FDA revises description of mental health side effects of the stop-smoking medicines Chantix (varenicline) and Zyban (bupropion) to reflect clinical trial findings (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - January 5, 2017 Category: Drugs & Pharmacology Source Type: news

FDA Drug Safety Communication: FDA revises description of mental health side effects of the stop-smoking medicines Chantix (varenicline) and Zyban (bupropion) to reflect clinical trial findings
An FDA review found the side effects on mood, behavior, or thinking with the stop-smoking medicines Chantix (varenicline) and Zyban (bupropion) are lower than previously suspected. These risks still exist, but we believe the benefits of quitting smoking outweigh them. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - December 16, 2016 Category: Drugs & Pharmacology Source Type: news

How to Quit Smoking
By Stacy Simon Tobacco use remains the single largest preventable cause of disease and premature death in the United States. Since the release of the Surgeon General’s Report on Smoking and Health 50 years ago, there have been 20 million deaths due to tobacco. Almost half the deaths from 12 different types of cancer combined – including lung, voice box, throat, esophagus, and bladder cancers – are attributable to cigarette smoking alone. In addition to cancer, smoking greatly increases the risk of debilitating long-term lung diseases like emphysema and chronic bronchitis. It also raises the risk for heart...
Source: American Cancer Society :: News and Features - November 16, 2016 Category: Cancer & Oncology Tags: Smoking/Tobacco Source Type: news

Wellbutrin XL (Bupropion Hydrochloride Extended-Release) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - November 14, 2016 Category: Drugs & Pharmacology Source Type: news

Forfivo XL (Bupropion Hydrochloride) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - November 10, 2016 Category: Drugs & Pharmacology Source Type: news

Varenicline and risk of self-harm: a nested case-control study - Tadrous M, Martins D, Yao Z, Mamdani MM, Juurlink DN, Gomes T, Antoniou T.
BACKGROUND: Smoking remains a serious public health concern. Pharmacotherapy for smoking cessation, including bupropion and varenicline, are proven means to increase quit rates. Post-marketing reports describing suicidal behaviours have raised concerns abo... (Source: SafetyLit)
Source: SafetyLit - November 9, 2016 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Orexigen Therapeutics Announces Commercialization and Distributorship Agreement with Valeant for Contrave(R) (naltrexone HCl / bupropion HCl extended release) in Australia and New Zealand
SAN DIEGO, Calif., Nov. 8, 2016 -- (Healthcare Sales & Marketing Network) -- Orexigen Therapeutics, Inc. (OREX) today announced that Valeant Pharmaceuticals International, Inc. (Valeant), through a wholly owned subsidiary, will commercialize Contrave®... Biopharmaceuticals, Distribution Orexigen Therapeutics, Valeant Pharmaceuticals, Contrave, naltrexone, bupropion (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - November 8, 2016 Category: Pharmaceuticals Source Type: news

Seizure due to multiple drugs intoxication: a case report - Gulec H, Babayigit M, Kurtay A, Sahap M, Ulus F, Tutal Z, Horasanli E.
The mechanism of the antidepressant effect of bupropion is not fully understood. Besides, using it in the treatment of depression, it is found to be effective in reducing withdrawal symptoms due to smoking cessation. A 28-year-old female patient with a his... (Source: SafetyLit)
Source: SafetyLit - November 6, 2016 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

UCLA awarded grant to study depression in older adults
More than half of older adults who are treated for depression find that eventually their treatments are no longer effective. When depression persists, these people are at greater risk of accelerated aging, declining mental health and even suicide.To help address this, UCLA and four other institutions have been awarded a $13.9 million grant to evaluate treatment strategies for older adults with depression who have not responded to medications. UCLA psychiatry professor Dr. Helen Lavretsky will serve as principal investigator on this new study.“No more than 30 to 40 percent of people respond to first-line treatments,&r...
Source: UCLA Newsroom: Health Sciences - September 30, 2016 Category: Universities & Medical Training Source Type: news

The relationship between bupropion and suicide in post-mortem investigations - Kriikku P, Ojanper ä I.
We reviewed the 33 727 postmortem toxicology investigations performed in Finland over a period of 5 years (2009-2013) and identified those in which the antidepressant bupropion was detected. Cases positive for other antidepressant drugs were reviewed for c... (Source: SafetyLit)
Source: SafetyLit - September 19, 2016 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

FDA Questions Validity of Smoking Cessation Drug Research FDA Questions Validity of Smoking Cessation Drug Research
The FDA has raised concerns about a postmarketing study that examined adverse neuropsychiatric events associated with smoking cessation drugs varenicline and bupropion.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 13, 2016 Category: Consumer Health News Tags: Psychiatry News Source Type: news

Wellbutrin SR (Bupropion Hydrochloride Sustained-Release) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - September 9, 2016 Category: Drugs & Pharmacology Source Type: news

Weight Loss Pills And Products Don't Work And Aren't Safe
Our ancestors lived in a feast or famine world. When you don't know where your next meal is coming from, or when it will arrive, the smart play is to pig out every time food is available. Our genes are programmed to extract as much energy as possible from what we eat and to store any extra energy in fat reservoirs, available in reserve for future famines. These deeply ingrained genetic tendencies worked great in the austere world of our ancestors, but are a disaster in our current world of refrigerators, ubiquitous fast food joints and milk shakes. Only one third of Americans are now able to maintain a normal weight; one ...
Source: Science - The Huffington Post - September 5, 2016 Category: Science Source Type: news

Bupropion "abuse" reported to US poison centers - Stassinos GL, Klein-Schwartz W.
The objective was to determine the prevalence, characteristics, clinical effects, and outcomes of bupropion "abuse." METHODS: A 14-year retrospective review was conducte... (Source: SafetyLit)
Source: SafetyLit - August 12, 2016 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news